The Role of MiRNA in Gastric Cancer Progression_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 DUYa-qiong , JIANGBo-jian ,  YUJi-wei

The First Department of General Surgery, Ninth People's Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 201900, China;

Corresponding author：

YUJi-wei, Email: jenniferyu919@126.com

Keywords：

MiRNAs; Gastric cancer; Tumorigenesis and development

DOI：

10.7507/1007-9424.20160132

Video：

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Objective To summarize the recent years' researches of the role of microRNAs (miRNAs) in gastric cancer. Methods Domestic and international publications related to miRNAs biological functions and its role in gastric cancer in recent years were collected and reviewed. Results MiRNAs are binded to some target mRNAs which are related to gastric cancer, then result in these mRNAs silence and target-genes abnormal expression. Conciusions MiRNAs play a crucial role in tumorigenesis and development of gastric cancer, and act as a oncogene or anti-oncogene in gastric cancer.

Citation： DUYa-qiong, JIANGBo-jian, YUJi-wei. The Role of MiRNA in Gastric Cancer Progression. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(4): 499-502. doi: 10.7507/1007-9424.20160132 Copy

1.	Bray F, Jemal A, Grey N, et al. Global cancer transitions according to the Human Development Index (2008-2030): a population-based study. Lancet Oncol, 2012, 13(8): 790-801.
2.	Hamano S, Mori Y, Aoyama M, et al. Oncolytic reovirus combined with trastuzumab enhances antitumor efficacy through TRAIL signaling in human HER2-positive gastric cancer cells. Cancer Lett, 2015, 356(2 Pt B): 846-854.
3.	Zhao Y, Huang J, Zhang L, et al. MiR-133b is frequently decreased in gastric cancer and its overexpression reduces the metastatic potential of gastric cancer cells. BMC Cancer, 2014, 14: 34.
4.	Betel D, Wilson M, Gabow A, et al. The microRNA.org resource: targets and expression. Nucleic Acids Res, 2008, 36(Database issue): D149-153.
5.	Tong F, Cao P, Yin Y, et al. MicroRNAs in gastric cancer: from benchtop to bedside. Dig Dis Sci, 2014, 59(1): 24-30.
6.	Winter J, Jung S, Keller S, et al. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol, 2009, 11(3): 228-234.
7.	Esquela-Kerscher A, Slack FJ. Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer, 2006, 6(4): 259-269.
8.	Ma J, Hong L, Chen Z, et al. Epigenetic regulation of microRNAs in gastric cancer. Dig Dis Sci, 2014, 59(4): 716-723.
9.	Hayashi Y, Tsujii M, Wang J, et al. CagA mediates epigenetic regulation to attenuate let-7 expression in Helicobacter pylori-related carcinogenesis. Gut, 2013, 62(11): 1536-1546.
10.	Liu J, Wang X, Yang X, et al. miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells. Cancer Lett, 2014, 347(1): 98-104.
11.	Cheng Y, Li Y, Liu D, et al. miR-137 effects on gastric carcinogenesis are mediated by targeting Cox-2-activated PI3K/AKT signaling pathway. FEBS Lett, 2014, 588(17): 3274-3281.
12.	Fan C, Liu S, Zhao Y, et al. Upregulation of miR-370 contributes to the progression of gastric carcinoma via suppression of FOXO1. Biomed Pharmacother, 2013, 67(6): 521-526.
13.	Li W, Jin X, Deng X, et al. The putative tumor suppressor microRNA-497 modulates gastric cancer cell proliferation and invasion by repressing eIF4E. Biochem Biophys Res Commun, 2014, 449(2): 235-240.
14.	Zhao X, Dou W, He L, et al. MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor. Oncogene, 2013, 32(11): 1363-1372.
15.	Kong D, Piao YS, Yamashita S, et al. Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells. Oncogene. 2012, 31(35): 3949-3960.
16.	Yu N, Huangyang P, Yang X, et al. microRNA-7 suppresses the invasive potential of breast cancer cells and sensitizes cells to DNA damages by targeting histone methyltransferase SET8. J Biol Chem. 2013, 288(27): 19633-19642.
17.	Yao Q, Cao Z, Tu C, et al. MicroRNA-146a acts as a metastasis suppressor in gastric cancer by targeting WASF2. Cancer Lett, 2013, 335(1): 219-224.
18.	Li CL, Nie H, Wang M, et al. microRNA-155 is downregulated in gastric cancer cells and involved in cell metastasis. Oncol Rep. 2012, 27(6): 1960-1966.
19.	Xu Y, Zhao F, Wang Z, et al. MicroRNA-335 acts as a metastasis suppressor in gastric cancer by targeting Bcl-w and specificity protein 1. Oncogene. 2012, 31(11): 1398-1407.
20.	Petrocca F, Visone R, Onelli MR, et al. E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell, 2008, 13(3): 272-286.
21.	Wang F, Li T, Zhang B, et al. MicroRNA-19a/b regulates multidrug resistance in human gastric cancer cells by targeting PTEN. Biochem Biophys Res Commun, 2013, 434(3): 688-694.
22.	Gravalos C, Jimeno A. HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target. Ann Oncol, 2008, 19(9): 1523-1529.
23.	Eto K, Iwatsuki M, Watanabe M, et al. The microRNA-21/PTEN pathway regulates the sensitivity of HER2-positive gastric cancer cells to trastuzumab. Ann Surg Oncol, 2014, 21(1): 343-350.
24.	Yang SM, Huang C, Li XF, et al. miR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN. Toxicology, 2013, 306: 162-168.
25.	Liu Y, Xing R, Zhang X, et al. miR-375 targets the p53 gene to regulate cellular response to ionizing radiation and etoposide in gastric cancer cells. DNA Repair (Amst), 2013, 12(9): 741-750.
26.	Wu H, Huang M, Lu M, et al. Regulation of microtubule-associated protein tau (MAPT) by miR-34c-5p determines the chemosensitivity of gastric cancer to paclitaxel. Cancer Chemother Pharmacol, 2013, 71(5): 1159-1171.
27.	Tang H, Kong Y, Guo J, et al. Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22. Cancer Lett, 2013, 340(1): 72-81.
28.	Cheng CJ, Bahal R, Babar IA, et al. MicroRNA silencing for cancer therapy targeted to the tumour microenvironment. Nature, 2015, 518(7537): 107-110.
29.	Li C, Li JF, Cai Q, et al. miRNA-199a-3p in plasma as a potential diagnostic biomarker for gastric cancer. Ann Surg Oncol, 2013, 3: S397-405.
30.	Li C, Li JF, Cai Q, et al. MiRNA-199a-3p: A potential circulating diagnostic biomarker for early gastric cancer. J Surg Oncol, 2013, 108(2): 89-92.
31.	Yu X, Luo L, Wu Y, et al. Gastric juice miR-129 as a potential biomarker for screening gastric cancer. Med Oncol, 2013, 30(1): 365.
32.	Greenhill C Gastric cancer. Metformin improves survival and recurrence rate in patients with diabetes and gastric cancer. Nat Rev Gastroenterol Hepatol, 2015, 12(3): 124.
33.	Han G, Gong H, Wang Y, et al. AMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell. Cancer Biol Ther, 2015, 16(1): 77-87.
34.	Kato K, Gong J, Iwama H, et al. The antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivo. Mol Cancer Ther, 2012, 11(3): 549-560.
35.	Sekar D, Venugopal B, Sekar P, et al. Role of microRNA 21 in diabetes and associated/related diseases. Gene, 2016.
36.	Tsukamoto Y, Nakada C, Noguchi T, et al. MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta. Cancer Res. 2010, 70(6): 2339-2349.
37.	Zhang B, Li J, Yu B, et al. microRNA-21 promotes tumor proliferation and invasion in gastric cancer by targeting PTEN. Oncol Rep. 2012, 27(4): 1019-1026.
38.	Motoyama K, Inoue H, Mimori K, et al. Clinicopathological and prognostic significance of PDCD4 and microRNA-21 in human gastric cancer. nt J Oncol. 2010, 36(5): 1089-1095.
39.	Henry J, Azevedo-Pouly ACP, Schmittgen T. MicroRNA replacement therapy for cancer. Pharmaceutical Res, 2011, 28(12): 3030-3042.

1. Bray F, Jemal A, Grey N, et al. Global cancer transitions according to the Human Development Index (2008-2030): a population-based study. Lancet Oncol, 2012, 13(8): 790-801.
2. Hamano S, Mori Y, Aoyama M, et al. Oncolytic reovirus combined with trastuzumab enhances antitumor efficacy through TRAIL signaling in human HER2-positive gastric cancer cells. Cancer Lett, 2015, 356(2 Pt B): 846-854.
3. Zhao Y, Huang J, Zhang L, et al. MiR-133b is frequently decreased in gastric cancer and its overexpression reduces the metastatic potential of gastric cancer cells. BMC Cancer, 2014, 14: 34.
4. Betel D, Wilson M, Gabow A, et al. The microRNA.org resource: targets and expression. Nucleic Acids Res, 2008, 36(Database issue): D149-153.
5. Tong F, Cao P, Yin Y, et al. MicroRNAs in gastric cancer: from benchtop to bedside. Dig Dis Sci, 2014, 59(1): 24-30.
6. Winter J, Jung S, Keller S, et al. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol, 2009, 11(3): 228-234.
7. Esquela-Kerscher A, Slack FJ. Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer, 2006, 6(4): 259-269.
8. Ma J, Hong L, Chen Z, et al. Epigenetic regulation of microRNAs in gastric cancer. Dig Dis Sci, 2014, 59(4): 716-723.
9. Hayashi Y, Tsujii M, Wang J, et al. CagA mediates epigenetic regulation to attenuate let-7 expression in Helicobacter pylori-related carcinogenesis. Gut, 2013, 62(11): 1536-1546.
10. Liu J, Wang X, Yang X, et al. miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells. Cancer Lett, 2014, 347(1): 98-104.
11. Cheng Y, Li Y, Liu D, et al. miR-137 effects on gastric carcinogenesis are mediated by targeting Cox-2-activated PI3K/AKT signaling pathway. FEBS Lett, 2014, 588(17): 3274-3281.
12. Fan C, Liu S, Zhao Y, et al. Upregulation of miR-370 contributes to the progression of gastric carcinoma via suppression of FOXO1. Biomed Pharmacother, 2013, 67(6): 521-526.
13. Li W, Jin X, Deng X, et al. The putative tumor suppressor microRNA-497 modulates gastric cancer cell proliferation and invasion by repressing eIF4E. Biochem Biophys Res Commun, 2014, 449(2): 235-240.
14. Zhao X, Dou W, He L, et al. MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor. Oncogene, 2013, 32(11): 1363-1372.
15. Kong D, Piao YS, Yamashita S, et al. Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells. Oncogene. 2012, 31(35): 3949-3960.
16. Yu N, Huangyang P, Yang X, et al. microRNA-7 suppresses the invasive potential of breast cancer cells and sensitizes cells to DNA damages by targeting histone methyltransferase SET8. J Biol Chem. 2013, 288(27): 19633-19642.
17. Yao Q, Cao Z, Tu C, et al. MicroRNA-146a acts as a metastasis suppressor in gastric cancer by targeting WASF2. Cancer Lett, 2013, 335(1): 219-224.
18. Li CL, Nie H, Wang M, et al. microRNA-155 is downregulated in gastric cancer cells and involved in cell metastasis. Oncol Rep. 2012, 27(6): 1960-1966.
19. Xu Y, Zhao F, Wang Z, et al. MicroRNA-335 acts as a metastasis suppressor in gastric cancer by targeting Bcl-w and specificity protein 1. Oncogene. 2012, 31(11): 1398-1407.
20. Petrocca F, Visone R, Onelli MR, et al. E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell, 2008, 13(3): 272-286.
21. Wang F, Li T, Zhang B, et al. MicroRNA-19a/b regulates multidrug resistance in human gastric cancer cells by targeting PTEN. Biochem Biophys Res Commun, 2013, 434(3): 688-694.
22. Gravalos C, Jimeno A. HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target. Ann Oncol, 2008, 19(9): 1523-1529.
23. Eto K, Iwatsuki M, Watanabe M, et al. The microRNA-21/PTEN pathway regulates the sensitivity of HER2-positive gastric cancer cells to trastuzumab. Ann Surg Oncol, 2014, 21(1): 343-350.
24. Yang SM, Huang C, Li XF, et al. miR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN. Toxicology, 2013, 306: 162-168.
25. Liu Y, Xing R, Zhang X, et al. miR-375 targets the p53 gene to regulate cellular response to ionizing radiation and etoposide in gastric cancer cells. DNA Repair (Amst), 2013, 12(9): 741-750.
26. Wu H, Huang M, Lu M, et al. Regulation of microtubule-associated protein tau (MAPT) by miR-34c-5p determines the chemosensitivity of gastric cancer to paclitaxel. Cancer Chemother Pharmacol, 2013, 71(5): 1159-1171.
27. Tang H, Kong Y, Guo J, et al. Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22. Cancer Lett, 2013, 340(1): 72-81.
28. Cheng CJ, Bahal R, Babar IA, et al. MicroRNA silencing for cancer therapy targeted to the tumour microenvironment. Nature, 2015, 518(7537): 107-110.
29. Li C, Li JF, Cai Q, et al. miRNA-199a-3p in plasma as a potential diagnostic biomarker for gastric cancer. Ann Surg Oncol, 2013, 3: S397-405.
30. Li C, Li JF, Cai Q, et al. MiRNA-199a-3p: A potential circulating diagnostic biomarker for early gastric cancer. J Surg Oncol, 2013, 108(2): 89-92.
31. Yu X, Luo L, Wu Y, et al. Gastric juice miR-129 as a potential biomarker for screening gastric cancer. Med Oncol, 2013, 30(1): 365.
32. Greenhill C Gastric cancer. Metformin improves survival and recurrence rate in patients with diabetes and gastric cancer. Nat Rev Gastroenterol Hepatol, 2015, 12(3): 124.
33. Han G, Gong H, Wang Y, et al. AMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell. Cancer Biol Ther, 2015, 16(1): 77-87.
34. Kato K, Gong J, Iwama H, et al. The antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivo. Mol Cancer Ther, 2012, 11(3): 549-560.
35. Sekar D, Venugopal B, Sekar P, et al. Role of microRNA 21 in diabetes and associated/related diseases. Gene, 2016.
36. Tsukamoto Y, Nakada C, Noguchi T, et al. MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta. Cancer Res. 2010, 70(6): 2339-2349.
37. Zhang B, Li J, Yu B, et al. microRNA-21 promotes tumor proliferation and invasion in gastric cancer by targeting PTEN. Oncol Rep. 2012, 27(4): 1019-1026.
38. Motoyama K, Inoue H, Mimori K, et al. Clinicopathological and prognostic significance of PDCD4 and microRNA-21 in human gastric cancer. nt J Oncol. 2010, 36(5): 1089-1095.
39. Henry J, Azevedo-Pouly ACP, Schmittgen T. MicroRNA replacement therapy for cancer. Pharmaceutical Res, 2011, 28(12): 3030-3042.

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The Role of MiRNA in Gastric Cancer Progression

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