Expression and clinical significance of notch-1 protein in papillary thyroid carcinoma tissues and cervical lymph node metastases_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

MAJingyou ^1,2 , CUIZhexu ^1,2 , LIHuagen ^1,2 , YANGFuqiang ^1,2 , WANGYan ^1,2 , SHENHao ¹ ,  LIUZhen ^1,2

1. Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia Autonomous Region 028000, P.R.China;
2. Department of General Surgery, The Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia autonomous Region 028000, P.R.China;

Corresponding author：

LIUZhen, Email: liuzhen95@sohu.com

Keywords：

papillary thyroid carcinoma; metastatic lymph nodes; Notch-1 protein

DOI：

10.7507/1007-9424.201607012

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the expression and clinical significance of Notch-1 protein in papillary thyroid carcinoma (PTC) tissues and cervical lymph node metastases. Methods Immunohistochemical method was used to detect the expression of Notch-1 protein in 69 cases of PTC tissues, along with tumor adjacent tissues and 34 cases of metastatic lymph node tissues, and to analyze its role in PTC and metastatic lymph node tissue. Results Compared with PTC tissues or cervical lymph node metastases and tumor adjacent tissues, the positive rates of expression of Notch-1 protein in PTC tissues or cervical lymph node metastases were significantly lower than that in cancer adjacent tissues (P＜0.05). The expression of Notch-1 protein was correlated with the tumor size and capsule invasion of patients with PTC. Conclusions Notch-1 protein expression is decreased in PTC tissues and metastatic lymph node tissues, suggesting that the Notch-1 protein may play an important role in the development, invasion and metastasis of PTC. There is no significant difference in the positive rates of Notch-1 protein expression in PTC tissues and metastatic lymph node tissues, it's suggested that the malignant degree of cancer cells in lymph node metastasis is not significantly increased, and the biological behavior remained relatively stable.

Citation： MAJingyou, CUIZhexu, LIHuagen, YANGFuqiang, WANGYan, SHENHao, LIUZhen. Expression and clinical significance of notch-1 protein in papillary thyroid carcinoma tissues and cervical lymph node metastases. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(1): 70-73. doi: 10.7507/1007-9424.201607012 Copy

1.	陈振宇, 吴毅. 双侧甲状腺癌的临床新特点. 中国实用外科杂志, 2012, 32(1): 77-79, 84.
2.	任立军, 杨延芳, 张成雷. 甲状腺乳头状癌淋巴结转移规律的临床研究. 中国普外基础与临床杂志, 2011, 11(4): 419-422.
3.	Chung YS, Kim JY, Bae JS,et al. Lateral lymph node metastasis in papillary thyroid carcinoma: results of therapeutic lymph node dissection. Thyroid, 2009, 19(3): 241-246.
4.	Yap LF, Lee D, Khairuddin A,et al. The opposing roles of NOTCH signaling in head and neck cancer: a mini review. Oral Dis, 2015, 21(7): 850-857.
5.	Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell, 2009, 137(2): 216-233.
6.	Garcia A, Kandel JJ. Notch: a key regulator of tumor angiogenesis and metastasis. Histology Histopathol, 2012, 27(2): 151-156.
7.	金晓燕, 梁勇, 陈佳玉, 等. Notch-1在甲状腺乳头状癌中的表达及意义. 中国卫生检验杂志, 2011, 21(1): 1-3.
8.	曹子龙, 张卓, 胡建立, 等. NKD1和APC在乳腺癌组织中的表达及意义. 中国普外基础与临床杂志, 2015, 23(10): 1226-1229.
9.	Sato C, Zhao G, Ilagan MX. An overview of Notch signaling in adult tissue renewal and maintenance. Curr Alzheimer Res, 2012, 9(2): 227-240.
10.	Dang TP. Notch, apoptosis and cancer. Adv Exp Med Biol, 2012, 727: 199-209.
11.	Hu YY, Zheng MH, Zhang R,et al. Notch signaling pathway and cancer metastasis. Adv Exp Med Biol, 2012, 727: 186-198.
12.	Fernandezmarcos PJ, Serrano M, Maraver A. Bladder cancer and the Notch pathway. Oncotarget, 2015, 6(3): 1346-1347.
13.	Guo H, Lu Y, Wang J,et al. Targeting the Notch signaling pathway in cancer therapeutics. Thoracic Cancer, 2014, 5(6): 473-486.
14.	盖大伟, 郭凌云, 刘涛, 等. Notch信号通路在消化系肿瘤中的研究进展. 中国普外基础与临床杂志, 2013, 20(10): 1188-1192.
15.	Doshi WB, Thury PG, Chen R,et al. Synergistic interaction between AKT and Notch-1 signaling in cervical cancer: a critical role in tumor cell migration and invasion. Am J Biomed, 2014, 2(2): 200-211.
16.	Park HS, Jung CK, Lee SH,et al. Notch-1 receptor as a marker of lymph node metastases in papillary thyroid cancer. Cancer Sci, 2012, 103(2): 305-309.
17.	Fu H, Ma C, Guan W,et al. Expression of Notch 1 receptor associated with tumor aggressiveness in papillary thyroid carcinoma. Onco Targets Ther, 2016, 9: 1519-1523.
18.	Besic N, Pilko G, Petric R,et al. Papillary thyroid microcarcinoma: prognostic factors and treatment. J Surg Oncol, 2008, 97(3): 221-225.
19.	Takebe N, Nguyen D, Yang SX. Targeting notch signaling pathway in cancer: clinical development advances and challenges. Pharmacol Ther, 2014, 141(2): 140-149.
20.	陶久梅, 王艳, 朱姝, 等. 甲状腺乳头状癌颈部淋巴结转移规律及影响因素分析. 临床耳鼻咽喉头颈外科杂志, 2014, 28(12): 859-861, 864.
21.	Hou L, Ren S, Su B,et al. High concordance of ALK rearrangement between primary tumor and paired metastatic lymph node in patients with lung adenocarcinoma. J Thorac Dis, 2016, 8(6): 1103-1111.
22.	边学. 甲状腺乳头状癌与转移淋巴结组织蛋白质组学差异表达分析. 中国耳鼻咽喉头颈外科, 2011, 18(7): 363-366.
23.	曾令瑞, 韩玉贞, 马英路, 等. 乳腺原发癌和相应淋巴结转移癌干细胞Wnt、Notch信号通路相关分子的比较. 临床与实验病理学杂志, 2014, 30(9): 963-966.
24.	Krook KA, Fedewa SA, Amy Y,et al. Prognostic indicators in well-differentiated thyroid carcinoma when controlling for stage and treatment. Laryngoscope, 2015, 125(4): 1021-1027.
25.	丛慧, 梁军, 李方, 等. 分化型甲状腺癌治疗后TgAb变化趋势及其影响因素. 中国医学科学院学报, 2015, 37(1): 61-65.

1. 陈振宇, 吴毅. 双侧甲状腺癌的临床新特点. 中国实用外科杂志, 2012, 32(1): 77-79, 84.
2. 任立军, 杨延芳, 张成雷. 甲状腺乳头状癌淋巴结转移规律的临床研究. 中国普外基础与临床杂志, 2011, 11(4): 419-422.
3. Chung YS, Kim JY, Bae JS,et al. Lateral lymph node metastasis in papillary thyroid carcinoma: results of therapeutic lymph node dissection. Thyroid, 2009, 19(3): 241-246.
4. Yap LF, Lee D, Khairuddin A,et al. The opposing roles of NOTCH signaling in head and neck cancer: a mini review. Oral Dis, 2015, 21(7): 850-857.
5. Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell, 2009, 137(2): 216-233.
6. Garcia A, Kandel JJ. Notch: a key regulator of tumor angiogenesis and metastasis. Histology Histopathol, 2012, 27(2): 151-156.
7. 金晓燕, 梁勇, 陈佳玉, 等. Notch-1在甲状腺乳头状癌中的表达及意义. 中国卫生检验杂志, 2011, 21(1): 1-3.
8. 曹子龙, 张卓, 胡建立, 等. NKD1和APC在乳腺癌组织中的表达及意义. 中国普外基础与临床杂志, 2015, 23(10): 1226-1229.
9. Sato C, Zhao G, Ilagan MX. An overview of Notch signaling in adult tissue renewal and maintenance. Curr Alzheimer Res, 2012, 9(2): 227-240.
10. Dang TP. Notch, apoptosis and cancer. Adv Exp Med Biol, 2012, 727: 199-209.
11. Hu YY, Zheng MH, Zhang R,et al. Notch signaling pathway and cancer metastasis. Adv Exp Med Biol, 2012, 727: 186-198.
12. Fernandezmarcos PJ, Serrano M, Maraver A. Bladder cancer and the Notch pathway. Oncotarget, 2015, 6(3): 1346-1347.
13. Guo H, Lu Y, Wang J,et al. Targeting the Notch signaling pathway in cancer therapeutics. Thoracic Cancer, 2014, 5(6): 473-486.
14. 盖大伟, 郭凌云, 刘涛, 等. Notch信号通路在消化系肿瘤中的研究进展. 中国普外基础与临床杂志, 2013, 20(10): 1188-1192.
15. Doshi WB, Thury PG, Chen R,et al. Synergistic interaction between AKT and Notch-1 signaling in cervical cancer: a critical role in tumor cell migration and invasion. Am J Biomed, 2014, 2(2): 200-211.
16. Park HS, Jung CK, Lee SH,et al. Notch-1 receptor as a marker of lymph node metastases in papillary thyroid cancer. Cancer Sci, 2012, 103(2): 305-309.
17. Fu H, Ma C, Guan W,et al. Expression of Notch 1 receptor associated with tumor aggressiveness in papillary thyroid carcinoma. Onco Targets Ther, 2016, 9: 1519-1523.
18. Besic N, Pilko G, Petric R,et al. Papillary thyroid microcarcinoma: prognostic factors and treatment. J Surg Oncol, 2008, 97(3): 221-225.
19. Takebe N, Nguyen D, Yang SX. Targeting notch signaling pathway in cancer: clinical development advances and challenges. Pharmacol Ther, 2014, 141(2): 140-149.
20. 陶久梅, 王艳, 朱姝, 等. 甲状腺乳头状癌颈部淋巴结转移规律及影响因素分析. 临床耳鼻咽喉头颈外科杂志, 2014, 28(12): 859-861, 864.
21. Hou L, Ren S, Su B,et al. High concordance of ALK rearrangement between primary tumor and paired metastatic lymph node in patients with lung adenocarcinoma. J Thorac Dis, 2016, 8(6): 1103-1111.
22. 边学. 甲状腺乳头状癌与转移淋巴结组织蛋白质组学差异表达分析. 中国耳鼻咽喉头颈外科, 2011, 18(7): 363-366.
23. 曾令瑞, 韩玉贞, 马英路, 等. 乳腺原发癌和相应淋巴结转移癌干细胞Wnt、Notch信号通路相关分子的比较. 临床与实验病理学杂志, 2014, 30(9): 963-966.
24. Krook KA, Fedewa SA, Amy Y,et al. Prognostic indicators in well-differentiated thyroid carcinoma when controlling for stage and treatment. Laryngoscope, 2015, 125(4): 1021-1027.
25. 丛慧, 梁军, 李方, 等. 分化型甲状腺癌治疗后TgAb变化趋势及其影响因素. 中国医学科学院学报, 2015, 37(1): 61-65.

Previous Article
Next Article
Selective galactography features in breast carcinoma patients with nipple discharge

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression and clinical significance of notch-1 protein in papillary thyroid carcinoma tissues and cervical lymph node metastases

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content