The Role of Preoperative Evaluation of Serum Tumor Markers in Gastric Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 ZHOULin , WANGHuan ,  LIANGDao-ming , WANBao-sheng , WANGHua , SUNFeng

Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China;

Corresponding author：

LIANGDao-ming, Email: daoming-liang@sina.cn

Keywords：

Gastric Cancer; Tumor marker; Preoperative staging

DOI：

10.7507/1007-9424.20160113

Video：

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Objective To study the preoperative evaluation value of serum tumor markers (CA72-4, CEA, CA199 and CA125) in patients with gastric cancer. Methods Serum levels of tumor markers (CA72-4, CEA, CA199 and CA125) and clinical pathological data of 70 patients with gastric cancer before operation who underwent surgical treatment in the Gastrointestinal Surgery Department of Second Affiliated Hospital of Kunming Medical University in June 2013 to 2014 June were retrospectively analyzed. Results There were some connection between the concentration of the serum CA72-4 and the tumor diameter, TNM staging, invasion depth, and the number of lymph node metastasis (P < 0.05), between CA199 and tumor size, TNM staging, and invasion depth (P < 0.05), between CEA, CA125 and tumor diameter, TNM staging and distant metastasis (P < 0.05), but the CA72-4, CA72-4, CEA and CA125 had nothing to do with patient' age and gender. Conclusion The serum tumor markers of CA724, CEA, CA199, and CA125 have clinical application value in preoperative evaluation of gastric cancer.

Citation： ZHOULin, WANGHuan, LIANGDao-ming, WANBao-sheng, WANGHua, SUNFeng. The Role of Preoperative Evaluation of Serum Tumor Markers in Gastric Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(4): 425-428. doi: 10.7507/1007-9424.20160113 Copy

1.	Choi SR, Jang JS, Lee JH, et al. Role of serum tumor markers in moni toring for recurrence of gastric cancer following radical gastrectomy. Dig Dis Sci, 2006, 51(11): 2081-2086.
2.	刘英强, 姬社青, 龚建平, 等.多层螺旋CT在胃癌术前分期及评估中的应用价值.中华实用诊断与治疗杂志, 2010, 24(4): 364-367.
3.	杨小波, 邹亮, 章园.肿瘤标志物在胃癌治疗及预后判断应用中的研究进展.中国普通外科杂志, 2013, 22(10): 1334-1337.
4.	王洋, 王欢, 莫佳美, 等.血清肿瘤标志物在胃癌诊断中的价值.现代肿瘤医学, 2014, 22(4): 883-885.
5.	张金锋.血清胃蛋白酶原、CEA、CA199及CA72-4检测对胃癌的诊断价值探讨.检验医学, 2014, (8): 831-834．.
6.	张军华, 李中.联合检测血清CEA、CA199、CA50、CA72-4水平对胃癌的临床诊断价值.实用临床医药杂志, 2014, 18(5): 1-3．.
7.	金秀颖, 孙红花, 金永民, 等.联合检测CEA、CA199在D2胃癌术后随访中的价值.现代肿瘤医学, 2014, 22(6): 1360-1362．.
8.	Fernandes LL, Martins LC, Nagashime CA, et al. CA72-4 antigen levels in serum and peritoneal washing in gastric cancer:Correla tion with morphological aspects of neoplasia. Arq Gastroenterol, 2007, 44(3): 235-239．.
9.	Zou L, Qian J. Decline of serum CA72-4 as aprobable predictive factor for tumor response during chemotherapy of advanced gastric carcinoma. Chin J Cancer Res, 2014, 26(4): 404-409.
10.	盛卫忠, 张延伟, 张轶斌.血清CA72-4、CA19-9及CEA免疫放射量度分析在胃癌诊治中的意义.上海医科大学学报, 2000, 27(2): 94-97.
11.	郭花, 朱金水, 朱励, 等.肿瘤标志物对胃癌诊断应用价值的比较.中国临床医学, 2009, 16(3): 369-371.
12.	Ubukata H, Katano M, Motohashi G, et al. Evaluation of CA72-4 as a tumor marker in patients with gastric cancer. Gan To Kagaku Ryoho, 2003, 30(11): 1821-1824．.
13.	Mattar R, Andrade CR, Difavero GM, et al. Preoperative serum levels of CA 72-4, CEA, CA 19-9 and alpha-fetoprotein in patients with gastric cancer. Rev Hosp Clin Fac Med Sao Paulo, 2002, 57(3): 89-92.
14.	Ikeguchi M, Katano K, Saitou H, et al. Pre-operative serum levels of CA72-4 in patientswith gastric adenocarcinoma. Hepatogastroen terology, 1997, 44(15): 866-871.
15.	Kanellos I, Zacharakis E, Kanellos D, et al. Prognositic significance of CEA levels and detection of CEAmRNA in draining venous blood in patients with colorectal cancer. Surg Oncol, 2006, 94(1): 3-8.
16.	Miyazono F, Natsugoe S, Takao S, et al. Surgical maneuvers enhance molecular detection of circulating tumor cells during gastric cancer surgery. Ann Surg, 2001, 233(2): 189-194.
17.	Ikeda Y, Mori M, Kajiyama K, et al. Indicative value of carcinoem bryonic antigen (CEA) for liver recurrence following curative resec tion of stageⅡandⅢgastric cancer. Hepatogastroenterology, 1996, 43(11): 1281-1287.
18.	张永乐, 薛英威, 蓝秀文, 等.肿瘤标记物CAl99、CEA对胃癌转移和预后预测价值的分析.哈尔滨医科大学学报, 2010, 44(2):181-184．.
19.	Pectasides D, Myloanlakis A, Kostopouiou M, et al. CEA, CA19-9 and CA-50 in monitoring gastric carcinoma. Am J Clin Oncol, 1997, 20(4): 348-353.
20.	Kochi M, Fuji M, Kanamor N, et al. Evalution of serum CEA and CA19-9 levels as prognostic factors in patients with gastric cancer. GastricCancer, 2003, 3(4): 177-186.
21.	李岩.血清胃癌肿瘤标志物的临床价值.继续医学教育, 2006, 20(3): 58-63.
22.	Yang SH. Risk factors for peritoneal dissemination of colorectal cancer. Surg Oncol, 2004, 87(4):167-173.
23.	Takahashi Y. Gastrointestinal cancer. Gan To Kagaku Ryoho, 2004, 31(8): 1275-1279．.
24.	张燕华, 李雁, 陈创, 等.多种肿瘤标志物与胃癌进展及预后的关系.武汉大学学报:医学版, 2009, 30(4): 455-462．.
25.	Lai IR, Lee WJ, Huang MT, et al. Comparison of serumCA72-4, CEA, TPA, CAl9-9 and CAl25 levels in gastric cancer patients and correlation with recurrence. Hepatogastroenterology, 2002, 49(46): 1157-1160．.
26.	余志金, 陈惠新, 彭晓峰, 等.多种肿瘤标志物联合监测胃癌术后复发.现代临床医学, 2013, 39(5): 354-356.
27.	周鹏, 曲辉, 史惠文, 等.血清糖类抗原125对胃癌腹膜转移及其预后的预测价值.中华胃肠外科杂志, 2014, 17(10): 1027-1030.

1. Choi SR, Jang JS, Lee JH, et al. Role of serum tumor markers in moni toring for recurrence of gastric cancer following radical gastrectomy. Dig Dis Sci, 2006, 51(11): 2081-2086.
2. 刘英强, 姬社青, 龚建平, 等.多层螺旋CT在胃癌术前分期及评估中的应用价值.中华实用诊断与治疗杂志, 2010, 24(4): 364-367.
3. 杨小波, 邹亮, 章园.肿瘤标志物在胃癌治疗及预后判断应用中的研究进展.中国普通外科杂志, 2013, 22(10): 1334-1337.
4. 王洋, 王欢, 莫佳美, 等.血清肿瘤标志物在胃癌诊断中的价值.现代肿瘤医学, 2014, 22(4): 883-885.
5. 张金锋.血清胃蛋白酶原、CEA、CA199及CA72-4检测对胃癌的诊断价值探讨.检验医学, 2014, (8): 831-834．.
6. 张军华, 李中.联合检测血清CEA、CA199、CA50、CA72-4水平对胃癌的临床诊断价值.实用临床医药杂志, 2014, 18(5): 1-3．.
7. 金秀颖, 孙红花, 金永民, 等.联合检测CEA、CA199在D2胃癌术后随访中的价值.现代肿瘤医学, 2014, 22(6): 1360-1362．.
8. Fernandes LL, Martins LC, Nagashime CA, et al. CA72-4 antigen levels in serum and peritoneal washing in gastric cancer:Correla tion with morphological aspects of neoplasia. Arq Gastroenterol, 2007, 44(3): 235-239．.
9. Zou L, Qian J. Decline of serum CA72-4 as aprobable predictive factor for tumor response during chemotherapy of advanced gastric carcinoma. Chin J Cancer Res, 2014, 26(4): 404-409.
10. 盛卫忠, 张延伟, 张轶斌.血清CA72-4、CA19-9及CEA免疫放射量度分析在胃癌诊治中的意义.上海医科大学学报, 2000, 27(2): 94-97.
11. 郭花, 朱金水, 朱励, 等.肿瘤标志物对胃癌诊断应用价值的比较.中国临床医学, 2009, 16(3): 369-371.
12. Ubukata H, Katano M, Motohashi G, et al. Evaluation of CA72-4 as a tumor marker in patients with gastric cancer. Gan To Kagaku Ryoho, 2003, 30(11): 1821-1824．.
13. Mattar R, Andrade CR, Difavero GM, et al. Preoperative serum levels of CA 72-4, CEA, CA 19-9 and alpha-fetoprotein in patients with gastric cancer. Rev Hosp Clin Fac Med Sao Paulo, 2002, 57(3): 89-92.
14. Ikeguchi M, Katano K, Saitou H, et al. Pre-operative serum levels of CA72-4 in patientswith gastric adenocarcinoma. Hepatogastroen terology, 1997, 44(15): 866-871.
15. Kanellos I, Zacharakis E, Kanellos D, et al. Prognositic significance of CEA levels and detection of CEAmRNA in draining venous blood in patients with colorectal cancer. Surg Oncol, 2006, 94(1): 3-8.
16. Miyazono F, Natsugoe S, Takao S, et al. Surgical maneuvers enhance molecular detection of circulating tumor cells during gastric cancer surgery. Ann Surg, 2001, 233(2): 189-194.
17. Ikeda Y, Mori M, Kajiyama K, et al. Indicative value of carcinoem bryonic antigen (CEA) for liver recurrence following curative resec tion of stageⅡandⅢgastric cancer. Hepatogastroenterology, 1996, 43(11): 1281-1287.
18. 张永乐, 薛英威, 蓝秀文, 等.肿瘤标记物CAl99、CEA对胃癌转移和预后预测价值的分析.哈尔滨医科大学学报, 2010, 44(2):181-184．.
19. Pectasides D, Myloanlakis A, Kostopouiou M, et al. CEA, CA19-9 and CA-50 in monitoring gastric carcinoma. Am J Clin Oncol, 1997, 20(4): 348-353.
20. Kochi M, Fuji M, Kanamor N, et al. Evalution of serum CEA and CA19-9 levels as prognostic factors in patients with gastric cancer. GastricCancer, 2003, 3(4): 177-186.
21. 李岩.血清胃癌肿瘤标志物的临床价值.继续医学教育, 2006, 20(3): 58-63.
22. Yang SH. Risk factors for peritoneal dissemination of colorectal cancer. Surg Oncol, 2004, 87(4):167-173.
23. Takahashi Y. Gastrointestinal cancer. Gan To Kagaku Ryoho, 2004, 31(8): 1275-1279．.
24. 张燕华, 李雁, 陈创, 等.多种肿瘤标志物与胃癌进展及预后的关系.武汉大学学报:医学版, 2009, 30(4): 455-462．.
25. Lai IR, Lee WJ, Huang MT, et al. Comparison of serumCA72-4, CEA, TPA, CAl9-9 and CAl25 levels in gastric cancer patients and correlation with recurrence. Hepatogastroenterology, 2002, 49(46): 1157-1160．.
26. 余志金, 陈惠新, 彭晓峰, 等.多种肿瘤标志物联合监测胃癌术后复发.现代临床医学, 2013, 39(5): 354-356.
27. 周鹏, 曲辉, 史惠文, 等.血清糖类抗原125对胃癌腹膜转移及其预后的预测价值.中华胃肠外科杂志, 2014, 17(10): 1027-1030.

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The Role of Preoperative Evaluation of Serum Tumor Markers in Gastric Cancer

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