Research Progress of Graft-Versus-Host Disease Following Liver Transplantation_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 MINGYing-zi , YUMeng , SHEXing-guo , NIUYing , ZHUANGQuan ,  LIUHong

Organ Transplantation Center, The Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China;

Corresponding author：

LIUHong, Email: hong804@sohu.com

Keywords：

Liver transplantation; Graft-versus-host disease

DOI：

10.7507/1007-9424.20150380

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate characteristics and research progress of graft-versus-host disease following liver transplantation, and provide guidance for diagnosis and treatment of this disease. Methods The relevant literatures on graft-versus-host disease following liver transplantation were reviewed, and the related articles on the reference of bone marrow transplantation and other solid organ transplantation were summarized. Results The incidence of graft-versus-host disease following liver transplantation was 0.1% to 2%, and the mortality was > 75%. The pathogenesis was not clear, and the diagnosis was based on the clinical symptoms, the histological examination, and the evidence of human leukocyte antigen(HLA) or DNA from donor lymphocytes. There were numerous treatment options, most of which, however, could not work effectively. A unified standard was needed. Conclusions Graft-versus-host disease is a rare complication following liver transplantation, and prognosis is very poor. On one hand, it should be paid more attention to prevention before transplantation, such as the large age gap between donor and recipient, the similarity of HLA matching and so on. On the other hand, it should be strengthened the prevention awareness and actively carry out tissue biopsy, HLA typing, and chimera study. More studies from multiple centers should be carried out to actively explore the criteria for clinical treatment.

Citation： MINGYing-zi, YUMeng, SHEXing-guo, NIUYing, ZHUANGQuan, LIUHong. Research Progress of Graft-Versus-Host Disease Following Liver Transplantation. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(12): 1447-1452. doi: 10.7507/1007-9424.20150380 Copy

1.	Triulzi DJ, Nalesnik MA. Microchimerism, GVHD, and tolerance in solid organ transplantation. Transfusion, 2001, 41(3): 419-426.
2.	Akbulut S, Yilmaz M, Yilmaz S. Graft-versus-host disease after liver transplantation: a comprehensive literature review. World J Gastroenterol, 2012, 18(37): 5240-5248.
3.	Sun B, Zhao C, Xia Y, et al. Late onset of severe graft-versus-host disease following liver transplantation. Transpl Immunol, 2006, 16(3/4): 250-253.
4.	Chaib E, Silva FD, Figueira E, et al. Graft-versus-host disease after liver transplantation. Clinics(Sao Paulo), 2011, 66(6): 1115-1118.
5.	Billingham RE. The biology of graft-versus-host reactions. Harvey Lect, 1966-1967, 62: 21-78.
6.	Starzl TE, Iwatsuki S, Shaw BW, et al. Pancreaticoduodenal transp-lantation in humans. Surg Gynecol Obstet, 1984, 159(3): 265-272.
7.	Burdick JF, Vogelsang GB, Smith WJ, et al. Severe graft-versus-host disease in a liver-transplant recipient. N Engl J Med, 1988, 318(11): 689-691.
8.	Martin PJ. Increased disparity for minor histocompatibility antigensas a potential cause of increased GVHD risk in marrow transplan-tation from unrelated donors compared with related donors. Bone Marrow Transplant, 1991, 8(3): 217-223.
9.	Schlitt HJ, Raddatz G, Steinhoff G, et al. Passenger lymphocytes in human liver allografts and their potential role after transplantation. Transplantation, 1993, 56(4): 951-955.
10.	Rogulj IM, Deeg J, Lee SJ. Acute graft versus host disease after orthotopic liver transplantation. J Hematol Oncol, 2012, 5: 50.
11.	Norris S, Collins C, Doherty DG, et al. Resident human hepatic lymphocytes are phenotypically different from circulating lympho-cytes. J Hepatol, 1998, 28(1): 84-90.
12.	Collins RH, Anastasi J, Terstappen LW, et al. Brief report: donor-derived long-term multilineage hematopoiesis in a liver-transplant recipient. N Engl J Med, 1993, 328(11): 762-765.
13.	Kambham N, Higgins JP, Sundram U, et al. Hematopoietic stem cell transplantation: graft versus host disease and pathology of gastrointestinal tract, liver, and lung. Adv Anat Pathol, 2014, 21(5): 301-320.
14.	Yuksekkaya HA, Arikan C, Tumgor G, et al. Late-onset graft-versus-host disease after pediatric living-related liver transplantation for Langerhans cell histiocytosis. Pediatr Transplant, 2011, 15(6): E105-E109.
15.	Kohler S, Pascher A, Junge G, et al. Graft versus host disease after liver transplantation-a single center experience and review of literature. Transpl Int, 2008, 21(5): 441-451.
16.	Chan EY, Larson AM, Gernsheimer TB, et al. Recipient and donor factors influence the incidence of graft-vs.-host disease in liver transplant patients. Liver Transpl, 2007, 13(4): 516-522.
17.	Thin L, Macquillan G, Adams L, et al. Acute graft-versus-host disease after liver transplant: novel use of etanercept and the role of tumor necrosis factor alpha inhibitors. Liver Transpl, 2009, 15(4): 421-426.
18.	Smith DM, Agura E, Netto G, et al. Liver transplant-associated graft-versus-host disease. Transplantation, 2003, 75(1): 118-126.
19.	Kamei H, Oike F, Fujimoto Y, et al. Fatal graft-versus-host disease after living donor liver transplantation: differential impact of donor-dominant one-way HLA matching. Liver Transpl, 2006, 12(1): 140-145.
20.	Soejima Y, Shimada M, Suehiro T, et al. Graft-versus-host disease following living donor liver transplantation. Liver Transpl, 2004, 10(3): 460-464.
21.	Mawad R, Hsieh A, Damon L. Graft-versus-host disease presenting with pancytopenia after en bloc multiorgan transplantation: case report and literature review. Transplant Proc, 2009, 41(10): 4431-4433.
22.	Guo ZY, He XS, Wu LW, et al. Graft-verse-host disease after liver transplantation: a report of two cases and review of literature. World J Gastroenterol, 2008, 14(6): 974-979.
23.	Schrager JJ, Vnencak-Jones CL, Graber SE, et al. Use of short tandemrepeats for DNA fingerprinting to rapidly diagnose graft-versus-host disease in solid organ transplant patients. Transplantation, 2006, 81(1): 21-25.
24.	Sudhindran S, Taylor A, Delriviere L, et al. Treatment of graft-versus-host disease after liver transplantation with basiliximab followed by bowel resection. Am J Transplant, 2003, 3(8): 1024-1029.
25.	Lehner F, Becker T, Sybrecht L, et al. Successful outcome of acute graft-versus-host disease in a liver allograft recipient by withdrawal of immunosuppression. Transplantation, 2002, 73(2): 307-310.
26.	Schöniger-Hekele M, Müller C, Kramer L, et al. Graft versus host disease after orthotopic liver transplantation documented by analysis of short tandem repeat polymorphisms. Digestion, 2006, 74(3/4): 169-173.
27.	Moody MN, Kazakevich N, Smith JR, et al. Sweat the small stuff: the importance of clinical-pathologic correlation in cutaneous GVHD following orthotopic liver transplant. Arch Dermatol, 2011, 147(11): 1345-1346.
28.	Meves A, El-Azhary RA, Talwalkar JA, et al. Acute graft-versus-host disease after liver transplantation diagnosed by fluorescent in situ hybridization testing of skin biopsy specimens. J Am Acad Dermatol, 2006, 55(4): 642-646.
29.	Taylor AL, Gibbs P, Sudhindran S, et al. Monitoring systemic donor lymphocyte macrochimerism to aid the diagnosis of graft-versus-host disease after liver transplantation. Transplantation, 2004, 77(3): 441-446.
30.	Domiati-Saad R, Klintmalm GB, Netto G, et al. Acute graft versus host disease after liver transplantation: patterns of lymphocyte chimerism. Am J Transplant, 2005, 5(12): 2968-2973.
31.	Kanehira K, Riegert-Johnson DL, Chen D, et al. FISH diagnosis of acute graft-versus-host disease following living-related liver transplant. J Mol Diagn, 2009, 11(4): 355-358.
32.	Wu D, Vu Q, Nguyen A, et al. In situ genetic analysis of cellular chimerism. Nat Med, 2009, 15(2): 215-219.
33.	Wu Z, Shi W. Rash as the first manifestation of acute graft-versus-host disease after orthotopic liver transplantation. Eur J Dermatol, 2012, 21(6): 997-998.
34.	Hahn AB, Baliga P. Rapid method for the analysis of peripheral chimerism in suspected graft-versus-host disease after liver transplantation. Liver Transpl, 2000, 6(2): 180-184.
35.	Whitington PF, Rubin CM, Alonso EM, et al. Complete lymphoid chimerism and chronic graft-versus-host disease in an infant recipient of a hepatic allograft from an HLA-homozygous parental living donor. Transplantation, 1996, 62(10): 1516-1519.
36.	Pinna AD, Weppler D, Berho M, et al. Unusual presentation of graft-versus-host disease in pediatric liver transplant recipients: evidence of late and recurrent disease. Pediatr Transplant, 1999, 3(3): 236-242.
37.	Hanaway MJ, Buell JF, Musat AI, et al. Graft-versus-host disease in solid organ transplantation. Graft(Georget Tex), 2001, 4: 205-208.
38.	Gregoire-Gauthier J, Selleri S, Fontaine F, et al. Therapeutic efficacy of cord blood-derived mesenchymal stromal cells for the prevention of acute graft-versus-host disease in a xenogenic mouse model. Stem Cells Dev, 2012, 21(10): 1616-1626.
39.	Sanchez-Izquierdo JA, Lumbreras C, Colina F, et al. Severe graft versus host disease following liver transplantation confirmed by PCR-HLA-B sequencing: report of a case and literature review. Hepatogastroenterology, 1997, 43(10): 1057-1061.

1. Triulzi DJ, Nalesnik MA. Microchimerism, GVHD, and tolerance in solid organ transplantation. Transfusion, 2001, 41(3): 419-426.
2. Akbulut S, Yilmaz M, Yilmaz S. Graft-versus-host disease after liver transplantation: a comprehensive literature review. World J Gastroenterol, 2012, 18(37): 5240-5248.
3. Sun B, Zhao C, Xia Y, et al. Late onset of severe graft-versus-host disease following liver transplantation. Transpl Immunol, 2006, 16(3/4): 250-253.
4. Chaib E, Silva FD, Figueira E, et al. Graft-versus-host disease after liver transplantation. Clinics(Sao Paulo), 2011, 66(6): 1115-1118.
5. Billingham RE. The biology of graft-versus-host reactions. Harvey Lect, 1966-1967, 62: 21-78.
6. Starzl TE, Iwatsuki S, Shaw BW, et al. Pancreaticoduodenal transp-lantation in humans. Surg Gynecol Obstet, 1984, 159(3): 265-272.
7. Burdick JF, Vogelsang GB, Smith WJ, et al. Severe graft-versus-host disease in a liver-transplant recipient. N Engl J Med, 1988, 318(11): 689-691.
8. Martin PJ. Increased disparity for minor histocompatibility antigensas a potential cause of increased GVHD risk in marrow transplan-tation from unrelated donors compared with related donors. Bone Marrow Transplant, 1991, 8(3): 217-223.
9. Schlitt HJ, Raddatz G, Steinhoff G, et al. Passenger lymphocytes in human liver allografts and their potential role after transplantation. Transplantation, 1993, 56(4): 951-955.
10. Rogulj IM, Deeg J, Lee SJ. Acute graft versus host disease after orthotopic liver transplantation. J Hematol Oncol, 2012, 5: 50.
11. Norris S, Collins C, Doherty DG, et al. Resident human hepatic lymphocytes are phenotypically different from circulating lympho-cytes. J Hepatol, 1998, 28(1): 84-90.
12. Collins RH, Anastasi J, Terstappen LW, et al. Brief report: donor-derived long-term multilineage hematopoiesis in a liver-transplant recipient. N Engl J Med, 1993, 328(11): 762-765.
13. Kambham N, Higgins JP, Sundram U, et al. Hematopoietic stem cell transplantation: graft versus host disease and pathology of gastrointestinal tract, liver, and lung. Adv Anat Pathol, 2014, 21(5): 301-320.
14. Yuksekkaya HA, Arikan C, Tumgor G, et al. Late-onset graft-versus-host disease after pediatric living-related liver transplantation for Langerhans cell histiocytosis. Pediatr Transplant, 2011, 15(6): E105-E109.
15. Kohler S, Pascher A, Junge G, et al. Graft versus host disease after liver transplantation-a single center experience and review of literature. Transpl Int, 2008, 21(5): 441-451.
16. Chan EY, Larson AM, Gernsheimer TB, et al. Recipient and donor factors influence the incidence of graft-vs.-host disease in liver transplant patients. Liver Transpl, 2007, 13(4): 516-522.
17. Thin L, Macquillan G, Adams L, et al. Acute graft-versus-host disease after liver transplant: novel use of etanercept and the role of tumor necrosis factor alpha inhibitors. Liver Transpl, 2009, 15(4): 421-426.
18. Smith DM, Agura E, Netto G, et al. Liver transplant-associated graft-versus-host disease. Transplantation, 2003, 75(1): 118-126.
19. Kamei H, Oike F, Fujimoto Y, et al. Fatal graft-versus-host disease after living donor liver transplantation: differential impact of donor-dominant one-way HLA matching. Liver Transpl, 2006, 12(1): 140-145.
20. Soejima Y, Shimada M, Suehiro T, et al. Graft-versus-host disease following living donor liver transplantation. Liver Transpl, 2004, 10(3): 460-464.
21. Mawad R, Hsieh A, Damon L. Graft-versus-host disease presenting with pancytopenia after en bloc multiorgan transplantation: case report and literature review. Transplant Proc, 2009, 41(10): 4431-4433.
22. Guo ZY, He XS, Wu LW, et al. Graft-verse-host disease after liver transplantation: a report of two cases and review of literature. World J Gastroenterol, 2008, 14(6): 974-979.
23. Schrager JJ, Vnencak-Jones CL, Graber SE, et al. Use of short tandemrepeats for DNA fingerprinting to rapidly diagnose graft-versus-host disease in solid organ transplant patients. Transplantation, 2006, 81(1): 21-25.
24. Sudhindran S, Taylor A, Delriviere L, et al. Treatment of graft-versus-host disease after liver transplantation with basiliximab followed by bowel resection. Am J Transplant, 2003, 3(8): 1024-1029.
25. Lehner F, Becker T, Sybrecht L, et al. Successful outcome of acute graft-versus-host disease in a liver allograft recipient by withdrawal of immunosuppression. Transplantation, 2002, 73(2): 307-310.
26. Schöniger-Hekele M, Müller C, Kramer L, et al. Graft versus host disease after orthotopic liver transplantation documented by analysis of short tandem repeat polymorphisms. Digestion, 2006, 74(3/4): 169-173.
27. Moody MN, Kazakevich N, Smith JR, et al. Sweat the small stuff: the importance of clinical-pathologic correlation in cutaneous GVHD following orthotopic liver transplant. Arch Dermatol, 2011, 147(11): 1345-1346.
28. Meves A, El-Azhary RA, Talwalkar JA, et al. Acute graft-versus-host disease after liver transplantation diagnosed by fluorescent in situ hybridization testing of skin biopsy specimens. J Am Acad Dermatol, 2006, 55(4): 642-646.
29. Taylor AL, Gibbs P, Sudhindran S, et al. Monitoring systemic donor lymphocyte macrochimerism to aid the diagnosis of graft-versus-host disease after liver transplantation. Transplantation, 2004, 77(3): 441-446.
30. Domiati-Saad R, Klintmalm GB, Netto G, et al. Acute graft versus host disease after liver transplantation: patterns of lymphocyte chimerism. Am J Transplant, 2005, 5(12): 2968-2973.
31. Kanehira K, Riegert-Johnson DL, Chen D, et al. FISH diagnosis of acute graft-versus-host disease following living-related liver transplant. J Mol Diagn, 2009, 11(4): 355-358.
32. Wu D, Vu Q, Nguyen A, et al. In situ genetic analysis of cellular chimerism. Nat Med, 2009, 15(2): 215-219.
33. Wu Z, Shi W. Rash as the first manifestation of acute graft-versus-host disease after orthotopic liver transplantation. Eur J Dermatol, 2012, 21(6): 997-998.
34. Hahn AB, Baliga P. Rapid method for the analysis of peripheral chimerism in suspected graft-versus-host disease after liver transplantation. Liver Transpl, 2000, 6(2): 180-184.
35. Whitington PF, Rubin CM, Alonso EM, et al. Complete lymphoid chimerism and chronic graft-versus-host disease in an infant recipient of a hepatic allograft from an HLA-homozygous parental living donor. Transplantation, 1996, 62(10): 1516-1519.
36. Pinna AD, Weppler D, Berho M, et al. Unusual presentation of graft-versus-host disease in pediatric liver transplant recipients: evidence of late and recurrent disease. Pediatr Transplant, 1999, 3(3): 236-242.
37. Hanaway MJ, Buell JF, Musat AI, et al. Graft-versus-host disease in solid organ transplantation. Graft(Georget Tex), 2001, 4: 205-208.
38. Gregoire-Gauthier J, Selleri S, Fontaine F, et al. Therapeutic efficacy of cord blood-derived mesenchymal stromal cells for the prevention of acute graft-versus-host disease in a xenogenic mouse model. Stem Cells Dev, 2012, 21(10): 1616-1626.
39. Sanchez-Izquierdo JA, Lumbreras C, Colina F, et al. Severe graft versus host disease following liver transplantation confirmed by PCR-HLA-B sequencing: report of a case and literature review. Hepatogastroenterology, 1997, 43(10): 1057-1061.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research Progress of Graft-Versus-Host Disease Following Liver Transplantation

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content