Correlation between –765G>C polymorphism of cyclooxygenase-2 gene and susceptibility to colorectal cancer: a meta-analysis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YE Yanjun ¹ , HAO Fujun ¹ ,  ZHANG Ling ²

1. Department of General Surgery, Baoji People’s Hospital, Baoji, Shanxi 721000, P. R. China;
2. Department of Hematology and Rheumatology, Baoji Central Hospital, Baoji, Shanxi 721008, P. R. China;

Corresponding author：

ZHANG Ling, Email: 15091609626@163.com

Keywords：

colorectal cancer; cyclooxygenase-2; meta-analysis

DOI：

10.7507/1007-9424.201704047

Video：

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Objective To evaluate correlation between –765G>C polymorphism of cyclooxygenase-2 (COX-2) gene and susceptibility to colorectal cancer. Methods The PubMed, Embase, The Cochrane Library, CNKI, CBM, VIP, and Wanfang databases were searched from inception to May 2016 to collect case-control studies about the –765G>C polymorphism of COX-2 gene and the susceptibility to colorectal cancer. Two reviewers independently screened the literatures and extracted data of included studies. The meta-analysis was performed using Stata 12.0 software. Results A total of 13 studies involving 4 998 cases and 7 750 controls were included in this meta-analysis. The overall meta-analysis showed that all the genotypes of the –765G>C polymorphism of COX-2 gene were not associated with the susceptibility to colorectal cancer 〔GGvs. GC: OR=0.98, 95% CI (0.89, 1.07), P=0.590; GC vs. CC: OR=0.85, 95% CI (0.65, 1.11), P=0.236; GG vs. CC: OR=0.86, 95% CI (0.66, 1.12), P=0.275; GG+GC vs. CC:OR=0.87, 95% CI (0.67, 1.13), P=0.288; GG vs. GC+CC:OR=0.97, 95% CI (0.89, 1.05), P=0.425〕. The stratification analysis by ethnicity showed that, the GG vs. GC and GG vs. GC+CC modes of COX-2 gene –765G>C polymorphism might be associated with the susceptibility to colorectal cancer in Asians 〔GGvs. GC: OR=0.70, 95%CI (0.58, 0.86), P=0.001; GG vs. GC+CC: OR=0.71, 95% CI (0.58, 0.87), P=0.001〕, but the other modes were not associated with it 〔GC vs. CC: OR=1.74, 95% CI (0.61, 5.00), P=0.301; GG vs. CC: OR=1.18, 95% CI (0.40, 3.45), P=0.762; GG+GC vs. CC: OR=1.50, 95% CI (0.53, 4.23), P=0.440〕. The genotypes of the –765G>C polymorphism of COX-2 gene were not associated with the susceptibility to colorectal cancer in Caucasians 〔GGvs. GC: OR=1.05, 95% CI (0.95, 1.16), P=0.321; GC vs. CC: OR=0.80, 95% CI (0.61, 1.01), P=0.129; GG vs. CC: OR=0.85, 95% CI (0.64, 1.11), P=0.228; GG+GC vs. CC: OR=0.83, 95% CI (0.64, 1.09), P=0.198; GG vs. GC+CC: OR=1.03, 95% CI (0.94, 1.13), P=0.526〕. Conclusion Current evidence shows that –765G>C polymorphism of COX-2 gene might be a genetic risk factor for colorectal cancer in Asians, but not in Caucasians.

Citation： YE Yanjun, HAO Fujun, ZHANG Ling. Correlation between –765G>C polymorphism of cyclooxygenase-2 gene and susceptibility to colorectal cancer: a meta-analysis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(10): 1246-1253. doi: 10.7507/1007-9424.201704047 Copy

1.	Siegel RL, Miller KD, Fedewa SA, et al. Colorectal cancer statistics, 2017. CA Cancer J Clin, 2017, 67(3): 177-193.
2.	Vogtmann E, Xiang YB, Li HL, et al. Cruciferous vegetables, glutathione S-transferase polymorphisms, and the risk of colorectal cancer among Chinese men. Ann Epidemiol, 2014, 24(1): 44-49.
3.	Wu WK, Sung JJ, Lee CW, et al. Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: an update on the molecular mechanisms. Cancer Lett, 2010, 295(1): 7-16.
4.	Rizzo MT. Cyclooxygenase-2 in oncogenesis. Clin Chim Acta, 2011, 412(9-10): 671-687.
5.	Hamajima N, Takezaki T, Matsuo K, et al. Genotype frequencies of cyclooxygenease 2 (COX2) rare polymorphisms for Japanese with and without colorectal cancer. Asian Pac J Cancer Prev, 2001, 2(1): 57-62.
6.	Cox DG, Pontes C, Guino E, et al. Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer. Br J Cancer, 2004, 91(2): 339-343.
7.	Koh WP, Yuan JM, van den Berg D, et al. Interaction between cyclooxygenase-2 gene polymorphism and dietary n-6 polyunsaturated fatty acids on colon cancer risk: the Singapore Chinese Health Study. Br J Cancer, 2004, 90(9): 1760-1764.
8.	Tan W, Wu J, Zhang X, et al. Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer. Carcinogenesis, 2007, 28(6): 1197-1201.
9.	Xing LL, Wang ZN, Jiang L, et al. Cyclooxygenase 2 polymorphism and colorectal cancer:–765G>Cvariant modifies risk associated with smoking and body mass index. World J Gastroenterol, 2008, 14(11): 1785-1789.
10.	Iglesias D, Nejda N, Azcoita MM, et al. Effect of COX2–765G>Cand c. 3618A>G polymorphisms on the risk and survival of sporadic colorectal cancer. Cancer Causes Control, 2009, 20(8): 1421-1429.
11.	Thompson CL, Plummer SJ, Merkulova A, et al. No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk. World J Gastroenterol, 2009, 15(18): 2240-2244.
12.	Hoff JH, te Morsche RH, Roelofs HM, et al. COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk. World J Gastroenterol, 2009, 15(36): 4561-4565.
13.	Andersen V, Ostergaard M, Christensen J, et al. Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study. BMC Cancer, 2009, 9: 407.
14.	Pereira C, Pimentel-Nunes P, Brandão C, et al. COX-2 polymorphisms and colorectal cancer risk: a strategy for chemoprevention. Eur J Gastroenterol Hepatol, 2010, 22(5): 607-613.
15.	Daraei A, Salehi R, Mohamadhashem F. PTGS2 (COX2)–765G>Cgene polymorphism and risk of sporadic colorectal cancer in Iranian population. Mol Biol Rep, 2012, 39(5): 5219-5224.
16.	Makar KW, Poole EM, Resler AJ, et al. COX-1 (PTGS1) and COX-2 (PTGS2) polymorphisms, NSAID interactions, and risk of colon and rectal cancers in two independent populations. Cancer Causes Control, 2013, 24(12): 2059-2075.
17.	阮玉凤, 孙璟, 吴方, 等. COX-2 基因多态性与结直肠癌发病风险的关系研究. 国际消化病杂志, 2013, 33(4): 260-263, 272.0.
18.	Trifan OC, Hla T. Cyclooxygenase-2 modulates cellular growth and promotes tumorigenesis. J Cell Mol Med, 2003, 7(3): 207-222.
19.	van Rees BP, Ristimäki A. Cyclooxygenase-2 in carcinogenesis of the gastrointestinal tract. Scand J Gastroenterol, 2001, 36(9): 897-903.
20.	Oshima H, Oshima M. The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models. J Gastroenterol, 2012, 47(2): 97-106.
21.	Eberhart CE, Coffey RJ, Radhika A, et al. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology, 1994, 107(4): 1183-1188.
22.	Gupta RA, Dubois RN. Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nat Rev Cancer, 2001, 1(1): 11-21.
23.	Gasparini G, Longo R, Sarmiento R, et al. Inhibitors of cyclo-oxygenase 2: a new class of anticancer agents? Lancet Oncol, 2003, 4(10): 605-615.
24.	Wiesner GL, Platzer P, Buxbaum S, et al. Testing for colon neoplasia susceptibility variants at the human COX2 locus. J Natl Cancer Inst, 2001, 93(8): 635-639.
25.	Fujimura T, Ohta T, Oyama K, et al. Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal tract cancers: a review and report of personal experience. World J Gastroenterol, 2006, 12(9): 1336-1345.

1. Siegel RL, Miller KD, Fedewa SA, et al. Colorectal cancer statistics, 2017. CA Cancer J Clin, 2017, 67(3): 177-193.
2. Vogtmann E, Xiang YB, Li HL, et al. Cruciferous vegetables, glutathione S-transferase polymorphisms, and the risk of colorectal cancer among Chinese men. Ann Epidemiol, 2014, 24(1): 44-49.
3. Wu WK, Sung JJ, Lee CW, et al. Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: an update on the molecular mechanisms. Cancer Lett, 2010, 295(1): 7-16.
4. Rizzo MT. Cyclooxygenase-2 in oncogenesis. Clin Chim Acta, 2011, 412(9-10): 671-687.
5. Hamajima N, Takezaki T, Matsuo K, et al. Genotype frequencies of cyclooxygenease 2 (COX2) rare polymorphisms for Japanese with and without colorectal cancer. Asian Pac J Cancer Prev, 2001, 2(1): 57-62.
6. Cox DG, Pontes C, Guino E, et al. Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer. Br J Cancer, 2004, 91(2): 339-343.
7. Koh WP, Yuan JM, van den Berg D, et al. Interaction between cyclooxygenase-2 gene polymorphism and dietary n-6 polyunsaturated fatty acids on colon cancer risk: the Singapore Chinese Health Study. Br J Cancer, 2004, 90(9): 1760-1764.
8. Tan W, Wu J, Zhang X, et al. Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer. Carcinogenesis, 2007, 28(6): 1197-1201.
9. Xing LL, Wang ZN, Jiang L, et al. Cyclooxygenase 2 polymorphism and colorectal cancer:–765G>Cvariant modifies risk associated with smoking and body mass index. World J Gastroenterol, 2008, 14(11): 1785-1789.
10. Iglesias D, Nejda N, Azcoita MM, et al. Effect of COX2–765G>Cand c. 3618A>G polymorphisms on the risk and survival of sporadic colorectal cancer. Cancer Causes Control, 2009, 20(8): 1421-1429.
11. Thompson CL, Plummer SJ, Merkulova A, et al. No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk. World J Gastroenterol, 2009, 15(18): 2240-2244.
12. Hoff JH, te Morsche RH, Roelofs HM, et al. COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk. World J Gastroenterol, 2009, 15(36): 4561-4565.
13. Andersen V, Ostergaard M, Christensen J, et al. Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study. BMC Cancer, 2009, 9: 407.
14. Pereira C, Pimentel-Nunes P, Brandão C, et al. COX-2 polymorphisms and colorectal cancer risk: a strategy for chemoprevention. Eur J Gastroenterol Hepatol, 2010, 22(5): 607-613.
15. Daraei A, Salehi R, Mohamadhashem F. PTGS2 (COX2)–765G>Cgene polymorphism and risk of sporadic colorectal cancer in Iranian population. Mol Biol Rep, 2012, 39(5): 5219-5224.
16. Makar KW, Poole EM, Resler AJ, et al. COX-1 (PTGS1) and COX-2 (PTGS2) polymorphisms, NSAID interactions, and risk of colon and rectal cancers in two independent populations. Cancer Causes Control, 2013, 24(12): 2059-2075.
17. 阮玉凤, 孙璟, 吴方, 等. COX-2 基因多态性与结直肠癌发病风险的关系研究. 国际消化病杂志, 2013, 33(4): 260-263, 272.0.
18. Trifan OC, Hla T. Cyclooxygenase-2 modulates cellular growth and promotes tumorigenesis. J Cell Mol Med, 2003, 7(3): 207-222.
19. van Rees BP, Ristimäki A. Cyclooxygenase-2 in carcinogenesis of the gastrointestinal tract. Scand J Gastroenterol, 2001, 36(9): 897-903.
20. Oshima H, Oshima M. The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models. J Gastroenterol, 2012, 47(2): 97-106.
21. Eberhart CE, Coffey RJ, Radhika A, et al. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology, 1994, 107(4): 1183-1188.
22. Gupta RA, Dubois RN. Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nat Rev Cancer, 2001, 1(1): 11-21.
23. Gasparini G, Longo R, Sarmiento R, et al. Inhibitors of cyclo-oxygenase 2: a new class of anticancer agents? Lancet Oncol, 2003, 4(10): 605-615.
24. Wiesner GL, Platzer P, Buxbaum S, et al. Testing for colon neoplasia susceptibility variants at the human COX2 locus. J Natl Cancer Inst, 2001, 93(8): 635-639.
25. Fujimura T, Ohta T, Oyama K, et al. Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal tract cancers: a review and report of personal experience. World J Gastroenterol, 2006, 12(9): 1336-1345.

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Correlation between –765G>C polymorphism of cyclooxygenase-2 gene and susceptibility to colorectal cancer: a meta-analysis

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