Research progression of application of imagings and tumor markers in preoperative TN staging of colorectal cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LU Rongzeng , GAO Hongyan , LEI Xing , GAO Yongtao ,  BAI Tiecheng

Department of Gastrointestinal Surgery, Affiliated Hospital of Yan’an University, Yan’an, Shaanxi 716000, P. R. China;

Corresponding author：

BAI Tiecheng, Email: btch6849@163.com

Keywords：

colorectal cancer; preoperative staging; imaging; tumor marker

DOI：

10.7507/1007-9424.201612030

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To summarize progress of imagings and tumor markers in preoperative TN staging of colorectal cancer. Methods The domestic and international published literatures related to application of imagings such as EUS, CT, and MRI and tumor markers such as CEA, CA19-9, and CA-242 in preoperative TN staging of colorectal cancer were collected and reviewed. Results The imagings and tumor markers have different values in the preoperative TN staging of colorectal cancer, but the value of a single application is limited. The combination of imagings and tumor markers could improve the diagnostic accuracy of the preoperative TN staging of colorectal cancer. Conclusion In clinical work, combination of imagings and tumor markers should be selected basing on actual situation of patients so as to improve accuracy of preoperative TN staging of colorectal cancer, and guide clinical treatment and improve prognosis of patients.

Citation： LU Rongzeng, GAO Hongyan, LEI Xing, GAO Yongtao, BAI Tiecheng. Research progression of application of imagings and tumor markers in preoperative TN staging of colorectal cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(9): 1161-1166. doi: 10.7507/1007-9424.201612030 Copy

1.	Siegel RL, Miller KD, Fedewa SA, et al. Colorectal cancer statistics, 2017. CA Cancer J Clin, 2017, 67(3): 177-193.
2.	陈万青, 郑荣寿, 张思维, 等. 2012 年中国恶性肿瘤发病和死亡分析. 中国肿瘤, 2016, 25(1): 1-8.
3.	向国卿, 赵莹, 朱佳, 等. 9 769 例结直肠癌的构成特征及变化趋势. 现代肿瘤医学, 2016, 24(20): 3236-3239.
4.	Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin, 2015, 65(2): 87-108.
5.	May A, Ell C. Gastroenterological endoscopy. Dtsch Med Wochenschr, 2011, 136(5): 206-208.
6.	彭明, 徐海荣, 刘刚, 等. 超声内镜在结直肠癌术前精确诊断的临床价值. 广西医学, 2016, 38(2): 266-267, 279.
7.	余志金, 彭晓峰, 陈惠新. 超声内镜在大肠癌诊断及微创治疗中的应用. 中国临床新医学, 2015, 8(5): 408-410.
8.	Puli SR, Bechtold ML, Reddy JB, et al. How good is endoscopic ultrasound in differentiating various T stages of rectal cancer? Meta-analysis and systematic review. Ann Surg Oncol, 2009, 16(2): 254-265.
9.	德吉, 秦金玉, 郭天骄, 等. 超声内镜在结直肠癌术前分期中的应用. 四川医学, 2015, 36(3): 261-265.
10.	Cârțână ET, Gheonea DI, Săftoiu A. Advances in endoscopic ultrasound imaging of colorectal diseases. World J Gastroenterol, 2016, 22(5): 1756-1766.
11.	韦捷, 杜凌, 陈刚, 等. 超声内镜在结直肠癌术前分期及手术方案指导中的应用. 广州医药, 2016, 47(3): 56-58.
12.	Maleki Z, Erozan Y, Geddes S, et al. Endorectal ultrasound-guided fine-needle aspiration: a useful diagnostic tool for perirectal and intraluminal lesions. Acta Cytol, 2013, 57(1): 9-18.
13.	Waage JE, Bach SP, Pfeffer F, et al. Combined endorectal ultrasonography and strain elastography for the staging of early rectal cancer. Colorectal Dis, 2015, 17(1): 50-56.
14.	Kolev NY, Tonev AY, Ignatov VL, et al. The role of 3-D endorectal ultrasound in rectal cancer: our experience. Int Surg, 2014, 99(2): 106-111.
15.	Karabacak OR, Cakmakci E, Ozturk U, et al. Virtual cystoscopy: the evaluation of bladder lesions with computed tomographic virtual cystoscopy. Can Urol Assoc J, 2011, 5(1): 34-37.
16.	路成文, 张彬. CT、MR 对盆腔结、直肠癌术前 TN 分期的应用价值. 医学影像学杂志, 2015, 25(7): 1204-1208, 1220.
17.	陈凤丽, 郝粉娥, 黄应龙. 常规全腹部增强 CT 结直肠癌术前评估的初步研究. 局解手术学杂志, 2016, 25(9): 640-643.
18.	Tezcan D, Türkvatan A, Türkoğlu MA, et al. Preoperative staging of colorectal cancer: accuracy of single portal venous phase multidetector computed tomography. Clin Imaging, 2013, 37(6): 1048-1053.
19.	Stagnitti A, Barchetti F, Barchetti G, et al. Preoperative staging of colorectal cancer using virtual colonoscopy: correlation with surgical results. Eur Rev Med Pharmacol Sci, 2015, 19(9): 1645-1651.
20.	Kijima S, Sasaki T, Nagata K, et al. Preoperative evaluation of colorectal cancer using CT colonography, MRI, and PET/CT. World J Gastroenterol, 2014, 20(45): 16964-16975.
21.	官晓晖, 马隆佰, 林华. 64 排螺旋 CT 扫描对大肠癌诊断及分期的价值. 中国CT和MRI杂志, 2014, 12(5): 73-76, 89.
22.	Lee JH, Lee MR. Positron emission tomography/computed tomography in the staging of colon cancer. Ann Coloproctol, 2014, 30(1): 23-27.
23.	任浩棠, 王毅均, 李瑞平, 等. 64 层 ¹⁸F-FDG PET/CT 在结肠癌 N 分期中的诊断价值 (附 73 例报告). 结直肠肛门外科, 2015, 21(6): 402-406.
24.	Schmoll HJ, Van Cutsem E, Stein A, et al. ESMO Consensus Guidelines for management of patients with colon and rectal cancer. a personalized approach to clinical decision making. Ann Oncol, 2012, 23(10): 2479-2516.
25.	张彬, 张禀评, 毛宁, 等. MRI 常规序列结合 DWI 对盆腔内结直肠癌术前临床分期的价值. 中国中西医结合影像学杂志, 2016, 14(2): 143-145, 149.
26.	Iannicelli E, Di Renzo S, Ferri M, et al. Accuracy of high-resolution MRI with lumen distention in rectal cancer staging and circumferential margin involvement prediction. Korean J Radiol, 2014, 15(1): 37-44.
27.	刘海博, 姜微, 曲实. 高分辨力 MRI 在直肠癌 TNM 分期评估中的应用. 中国中西医结合影像学杂志, 2016, 14(2): 137-139.
28.	刘国兵,吴光耀. 直肠癌术前影像学分期. 武汉大学学报(医学版), 2010, 31(5): 701-705.
29.	Tamakawa M, Kawaai Y, Shirase R, et al. Gadolinium-enhanced dynamic magnetic resonance imaging with endorectal coil for local staging of rectal cancer. Jpn J Radiol, 2010, 28(4): 290-298.
30.	Heijnen LA, Lambregts DM, Mondal D, et al. Diffusion-weighted MR imaging in primary rectal cancer staging demonstrates but does not characterise lymph nodes. Eur Radiol, 2013, 23(12): 3354-3360.
31.	苏艳, 龚永泉, 刘振兴, 等. MRI 常规序列联合 DWI 对结直肠癌病变的诊断意义. 实用肿瘤杂志, 2017, 32(2): 156-158.
32.	Tapan U, Ozbayrak M, Tatlı S. MRI in local staging of rectal cancer: an update. Diagn Interv Radiol, 2014, 20(5): 390-398.
33.	刘立恒, 靳二虎, 王振常, 等. MRI 对直肠癌术前评估应用进展. 中华肿瘤防治杂志, 2016, 23(13): 897-902.
34.	Koh DM, George C, Temple L, et al. Diagnostic accuracy of nodal enhancement pattern of rectal cancer at MRI enhanced with ultrasmall superparamagnetic iron oxide: findings in pathologically matched mesorectal lymph nodes. AJR Am J Roentgenol, 2010, 194(6): W505-W513.
35.	林双明, 郑志学, 步召德, 等. 术前血清肿瘤标志物水平在直肠癌术前分期中的应用评价. 中国肿瘤, 2014, 23(7): 616-620.
36.	Pakdel A, Malekzadeh M, Naghibalhossaini F. The association between preoperative serum CEA concentrations and synchronous liver metastasis in colorectal cancer patients. Cancer Biomark, 2016, 16(2): 245-252.
37.	Tsai HL, Huang CW, Chen CW, et al. Survival in resected stage Ⅱ colorectal cancer is dependent on tumor depth, vascular invasion, postoperative CEA level, and the number of examined lymph nodes. World J Surg, 2016, 40(4): 1002-1009.
38.	Vukobrat-Bijedic Z, Husic-Selimovic A, Sofic A, et al. Cancer antigens (CEA and CA 19-9) as markers of advanced stage of colorectal carcinoma. Med Arch, 2013, 67(6): 397-401.
39.	Kirat HT, Ozturk E, Lavery IC, et al. The predictive value of preoperative carcinoembryonic antigen level in the prognosis of colon cancer. Am J Surg, 2012, 204(4): 447-452.
40.	刘琳, 张养民. 血清多种肿瘤标志物联合检测对结直肠癌的诊断价值. 实用癌症杂志, 2016, 31(6): 976-978, 982.
41.	刘峰, 杨伟金, 孙政, 等. TNM Ⅰ～Ⅲ期结直肠癌病人治疗前血清癌胚抗原水平与预后的关系. 南方医科大学学报, 2016, 36(9): 1281-1285.
42.	Thirunavukarasu P, Talati C, Munjal S, et al. Effect of incorporation of pretreatment serum carcinoembryonic antigen levels into AJCC staging for colon cancer on 5-year survival. JAMA Surg, 2015, 150(8): 747-755.
43.	Polat E, Duman U, Duman M, et al. Diagnostic value of preoperative serum carcinoembryonic antigen and carbohydrate antigen 19-9 in colorectal cancer. Curr Oncol, 2014, 21(1): e1-e7.
44.	Wang J, Wang X, Yu F, et al. Combined detection of preoperative serum CEA, CA19-9 and CA242 improve prognostic prediction of surgically treated colorectal cancer patients. Int J Clin Exp Pathol, 2015, 8(11): 14853-14863.
45.	节可歌, 熊鹰飞, 钱江南, 等. 肿瘤标志物 CEA、CA199 对结直肠癌 TNM 分期的预判价值. 生物技术通讯, 2014, 25(3): 391-393.
46.	Zhong W, Yu Z, Zhan J, et al. Association of serum levels of CEA, CA199, CA125, CYFRA21-1 and CA72-4 and disease characteristics in colorectal cancer. Pathol Oncol Res, 2015, 21(1): 83-95.
47.	潘利锋, 梁君林. 初治结直肠癌患者血清 CA242 水平的表达特点. 中国实用医药, 2015, 10(10): 58-60.
48.	Yang XQ, Chen C, Hou JX, et al. Preoperative serum carbohydrate antigen 242 is a useful predictive and prognostic marker in colorectal cancer. Hepatogastroenterology, 2011, 58(106): 377-382.
49.	王振青, 王海波, 刘海春, 等. CT、腔内超声和血清 CEA 联合检查对直肠癌分期诊断的价值. 宁夏医科大学学报, 2015, 37(2): 187-189.
50.	臧健. MRI、TRUS 联合 CEA 量化指标对直肠癌术前分期价值的临床研究. 南开大学, 2014.
51.	刘春海, 张云, 栗瑞敏, 等. ¹⁸F-FDG PET/CT 与 CEA、CA19-9 对大肠癌分期的诊断价值. 国际检验医学杂志, 2014, 35(5): 617-619.

1. Siegel RL, Miller KD, Fedewa SA, et al. Colorectal cancer statistics, 2017. CA Cancer J Clin, 2017, 67(3): 177-193.
2. 陈万青, 郑荣寿, 张思维, 等. 2012 年中国恶性肿瘤发病和死亡分析. 中国肿瘤, 2016, 25(1): 1-8.
3. 向国卿, 赵莹, 朱佳, 等. 9 769 例结直肠癌的构成特征及变化趋势. 现代肿瘤医学, 2016, 24(20): 3236-3239.
4. Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin, 2015, 65(2): 87-108.
5. May A, Ell C. Gastroenterological endoscopy. Dtsch Med Wochenschr, 2011, 136(5): 206-208.
6. 彭明, 徐海荣, 刘刚, 等. 超声内镜在结直肠癌术前精确诊断的临床价值. 广西医学, 2016, 38(2): 266-267, 279.
7. 余志金, 彭晓峰, 陈惠新. 超声内镜在大肠癌诊断及微创治疗中的应用. 中国临床新医学, 2015, 8(5): 408-410.
8. Puli SR, Bechtold ML, Reddy JB, et al. How good is endoscopic ultrasound in differentiating various T stages of rectal cancer? Meta-analysis and systematic review. Ann Surg Oncol, 2009, 16(2): 254-265.
9. 德吉, 秦金玉, 郭天骄, 等. 超声内镜在结直肠癌术前分期中的应用. 四川医学, 2015, 36(3): 261-265.
10. Cârțână ET, Gheonea DI, Săftoiu A. Advances in endoscopic ultrasound imaging of colorectal diseases. World J Gastroenterol, 2016, 22(5): 1756-1766.
11. 韦捷, 杜凌, 陈刚, 等. 超声内镜在结直肠癌术前分期及手术方案指导中的应用. 广州医药, 2016, 47(3): 56-58.
12. Maleki Z, Erozan Y, Geddes S, et al. Endorectal ultrasound-guided fine-needle aspiration: a useful diagnostic tool for perirectal and intraluminal lesions. Acta Cytol, 2013, 57(1): 9-18.
13. Waage JE, Bach SP, Pfeffer F, et al. Combined endorectal ultrasonography and strain elastography for the staging of early rectal cancer. Colorectal Dis, 2015, 17(1): 50-56.
14. Kolev NY, Tonev AY, Ignatov VL, et al. The role of 3-D endorectal ultrasound in rectal cancer: our experience. Int Surg, 2014, 99(2): 106-111.
15. Karabacak OR, Cakmakci E, Ozturk U, et al. Virtual cystoscopy: the evaluation of bladder lesions with computed tomographic virtual cystoscopy. Can Urol Assoc J, 2011, 5(1): 34-37.
16. 路成文, 张彬. CT、MR 对盆腔结、直肠癌术前 TN 分期的应用价值. 医学影像学杂志, 2015, 25(7): 1204-1208, 1220.
17. 陈凤丽, 郝粉娥, 黄应龙. 常规全腹部增强 CT 结直肠癌术前评估的初步研究. 局解手术学杂志, 2016, 25(9): 640-643.
18. Tezcan D, Türkvatan A, Türkoğlu MA, et al. Preoperative staging of colorectal cancer: accuracy of single portal venous phase multidetector computed tomography. Clin Imaging, 2013, 37(6): 1048-1053.
19. Stagnitti A, Barchetti F, Barchetti G, et al. Preoperative staging of colorectal cancer using virtual colonoscopy: correlation with surgical results. Eur Rev Med Pharmacol Sci, 2015, 19(9): 1645-1651.
20. Kijima S, Sasaki T, Nagata K, et al. Preoperative evaluation of colorectal cancer using CT colonography, MRI, and PET/CT. World J Gastroenterol, 2014, 20(45): 16964-16975.
21. 官晓晖, 马隆佰, 林华. 64 排螺旋 CT 扫描对大肠癌诊断及分期的价值. 中国CT和MRI杂志, 2014, 12(5): 73-76, 89.
22. Lee JH, Lee MR. Positron emission tomography/computed tomography in the staging of colon cancer. Ann Coloproctol, 2014, 30(1): 23-27.
23. 任浩棠, 王毅均, 李瑞平, 等. 64 层 ¹⁸F-FDG PET/CT 在结肠癌 N 分期中的诊断价值 (附 73 例报告). 结直肠肛门外科, 2015, 21(6): 402-406.
24. Schmoll HJ, Van Cutsem E, Stein A, et al. ESMO Consensus Guidelines for management of patients with colon and rectal cancer. a personalized approach to clinical decision making. Ann Oncol, 2012, 23(10): 2479-2516.
25. 张彬, 张禀评, 毛宁, 等. MRI 常规序列结合 DWI 对盆腔内结直肠癌术前临床分期的价值. 中国中西医结合影像学杂志, 2016, 14(2): 143-145, 149.
26. Iannicelli E, Di Renzo S, Ferri M, et al. Accuracy of high-resolution MRI with lumen distention in rectal cancer staging and circumferential margin involvement prediction. Korean J Radiol, 2014, 15(1): 37-44.
27. 刘海博, 姜微, 曲实. 高分辨力 MRI 在直肠癌 TNM 分期评估中的应用. 中国中西医结合影像学杂志, 2016, 14(2): 137-139.
28. 刘国兵,吴光耀. 直肠癌术前影像学分期. 武汉大学学报(医学版), 2010, 31(5): 701-705.
29. Tamakawa M, Kawaai Y, Shirase R, et al. Gadolinium-enhanced dynamic magnetic resonance imaging with endorectal coil for local staging of rectal cancer. Jpn J Radiol, 2010, 28(4): 290-298.
30. Heijnen LA, Lambregts DM, Mondal D, et al. Diffusion-weighted MR imaging in primary rectal cancer staging demonstrates but does not characterise lymph nodes. Eur Radiol, 2013, 23(12): 3354-3360.
31. 苏艳, 龚永泉, 刘振兴, 等. MRI 常规序列联合 DWI 对结直肠癌病变的诊断意义. 实用肿瘤杂志, 2017, 32(2): 156-158.
32. Tapan U, Ozbayrak M, Tatlı S. MRI in local staging of rectal cancer: an update. Diagn Interv Radiol, 2014, 20(5): 390-398.
33. 刘立恒, 靳二虎, 王振常, 等. MRI 对直肠癌术前评估应用进展. 中华肿瘤防治杂志, 2016, 23(13): 897-902.
34. Koh DM, George C, Temple L, et al. Diagnostic accuracy of nodal enhancement pattern of rectal cancer at MRI enhanced with ultrasmall superparamagnetic iron oxide: findings in pathologically matched mesorectal lymph nodes. AJR Am J Roentgenol, 2010, 194(6): W505-W513.
35. 林双明, 郑志学, 步召德, 等. 术前血清肿瘤标志物水平在直肠癌术前分期中的应用评价. 中国肿瘤, 2014, 23(7): 616-620.
36. Pakdel A, Malekzadeh M, Naghibalhossaini F. The association between preoperative serum CEA concentrations and synchronous liver metastasis in colorectal cancer patients. Cancer Biomark, 2016, 16(2): 245-252.
37. Tsai HL, Huang CW, Chen CW, et al. Survival in resected stage Ⅱ colorectal cancer is dependent on tumor depth, vascular invasion, postoperative CEA level, and the number of examined lymph nodes. World J Surg, 2016, 40(4): 1002-1009.
38. Vukobrat-Bijedic Z, Husic-Selimovic A, Sofic A, et al. Cancer antigens (CEA and CA 19-9) as markers of advanced stage of colorectal carcinoma. Med Arch, 2013, 67(6): 397-401.
39. Kirat HT, Ozturk E, Lavery IC, et al. The predictive value of preoperative carcinoembryonic antigen level in the prognosis of colon cancer. Am J Surg, 2012, 204(4): 447-452.
40. 刘琳, 张养民. 血清多种肿瘤标志物联合检测对结直肠癌的诊断价值. 实用癌症杂志, 2016, 31(6): 976-978, 982.
41. 刘峰, 杨伟金, 孙政, 等. TNM Ⅰ～Ⅲ期结直肠癌病人治疗前血清癌胚抗原水平与预后的关系. 南方医科大学学报, 2016, 36(9): 1281-1285.
42. Thirunavukarasu P, Talati C, Munjal S, et al. Effect of incorporation of pretreatment serum carcinoembryonic antigen levels into AJCC staging for colon cancer on 5-year survival. JAMA Surg, 2015, 150(8): 747-755.
43. Polat E, Duman U, Duman M, et al. Diagnostic value of preoperative serum carcinoembryonic antigen and carbohydrate antigen 19-9 in colorectal cancer. Curr Oncol, 2014, 21(1): e1-e7.
44. Wang J, Wang X, Yu F, et al. Combined detection of preoperative serum CEA, CA19-9 and CA242 improve prognostic prediction of surgically treated colorectal cancer patients. Int J Clin Exp Pathol, 2015, 8(11): 14853-14863.
45. 节可歌, 熊鹰飞, 钱江南, 等. 肿瘤标志物 CEA、CA199 对结直肠癌 TNM 分期的预判价值. 生物技术通讯, 2014, 25(3): 391-393.
46. Zhong W, Yu Z, Zhan J, et al. Association of serum levels of CEA, CA199, CA125, CYFRA21-1 and CA72-4 and disease characteristics in colorectal cancer. Pathol Oncol Res, 2015, 21(1): 83-95.
47. 潘利锋, 梁君林. 初治结直肠癌患者血清 CA242 水平的表达特点. 中国实用医药, 2015, 10(10): 58-60.
48. Yang XQ, Chen C, Hou JX, et al. Preoperative serum carbohydrate antigen 242 is a useful predictive and prognostic marker in colorectal cancer. Hepatogastroenterology, 2011, 58(106): 377-382.
49. 王振青, 王海波, 刘海春, 等. CT、腔内超声和血清 CEA 联合检查对直肠癌分期诊断的价值. 宁夏医科大学学报, 2015, 37(2): 187-189.
50. 臧健. MRI、TRUS 联合 CEA 量化指标对直肠癌术前分期价值的临床研究. 南开大学, 2014.
51. 刘春海, 张云, 栗瑞敏, 等. ¹⁸F-FDG PET/CT 与 CEA、CA19-9 对大肠癌分期的诊断价值. 国际检验医学杂志, 2014, 35(5): 617-619.

Previous Article
The advances of ultrasound-guided thermal ablation for the treatment of papillary thyroid microcarcinoma
Next Article
热层析成像发现乳腺化生性癌 1 例报道

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research progression of application of imagings and tumor markers in preoperative TN staging of colorectal cancer

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content