Research progress on relationship between galectin-1 and invasion and metastasis of gastric cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

DU Hengrui , WANG Zhenjiang , MA Zhijian , REN Yanxian , WANG Keshen , ZHAN Hao ,  JIAO Zuoyi

The First Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, P. R. China;

Corresponding author：

JIAO Zuoyi, Email: jiaozx@lzu.edu.cn

Keywords：

galectin-1; gastric cancer; invasion; metastasis

DOI：

10.7507/1007-9424.201806094

Video：

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Objective To investigate relationship between galectin-1 (Gal-1) and invasion and metastasis of gastric cancer.Method The related literatures on the relationship between the Gal-1 and the invasion and metastasis of gastric cancer in recent years were reviewed.Results The expression of Gal-1 in the gastric cancer tissue was closely related to the invasion, metastasis ability, immunosuppression, and angiogenesis of tumor cells, and played the important role in the progression and evolution of the gastric cancer. The expression of Gal-1 was higher, the malignancy of the tumor was higher, and the prognosis of the patient was worse.Conclusion Expression of Gal-1 can promote invasion and metastasis of gastric cancer, but further clinical trials need to be verified.

Citation： DU Hengrui, WANG Zhenjiang, MA Zhijian, REN Yanxian, WANG Keshen, ZHAN Hao, JIAO Zuoyi. Research progress on relationship between galectin-1 and invasion and metastasis of gastric cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2018, 25(12): 1527-1530. doi: 10.7507/1007-9424.201806094 Copy

1.	Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer, 2015, 136(5): E359-E386.
2.	张耕源, 罗长江, 龙勃, 等. 含多西他赛的新辅助化疗治疗进展期胃癌有效性和安全性的 Meta 分析. 中国普通外科杂志, 2016, 25(10): 1388-1396.
3.	陈国宁, 蔡茂怀. 紫杉醇、奥沙利铂联合榄香烯腹腔灌注治疗胃癌晚期癌性腹水的临床观察. 中国药房, 2016, 27(36): 5095-5097.
4.	Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Dicker D, et al. The global burden of cancer 2013. JAMA Oncol, 2015, 1(4): 505-527.
5.	Bacigalupo ML, Carabias P, Troncoso MF. Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression. World J Gastroenterol, 2017, 23(29): 5266-5281.
6.	Long B, Yu Z, Zhou H, et al. Clinical characteristics and prognostic significance of galectins for patients with gastric cancer: A meta-analysis. Int J Surg, 2018, 56: 242-249.
7.	Yang RY, Rabinovich GA, Liu FT. Galectins: structure, function and therapeutic potential. Expert Rev Mol Med, 2008, 10: e17.
8.	Lau KS, Dennis JW. N-Glycans in cancer progression. Glycobiology, 2008, 18(10): 750-760.
9.	Liu FT, Rabinovich GA. Galectins as modulators of tumour progression. Nat Rev Cancer, 2005, 5(1): 29-41.
10.	李富新. 半乳糖凝集素 1 与胃癌侵袭转移的相关性研究. 天津医科大学, 2007.
11.	Blaževitš O, Mideksa YG, Šolman M, et al. Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering. Sci Rep, 2016, 6: 24165.
12.	Astorgues-Xerri L, Riveiro ME, Tijeras-Raballand A, et al. Unraveling galectin-1 as a novel therapeutic target for cancer. Cancer Treat Rev, 2014, 40(2): 307-319.
13.	Rabinovich GA, Conejo-García JR. Shaping the immune landscape in cancer by galectin-driven regulatory pathways. J Mol Biol, 2016, 428(16): 3266-3281.
14.	Jorge YC, Mataruco MM, Araújo LP, et al. Expression of annexin-A1 and galectin-1 anti-inflammatory proteins and mRNA in chronic gastritis and gastric cancer. Mediators Inflamm, 2013, 2013: 152860.
15.	He XJ, Tao HQ, Hu ZM, et al. Expression of galectin-1 in carcinoma-associated fibroblasts promotes gastric cancer cell invasion through upregulation of integrin β1. Cancer Sci, 2014, 105(11): 1402-1410.
16.	Zheng L, Xu C, Guan Z, et al. Galectin-1 mediates TGF-β-induced transformation from normal fibroblasts into carcinoma-associated fibroblasts and promotes tumor progression in gastric cancer. Am J Transl Res, 2016, 8(4): 1641-1658.
17.	吕宜梅. 半乳糖凝集素家族与肿瘤的研究进展. 实用妇科内分泌电子杂志, 2016, 3(10): 54-56.
18.	赵艳, 金鑫, 李楠, 等. ALDH1、CXCR4、E-cadherin 在胃癌组织中的表达及与淋巴结转移的关系. 南方医科大学学报, 2016, 36(10): 1390-1395.
19.	Chong Y, Tang D, Gao J, et al. Galectin-1 induces invasion and the epithelial-mesenchymal transition in human gastric cancer cells via non-canonical activation of the hedgehog signaling pathway. Oncotarget, 2016, 7(50): 83611-83626.
20.	Chen J, Tang D, Wang S, et al. High expressions of galectin-1 and VEGF are associated with poor prognosis in gastric cancer patients. Tumour Biol, 2014, 35(3): 2513-2519.
21.	You X, Wang Y, Wu J, et al. Prognostic significance of galectin-1 and vasculogenic mimicry in patients with gastric cancer. Onco Targets Ther, 2018, 11: 3237-3244.
22.	Estofolete CF, Zucoloto S, Oliani SM, et al. Myenteric denervation downregulates galectin-1 and -3 expression in gastric carcinogenesis. Dig Dis Sci, 2011, 56(6): 1637-1644.
23.	Polli-Lopes AC, Zucoloto S, de Queirós Cunha F, et al. Myenteric denervation reduces the incidence of gastric tumors in rats. Cancer Lett, 2003, 190(1): 45-50.
24.	Tang D, Gao J, Wang S, et al. Cancer-associated fibroblasts promote angiogenesis in gastric cancer through galectin-1 expression. Tumour Biol, 2016, 37(2): 1889-1899.
25.	Lim JW, Kim H, Kim KH. Cell adhesion-related gene expression by Helicobacter pylori in gastric epithelial AGS cells. Int J Biochem Cell Biol, 2003, 35(8): 1284-1296.
26.	Chen YR, Juan HF, Huang HC, et al. Quantitative proteomic and genomic profiling reveals metastasis-related protein expression patterns in gastric cancer cells. J Proteome Res, 2006, 5(10): 2727-2742.
27.	Chong Y, Tang D, Xiong Q, et al. Galectin-1 from cancer-associated fibroblasts induces epithelial-mesenchymal transition through β1 integrin-mediated upregulation of Gli1 in gastric cancer. J Exp Clin Cancer Res, 2016, 35(1): 175.
28.	李明辉, 董永杰, 赵静雅, 等. SIRT-1 及 E-cadherin 在胃癌组织中表达的相关研究. 中国普外基础与临床杂志, 2018, 25(1): 42-47.
29.	Yoshii M, Tanaka H, Ohira M, et al. Expression of Forkhead box P3 in tumour cells causes immunoregulatory function of signet ring cell carcinoma of the stomach. Br J Cancer, 2012, 106(10): 1668-1674.
30.	Zhao Y, Li J, Xing Y, et al. N-acetylglucosaminyltransferase Ⅴ mediates cell migration and invasion of mouse mammary tumor cells 4TO7 via RhoA and Rac1 signaling pathway. Mol Cell Biochem, 2008, 309(1-2): 199-208.
31.	Pinho SS, Figueiredo J, Cabral J, et al. E-cadherin and adherens-junctions stability in gastric carcinoma: functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases Ⅲ and Ⅴ. Biochim Biophys Acta, 2013, 1830(3): 2690-2700.
32.	Taniguchi N, Korekane H. Branched N-glycans and their implications for cell adhesion, signaling and clinical applications for cancer biomarkers and in therapeutics. BMB Rep, 2011, 44(12): 772-781.
33.	Croci DO, Cerliani JP, Dalotto-Moreno T, et al. Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors. Cell, 2014, 156(4): 744-758.
34.	文静, 任孟军, 谭伟. 亚洲人群环氧化酶-2 基因多态性与胃癌关联性的系统性回顾与 Meta 分析. 重庆医科大学学报, 2016, 41(6): 609-613.
35.	Zhao Q, Li Y, Huang J, et al. Short-term curative effect of S-1 plus oxaliplatin as perioperative chemotherapy for locally advanced gastric cancer: a prospective comparison study. Pharmazie, 2017, 72(4): 236-240.
36.	李延武, 张有成. 胃癌淋巴结转移及其组织病理特征的回顾性研究. 中国普外基础与临床杂志, 2017, 24(5): 572-579.
37.	张耕源, 杜恒锐, 王振江, 等. 多西他赛在胃癌治疗中的研究进展. 中南大学学报(医学版), 2018, 43(2): 216-221.
38.	Chen JW, Luo YJ, Yang ZF, et al. Knockdown of angiopoietin-like 4 inhibits the development of human gastric cancer. Oncol Rep, 2018, 39(4): 1739-1746.

1. Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer, 2015, 136(5): E359-E386.
2. 张耕源, 罗长江, 龙勃, 等. 含多西他赛的新辅助化疗治疗进展期胃癌有效性和安全性的 Meta 分析. 中国普通外科杂志, 2016, 25(10): 1388-1396.
3. 陈国宁, 蔡茂怀. 紫杉醇、奥沙利铂联合榄香烯腹腔灌注治疗胃癌晚期癌性腹水的临床观察. 中国药房, 2016, 27(36): 5095-5097.
4. Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Dicker D, et al. The global burden of cancer 2013. JAMA Oncol, 2015, 1(4): 505-527.
5. Bacigalupo ML, Carabias P, Troncoso MF. Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression. World J Gastroenterol, 2017, 23(29): 5266-5281.
6. Long B, Yu Z, Zhou H, et al. Clinical characteristics and prognostic significance of galectins for patients with gastric cancer: A meta-analysis. Int J Surg, 2018, 56: 242-249.
7. Yang RY, Rabinovich GA, Liu FT. Galectins: structure, function and therapeutic potential. Expert Rev Mol Med, 2008, 10: e17.
8. Lau KS, Dennis JW. N-Glycans in cancer progression. Glycobiology, 2008, 18(10): 750-760.
9. Liu FT, Rabinovich GA. Galectins as modulators of tumour progression. Nat Rev Cancer, 2005, 5(1): 29-41.
10. 李富新. 半乳糖凝集素 1 与胃癌侵袭转移的相关性研究. 天津医科大学, 2007.
11. Blaževitš O, Mideksa YG, Šolman M, et al. Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering. Sci Rep, 2016, 6: 24165.
12. Astorgues-Xerri L, Riveiro ME, Tijeras-Raballand A, et al. Unraveling galectin-1 as a novel therapeutic target for cancer. Cancer Treat Rev, 2014, 40(2): 307-319.
13. Rabinovich GA, Conejo-García JR. Shaping the immune landscape in cancer by galectin-driven regulatory pathways. J Mol Biol, 2016, 428(16): 3266-3281.
14. Jorge YC, Mataruco MM, Araújo LP, et al. Expression of annexin-A1 and galectin-1 anti-inflammatory proteins and mRNA in chronic gastritis and gastric cancer. Mediators Inflamm, 2013, 2013: 152860.
15. He XJ, Tao HQ, Hu ZM, et al. Expression of galectin-1 in carcinoma-associated fibroblasts promotes gastric cancer cell invasion through upregulation of integrin β1. Cancer Sci, 2014, 105(11): 1402-1410.
16. Zheng L, Xu C, Guan Z, et al. Galectin-1 mediates TGF-β-induced transformation from normal fibroblasts into carcinoma-associated fibroblasts and promotes tumor progression in gastric cancer. Am J Transl Res, 2016, 8(4): 1641-1658.
17. 吕宜梅. 半乳糖凝集素家族与肿瘤的研究进展. 实用妇科内分泌电子杂志, 2016, 3(10): 54-56.
18. 赵艳, 金鑫, 李楠, 等. ALDH1、CXCR4、E-cadherin 在胃癌组织中的表达及与淋巴结转移的关系. 南方医科大学学报, 2016, 36(10): 1390-1395.
19. Chong Y, Tang D, Gao J, et al. Galectin-1 induces invasion and the epithelial-mesenchymal transition in human gastric cancer cells via non-canonical activation of the hedgehog signaling pathway. Oncotarget, 2016, 7(50): 83611-83626.
20. Chen J, Tang D, Wang S, et al. High expressions of galectin-1 and VEGF are associated with poor prognosis in gastric cancer patients. Tumour Biol, 2014, 35(3): 2513-2519.
21. You X, Wang Y, Wu J, et al. Prognostic significance of galectin-1 and vasculogenic mimicry in patients with gastric cancer. Onco Targets Ther, 2018, 11: 3237-3244.
22. Estofolete CF, Zucoloto S, Oliani SM, et al. Myenteric denervation downregulates galectin-1 and -3 expression in gastric carcinogenesis. Dig Dis Sci, 2011, 56(6): 1637-1644.
23. Polli-Lopes AC, Zucoloto S, de Queirós Cunha F, et al. Myenteric denervation reduces the incidence of gastric tumors in rats. Cancer Lett, 2003, 190(1): 45-50.
24. Tang D, Gao J, Wang S, et al. Cancer-associated fibroblasts promote angiogenesis in gastric cancer through galectin-1 expression. Tumour Biol, 2016, 37(2): 1889-1899.
25. Lim JW, Kim H, Kim KH. Cell adhesion-related gene expression by Helicobacter pylori in gastric epithelial AGS cells. Int J Biochem Cell Biol, 2003, 35(8): 1284-1296.
26. Chen YR, Juan HF, Huang HC, et al. Quantitative proteomic and genomic profiling reveals metastasis-related protein expression patterns in gastric cancer cells. J Proteome Res, 2006, 5(10): 2727-2742.
27. Chong Y, Tang D, Xiong Q, et al. Galectin-1 from cancer-associated fibroblasts induces epithelial-mesenchymal transition through β1 integrin-mediated upregulation of Gli1 in gastric cancer. J Exp Clin Cancer Res, 2016, 35(1): 175.
28. 李明辉, 董永杰, 赵静雅, 等. SIRT-1 及 E-cadherin 在胃癌组织中表达的相关研究. 中国普外基础与临床杂志, 2018, 25(1): 42-47.
29. Yoshii M, Tanaka H, Ohira M, et al. Expression of Forkhead box P3 in tumour cells causes immunoregulatory function of signet ring cell carcinoma of the stomach. Br J Cancer, 2012, 106(10): 1668-1674.
30. Zhao Y, Li J, Xing Y, et al. N-acetylglucosaminyltransferase Ⅴ mediates cell migration and invasion of mouse mammary tumor cells 4TO7 via RhoA and Rac1 signaling pathway. Mol Cell Biochem, 2008, 309(1-2): 199-208.
31. Pinho SS, Figueiredo J, Cabral J, et al. E-cadherin and adherens-junctions stability in gastric carcinoma: functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases Ⅲ and Ⅴ. Biochim Biophys Acta, 2013, 1830(3): 2690-2700.
32. Taniguchi N, Korekane H. Branched N-glycans and their implications for cell adhesion, signaling and clinical applications for cancer biomarkers and in therapeutics. BMB Rep, 2011, 44(12): 772-781.
33. Croci DO, Cerliani JP, Dalotto-Moreno T, et al. Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors. Cell, 2014, 156(4): 744-758.
34. 文静, 任孟军, 谭伟. 亚洲人群环氧化酶-2 基因多态性与胃癌关联性的系统性回顾与 Meta 分析. 重庆医科大学学报, 2016, 41(6): 609-613.
35. Zhao Q, Li Y, Huang J, et al. Short-term curative effect of S-1 plus oxaliplatin as perioperative chemotherapy for locally advanced gastric cancer: a prospective comparison study. Pharmazie, 2017, 72(4): 236-240.
36. 李延武, 张有成. 胃癌淋巴结转移及其组织病理特征的回顾性研究. 中国普外基础与临床杂志, 2017, 24(5): 572-579.
37. 张耕源, 杜恒锐, 王振江, 等. 多西他赛在胃癌治疗中的研究进展. 中南大学学报(医学版), 2018, 43(2): 216-221.
38. Chen JW, Luo YJ, Yang ZF, et al. Knockdown of angiopoietin-like 4 inhibits the development of human gastric cancer. Oncol Rep, 2018, 39(4): 1739-1746.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research progress on relationship between galectin-1 and invasion and metastasis of gastric cancer

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