Advancement of long non-coding RNA in papillary thyroid carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Yichao , LI Zhihui , CHEN Wenjie ,  ZHU Jingqiang

Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu 610041, P.R.China;

Corresponding author：

ZHU Jingqiang, Email: zjq-wkys@163.com

Keywords：

papillary thyroid carcinoma; long non-coding RNA; gene expression

DOI：

10.7507/1007-9424.201611028

Video：

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Objective The aim of this study is to review the association between long non-coding RNA (lncRNA) and papillary thyroid carcinoma (PTC). Method The relevant literatures about lncRNA associated with PTC were retrospectively analyzed and summarized. Results The expression levels of noncoding RNA associated with MAP kinase pathway and growth arrest (NAMA), PTC susceptibility candidate 3 (PTCSC3), BRAF activated non-coding RNA (BANCR), maternally expressed gene 3 (MEG3), NONHSAT037832, and GAS8-AS1 in PTC tissues were significantly lower than those in non-thyroid carcinoma tissues. The expression levels of ENST00000537266, ENST00000426615, XLOC051122, XLOC006074, HOX transcript antisense RNA (HOTAIR), antisense noncoding RNA in the INK4 locus (ANRIL), and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in PTC tissues were upregulated in PTC tissues, comparing with the non-thyroid carcinoma tissues. These lncRNAs were possibly involved in cell proliferation, migration, and apoptosis of PTC. Conclusion LncRNAs may provide new insights into the molecular mechanism and gene-targeted therapy of PTC and become new molecular marker for the diagnosis of PTC.

Citation： WANG Yichao, LI Zhihui, CHEN Wenjie, ZHU Jingqiang. Advancement of long non-coding RNA in papillary thyroid carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(8): 1030-1034. doi: 10.7507/1007-9424.201611028 Copy

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2.	McLeod DS, Sawka AM, Cooper DS. Controversies in primary treatment of low-risk papillary thyroid cancer. Lancet, 2013, 381(9871): 1046-1057.
3.	Cummings AL, Goldfarb M. Thyroid carcinoma metastases to axillary lymph nodes: report of two rare cases of papillary and medullary thyroid carcinoma and literature review. Endocr Pract, 2014, 20(3): e34-e37.
4.	Sakorafas GH, Sampanis D, Safioleas M. Cervical lymph node dissection in papillary thyroid cancer: current trends, persisting controversies, and unclarified uncertainties. Surg Oncol, 2010, 19(2): e57-e70.
5.	Ponting CP, Oliver PL, Reik W. Evolution and functions of long noncoding RNAs. Cell, 2009, 136(4): 629-641.
6.	Caley DP, Pink RC, Trujillano D, et al. Long noncoding RNAs, chromatin, and development. Sci World J, 2010, 10: 90-102.
7.	Mercer TR, Dinger ME, Mattick JS. Long non-coding RNAs: insights into functions. Nat Rev Genet, 2009, 10(3): 155-159.
8.	Lee JT. Epigenetic regulation by long noncoding RNAs. Science, 2012, 338(6113): 1435-1439.
9.	Iyer MK, Niknafs YS, Malik R, et al. The landscape of long noncoding RNAs in the human transcriptome. Nat Genet, 2015, 47(3): 199-208.
10.	Rinn JL, Chang HY. Genome regulation by long noncoding RNAs. Annu Rev Biochem, 2012, 81: 145-166.
11.	Carraway H, Herman J. Monitoring methylation and gene expression in cancer. Methods Mol Biol, 2007, 383: 187-202.
12.	Cesana M, Cacchiarelli D, Legnini I, et al. A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell, 2011, 147(2): 358-369.
13.	Shang C, Guo Y, Zhang J, et al. Silence of long noncoding RNA UCA1 inhibits malignant proliferation and chemotherapy resistance to adriamycin in gastric cancer. Cancer Chemother Pharmacol, 2016, 77(5): 1061-1067.
14.	Chen DL, Ju HQ, Lu YX, et al. Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression. J Exp Clin Cancer Res, 2016, 35(1): 142.
15.	Ji TT, Huang X, Jin J, et al. Inhibition of long non-coding RNA TUG1 on gastric cancer cell transference and invasion through regulating and controlling the expression of miR-144/c-Met axis. Asian Pac J Trop Med, 2016, 9(5): 508-512.
16.	Yoon H, He H, Nagy R, et al. Identification of a novel noncoding RNA gene, NAMA, that is downregulated in papillary thyroid carcinoma with BRAF mutation and associated with growth arrest. Int J Cancer, 2007, 121(4): 767-775.
17.	Jendrzejewski J, He H, Radomska HS, et al. The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type. Proc Natl Acad Sci U S A, 2012, 109(22): 8646-8651.
18.	Jendrzejewski J, Thomas A, Liyanarachchi S, et al. PTCSC3 is involved in papillary thyroid carcinoma development by modulating S100A4 gene expression. J Clin Endocrinol Metab, 2015, 100(10): E1370-E1377.
19.	Wang Y, Guo Q, Zhao Y, et al. BRAF-activated long non-coding RNA contributes to cell proliferation and activates autophagy in papillary thyroid carcinoma. Oncol Lett, 2014, 8(5): 1947-1952.
20.	Liao T, Qu N, Shi RL, et al. BRAF-activated LncRNA functions as a tumor suppressor in papillary thyroid cancer. Oncotarget, 2017, 8(1): 238-247.
21.	He H, Li W, Liyanarachchi S, et al. Genetic predisposition to papillary thyroid carcinoma: involvement of FOXE1, TSHR, and a novel lincRNA gene, PTCSC2. J Clin Endocrinol Metab, 2015, 100(1): E164-E172.
22.	Wang C, Yan G, Zhang Y, et al. Long non-coding RNA MEG3 suppresses migration and invasion of thyroid carcinoma by targeting of Rac1. Neoplasma, 2015, 62(4): 541-549.
23.	Lan X, Sun W, Zhang P, et al. Downregulation of long noncoding RNA NONHSAT037832 in papillary thyroid carcinoma and its clinical significance. Tumour Biol, 2016, 37(5): 6117-6123.
24.	Pan W, Zhou L, Ge M, et al. Whole exome sequencing identifies lncRNA GAS8-AS1 and LPAR4 as novel papillary thyroid carcinoma driver alternations. Hum Mol Genet, 2016, 25(9): 1875-1884.
25.	Xu B, Shao Q, Xie K, et al. The long non-coding RNA ENST00000537266 and ENST00000426615 influence papillary thyroid cancer cell proliferation and motility. Cell Physiol Biochem, 2016, 38(1): 368-378.
26.	Yang M, Tian J, Guo X, et al. Long noncoding RNA are aberrantly expressed in human papillary thyroid carcinoma. Oncol Lett, 2016, 12(1): 544-552.
27.	Liyanarachchi S, Li W, Yan P, et al. Genome-wide expression screening discloses long noncoding RNAs involved in thyroid carcinogenesis. J Clin Endocrinol Metab, 2016, 101(11): 4005-4013.
28.	Sun W, Lan X, Wang Z, et al. Overexpression of long non-coding RNA NR_036575.1 contributes to the proliferation and migration of papillary thyroid cancer. Med Oncol, 2016, 33(9): 102.
29.	Jeong S, Lee J, Kim D, et al. Relationship of focally amplified long noncoding on chromosome 1 (FAL1) lncRNA with E2F transcription factors in thyroid cancer. Medicine (Baltimore), 2016, 95(4): e2592.
30.	Zhu H, Lv Z, An C, et al. Onco-lncRNA HOTAIR and its functional genetic variants in papillary thyroid carcinoma. Sci Rep, 2016, 6: 31969.
31.	Zhou Q, Chen J, Feng J, et al. Long noncoding RNA PVT1 modulates thyroid cancer cell proliferation by recruiting EZH2 and regulating thyroid-stimulating hormone receptor (TSHR). Tumour Biol, 2016, 37(3): 3105-3113.
32.	Kim D, Lee WK, Jeong S, et al. Upregulation of long noncoding RNA LOC100507661 promotes tumor aggressiveness in thyroid cancer. Mol Cell Endocrinol, 2016, 431: 36-45.
33.	Zhao JJ, Hao S, Wang LL, et al. Long non-coding RNA ANRIL promotes the invasion and metastasis of thyroid cancer cells through TGF-β/Smad signaling pathway. Oncotarget, 2016, 7(36): 57903-57918.
34.	Zhang R, Hardin H, Huang W, et al. MALAT1 long non-coding RNA expression in thyroid tissues: analysis by in situ hybridization and real-time PCR. Endocr Pathol, 2017, 28(1): 7-12.
35.	Liu L, Yang J, Zhu X, et al. Long noncoding RNA H19 competitively binds miR-17-5p to regulate YES1 expression in thyroid cancer. FEBS J, 2016, 283(12): 2326-2339.
36.	Chen H, Xu C, Jin Q, et al. S100 protein family in human cancer. Am J Cancer Res, 2014, 4(2): 89-115.

1. Jankovic B, Le KT, Hershman JM. Clinical review: Hashimoto’s thyroiditis and papillary thyroid carcinoma: is there a correlation? J Clin Endocrinol Metab, 2013, 98(2): 474-482.
2. McLeod DS, Sawka AM, Cooper DS. Controversies in primary treatment of low-risk papillary thyroid cancer. Lancet, 2013, 381(9871): 1046-1057.
3. Cummings AL, Goldfarb M. Thyroid carcinoma metastases to axillary lymph nodes: report of two rare cases of papillary and medullary thyroid carcinoma and literature review. Endocr Pract, 2014, 20(3): e34-e37.
4. Sakorafas GH, Sampanis D, Safioleas M. Cervical lymph node dissection in papillary thyroid cancer: current trends, persisting controversies, and unclarified uncertainties. Surg Oncol, 2010, 19(2): e57-e70.
5. Ponting CP, Oliver PL, Reik W. Evolution and functions of long noncoding RNAs. Cell, 2009, 136(4): 629-641.
6. Caley DP, Pink RC, Trujillano D, et al. Long noncoding RNAs, chromatin, and development. Sci World J, 2010, 10: 90-102.
7. Mercer TR, Dinger ME, Mattick JS. Long non-coding RNAs: insights into functions. Nat Rev Genet, 2009, 10(3): 155-159.
8. Lee JT. Epigenetic regulation by long noncoding RNAs. Science, 2012, 338(6113): 1435-1439.
9. Iyer MK, Niknafs YS, Malik R, et al. The landscape of long noncoding RNAs in the human transcriptome. Nat Genet, 2015, 47(3): 199-208.
10. Rinn JL, Chang HY. Genome regulation by long noncoding RNAs. Annu Rev Biochem, 2012, 81: 145-166.
11. Carraway H, Herman J. Monitoring methylation and gene expression in cancer. Methods Mol Biol, 2007, 383: 187-202.
12. Cesana M, Cacchiarelli D, Legnini I, et al. A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell, 2011, 147(2): 358-369.
13. Shang C, Guo Y, Zhang J, et al. Silence of long noncoding RNA UCA1 inhibits malignant proliferation and chemotherapy resistance to adriamycin in gastric cancer. Cancer Chemother Pharmacol, 2016, 77(5): 1061-1067.
14. Chen DL, Ju HQ, Lu YX, et al. Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression. J Exp Clin Cancer Res, 2016, 35(1): 142.
15. Ji TT, Huang X, Jin J, et al. Inhibition of long non-coding RNA TUG1 on gastric cancer cell transference and invasion through regulating and controlling the expression of miR-144/c-Met axis. Asian Pac J Trop Med, 2016, 9(5): 508-512.
16. Yoon H, He H, Nagy R, et al. Identification of a novel noncoding RNA gene, NAMA, that is downregulated in papillary thyroid carcinoma with BRAF mutation and associated with growth arrest. Int J Cancer, 2007, 121(4): 767-775.
17. Jendrzejewski J, He H, Radomska HS, et al. The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type. Proc Natl Acad Sci U S A, 2012, 109(22): 8646-8651.
18. Jendrzejewski J, Thomas A, Liyanarachchi S, et al. PTCSC3 is involved in papillary thyroid carcinoma development by modulating S100A4 gene expression. J Clin Endocrinol Metab, 2015, 100(10): E1370-E1377.
19. Wang Y, Guo Q, Zhao Y, et al. BRAF-activated long non-coding RNA contributes to cell proliferation and activates autophagy in papillary thyroid carcinoma. Oncol Lett, 2014, 8(5): 1947-1952.
20. Liao T, Qu N, Shi RL, et al. BRAF-activated LncRNA functions as a tumor suppressor in papillary thyroid cancer. Oncotarget, 2017, 8(1): 238-247.
21. He H, Li W, Liyanarachchi S, et al. Genetic predisposition to papillary thyroid carcinoma: involvement of FOXE1, TSHR, and a novel lincRNA gene, PTCSC2. J Clin Endocrinol Metab, 2015, 100(1): E164-E172.
22. Wang C, Yan G, Zhang Y, et al. Long non-coding RNA MEG3 suppresses migration and invasion of thyroid carcinoma by targeting of Rac1. Neoplasma, 2015, 62(4): 541-549.
23. Lan X, Sun W, Zhang P, et al. Downregulation of long noncoding RNA NONHSAT037832 in papillary thyroid carcinoma and its clinical significance. Tumour Biol, 2016, 37(5): 6117-6123.
24. Pan W, Zhou L, Ge M, et al. Whole exome sequencing identifies lncRNA GAS8-AS1 and LPAR4 as novel papillary thyroid carcinoma driver alternations. Hum Mol Genet, 2016, 25(9): 1875-1884.
25. Xu B, Shao Q, Xie K, et al. The long non-coding RNA ENST00000537266 and ENST00000426615 influence papillary thyroid cancer cell proliferation and motility. Cell Physiol Biochem, 2016, 38(1): 368-378.
26. Yang M, Tian J, Guo X, et al. Long noncoding RNA are aberrantly expressed in human papillary thyroid carcinoma. Oncol Lett, 2016, 12(1): 544-552.
27. Liyanarachchi S, Li W, Yan P, et al. Genome-wide expression screening discloses long noncoding RNAs involved in thyroid carcinogenesis. J Clin Endocrinol Metab, 2016, 101(11): 4005-4013.
28. Sun W, Lan X, Wang Z, et al. Overexpression of long non-coding RNA NR_036575.1 contributes to the proliferation and migration of papillary thyroid cancer. Med Oncol, 2016, 33(9): 102.
29. Jeong S, Lee J, Kim D, et al. Relationship of focally amplified long noncoding on chromosome 1 (FAL1) lncRNA with E2F transcription factors in thyroid cancer. Medicine (Baltimore), 2016, 95(4): e2592.
30. Zhu H, Lv Z, An C, et al. Onco-lncRNA HOTAIR and its functional genetic variants in papillary thyroid carcinoma. Sci Rep, 2016, 6: 31969.
31. Zhou Q, Chen J, Feng J, et al. Long noncoding RNA PVT1 modulates thyroid cancer cell proliferation by recruiting EZH2 and regulating thyroid-stimulating hormone receptor (TSHR). Tumour Biol, 2016, 37(3): 3105-3113.
32. Kim D, Lee WK, Jeong S, et al. Upregulation of long noncoding RNA LOC100507661 promotes tumor aggressiveness in thyroid cancer. Mol Cell Endocrinol, 2016, 431: 36-45.
33. Zhao JJ, Hao S, Wang LL, et al. Long non-coding RNA ANRIL promotes the invasion and metastasis of thyroid cancer cells through TGF-β/Smad signaling pathway. Oncotarget, 2016, 7(36): 57903-57918.
34. Zhang R, Hardin H, Huang W, et al. MALAT1 long non-coding RNA expression in thyroid tissues: analysis by in situ hybridization and real-time PCR. Endocr Pathol, 2017, 28(1): 7-12.
35. Liu L, Yang J, Zhu X, et al. Long noncoding RNA H19 competitively binds miR-17-5p to regulate YES1 expression in thyroid cancer. FEBS J, 2016, 283(12): 2326-2339.
36. Chen H, Xu C, Jin Q, et al. S100 protein family in human cancer. Am J Cancer Res, 2014, 4(2): 89-115.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Advancement of long non-coding RNA in papillary thyroid carcinoma

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