Association between MTHFR A1298C polymorphism and breast cancer in Asain population: a meta-analysis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Zhitao ¹ , YANG Zhongjun ¹ , WANG Xiaoqiong ² ,  YAN Peng ¹

1. Department of Oncology Surgery, Zhangye People’s Hospital of Hexi College, Zhangye, Gansu 734000, P. R. China;
2. Department of Breast, Zhangye People’s Hospital of Hexi College, Zhangye, Gansu 734000, P. R. China;

Corresponding author：

YAN Peng, Email: 418878994@qq.com

Keywords：

breast cancer; methylene tetrahydrofolate reductase; genetic polymorphism; Asain population; meta-analysis

DOI：

10.7507/1007-9424.201705021

Video：

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Objective To evaluate the association between methylene tetrahydrofolate reductase (MTHFR) A1298C polymorphism and breast cancer in the Asain population. Methods PubMed, EMBASE, Web of science, Chinese Biomedical Literature Database, Chinese Science and Technology Academic Periodical Database, Chinese Journal Full-Text Database, and Wanfang Database were searched to identify relevant articles that investigated the association of MTHFR A1298C polymorphism with breast cancer, the articles published time was from inception of database to March 2017. A meta-analysis was performed by using the Stata 12.0 software. Results A meta-analysis of 19 case-control studies was performed including 7 454 cases of breast cancer and 8 255 controls. The results of meta-analysis suggested that there was no signiﬁcant association between MTHFR A1298C polymorphism and breast cancer for the Asain population under ﬁve genetic models 〔AA vs AC: OR=0.97, 95% CI was (0.91, 1.04), P=0.374; AC vs CC: OR=0.87, 95% CI was (0.75, 1.01）, P=0.060; AA vs CC: OR=0.87, 95% CI was (0.76, 1.01), P=0.061; AA+AC vs CC: OR=0.88, 95% CI was (0.76, 1.01), P=0.061; AC+CC vs AA: OR=0.99, 95% CI was (0.93, 1.06), P=0.737〕. Conclusion MTHFR A1298C polymorphism is not associated with breast cancer in the Asain population.

Citation： ZHANG Zhitao, YANG Zhongjun, WANG Xiaoqiong, YAN Peng. Association between MTHFR A1298C polymorphism and breast cancer in Asain population: a meta-analysis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(11): 1371-1379. doi: 10.7507/1007-9424.201705021 Copy

1.	Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
2.	Naushad SM, Ramaiah MJ, Pavithrakumari M, et al. Artificial neural network-based exploration of gene-nutrient interactions in folate and xenobiotic metabolic pathways that modulate susceptibility to breast cancer. Gene, 2016, 580(2): 159-168.
3.	Shrubsole MJ, Gao YT, Cai Q, et al. MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Epidemiol Biomarkers Prev, 2004, 13(2): 190-196.
4.	Chou YC, Wu MH, Yu JC, et al. Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case-control study in Taiwan. Carcinogenesis, 2006, 27(11): 2295-2300.
5.	Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
6.	Mir MM, Dar JA, Dar NA, et al. Combined impact of polymorphism of folate metabolism genes; glutamate carboxypeptidase, methylene tetrahydrofolate reductase and methionine synthase reductase on breast cancer susceptibility in kashmiri women. Int J Health Sci (Qassim), 2008, 2(1): 3-14.
7.	Inoue M, Robien K, Wang R, et al. Green tea intake, MTHFR/TYMS genotype and breast cancer risk: the Singapore Chinese Health Study. Carcinogenesis, 2008, 29(10): 1967-1972.
8.	Sangrajrang S, Sato Y, Sakamoto H, et al. Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case-control study in Thai women. Breast Cancer Res Treat, 2010, 123(3): 885-893.
9.	Awwad N, Yousef AM, Abuhaliema A, et al. Relationship between genetic polymorphisms in MTHFR (C677T, A1298C and their haplotypes) and the incidence of breast cancer among Jordanian females——case-control study. Asian Pac J Cancer Prev, 2015, 16(12): 5007-5011.
10.	齐军, 缪小平, 谭文, 等. 亚甲基四氢叶酸还原酶基因单核苷酸多态与乳腺癌风险. 中华肿瘤杂志, 2004, 26(05): 34-36.
11.	阚祥绪, 邹天宁, 吴瑕玉, 等. 云南人亚甲基四氢叶酸还原酶基因型多态性与乳腺癌易感性的关联. 肿瘤防治研究, 2007, 34(9): 716-718.
12.	Cheng CW, Yu JC, Huang CS, et al. Polymorphism of cytosolic serine hydroxymethyltransferase, estrogen and breast cancer risk among Chinese women in Taiwan. Breast Cancer Res Treat, 2008, 111(1): 145-155.
13.	Gao CM, Tang JH, Cao HX, et al. MTHFR polymorphisms, dietary folate intake and breast cancer risk in Chinese women. J Hum Genet, 2009, 54(7): 414-418.
14.	滑志鹏, 王永斌, 倪娟, 等. 血清叶酸、维生素 B₁₂ 浓度及 MTHFR、MS 基因多态性与乳腺癌风险相关性研究. 现代肿瘤医学, 2011, 19(3): 428-431.
15.	Wu XY, Ni J, Xu WJ, et al. Interactions between MTHFR C677T-A1298C variants and folic acid deficiency affect breast cancer risk in a Chinese population. Asian Pac J Cancer Prev, 2012, 13(5): 2199-2206.
16.	Liu Y, Zhou LS, Xu XM, et al. Association of dietary intake of folate, vitamin B6 and B12 and MTHFR genotype with breast cancer risk. Asian Pac J Cancer Prev, 2013, 14(9): 5189-5192.
17.	Qiao JH, Jiao DC, Lu ZD, et al. Association of methylenetetrahydrofolate reductase and methionine synthase polymorphisms with breast cancer risk and interaction with folate, vitamin B6, and vitamin B12 intakes. Tumour Biol, 2014, 35(12): 11895-11901.
18.	He JM, Pu YD, Wu YJ, et al. Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer. Genet Mol Res, 2014, 13(4): 8925-8931.
19.	Zheng WW, Chen LP, Li DQ. Association between dietary intake of folate, vitamin B₆, B₁₂ & MTHFR, MTR Genotype and breast cancer risk. Pak J Med Sci, 2014, 30(1): 106-110.
20.	Huang CY, Chang WS, Shui HA, et al. Evaluation of the contribution of methylenetetrahydrofolate reductase genotypes to Taiwan breast cancer. Anticancer Res, 2014, 34(8): 4109-4115.
21.	Zhang XF, Liu T, Li Y, et al. Association between MTHFR 677C/T and 1298A/C gene polymorphisms and breast cancer risk. Genet Mol Res, 2015, 14(4): 16425-16430.
22.	Lu Q, Jiang K, Li Q, et al. Polymorphisms in the MTHFR gene are associated with breast cancer risk and prognosis in a Chinese population. Tumour Biol, 2015, 36(5): 3757-3762.
23.	熊萍, 帅平, 李卉, 等. 膳食叶酸和 MTHFR 基因多态性对乳腺癌发病的影响. 现代预防医学, 2016, 43(23): 4267-4271.
24.	陶世龙, 王欢, 何帮顺, 等. 叶酸代谢相关酶单核苷酸基因多态性与乳腺癌的相关性研究. 南京医科大学学报 (自然科学版), 2016, 4(4): 473-478.
25.	宋姗姗, 杨博逸, 孙贵范. 中国人群中亚甲基四氢叶酸还原酶 C677T 和 A1298C 基因多态性与乳腺癌相关性的 Meta 分析. 中国慢性病预防与控制, 2013, 21(5): 560-564.
26.	Wang Y, Yang H, Duan G. MTHFR gene A1298C polymorphisms are associated with breast cancer risk among Chinese population: evidence based on an updated cumulative meta-analysis. Int J Clin Exp Med, 2015, 8(11): 20146-20156.

1. Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
2. Naushad SM, Ramaiah MJ, Pavithrakumari M, et al. Artificial neural network-based exploration of gene-nutrient interactions in folate and xenobiotic metabolic pathways that modulate susceptibility to breast cancer. Gene, 2016, 580(2): 159-168.
3. Shrubsole MJ, Gao YT, Cai Q, et al. MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Epidemiol Biomarkers Prev, 2004, 13(2): 190-196.
4. Chou YC, Wu MH, Yu JC, et al. Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case-control study in Taiwan. Carcinogenesis, 2006, 27(11): 2295-2300.
5. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
6. Mir MM, Dar JA, Dar NA, et al. Combined impact of polymorphism of folate metabolism genes; glutamate carboxypeptidase, methylene tetrahydrofolate reductase and methionine synthase reductase on breast cancer susceptibility in kashmiri women. Int J Health Sci (Qassim), 2008, 2(1): 3-14.
7. Inoue M, Robien K, Wang R, et al. Green tea intake, MTHFR/TYMS genotype and breast cancer risk: the Singapore Chinese Health Study. Carcinogenesis, 2008, 29(10): 1967-1972.
8. Sangrajrang S, Sato Y, Sakamoto H, et al. Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case-control study in Thai women. Breast Cancer Res Treat, 2010, 123(3): 885-893.
9. Awwad N, Yousef AM, Abuhaliema A, et al. Relationship between genetic polymorphisms in MTHFR (C677T, A1298C and their haplotypes) and the incidence of breast cancer among Jordanian females——case-control study. Asian Pac J Cancer Prev, 2015, 16(12): 5007-5011.
10. 齐军, 缪小平, 谭文, 等. 亚甲基四氢叶酸还原酶基因单核苷酸多态与乳腺癌风险. 中华肿瘤杂志, 2004, 26(05): 34-36.
11. 阚祥绪, 邹天宁, 吴瑕玉, 等. 云南人亚甲基四氢叶酸还原酶基因型多态性与乳腺癌易感性的关联. 肿瘤防治研究, 2007, 34(9): 716-718.
12. Cheng CW, Yu JC, Huang CS, et al. Polymorphism of cytosolic serine hydroxymethyltransferase, estrogen and breast cancer risk among Chinese women in Taiwan. Breast Cancer Res Treat, 2008, 111(1): 145-155.
13. Gao CM, Tang JH, Cao HX, et al. MTHFR polymorphisms, dietary folate intake and breast cancer risk in Chinese women. J Hum Genet, 2009, 54(7): 414-418.
14. 滑志鹏, 王永斌, 倪娟, 等. 血清叶酸、维生素 B₁₂ 浓度及 MTHFR、MS 基因多态性与乳腺癌风险相关性研究. 现代肿瘤医学, 2011, 19(3): 428-431.
15. Wu XY, Ni J, Xu WJ, et al. Interactions between MTHFR C677T-A1298C variants and folic acid deficiency affect breast cancer risk in a Chinese population. Asian Pac J Cancer Prev, 2012, 13(5): 2199-2206.
16. Liu Y, Zhou LS, Xu XM, et al. Association of dietary intake of folate, vitamin B6 and B12 and MTHFR genotype with breast cancer risk. Asian Pac J Cancer Prev, 2013, 14(9): 5189-5192.
17. Qiao JH, Jiao DC, Lu ZD, et al. Association of methylenetetrahydrofolate reductase and methionine synthase polymorphisms with breast cancer risk and interaction with folate, vitamin B6, and vitamin B12 intakes. Tumour Biol, 2014, 35(12): 11895-11901.
18. He JM, Pu YD, Wu YJ, et al. Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer. Genet Mol Res, 2014, 13(4): 8925-8931.
19. Zheng WW, Chen LP, Li DQ. Association between dietary intake of folate, vitamin B₆, B₁₂ & MTHFR, MTR Genotype and breast cancer risk. Pak J Med Sci, 2014, 30(1): 106-110.
20. Huang CY, Chang WS, Shui HA, et al. Evaluation of the contribution of methylenetetrahydrofolate reductase genotypes to Taiwan breast cancer. Anticancer Res, 2014, 34(8): 4109-4115.
21. Zhang XF, Liu T, Li Y, et al. Association between MTHFR 677C/T and 1298A/C gene polymorphisms and breast cancer risk. Genet Mol Res, 2015, 14(4): 16425-16430.
22. Lu Q, Jiang K, Li Q, et al. Polymorphisms in the MTHFR gene are associated with breast cancer risk and prognosis in a Chinese population. Tumour Biol, 2015, 36(5): 3757-3762.
23. 熊萍, 帅平, 李卉, 等. 膳食叶酸和 MTHFR 基因多态性对乳腺癌发病的影响. 现代预防医学, 2016, 43(23): 4267-4271.
24. 陶世龙, 王欢, 何帮顺, 等. 叶酸代谢相关酶单核苷酸基因多态性与乳腺癌的相关性研究. 南京医科大学学报 (自然科学版), 2016, 4(4): 473-478.
25. 宋姗姗, 杨博逸, 孙贵范. 中国人群中亚甲基四氢叶酸还原酶 C677T 和 A1298C 基因多态性与乳腺癌相关性的 Meta 分析. 中国慢性病预防与控制, 2013, 21(5): 560-564.
26. Wang Y, Yang H, Duan G. MTHFR gene A1298C polymorphisms are associated with breast cancer risk among Chinese population: evidence based on an updated cumulative meta-analysis. Int J Clin Exp Med, 2015, 8(11): 20146-20156.

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Association between MTHFR A1298C polymorphism and breast cancer in Asain population: a meta-analysis

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