Research Progress of Autophagy on Regulation of Energy Metabolism in Tumor Cells_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YANGZhao-guo , ZHANGXiao-dong , TANGShi-lei ,  LIHang-yu.

Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China;

Corresponding author：

LIHang-yu., Email: li_hangyu@126.com

Keywords：

Autophagy; Energy metabolism; Tumor

DOI：

10.7507/1007-9424.20150397

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the latest research progress of autophagy on regulation of tumor energy metabolism. Method The latest research progresses of the regulation mechanism of autophagy on the energy metabolism of tumor cells and the influence on the biologic behavior of tumor in recent years were reviewed. Result The autophagy could affect the biological behavior of the tumor by influence of the tumor cell glucose uptake, glycolysis, oxidative phosphorylation, lipid metabolism, and amino acid metabolism. Conclusions The regulation of autophagy on tumor energy metabolism provides a theoretical basis for the survival mechanism of tumor under the stress condition. What's more, to research the mechanism of autophagy on regulation of energy metabolism and the effect on tumor biologic behavior will contribute to the development of new and more effective personalized anticancer therapy. As far as the research progress about tumor cells energy metabolism regulated by autophagy, what we must be revealed is whether other factors including oncogene, anti-oncogene, and signaling pathways take part in this regulation and what influence would be on the biological behavior of different tumors.

Citation： YANGZhao-guo, ZHANGXiao-dong, TANGShi-lei, LIHang-yu.. Research Progress of Autophagy on Regulation of Energy Metabolism in Tumor Cells. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(12): 1525-1529. doi: 10.7507/1007-9424.20150397 Copy

1.	Jiang P, Mizushima N. Autophagy and human diseases. Cell Res, 2014, 24(1): 69-79.
2.	Rinchai D, Riyapa D, Buddhisa S, et al. Macroautophagy is essential for killing of intracellular Burkholderia pseudomallei in human neutrophils. Autophagy, 2015, 11(5): 748-755.
3.	Li WW, Li J, Bao JK. Microautophagy: lesser-known self-eating. Cell Mol Life Sci, 2012, 69(7): 1125-1136.
4.	Cuervo AM, Wong E. Chaperone-mediated autophagy: roles in disease and aging. Cell Res, 2014, 24(1): 92-104.
5.	De Meyer GR, Grootaert MO, Michiels CF, et al. Autophagy in vascular disease. Circ Res, 2015, 116(3): 468-479.
6.	Ryter SW, Choi AM. Autophagy in lung disease pathogenesis and therapeutics. Redox Biol, 2015, 4: 215-225.
7.	Ghavami S, Gupta S, Ambrose E, et al. Autophagy and heart disease: implications for cardiac ischemia-reperfusion damage. Curr Mol Med, 2014, 14(5): 616-629.
8.	Hashimoto D, Bläuer M, Hirota M, et al. Autophagy is needed for the growth of pancreatic adenocarcinoma and has a cytoprotective effect against anticancer drugs. Eur J Cancer, 2014, 50(7): 1382-1390.
9.	Song L, Liu H, Ma L, et al. Inhibition of autophagy by 3-MA enhances endoplasmic reticulum stress-induced apoptosis in human nasop-haryngeal carcinoma cells. Oncol Lett, 2013, 6(4): 1031-1038.
10.	Li J, Yang B, Zhou Q, et al. Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial-mesench-ymal transition. Carcinogenesis, 2013, 34(6): 1343-1351.
11.	Dang CV. Links between metabolism and cancer. Genes Dev, 2012, 26(9): 877-890.
12.	Jiang X, Overholtzer M, Thompson CB. Autophagy in cellular metabolism and cancer. J Clin Invest, 2015, 125(1): 47-54.
13.	Goldsmith J, Levine B, Debnath J. Autophagy and cancer metabolism. Methods Enzymol, 2014, 542: 25-57.
14.	Guo JY, Karsli-Uzunbas G, Mathew R, et al. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev, 2013, 27(13): 1447-1461.
15.	Strohecker AM, Guo JY, Karsli-Uzunbas G, et al. Autophagy sustains mitochondrial glutamine metabolism and growth of Braf(V600E)-driven lung tumors. Cancer Discov, 2013, 3(11): 1272-1285.
16.	Elf SE, Chen J. Targeting glucose metabolism in patients with cancer. Cancer, 2014, 120(6): 774-780.
17.	Lock R, Roy S, Kenific CM, et al. Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol Biol Cell, 2011, 22(2): 165-178.
18.	Parkhitko AA, Priolo C, Coloff JL, et al. Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. Mol Cancer Res, 2014, 12(1): 48-57.
19.	Lv L, Li D, Zhao D, et al. Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell, 2011, 42(6): 719-730.
20.	Zhao D, Zou SW, Liu Y, et al. Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer. Cancer Cell, 2013, 23(4): 464-476.
21.	Lin G, Andrejeva G, Wong Te Fong AC, et al. Reduced warburg effect in cancer cells undergoing autophagy: steady-state 1H-MRS and real-time hyperpolarized 13C-MRS studies. PLoS One, 2014, 9(3): e92645.
22.	Guo JY, Chen HY, Mathew R, et al. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev, 2011, 25(5): 460-470.
23.	Martinez-Outschoorn UE, Lisanti MP, Sotgia F. Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth. Semin Cancer Biol, 2014, 25: 47-60.
24.	Xu CF, Liu Y, Shen S, et al. Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy. Biomaterials, 2015, 51: 1-11.
25.	Morani F, Phadngam S, Follo C, et al. PTEN regulates plasma membrane expression of glucose transporter 1 and glucose uptake in thyroid cancer cells. J Mol Endocrinol, 2014, 53(2): 247-258.
26.	Ciavardelli D, Rossi C, Barcaroli D, et al. Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment. Cell Death Dis, 2014, 5: e1336.
27.	Maiuri MC, Kroemer G. Essential role for oxidative phosphoryla-tion in cancer progression. Cell Metab, 2015, 21(1): 11-12.
28.	Zheng J. Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation(Review). Oncol Lett, 2012, 4(6): 1151-1157.
29.	Toshima T, Shirabe K, Matsumoto Y, et al. Autophagy enhances hepatocellular carcinoma progression by activation of mitochondrialβ-oxidation. J Gastroenterol, 2014, 49(5): 907-916.
30.	Walter KM, Schönenberger MJ, Trötzmüller M, et al. HIF-2αpromotes degradation of mammalian peroxisomes by selective autophagy. Cell Metab, 2014, 20(5): 882-897.
31.	Lin TC, Chen YR, Kensicki E, et al. Autophagy: resetting glutamine-dependent metabolism and oxygen consumption. Autophagy, 2012, 8(10): 1477-1493.
32.	Kim S, Kim do H, Jung WH, et al. Metabolic phenotypes in triple-negative breast cancer. Tumour Biol, 2013, 34(3): 1699-1712.
33.	Whitaker-Menezes D, Martinez-Outschoorn UE, Lin Z, et al. Evidence for a stromal-epithelial "lactate shuttle" in human tumors:MCT4 is a marker of oxidative stress in cancer-associated fibrob-lasts. Cell Cycle, 2011, 10(11): 1772-1783.
34.	Sonveaux P, Vegran F, Schroeder T, et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest, 2008, 118(12): 3930-3942.
35.	Strohecker AM, White E. Targeting mitochondrial metabolism by inhibiting autophagy in BRAF-driven cancers. Cancer Discov, 2014, 4(7): 766-772.
36.	Li Z, Zhu WG. Targeting histone deacetylases for cancer therapy: from molecular mechanisms to clinical implications. Int J Biol Sci, 2014, 10(7): 757-770.

1. Jiang P, Mizushima N. Autophagy and human diseases. Cell Res, 2014, 24(1): 69-79.
2. Rinchai D, Riyapa D, Buddhisa S, et al. Macroautophagy is essential for killing of intracellular Burkholderia pseudomallei in human neutrophils. Autophagy, 2015, 11(5): 748-755.
3. Li WW, Li J, Bao JK. Microautophagy: lesser-known self-eating. Cell Mol Life Sci, 2012, 69(7): 1125-1136.
4. Cuervo AM, Wong E. Chaperone-mediated autophagy: roles in disease and aging. Cell Res, 2014, 24(1): 92-104.
5. De Meyer GR, Grootaert MO, Michiels CF, et al. Autophagy in vascular disease. Circ Res, 2015, 116(3): 468-479.
6. Ryter SW, Choi AM. Autophagy in lung disease pathogenesis and therapeutics. Redox Biol, 2015, 4: 215-225.
7. Ghavami S, Gupta S, Ambrose E, et al. Autophagy and heart disease: implications for cardiac ischemia-reperfusion damage. Curr Mol Med, 2014, 14(5): 616-629.
8. Hashimoto D, Bläuer M, Hirota M, et al. Autophagy is needed for the growth of pancreatic adenocarcinoma and has a cytoprotective effect against anticancer drugs. Eur J Cancer, 2014, 50(7): 1382-1390.
9. Song L, Liu H, Ma L, et al. Inhibition of autophagy by 3-MA enhances endoplasmic reticulum stress-induced apoptosis in human nasop-haryngeal carcinoma cells. Oncol Lett, 2013, 6(4): 1031-1038.
10. Li J, Yang B, Zhou Q, et al. Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial-mesench-ymal transition. Carcinogenesis, 2013, 34(6): 1343-1351.
11. Dang CV. Links between metabolism and cancer. Genes Dev, 2012, 26(9): 877-890.
12. Jiang X, Overholtzer M, Thompson CB. Autophagy in cellular metabolism and cancer. J Clin Invest, 2015, 125(1): 47-54.
13. Goldsmith J, Levine B, Debnath J. Autophagy and cancer metabolism. Methods Enzymol, 2014, 542: 25-57.
14. Guo JY, Karsli-Uzunbas G, Mathew R, et al. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev, 2013, 27(13): 1447-1461.
15. Strohecker AM, Guo JY, Karsli-Uzunbas G, et al. Autophagy sustains mitochondrial glutamine metabolism and growth of Braf(V600E)-driven lung tumors. Cancer Discov, 2013, 3(11): 1272-1285.
16. Elf SE, Chen J. Targeting glucose metabolism in patients with cancer. Cancer, 2014, 120(6): 774-780.
17. Lock R, Roy S, Kenific CM, et al. Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol Biol Cell, 2011, 22(2): 165-178.
18. Parkhitko AA, Priolo C, Coloff JL, et al. Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. Mol Cancer Res, 2014, 12(1): 48-57.
19. Lv L, Li D, Zhao D, et al. Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell, 2011, 42(6): 719-730.
20. Zhao D, Zou SW, Liu Y, et al. Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer. Cancer Cell, 2013, 23(4): 464-476.
21. Lin G, Andrejeva G, Wong Te Fong AC, et al. Reduced warburg effect in cancer cells undergoing autophagy: steady-state 1H-MRS and real-time hyperpolarized 13C-MRS studies. PLoS One, 2014, 9(3): e92645.
22. Guo JY, Chen HY, Mathew R, et al. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev, 2011, 25(5): 460-470.
23. Martinez-Outschoorn UE, Lisanti MP, Sotgia F. Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth. Semin Cancer Biol, 2014, 25: 47-60.
24. Xu CF, Liu Y, Shen S, et al. Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy. Biomaterials, 2015, 51: 1-11.
25. Morani F, Phadngam S, Follo C, et al. PTEN regulates plasma membrane expression of glucose transporter 1 and glucose uptake in thyroid cancer cells. J Mol Endocrinol, 2014, 53(2): 247-258.
26. Ciavardelli D, Rossi C, Barcaroli D, et al. Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment. Cell Death Dis, 2014, 5: e1336.
27. Maiuri MC, Kroemer G. Essential role for oxidative phosphoryla-tion in cancer progression. Cell Metab, 2015, 21(1): 11-12.
28. Zheng J. Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation(Review). Oncol Lett, 2012, 4(6): 1151-1157.
29. Toshima T, Shirabe K, Matsumoto Y, et al. Autophagy enhances hepatocellular carcinoma progression by activation of mitochondrialβ-oxidation. J Gastroenterol, 2014, 49(5): 907-916.
30. Walter KM, Schönenberger MJ, Trötzmüller M, et al. HIF-2αpromotes degradation of mammalian peroxisomes by selective autophagy. Cell Metab, 2014, 20(5): 882-897.
31. Lin TC, Chen YR, Kensicki E, et al. Autophagy: resetting glutamine-dependent metabolism and oxygen consumption. Autophagy, 2012, 8(10): 1477-1493.
32. Kim S, Kim do H, Jung WH, et al. Metabolic phenotypes in triple-negative breast cancer. Tumour Biol, 2013, 34(3): 1699-1712.
33. Whitaker-Menezes D, Martinez-Outschoorn UE, Lin Z, et al. Evidence for a stromal-epithelial "lactate shuttle" in human tumors:MCT4 is a marker of oxidative stress in cancer-associated fibrob-lasts. Cell Cycle, 2011, 10(11): 1772-1783.
34. Sonveaux P, Vegran F, Schroeder T, et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest, 2008, 118(12): 3930-3942.
35. Strohecker AM, White E. Targeting mitochondrial metabolism by inhibiting autophagy in BRAF-driven cancers. Cancer Discov, 2014, 4(7): 766-772.
36. Li Z, Zhu WG. Targeting histone deacetylases for cancer therapy: from molecular mechanisms to clinical implications. Int J Biol Sci, 2014, 10(7): 757-770.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research Progress of Autophagy on Regulation of Energy Metabolism in Tumor Cells

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