Therapy advances of non-biological artificial liver_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZOU Long , LIU Hong , MA Linjie , CHEN Xiao ,  CHEN Gang

Department of Hepatobiliary Surgery, Affiliated Calmette Hospital of Kunming Medical University, Kunming 650011, P.R.China;

Corresponding author：

CHEN Gang, Email: kmcg123@163.com

Keywords：

artificial liver; liver function failure; therapy; progress

DOI：

10.7507/1007-9424.201607025

Video：

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Objective To summarize present situation and development of non-biological artificial liver. Method The related literatures about artificial liver treatment in recent years were reviewed. Results The current artificial liver which applied to clinic mainly are non-biological artificial liver, including plasma exchange, hemodialysis, hemofiltration, bilirubin adsorption, hemoperfusion, molecular adsorption recycling, etc. Because of the individual clinical cases, the individualized requirements for treatment are put forward. Single treatment of non-biological artificial liver is often unable to satisfy the individualized requirements, combined the advantages of each treatment so as to maximum therapeutic effect for patients has become a trend. Conclusion Combined treatment of non-biological artificial liver is superior to single treatment, individual treatment concept should be carried out in whole process of treatment.

Citation： ZOU Long, LIU Hong, MA Linjie, CHEN Xiao, CHEN Gang. Therapy advances of non-biological artificial liver. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(5): 634-637. doi: 10.7507/1007-9424.201607025 Copy

1.	宋传芳, 刘冰熔. 急性肝衰竭的综合治疗. 世界华人消化杂志, 2012, 20(33): 3237-3243.
2.	中华医学会感染病学分会肝衰竭与人工肝学组, 中华医学会肝病学分会重型肝病与人工肝学组. 肝衰竭诊治指南(2012 年版). 实用肝脏病杂志, 2013, 16(3): 210-216.
3.	Rademacher S, Oppert M, Jörres A. Artificial extracorporeal liver support therapy in patients with severe liver failure. Expert Rev Gastroenterol Hepatol, 2011, 5(5): 591-599.
4.	Kiley JE, Welch hf, Pender JC,et al. Removal of blood ammonia by hemodialysis. Proc Soc Exp Biol Med, 1956, 91(3): 489-490.
5.	Norman JC, Saravis CA, Brown ME,et al. Immunological observations in clinical heterologous (xenogeneic) liver perfusions. Surgery, 1966, 60: 179-190.
6.	Carpentier B, Gautier A, Legallais C. Artificial and bioartificial liver devices: present and future. Gut, 2009, 58(12): 1690-1702.
7.	Millis JM, Losanoff JE. Technology insight: liver support systems. Nat Clin Pract Gastroenterol Hepatol, 2005, 9(2): 398-405.
8.	Onodera K, Sakata H, Yonekaua M,et al. Artificial liver support at present and in the future. J Artif Organs, 2006, 9(1): 17-28.
9.	Aron J, Agarwal B, Daven Port A. Extracorporal support for patients with acute on chronic liver failure . Exp Rev Med Dev, 2016, 10(2): 390-405.
10.	Li LJ, Zhang YM, Liu XL,et al. Artificial liver support system in China: a review over the last 30 years. Ther Apher Dial, 2006, 10(2): 160-167.
11.	Li LJ, Liu XL, Xu XW,et al. Comparison of plasma exchange with different membrane pore sizes in the treatment of severe viral hepatitis. Ther Apher Dial, 2005, 9(5): 396-401.
12.	Larsen FS, Hansen BA, Jørgensen LG,et al. High-volume plasmapheresis and acute liver transplantation in fulminant hepatic failure. Transplant Proc, 1994, 26(3): 1788.
13.	Pless G. Artificial and bioartifical liver support. Organogenesis, 2007, 3(1): 20-24.
14.	邹和群, 刘新宇. 加强血浆净化技术临床推广应用研究. 中华临床医师杂志(电子版), 2015, 9(17): 3165-3167.
15.	程芝灵, 孙桂香, 林辉, 等. 血浆置换治疗肝衰竭临床疗效和安全性的 Meta 分析. 中国循证医学杂志, 2015, 15(6): 664-671.
16.	杨文龙, 孙水林, 周锡进, 等. 终末期肝病模型评分与 Child-Turcotte-Pugh 分级对非生物型人工肝治疗乙型肝炎相关性肝衰竭患者预测价值的研究. 中华危重症医学杂志(电子版), 2016, 9(1): 22-27.
17.	中华传染病与寄生虫病学会人工肝学组. 人工肝支持系统治疗的操作指南. 中华肝脏病杂志, 2002, 10(5): 329-333.
18.	曾义岚, 陈竹, 王丽, 等. 人工肝联合抗病毒治疗乙型肝炎相关慢加急性肝功能衰竭患者的疗效及影响因素分析. 中国肝脏病杂志(电子版), 2015, 7(4): 26-30.
19.	Patzer JF 2nd, Bane SE. Bound solute dialysis. ASAIO J, 2003, 49(3): 271-281.
20.	Jalan R, Sen S, Steiner C,et al. Extracorporeal liver support with molecular adsorbents recirculating system in patients with severe acute alcoholic hepatitis. J Hepatol, 2003, 38(1): 24-31.
21.	Inderbitzin D, Muggli B, Ringger A,et al. Molecular absorbent recirculating system for the treatment of acute liver failure in surgical patients. J Gastrointest Surg, 2005, 9(8): 1155-1162.
22.	Olin P, Hausken J, Foss A,et al. Continuous molecular adsorbent recirculating system treatment in 69 patients listed for liver transplantation. Scand J Gastroenterol, 2015, 50(9): 1127-1134.
23.	Lexmond WS, Van Dael CM, Scheenstra R,et al. Experience with molecular adsorbent recirculating system treatment in 20 children listed for high-urgency liver transplantation. Liver Transpl, 2015, 21(3): 369-380.
24.	Sponholz C, Matthes K, Rupp D,et al. Molecular adsorbent recirculating system and single-pass albumin dialysis in liver failure—a prospective, randomised crossover study. Crit Care, 2016, 20: 2.
25.	李兰娟. 人工肝临床应用若干进展. 中华肝脏病志, 2005, 13(11): 844-845.
26.	Mitzner SR, Stange J, Klammt S,et al. Albumin dialysis MARS: knowledge from 10 years of clinical investigation. ASAIO J, 2009, 5(5): 498-502.
27.	Saliba F , Samuel D. Artificial liver support: a real step forward. Minerva Med, 2015, 106(1): 35-43.
28.	Hassanein T, Blei AT, Perry W,et al. Performance of the hepatic encephalopathy scoring algorithm in a clinical trial of patients with cirrhosis and severe hepatic encephalopathy. Am J Gastroenterol, 2009, 104(6): 1392-1400.
29.	Leckie P, Tritto G, Mookerjee R,et al. ‘Out-patient’ albumin dialysis for cholestatic patients with intractable pruritus. Aliment Pharmacol Ther, 2012, 35(6): 696-704.
30.	徐秋仙, 张振纲, 吴亮, 等. 非生物型人工肝对肝衰竭患者疗效和预后的影响. 临床内科杂志, 2015, 32(7): 465-468.
31.	董庆华, 郭利民, 王宇, 等. CAPS 人工肝治疗肝衰竭的临床研究. 实用肝脏病杂志, 2009, 12(5): 352-354.
32.	Parés A, Herrera M, Avilés J,et al. Treatment of resistant pruritus from cholestasis with albumin dialysis: combined analysis of patients from three centers. J Hepatol, 2010, 53(2): 307-312.
33.	Laleman W, Wilmer A, Evenepoel P,et al. Review article: non-biological liver support in liver failure. Aliment Pharmocol Ther, 2006, 23(3): 351-363.
34.	Rifai K, Ernst T, Kretschmer U,et al. Removal selectivity of prometheus: A new extracorporeal liver support device. World J Gastroenterol, 2006, 12(6): 940-944.
35.	Peter K, Bernd H, Rudolf S,et al.In vivo quantification of liver diaiysis: comparison of albumin dialysis and fractionated plasma separation. J Hepatol, 2005, 43(3): 451-457.
36.	Rodrigues J, Castro SG , Moya B,et al. Liver depurative techniques: a single liver transplantation center experience. Transplant Proc, 2015, 47(4): 996-1000.
37.	Grodzicki M, Kotulski M, Leonowicz D,et al. Results of treatment of acute liver failure patients with use of the prometheus FPSA system. Transplant Proc, 2009, 41(8): 3079-3081.
38.	章莉莎, 赵满芝, 许东. 少量血浆进行人工肝治疗慢加急性肝衰竭的探讨. 华中科技大学学报(医学版), 2015, 44(1): 87-91.
39.	Mitzner S, Klammt S, Stange J,et al. Albumin regeneration in liver support – comparison of different methods. Ther Apher Dial, 2006, 10(2): 108-117.
40.	林文, 黄健, 林松伟, 等. 血浆置换联合持续静脉-静脉血液滤过治疗 HBV 相关性肝衰竭患者疗效评估. 肝脏, 2015, 20(10): 802-805.
41.	黎代强. 双重血浆分子吸附系统 (DPMAS) 治疗重型肝病新进展. 中国医学工程, 2015, 23(8): 198-200.
42.	孙潺, 彭程, 揭盛华, 等. 羟乙基淀粉代血浆在人工肝支持系统中治疗肝衰竭的应用及安全性. 华中科技大学学报(医学版), 2013, 42(6): 681-684.

1. 宋传芳, 刘冰熔. 急性肝衰竭的综合治疗. 世界华人消化杂志, 2012, 20(33): 3237-3243.
2. 中华医学会感染病学分会肝衰竭与人工肝学组, 中华医学会肝病学分会重型肝病与人工肝学组. 肝衰竭诊治指南(2012 年版). 实用肝脏病杂志, 2013, 16(3): 210-216.
3. Rademacher S, Oppert M, Jörres A. Artificial extracorporeal liver support therapy in patients with severe liver failure. Expert Rev Gastroenterol Hepatol, 2011, 5(5): 591-599.
4. Kiley JE, Welch hf, Pender JC,et al. Removal of blood ammonia by hemodialysis. Proc Soc Exp Biol Med, 1956, 91(3): 489-490.
5. Norman JC, Saravis CA, Brown ME,et al. Immunological observations in clinical heterologous (xenogeneic) liver perfusions. Surgery, 1966, 60: 179-190.
6. Carpentier B, Gautier A, Legallais C. Artificial and bioartificial liver devices: present and future. Gut, 2009, 58(12): 1690-1702.
7. Millis JM, Losanoff JE. Technology insight: liver support systems. Nat Clin Pract Gastroenterol Hepatol, 2005, 9(2): 398-405.
8. Onodera K, Sakata H, Yonekaua M,et al. Artificial liver support at present and in the future. J Artif Organs, 2006, 9(1): 17-28.
9. Aron J, Agarwal B, Daven Port A. Extracorporal support for patients with acute on chronic liver failure . Exp Rev Med Dev, 2016, 10(2): 390-405.
10. Li LJ, Zhang YM, Liu XL,et al. Artificial liver support system in China: a review over the last 30 years. Ther Apher Dial, 2006, 10(2): 160-167.
11. Li LJ, Liu XL, Xu XW,et al. Comparison of plasma exchange with different membrane pore sizes in the treatment of severe viral hepatitis. Ther Apher Dial, 2005, 9(5): 396-401.
12. Larsen FS, Hansen BA, Jørgensen LG,et al. High-volume plasmapheresis and acute liver transplantation in fulminant hepatic failure. Transplant Proc, 1994, 26(3): 1788.
13. Pless G. Artificial and bioartifical liver support. Organogenesis, 2007, 3(1): 20-24.
14. 邹和群, 刘新宇. 加强血浆净化技术临床推广应用研究. 中华临床医师杂志(电子版), 2015, 9(17): 3165-3167.
15. 程芝灵, 孙桂香, 林辉, 等. 血浆置换治疗肝衰竭临床疗效和安全性的 Meta 分析. 中国循证医学杂志, 2015, 15(6): 664-671.
16. 杨文龙, 孙水林, 周锡进, 等. 终末期肝病模型评分与 Child-Turcotte-Pugh 分级对非生物型人工肝治疗乙型肝炎相关性肝衰竭患者预测价值的研究. 中华危重症医学杂志(电子版), 2016, 9(1): 22-27.
17. 中华传染病与寄生虫病学会人工肝学组. 人工肝支持系统治疗的操作指南. 中华肝脏病杂志, 2002, 10(5): 329-333.
18. 曾义岚, 陈竹, 王丽, 等. 人工肝联合抗病毒治疗乙型肝炎相关慢加急性肝功能衰竭患者的疗效及影响因素分析. 中国肝脏病杂志(电子版), 2015, 7(4): 26-30.
19. Patzer JF 2nd, Bane SE. Bound solute dialysis. ASAIO J, 2003, 49(3): 271-281.
20. Jalan R, Sen S, Steiner C,et al. Extracorporeal liver support with molecular adsorbents recirculating system in patients with severe acute alcoholic hepatitis. J Hepatol, 2003, 38(1): 24-31.
21. Inderbitzin D, Muggli B, Ringger A,et al. Molecular absorbent recirculating system for the treatment of acute liver failure in surgical patients. J Gastrointest Surg, 2005, 9(8): 1155-1162.
22. Olin P, Hausken J, Foss A,et al. Continuous molecular adsorbent recirculating system treatment in 69 patients listed for liver transplantation. Scand J Gastroenterol, 2015, 50(9): 1127-1134.
23. Lexmond WS, Van Dael CM, Scheenstra R,et al. Experience with molecular adsorbent recirculating system treatment in 20 children listed for high-urgency liver transplantation. Liver Transpl, 2015, 21(3): 369-380.
24. Sponholz C, Matthes K, Rupp D,et al. Molecular adsorbent recirculating system and single-pass albumin dialysis in liver failure—a prospective, randomised crossover study. Crit Care, 2016, 20: 2.
25. 李兰娟. 人工肝临床应用若干进展. 中华肝脏病志, 2005, 13(11): 844-845.
26. Mitzner SR, Stange J, Klammt S,et al. Albumin dialysis MARS: knowledge from 10 years of clinical investigation. ASAIO J, 2009, 5(5): 498-502.
27. Saliba F , Samuel D. Artificial liver support: a real step forward. Minerva Med, 2015, 106(1): 35-43.
28. Hassanein T, Blei AT, Perry W,et al. Performance of the hepatic encephalopathy scoring algorithm in a clinical trial of patients with cirrhosis and severe hepatic encephalopathy. Am J Gastroenterol, 2009, 104(6): 1392-1400.
29. Leckie P, Tritto G, Mookerjee R,et al. ‘Out-patient’ albumin dialysis for cholestatic patients with intractable pruritus. Aliment Pharmacol Ther, 2012, 35(6): 696-704.
30. 徐秋仙, 张振纲, 吴亮, 等. 非生物型人工肝对肝衰竭患者疗效和预后的影响. 临床内科杂志, 2015, 32(7): 465-468.
31. 董庆华, 郭利民, 王宇, 等. CAPS 人工肝治疗肝衰竭的临床研究. 实用肝脏病杂志, 2009, 12(5): 352-354.
32. Parés A, Herrera M, Avilés J,et al. Treatment of resistant pruritus from cholestasis with albumin dialysis: combined analysis of patients from three centers. J Hepatol, 2010, 53(2): 307-312.
33. Laleman W, Wilmer A, Evenepoel P,et al. Review article: non-biological liver support in liver failure. Aliment Pharmocol Ther, 2006, 23(3): 351-363.
34. Rifai K, Ernst T, Kretschmer U,et al. Removal selectivity of prometheus: A new extracorporeal liver support device. World J Gastroenterol, 2006, 12(6): 940-944.
35. Peter K, Bernd H, Rudolf S,et al.In vivo quantification of liver diaiysis: comparison of albumin dialysis and fractionated plasma separation. J Hepatol, 2005, 43(3): 451-457.
36. Rodrigues J, Castro SG , Moya B,et al. Liver depurative techniques: a single liver transplantation center experience. Transplant Proc, 2015, 47(4): 996-1000.
37. Grodzicki M, Kotulski M, Leonowicz D,et al. Results of treatment of acute liver failure patients with use of the prometheus FPSA system. Transplant Proc, 2009, 41(8): 3079-3081.
38. 章莉莎, 赵满芝, 许东. 少量血浆进行人工肝治疗慢加急性肝衰竭的探讨. 华中科技大学学报(医学版), 2015, 44(1): 87-91.
39. Mitzner S, Klammt S, Stange J,et al. Albumin regeneration in liver support – comparison of different methods. Ther Apher Dial, 2006, 10(2): 108-117.
40. 林文, 黄健, 林松伟, 等. 血浆置换联合持续静脉-静脉血液滤过治疗 HBV 相关性肝衰竭患者疗效评估. 肝脏, 2015, 20(10): 802-805.
41. 黎代强. 双重血浆分子吸附系统 (DPMAS) 治疗重型肝病新进展. 中国医学工程, 2015, 23(8): 198-200.
42. 孙潺, 彭程, 揭盛华, 等. 羟乙基淀粉代血浆在人工肝支持系统中治疗肝衰竭的应用及安全性. 华中科技大学学报(医学版), 2013, 42(6): 681-684.

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Therapy advances of non-biological artificial liver

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