Research Progress on The Mechanism of ARDl Resistance The Colorectal Cancer Cell_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 CHENChao ,  BAISong , CHENZhan-qi

Department of Gerontology, The First Affiliated Hospital of Kunming Medical University, Kunming 650000, Yunnan Province, China;

Corresponding author：

BAISong, Email: baisong523@163.com

Keywords：

Human arrest defective 1; Apoptosis; Proliferation; Colorectal cancer; Mechanism

DOI：

10.7507/1007-9424.20160134

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the recent research progress on pathogenesis of human arrest defective 1(ARD1) protein in colorectal cancer and treatment process. Methods Searched the related literatures from the databases such as CNKI, PubMed and so on, the relevant ARD1 in the development, diagnosis and treatment of colorectal cancer were reviewed. Results ARD1 has effect of anti colorectal cancer, it can inhibit the proliferation and promote apoptosis of colorectal cancer cells, and improve the sensitivity of colorectal cancer cells to anticancer drugs at the cellular level. The treatment is mainly through the induction of cancer cell apoptosis or (and) decreased the proliferation ability of cancer cells, thus delaying the disease process. However, it is still in the research stage of animal experiments, which can not be directly applied to clinical practice. Conciusions ARDl study on the mechanism of anti colorectal cancer cells has become the focus of research with animal research and promotion, and provide new therapy concepts and measures for diagnosis and treatment of colorectal cancer.

Citation： CHENChao, BAISong, CHENZhan-qi. Research Progress on The Mechanism of ARDl Resistance The Colorectal Cancer Cell. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(4): 507-510. doi: 10.7507/1007-9424.20160134 Copy

1.	Meinnel T, Peynot P, Giglione C. Processed N-termini of mature proteins in higher eukaryotes and their major contribution to dynamic proteomics. Biochimie, 2005, 87(8): 701-712.
2.	Silva RD, Martinho RG. Developmental roles of protein N-terminal acetylation. Proteomics, 2015, 15(14): 2402-2409.
3.	Dörfel MJ, Lyon GJ. The biological functions of Naa10—From aminoterminal acetylation to human disease. Gene, 2015, 567(2): 103-131.
4.	Park JH, Seo JH, Wee HJ, et al. Nuclear translocation of hARD1 contributes to proper cell cycle progression. PloS One, 2014, 9(8): e105185.
5.	Chang YY, Hsu CH. Structural basis for substrate-specific acetylation of Nα-acetyltransferase Ard1 from Sulfolobus solfataricus. Sci Rep, 2015, 5: 8673.
6.	Kuo HP, Lee DF, Chen CT, et al. ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway. Sci Signal, 2010, 3(108): ra9.
7.	Ma C, Pathak C, Jiang S, et al. Structure of Thermoplasma volcanium Ard1 belongs to N-acetyltransferase family member suggesting multiple ligand binding modes with acetyl coenzyme A and coenzyme A. Biochim Biophys Acta, 2014, 1844(10): 1790-1797.
8.	Gioeli D, Paschal BM. Post-translational modification of the androgen receptor. Mol Cell Endocrinol. 2012, 352(1-2): 70-78.
9.	Hanahan D, Weinberg RA. Hallmarks of cancer:the next generation. Cell, 2011, 144(5): 646-674.
10.	Zeng Y, Min L, Han Y, et al. Inhibition of STAT5a by Naa10p contributes to decreased breast cancer metastasis. Carcinogenesis, 2014, 35(10): 2244-2253.
11.	白松, 周媛媛, 田风, 等. ARD1在人大肠腺癌细胞SW620、LS-174T和HCT-8中的表达.南方医科大学学报, 2011, 31(5): 914-916.
12.	Wang ZH, Wang ZM, Guo JH, et al. Inactivation of androgen-induced regulator ARD1 inhibits androgen receptor acetylation and prostate tumorigenesis. Proc Natl Acad Sci U S A, 2012, 109(8): 3053-3058.
13.	Arnesen T, Kong X, Evjenth R, et al. Interaction between HIF-1α(ODD) and hARD1 does not induce acetylation and destabilization of HIF-1α. FEBS Lett, 2005, 579(28): 6428-6432.
14.	Ren T, Jiang B, Jin G, et al. Generation of novel monoclonal antibodies and their application for detecting ARD1 expression in colorectal cancer. Cancer let, 2008, 264(1): 83-92.
15.	Crabtree MD, Fletcher C, Churchman M, et al. Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases. Gut, 2004, 53(2): 271-276.
16.	Xu HY, Jiang B, Meng L, et al. N-α-acetyltransferase 10 protein inhibits apoptosis through RelA/p65-regulated MCL1 expression. Carcinogenesis, 2012, 33(6): 1193-1202.
17.	余敏, 黄超, 向明钧, 等.抗hARD1抗血清制备及其初步肿瘤免疫组化分析.生物工程学报, 2008, 52(7): 1155-1161.
18.	Shin SH, Yoon H, Chun YS, et al. Arrest defective 1 regulates the oxidative stress response in human cells and mice by acetylating methionine sulfoxide reductase A. Cell Death Dis, 2014, 5: e1490.
19.	Önal M, Yılmaz T, Bilgiç E, et al. Possible role of apoptosis in pathogenesis of adenoid hypertrophy and chronic adenoiditis: Prospective case-control study. Auris Nasus Larynx, 2015, 42 (6): 449-452.
20.	Xu HL, Yu XF, Qu SC, et al. Anti-proliferative effect of Juglone from Juglans mandshurica Maxim on human leukemia cell HL-60 by inducing apoptosis through the mitochondria-dependent pathway. Eur J Pharmacol, 2010, 645(1-3): 14-22.
21.	Min L, Xu H, Wang J, et al. N-α-acetyltransferase 10 protein is a negative regulator of 28S proteasome through interaction with PA28β. FEBS Lett, 2013, 587(11): 1630-1637.
22.	Hickman JA. Apoptosis induced by anticancer drugs. Cancer Metastasis Rev, 1992, 11(2): 121-139.
23.	Park J, Kanayama A, Yamamoto K, et al. ARD1 binding to RIP1 mediates doxorubicin-induced NF-κB activation. Biochem Biophys Res Commun, 2012, 422(2): 291-297.
24.	Fisher TS, Etages SD, Hayes L, et al. Analysis of h ARD1 function in hypoxia response using retroviral RNA interference. J Biol Chem, 2005, 280(18): 17749-17757.
25.	Perez RE, Knights CD, Sahu G, et al. Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway. J Cell Physiol, 2010, 225(2): 394-405.
26.	Rocha G, Villalobos E, Fuentes C, et al. Preadipocyte proliferation is elevated by calcium sensing receptor activation. Mol Cell Endocrinol, 2015, 412: 251-256.
27.	Hartwell LH, Kastan MB. Cell cycle control and cancer. Science, 1994, 266(5192): 1821-1828.
28.	Foyn H, Jones JE, Lewallen D, et al. Design, synthesis, and kinetic characterization of protein N-terminal acetyltransferase inhibitors. ACS Chem Biol, 2013, 8(6): 1121-1127.
29.	Seo JH, Park JH, Lee EJ, et al. Different subcellular localizations and functions of human ARD1 variants. Int J Oncol, 2015, 46(2): 701-707.
30.	Seo JH, Park JH, Lee EJ, et al. Autoacetylation regulates differentially the roles of ARD1 variants in tumorigenesis. Int J Oncol, 2015, 46(1): 99-106.
31.	Liu C, Qu L, Dong B, et al. Combined phenotype of 4 markers improves prognostic value of patients with colon cancer. Am J Med Sci, 2012, 343(4): 295-302.
32.	Yamada HY, Rao CV. BRD8 is a potential chemosensitizing target for spindle poisons in colorectal cancer therapy. Int J Oncol, 2009, 35(5): 1101-1109.
33.	白松, 邵佳发, 王维琦, 等. hARD1在人大肠腺癌中的表达及与肿瘤分化的相关性.世界华人消化杂志, 2011, 19(15): 1585-1590.
34.	Steffens CC, Tschechne B, Schardt C, et al. Observational study of adjuvant therapy with capecitabine in colon cancer. Curr Med Res Opin, 2015, 31(4): 731-741.
35.	Wang ZH, Gong JL, Yu M, et al. Up-regulation of human arrest-defective 1 protein is correlated with metastatic phenotype and poor prognosis in breast cancer. Asian Pac J Cancer Prev, 2011, 12(8): 1973-1977.
36.	Chen D, Zhang J, Minnerly J, et al. daf-31 encodes the catalytic subunit of N alpha-acetyltransferase that regulates Caenorhabditis elegans development, metabolism and adult lifespan. PLoS Genet, 2014, 10(10): e1004699.
37.	Meza-Carmen V, Pacheco-Rodriguez G, Kang GS, et al. Regulation of growth factor receptor degradation by ADP-ribosylation factor domain protein (ARD) 1. Proc Natl Acad Sci U S A, 2011, 108(26): 10454-10459.

1. Meinnel T, Peynot P, Giglione C. Processed N-termini of mature proteins in higher eukaryotes and their major contribution to dynamic proteomics. Biochimie, 2005, 87(8): 701-712.
2. Silva RD, Martinho RG. Developmental roles of protein N-terminal acetylation. Proteomics, 2015, 15(14): 2402-2409.
3. Dörfel MJ, Lyon GJ. The biological functions of Naa10—From aminoterminal acetylation to human disease. Gene, 2015, 567(2): 103-131.
4. Park JH, Seo JH, Wee HJ, et al. Nuclear translocation of hARD1 contributes to proper cell cycle progression. PloS One, 2014, 9(8): e105185.
5. Chang YY, Hsu CH. Structural basis for substrate-specific acetylation of Nα-acetyltransferase Ard1 from Sulfolobus solfataricus. Sci Rep, 2015, 5: 8673.
6. Kuo HP, Lee DF, Chen CT, et al. ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway. Sci Signal, 2010, 3(108): ra9.
7. Ma C, Pathak C, Jiang S, et al. Structure of Thermoplasma volcanium Ard1 belongs to N-acetyltransferase family member suggesting multiple ligand binding modes with acetyl coenzyme A and coenzyme A. Biochim Biophys Acta, 2014, 1844(10): 1790-1797.
8. Gioeli D, Paschal BM. Post-translational modification of the androgen receptor. Mol Cell Endocrinol. 2012, 352(1-2): 70-78.
9. Hanahan D, Weinberg RA. Hallmarks of cancer:the next generation. Cell, 2011, 144(5): 646-674.
10. Zeng Y, Min L, Han Y, et al. Inhibition of STAT5a by Naa10p contributes to decreased breast cancer metastasis. Carcinogenesis, 2014, 35(10): 2244-2253.
11. 白松, 周媛媛, 田风, 等. ARD1在人大肠腺癌细胞SW620、LS-174T和HCT-8中的表达.南方医科大学学报, 2011, 31(5): 914-916.
12. Wang ZH, Wang ZM, Guo JH, et al. Inactivation of androgen-induced regulator ARD1 inhibits androgen receptor acetylation and prostate tumorigenesis. Proc Natl Acad Sci U S A, 2012, 109(8): 3053-3058.
13. Arnesen T, Kong X, Evjenth R, et al. Interaction between HIF-1α(ODD) and hARD1 does not induce acetylation and destabilization of HIF-1α. FEBS Lett, 2005, 579(28): 6428-6432.
14. Ren T, Jiang B, Jin G, et al. Generation of novel monoclonal antibodies and their application for detecting ARD1 expression in colorectal cancer. Cancer let, 2008, 264(1): 83-92.
15. Crabtree MD, Fletcher C, Churchman M, et al. Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases. Gut, 2004, 53(2): 271-276.
16. Xu HY, Jiang B, Meng L, et al. N-α-acetyltransferase 10 protein inhibits apoptosis through RelA/p65-regulated MCL1 expression. Carcinogenesis, 2012, 33(6): 1193-1202.
17. 余敏, 黄超, 向明钧, 等.抗hARD1抗血清制备及其初步肿瘤免疫组化分析.生物工程学报, 2008, 52(7): 1155-1161.
18. Shin SH, Yoon H, Chun YS, et al. Arrest defective 1 regulates the oxidative stress response in human cells and mice by acetylating methionine sulfoxide reductase A. Cell Death Dis, 2014, 5: e1490.
19. Önal M, Yılmaz T, Bilgiç E, et al. Possible role of apoptosis in pathogenesis of adenoid hypertrophy and chronic adenoiditis: Prospective case-control study. Auris Nasus Larynx, 2015, 42 (6): 449-452.
20. Xu HL, Yu XF, Qu SC, et al. Anti-proliferative effect of Juglone from Juglans mandshurica Maxim on human leukemia cell HL-60 by inducing apoptosis through the mitochondria-dependent pathway. Eur J Pharmacol, 2010, 645(1-3): 14-22.
21. Min L, Xu H, Wang J, et al. N-α-acetyltransferase 10 protein is a negative regulator of 28S proteasome through interaction with PA28β. FEBS Lett, 2013, 587(11): 1630-1637.
22. Hickman JA. Apoptosis induced by anticancer drugs. Cancer Metastasis Rev, 1992, 11(2): 121-139.
23. Park J, Kanayama A, Yamamoto K, et al. ARD1 binding to RIP1 mediates doxorubicin-induced NF-κB activation. Biochem Biophys Res Commun, 2012, 422(2): 291-297.
24. Fisher TS, Etages SD, Hayes L, et al. Analysis of h ARD1 function in hypoxia response using retroviral RNA interference. J Biol Chem, 2005, 280(18): 17749-17757.
25. Perez RE, Knights CD, Sahu G, et al. Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway. J Cell Physiol, 2010, 225(2): 394-405.
26. Rocha G, Villalobos E, Fuentes C, et al. Preadipocyte proliferation is elevated by calcium sensing receptor activation. Mol Cell Endocrinol, 2015, 412: 251-256.
27. Hartwell LH, Kastan MB. Cell cycle control and cancer. Science, 1994, 266(5192): 1821-1828.
28. Foyn H, Jones JE, Lewallen D, et al. Design, synthesis, and kinetic characterization of protein N-terminal acetyltransferase inhibitors. ACS Chem Biol, 2013, 8(6): 1121-1127.
29. Seo JH, Park JH, Lee EJ, et al. Different subcellular localizations and functions of human ARD1 variants. Int J Oncol, 2015, 46(2): 701-707.
30. Seo JH, Park JH, Lee EJ, et al. Autoacetylation regulates differentially the roles of ARD1 variants in tumorigenesis. Int J Oncol, 2015, 46(1): 99-106.
31. Liu C, Qu L, Dong B, et al. Combined phenotype of 4 markers improves prognostic value of patients with colon cancer. Am J Med Sci, 2012, 343(4): 295-302.
32. Yamada HY, Rao CV. BRD8 is a potential chemosensitizing target for spindle poisons in colorectal cancer therapy. Int J Oncol, 2009, 35(5): 1101-1109.
33. 白松, 邵佳发, 王维琦, 等. hARD1在人大肠腺癌中的表达及与肿瘤分化的相关性.世界华人消化杂志, 2011, 19(15): 1585-1590.
34. Steffens CC, Tschechne B, Schardt C, et al. Observational study of adjuvant therapy with capecitabine in colon cancer. Curr Med Res Opin, 2015, 31(4): 731-741.
35. Wang ZH, Gong JL, Yu M, et al. Up-regulation of human arrest-defective 1 protein is correlated with metastatic phenotype and poor prognosis in breast cancer. Asian Pac J Cancer Prev, 2011, 12(8): 1973-1977.
36. Chen D, Zhang J, Minnerly J, et al. daf-31 encodes the catalytic subunit of N alpha-acetyltransferase that regulates Caenorhabditis elegans development, metabolism and adult lifespan. PLoS Genet, 2014, 10(10): e1004699.
37. Meza-Carmen V, Pacheco-Rodriguez G, Kang GS, et al. Regulation of growth factor receptor degradation by ADP-ribosylation factor domain protein (ARD) 1. Proc Natl Acad Sci U S A, 2011, 108(26): 10454-10459.

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Research Progress on The Mechanism of ARDl Resistance The Colorectal Cancer Cell

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