Application value of three-dimensional contrast-enhanced ultrasound angiography in differential diagnosis of breast masses_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Hongmei , WEI Tao ,  XIONG Runqing

Department of Ultrasound, The Second Hospital of Xiamen, Xiamen, Fujian 361021, P.R.China;

Corresponding author：

XIONG Runqing, Email: xiongrunqing75@163.com

Keywords：

breast masses; three-dimensional contrast-enhanced ultrasound angiography; two-dimensional ultrasound; differential diagnosis; value; new blood vessels

DOI：

10.7507/1007-9424.201608044

Video：

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Objective To explore the value of three-dimensional contrast-enhanced ultrasound angiography in the differential diagnosis of breast masses. Methods A total of 120 patients with breast masses who were treated in our hospital from July 2013 to February 2016 were selected as the research objects retrospectively, including 70 patients of benign tumor (benign group) and 50 patients of malignant tumor (malignant group) that confirmed by surgery and pathology. All patients were given conventional two-dimensional ultrasound and three-dimensional contrast-enhanced ultrasound angiography during the diagnosis. Compared the imaging features of benign group and malignant group, and compared the diagnostic value of two-dimensional ultrasound and three-dimensional contrast-enhanced ultrasound angiography for breast masses. Results Compared with benign group, the rates of irregular masses, unclear boundary, inhomogeneous echo, lateral shadowing, echo attenuation, and micro calcification in the malignant group were all higher (P<0.05). The three-dimensional contrast-enhanced ultrasound angiography scores in malignant group and benign group were significantly different with each other (P<0.05), the score of the malignant group was higher than that of benign group. The 2- and 3-score was common in benign group, but 4- and 5-score was common in malignant group. The diagnostic sensitivity of two-dimensional ultrasound and three-dimensional contrast-enhanced ultrasound angiography for breast masses were 97.1% (68/70) and 98.6% (69/70) respectively, and the specificity were 80.0% (40/50) and 96.0% (48/50) respectively, the specificity of three-dimensional contrast-enhanced ultrasound angiography was significantly higher than that of two-dimensional ultrasound (P<0.05). Conclusion Two-dimensional ultrasound and three-dimensional contrast-enhanced ultrasound angiography both have a certain diagnostic value in the differential diagnosis of breast masses, but the three dimensional contrast-enhanced ultrasound angiography can get more information through assessment of richness of the microvascular in tumor tissue, so as to improve the diagnostic specificity and is worthy of popularization and application.

Citation： WANG Hongmei, WEI Tao, XIONG Runqing. Application value of three-dimensional contrast-enhanced ultrasound angiography in differential diagnosis of breast masses. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(3): 333-337. doi: 10.7507/1007-9424.201608044 Copy

1.	王晔, 李国杰, 朱向明, 等. 超声显像对乳腺疾病的诊断进展. 中华全科医学, 2013, 11(4): 613-614.
2.	闫晨曦, 杨丽春. 乳腺癌的超声诊断现状及新技术应用进展. 医学综述, 2012, 18(12): 1919-1921.
3.	Liu D, Huang Y, Tian D,et al. Value of sonographic bidirectional arterial flow combined with elastography for diagnosis of breast imaging reporting and data system category 4 breast masses. J Ultrasound Med, 2015, 34(5): 759-766.
4.	李明慧, 刘翼, 柳莉莎, 等. 实时组织弹性成像和三维超声造影在乳腺肿块鉴别诊断中的应用价值. 中华医学杂志, 2016, 96(19): 1515-1518.
5.	Chen L, Chen Y, Diao XH,et al. Comparative study of automated breast 3-D ultrasound and handheld B-mode ultrasound for differentiation of benign and malignant breast masses. Ultrasound Med Biol, 2013, 39(10): 1735-1742.
6.	程玉玲, 周军. 二维、三维超声及超声造影在乳腺癌诊疗中的应用进展. 海南医学, 2015, 22(13): 1949-1951.
7.	王志远, 周启昌. 乳腺恶性肿瘤诊断及疗效监测的超声研究新进展. 临床超声医学杂志, 2014, 16(3): 185-187.
8.	Huang YH, Chen JH, Chang YC,et al. Diagnosis of solid breast tumors using vessel analysis in three-dimensional power Doppler ultrasound images. J Digit Imaging, 2013, 26(4): 731-739.
9.	李明慧, 刘翼, 李慧敏. 乳腺肿瘤动态三维超声造影的误诊分析. 中国医药导刊, 2016, 18(5): 437-439.
10.	Lo CM, Moon WK, Huang CS,et al. Intensity-invariant texture analysis for classification of BI-RADS category 3 breast masses. Ultrasound Med Biol, 2015, 41(7): 2039-2048.
11.	O’Connell AM, Karellas A, Vedantham S. The potential role of dedicated 3D breast CT as a diagnostic tool: review and early clinical examples. Breast J, 2014, 20(6): 592-605.
12.	柯文, 耿峰. 乳腺癌超声诊断技术的研究进展. 海军医学杂志, 2013, 34(6): 429-431.
13.	纪甜甜, 赵青, 翟虹. 超声声触诊量化在乳腺肿块良、恶性鉴别中的价值分析. 肿瘤学杂志, 2016, 22(1): 57-60.
14.	Trottmann M, Marcon J, D’Anastasi M,et al. Shear-wave elastography of the testis in the healthy man —— determination of standard values. Clin Hemorheol Microcirc, 2016, 62(3): 273-281.
15.	Li Z, Tian J, Wang X,et al. Differences in multi-modal ultrasound imaging between triple negative and non-triple negative breast cancer. Ultrasound Med Biol, 2016, 42(4): 882-890.
16.	郑磊, 吕夕明, 黄福光, 等. 乳腺硬化性腺病的超声诊断价值. 中华超声影像学杂志, 2016, 25(3): 263-264.
17.	Kupeli A, Kul S, Eyuboglu I,et al. Role of 3D power Doppler ultrasound in the further characterization of suspicious breast masses. Eur J Radiol, 2016, 85(1): 1-6.
18.	Kuzmiak CM, Ko EY, Tuttle LA,et al. Whole breast ultrasound: comparison of the visibility of suspicious lesions with automated breast volumetric scanningversus hand-held breast ultrasound. Acad Radiol, 2015, 22(7): 870-879.
19.	蒋艳平, 王欣, 李友芳. 高频彩色多普勒超声在鉴别诊断乳腺肿块的应用价值. 现代诊断与治疗, 2016, 27(1): 17-19.
20.	Clauser P, Londero V, Como G,et al. Comparison between different imaging techniques in the evaluation of malignant breast lesions: can 3D ultrasound be useful? Radiol Med, 2014, 119(4): 240-248.
21.	张丽芝, 曾涵江, 黄子星, 等. MRI 扩散加权成像对乳腺浸润性导管癌新辅助化疗效果的评价. 中国普外基础与临床杂志, 2013, 20(1): 88-91.
22.	钟颖, 孙强, 黄汉源, 等. 妊娠期乳腺癌的诊断和治疗. 中国普外基础与临床杂志, 2012, 19(12): 1332-1334.
23.	张伟民. 高频超声联合钼靶 X 线摄影诊断乳腺肿块的效果和价值. 中国实用医刊, 2016, 43(22): 120-122.
24.	李志华, 常爱敏, 吴刚. 基层医院 76 例乳腺肿块细针穿刺细胞学与组织病理学对照分析. 中国现代医生, 2016, 54(6): 88-90.
25.	周玮珺, 孔文韬, 张捷, 等. 超声影像学报告及数据系统鉴别乳腺肿块良恶性的多因素分析. 肿瘤学杂志, 2016, 22(4): 265-268.

1. 王晔, 李国杰, 朱向明, 等. 超声显像对乳腺疾病的诊断进展. 中华全科医学, 2013, 11(4): 613-614.
2. 闫晨曦, 杨丽春. 乳腺癌的超声诊断现状及新技术应用进展. 医学综述, 2012, 18(12): 1919-1921.
3. Liu D, Huang Y, Tian D,et al. Value of sonographic bidirectional arterial flow combined with elastography for diagnosis of breast imaging reporting and data system category 4 breast masses. J Ultrasound Med, 2015, 34(5): 759-766.
4. 李明慧, 刘翼, 柳莉莎, 等. 实时组织弹性成像和三维超声造影在乳腺肿块鉴别诊断中的应用价值. 中华医学杂志, 2016, 96(19): 1515-1518.
5. Chen L, Chen Y, Diao XH,et al. Comparative study of automated breast 3-D ultrasound and handheld B-mode ultrasound for differentiation of benign and malignant breast masses. Ultrasound Med Biol, 2013, 39(10): 1735-1742.
6. 程玉玲, 周军. 二维、三维超声及超声造影在乳腺癌诊疗中的应用进展. 海南医学, 2015, 22(13): 1949-1951.
7. 王志远, 周启昌. 乳腺恶性肿瘤诊断及疗效监测的超声研究新进展. 临床超声医学杂志, 2014, 16(3): 185-187.
8. Huang YH, Chen JH, Chang YC,et al. Diagnosis of solid breast tumors using vessel analysis in three-dimensional power Doppler ultrasound images. J Digit Imaging, 2013, 26(4): 731-739.
9. 李明慧, 刘翼, 李慧敏. 乳腺肿瘤动态三维超声造影的误诊分析. 中国医药导刊, 2016, 18(5): 437-439.
10. Lo CM, Moon WK, Huang CS,et al. Intensity-invariant texture analysis for classification of BI-RADS category 3 breast masses. Ultrasound Med Biol, 2015, 41(7): 2039-2048.
11. O’Connell AM, Karellas A, Vedantham S. The potential role of dedicated 3D breast CT as a diagnostic tool: review and early clinical examples. Breast J, 2014, 20(6): 592-605.
12. 柯文, 耿峰. 乳腺癌超声诊断技术的研究进展. 海军医学杂志, 2013, 34(6): 429-431.
13. 纪甜甜, 赵青, 翟虹. 超声声触诊量化在乳腺肿块良、恶性鉴别中的价值分析. 肿瘤学杂志, 2016, 22(1): 57-60.
14. Trottmann M, Marcon J, D’Anastasi M,et al. Shear-wave elastography of the testis in the healthy man —— determination of standard values. Clin Hemorheol Microcirc, 2016, 62(3): 273-281.
15. Li Z, Tian J, Wang X,et al. Differences in multi-modal ultrasound imaging between triple negative and non-triple negative breast cancer. Ultrasound Med Biol, 2016, 42(4): 882-890.
16. 郑磊, 吕夕明, 黄福光, 等. 乳腺硬化性腺病的超声诊断价值. 中华超声影像学杂志, 2016, 25(3): 263-264.
17. Kupeli A, Kul S, Eyuboglu I,et al. Role of 3D power Doppler ultrasound in the further characterization of suspicious breast masses. Eur J Radiol, 2016, 85(1): 1-6.
18. Kuzmiak CM, Ko EY, Tuttle LA,et al. Whole breast ultrasound: comparison of the visibility of suspicious lesions with automated breast volumetric scanningversus hand-held breast ultrasound. Acad Radiol, 2015, 22(7): 870-879.
19. 蒋艳平, 王欣, 李友芳. 高频彩色多普勒超声在鉴别诊断乳腺肿块的应用价值. 现代诊断与治疗, 2016, 27(1): 17-19.
20. Clauser P, Londero V, Como G,et al. Comparison between different imaging techniques in the evaluation of malignant breast lesions: can 3D ultrasound be useful? Radiol Med, 2014, 119(4): 240-248.
21. 张丽芝, 曾涵江, 黄子星, 等. MRI 扩散加权成像对乳腺浸润性导管癌新辅助化疗效果的评价. 中国普外基础与临床杂志, 2013, 20(1): 88-91.
22. 钟颖, 孙强, 黄汉源, 等. 妊娠期乳腺癌的诊断和治疗. 中国普外基础与临床杂志, 2012, 19(12): 1332-1334.
23. 张伟民. 高频超声联合钼靶 X 线摄影诊断乳腺肿块的效果和价值. 中国实用医刊, 2016, 43(22): 120-122.
24. 李志华, 常爱敏, 吴刚. 基层医院 76 例乳腺肿块细针穿刺细胞学与组织病理学对照分析. 中国现代医生, 2016, 54(6): 88-90.
25. 周玮珺, 孔文韬, 张捷, 等. 超声影像学报告及数据系统鉴别乳腺肿块良恶性的多因素分析. 肿瘤学杂志, 2016, 22(4): 265-268.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Application value of three-dimensional contrast-enhanced ultrasound angiography in differential diagnosis of breast masses

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