Clinicopathologic features of papillary thyroid carcinoma with coexistent chronic lymphocytic thyroiditis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHU Min ¹ , WANG Huguo ¹ , ZHANG Ying ² , Wufuer·Yimaer ¹ , MIAO Yutang ¹ ,  Sailike·Magaoweiya ¹

1. Department of Vascular and Thyroid Surgery, The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, P. R. China;
2. Department of Epidemiology and Health Statistics, School of Public Health, Xinjiang Medical University, Urumqi 830054, P. R. China;

Corresponding author：

Sailike·Magaoweiya, Email: sairike@126.com

Keywords：

thyroid neoplasm; chronic lymphocytic thyroiditis; clinicopathologic feature

DOI：

10.7507/1007-9424.201708060

Video：

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Objective To analyze clinical and pathological features of patients with papillary thyroid carcinoma (PTC) with coexistent chronic lymphocytic thyroiditis (CLT). Methods The clinicopathologic data of 756 cases of PTC were collected from January 2014 to January 2017 in the First Affiliated Hospital, Xinjiang Medical University were collected. The patients were designed to observational group (PTC with coexistent CLT, n=194) and control group (simple PTC, n=562) according to whether CLT was diagnosed by pathology, then the clinical data, ultrasonic features, thyroid function, and pathological features in these two groups were compared. Results The proportion of the female patients, the proportions of theserum thyroid stimulating hormone and thyroid autoimmune antibodies (thyroglobulin antibody and thyroid peroxidase antibody), and the proportion of multifocal carcinoma in the observational group were significantly higher than those in the control group (P<0.05). There were no significant differences in the preoperative ultrasound, tumor diameter, thyroid capsule invasion, central lymph node metastasis, and TNM stage in these two groups (P>0.05). The results of the multivariate analysis showed that the female, serum thyroid autoimmune antibodies, and the multifocal carcinoma were the independent predictive factors of PTC with CLT (P<0.05). Conclusions There might be a certain correlation between PTC and CLT, PTC with coexistent CLT is more common in female patient and with multifocal carcinoma. With coexistent CLT does not increase invasion of PTC. This may be associated with limit of CLT to development of PTC nodules. It is speculated that CLT may be a protective factor of PTC.

Citation： ZHU Min, WANG Huguo, ZHANG Ying, Wufuer·Yimaer, MIAO Yutang, Sailike·Magaoweiya. Clinicopathologic features of papillary thyroid carcinoma with coexistent chronic lymphocytic thyroiditis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2018, 25(3): 307-311. doi: 10.7507/1007-9424.201708060 Copy

1.	Zhu Y, Zheng K, Zhang H, et al. The clinicopathologic differences of central lymph node metastasis in predicting lateral lymph node metastasis and prognosis in papillary thyroid cancer associated with or without Hashimoto's thyroiditis. Tumour Biol, 2016, 37(6): 8037-8045.
2.	Zhang Y, Dai J, Wu T, et al. The study of the coexistence of Hashimoto's thyroiditis with papillary thyroid carcinoma. J Cancer Res Clin Oncol, 2014, 140(6): 1021-1026.
3.	刘捷. 甲状腺乳头状癌合并桥本氏甲状腺炎的临床病理特征. 现代肿瘤医学, 2016, 24(2): 222-225.
4.	陈诚, 余宁康, 龚进发, 等. 桥本甲状腺炎合并甲状腺乳头状癌的临床特点及外科治疗. 中华普通外科杂志, 2013, 28(7): 511-514.
5.	Ahn D, Heo SJ, Park JH, et al. Clinical relationship between Hashimoto's thyroiditis and papillary thyroid cancer. Acta Oncol, 2011, 50(8): 1228-1234.
6.	Eisenberg BL, Hensley SD. Thyroid cancer with coexistent Hashimoto's thyroiditis. Clinical assessment and management. Arch Surg, 1989, 124(9):1045-1047.
7.	Kim SG, Seo HS, Lee HH, et al. Comparison of the differences in survival rates between the 7th and 8th editions of the AJCC TNM staging system for gastric adenocarcinoma: a single-institution study of 5 507 patients in Korea. J Gastric Cancer, 2017, 17(3): 212-219.
8.	Tamimi DM. The association between chronic lymphocytic thyroiditis and thyroid tumors. Int J Surg Pathol, 2002, 10(2): 141-146.
9.	Kebebew E, Treseler PA, Ituarte PH, et al. Coexisting chronic lymphocytic thyroiditis and papillary thyroid cancer revisited. World J Surg, 2001, 25(5): 632-637.
10.	朱敏, 赛力克•马高维亚. 慢性淋巴细胞性甲状腺炎与甲状腺乳头状癌的相关性研究进展. 中国普外基础与临床杂志, 2017, 24(10): 1289-1294.
11.	Girardi FM, Barra MB, Zettler CG. Papillary thyroid carcinoma: does the association with Hashimoto's thyroiditis affect the clinicopathological characteristics of the disease? Braz J Otorhinolaryngol, 2015, 81(3): 283-287.
12.	郝战宇, 李波. 桥本甲状腺炎合并甲状腺乳头状癌的临床及病理学特征. 山东大学学报(医学版), 2016, 54(6): 73-77.
13.	黄伟钦, 薛恩生, 林礼务, 等. 桥本甲状腺炎背景下甲状腺癌的超声表现探讨. 中华医学超声杂志(电子版), 2009, 6(3): 61-64.
14.	刘友忠, 于洋, 赵翠, 等. 甲状腺乳头状癌合并桥本甲状腺炎的临床生物学特性分析. 中华普通外科杂志, 2013, 28(4): 256-258.
15.	邓江波. 甲状腺乳头状癌合并桥本氏甲状腺炎的临床和病理特点. 深圳中西医结合杂志, 2016, 26(13): 90-92.
16.	刘明明, 高莹, 张杨, 等. 抗甲状腺球蛋白抗体的亲合力在 Graves 病与 Graves 病合并桥本甲状腺炎鉴别诊断中的意义. 大连: 中华医学会内分泌学分会, 中华医学会第九次全国内分泌学学术会议, 2010.
17.	张德杰, 林国樑, 张铭, 等. 桥本氏甲状腺炎合并甲状腺癌的临床及病理研究. 兰州大学学报(医学版), 2017, 43(1): 31-35.
18.	杜婧, 武心萍, 丁文波, 等. 桥本氏甲状腺炎合并甲状腺乳头状癌患者血清 Tg-Ab 和 TPO-Ab 浓度的变化. 江苏医药, 2017, 43(5): 379-380.
19.	Azizi G, Keller JM, Lewis M, et al. Association of Hashimoto's thyroiditis with thyroid cancer. Endocr Relat Cancer, 2014, 21(6): 845-852.
20.	林琳, 郑向前, 刘磊, 等. 多灶性甲状腺乳头状癌的生物学特性及治疗分析. 中华普通外科杂志, 2010, 25(8): 621-623.
21.	周晓倩, 金慧, 郑淼, 等. 合并桥本甲状腺炎的甲状腺乳头状癌术式探讨. 中华普通外科杂志, 2016, 31(3): 236-237.
22.	茅建娅, 王薇, 别克扎提, 等. 甲状腺乳头状癌合并桥本甲状腺炎的临床病理研究. 中国普通外科杂志, 2016, 25(5): 665-669.
23.	Konturek A, Barczyński M, Wierzchowski W, et al. Coexistence of papillary thyroid cancer with Hashimoto thyroiditis. Langenbecks Arch Surg, 2013, 398(3): 389-394.
24.	徐冬冬, 论语, 刘勋, 等. Graves 病合并 PTC 与桥本甲状腺炎合并 PTC 的临床及病理特征比较. 中华医学杂志, 2017, 97(32): 2491-2495.
25.	伦语, 吴小雨, 辛世杰, 等. 桥本甲状腺炎与甲状腺乳头状癌关系的临床研究. 中国普通外科杂志, 2014, 23(5):484-590.

1. Zhu Y, Zheng K, Zhang H, et al. The clinicopathologic differences of central lymph node metastasis in predicting lateral lymph node metastasis and prognosis in papillary thyroid cancer associated with or without Hashimoto's thyroiditis. Tumour Biol, 2016, 37(6): 8037-8045.
2. Zhang Y, Dai J, Wu T, et al. The study of the coexistence of Hashimoto's thyroiditis with papillary thyroid carcinoma. J Cancer Res Clin Oncol, 2014, 140(6): 1021-1026.
3. 刘捷. 甲状腺乳头状癌合并桥本氏甲状腺炎的临床病理特征. 现代肿瘤医学, 2016, 24(2): 222-225.
4. 陈诚, 余宁康, 龚进发, 等. 桥本甲状腺炎合并甲状腺乳头状癌的临床特点及外科治疗. 中华普通外科杂志, 2013, 28(7): 511-514.
5. Ahn D, Heo SJ, Park JH, et al. Clinical relationship between Hashimoto's thyroiditis and papillary thyroid cancer. Acta Oncol, 2011, 50(8): 1228-1234.
6. Eisenberg BL, Hensley SD. Thyroid cancer with coexistent Hashimoto's thyroiditis. Clinical assessment and management. Arch Surg, 1989, 124(9):1045-1047.
7. Kim SG, Seo HS, Lee HH, et al. Comparison of the differences in survival rates between the 7th and 8th editions of the AJCC TNM staging system for gastric adenocarcinoma: a single-institution study of 5 507 patients in Korea. J Gastric Cancer, 2017, 17(3): 212-219.
8. Tamimi DM. The association between chronic lymphocytic thyroiditis and thyroid tumors. Int J Surg Pathol, 2002, 10(2): 141-146.
9. Kebebew E, Treseler PA, Ituarte PH, et al. Coexisting chronic lymphocytic thyroiditis and papillary thyroid cancer revisited. World J Surg, 2001, 25(5): 632-637.
10. 朱敏, 赛力克•马高维亚. 慢性淋巴细胞性甲状腺炎与甲状腺乳头状癌的相关性研究进展. 中国普外基础与临床杂志, 2017, 24(10): 1289-1294.
11. Girardi FM, Barra MB, Zettler CG. Papillary thyroid carcinoma: does the association with Hashimoto's thyroiditis affect the clinicopathological characteristics of the disease? Braz J Otorhinolaryngol, 2015, 81(3): 283-287.
12. 郝战宇, 李波. 桥本甲状腺炎合并甲状腺乳头状癌的临床及病理学特征. 山东大学学报(医学版), 2016, 54(6): 73-77.
13. 黄伟钦, 薛恩生, 林礼务, 等. 桥本甲状腺炎背景下甲状腺癌的超声表现探讨. 中华医学超声杂志(电子版), 2009, 6(3): 61-64.
14. 刘友忠, 于洋, 赵翠, 等. 甲状腺乳头状癌合并桥本甲状腺炎的临床生物学特性分析. 中华普通外科杂志, 2013, 28(4): 256-258.
15. 邓江波. 甲状腺乳头状癌合并桥本氏甲状腺炎的临床和病理特点. 深圳中西医结合杂志, 2016, 26(13): 90-92.
16. 刘明明, 高莹, 张杨, 等. 抗甲状腺球蛋白抗体的亲合力在 Graves 病与 Graves 病合并桥本甲状腺炎鉴别诊断中的意义. 大连: 中华医学会内分泌学分会, 中华医学会第九次全国内分泌学学术会议, 2010.
17. 张德杰, 林国樑, 张铭, 等. 桥本氏甲状腺炎合并甲状腺癌的临床及病理研究. 兰州大学学报(医学版), 2017, 43(1): 31-35.
18. 杜婧, 武心萍, 丁文波, 等. 桥本氏甲状腺炎合并甲状腺乳头状癌患者血清 Tg-Ab 和 TPO-Ab 浓度的变化. 江苏医药, 2017, 43(5): 379-380.
19. Azizi G, Keller JM, Lewis M, et al. Association of Hashimoto's thyroiditis with thyroid cancer. Endocr Relat Cancer, 2014, 21(6): 845-852.
20. 林琳, 郑向前, 刘磊, 等. 多灶性甲状腺乳头状癌的生物学特性及治疗分析. 中华普通外科杂志, 2010, 25(8): 621-623.
21. 周晓倩, 金慧, 郑淼, 等. 合并桥本甲状腺炎的甲状腺乳头状癌术式探讨. 中华普通外科杂志, 2016, 31(3): 236-237.
22. 茅建娅, 王薇, 别克扎提, 等. 甲状腺乳头状癌合并桥本甲状腺炎的临床病理研究. 中国普通外科杂志, 2016, 25(5): 665-669.
23. Konturek A, Barczyński M, Wierzchowski W, et al. Coexistence of papillary thyroid cancer with Hashimoto thyroiditis. Langenbecks Arch Surg, 2013, 398(3): 389-394.
24. 徐冬冬, 论语, 刘勋, 等. Graves 病合并 PTC 与桥本甲状腺炎合并 PTC 的临床及病理特征比较. 中华医学杂志, 2017, 97(32): 2491-2495.
25. 伦语, 吴小雨, 辛世杰, 等. 桥本甲状腺炎与甲状腺乳头状癌关系的临床研究. 中国普通外科杂志, 2014, 23(5):484-590.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinicopathologic features of papillary thyroid carcinoma with coexistent chronic lymphocytic thyroiditis

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