New mechanisms by which plants regulate human health and disease: cross-species regulation by plant microRNA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

DING Lixian ^1,2 , LIU Ming ^1,2 , LI Zhongsheng ^1,2 ,  LI Guodong ^1,2

1. Department of General Surgery, The Fourth Hospital of Harbin Medical University, Harbin 150001, P. R. China;
2. Bio-Bank of Department of General Surgery, The Fourth Hospital of Harbin Medical University, Harbin 150001, P. R. China;

Corresponding author：

LI Guodong, Email: jonathanlgd@163.com

Keywords：

phytochemical; microRNA; cross-species regulation; gastrointestinal pathway

DOI：

10.7507/1007-9424.201807071

Video：

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Objective To explore new mechanisms of cross-species regulation of plant microRNA (miRNA) to regulate human health and disease.Method The recently relevant literatures on the new mechanisms of cross-species regulation of the plant miRNA for the health and disease of human were reviewed.Results The phytochemicals played an important role in the maintaining human health and regulating diseases, and the plant miRNA cross-species regulation also played an important role in it. Its possible regulatory mechanism was that the mature plant miRNA came into the animal body through the gastrointestinal tract. It firstly passed through the gastrointestinal tract and then came into the microvesicles secreted by the small intestine. It was targeted to the organ or tissue through passing of the animal circulatory system. The plant miRNA passing through the gastrointestinal tract was highly matched with the target mRNA to perform its biological regulatory role.Conclusions Although studies have confirmed that plant miRNA can regulate animal specific biological functions across gastrointestinal tract and it provides an experimental basis for plants to participate in new mechanisms for regulating occurrence and development of human health and disease, whether or not miRNA in food is affected by way it is processed, transported, stored, and extent to which it is affected, remains to be explored. At the same time, content of plant miRNA in animals is very low and types of plant miRNA in different animals are not same. Although the above issues have been unresolved, it is believed that with research progresses, mastering mechanism of miRNA cross-species regulation will greatly help to prevent human diseases and maintain health of body.

Citation： DING Lixian, LIU Ming, LI Zhongsheng, LI Guodong. New mechanisms by which plants regulate human health and disease: cross-species regulation by plant microRNA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2019, 26(1): 102-105. doi: 10.7507/1007-9424.201807071 Copy

1.	郭甜甜, 刘聪敏, 高肇妤, 等. 蔬菜水果中植物化学物质防治肺癌作用及机制研究现状. 中国肺癌杂志, 2017, 20(12): 841-846.
2.	Chang SK, Alasalvar C, Shahidi F. Superfruits: Phytochemicals, antioxidant efficacies, and health effects—A comprehensive review. Crit Rev Food Sci Nutr, 2018: 1-25.
3.	Howes MJ, Simmonds MS. The role of phytochemicals as micronutrients in health and disease. Curr Opin Clin Nutr Metab Care, 2014, 17(6): 558-566.
4.	Zhang L, Hou D, Chen X, et al. Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res, 2012, 22(1): 107-126.
5.	LaMonte G, Philip N, Reardon J, et al. Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance. Cell Host Microbe, 2012, 12(2): 187-199.
6.	Alam MN, Almoyad M, Huq F. Polyphenols in colorectal cancer: current state of knowledge including clinical trials and molecular mechanism of action. Biomed Res Int, 2018, 2018: 4154185.
7.	Khan M, Maryam A, Zhang H, et al. Killing cancer with platycodin D through multiple mechanisms. J Cell Mol Med, 2016, 20(3): 389-402.
8.	Wang J, Hu S, Nie S, et al. Reviews on mechanisms of in vitro antioxidant activity of polysaccharides. Oxid Med Cell Longev, 2016, 2016: 5692852.
9.	Ji X, Peng Q, Wang M. Anti-colon-cancer effects of polysaccharides: A mini-review of the mechanisms. Int J Biol Macromol, 2018, 114: 1127-1133.
10.	李国东, 金俊超, 张津宁, 等. 大肠可利用越橘成分抑制人结直肠癌细胞生长的机制研究. 中华结直肠疾病电子杂志, 2015, 4(2): 144-150.
11.	刘明. 结直肠癌多酚类植物化学预防剂的研究进展. 中华结直肠疾病电子杂志, 2014, 3(5): 8-11.
12.	李安国, 贺石林, 邓常清. 食用植物及其植物化学物质对慢性疾病的化学预防概述. 湖南中医药大学学报, 2018, 38(2): 228-234.
13.	Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 2004, 116(2): 281-297.
14.	He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet, 2004, 5(7): 522-531.
15.	Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell, 2005, 120(1): 15-20.
16.	Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers. Nature, 2005, 435(7043): 834-838.
17.	Xia T, Li J, Cheng H, et al. Small-molecule regulators of microRNAs in biomedicine. Drug Dev Res, 2015, 76(7): 375-381.
18.	Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A, 2008, 105(30): 10513-10518.
19.	Chen X, Ba Y, Ma L, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res, 2008, 18(10): 997-1006.
20.	Kourembanas S. Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. Annu Rev Physiol, 2015, 77: 13-27.
21.	Yu B, Yang Z, Li J, et al. Methylation as a crucial step in plant microRNA biogenesis. Science, 2005, 307(5711): 932-935.
22.	Chen X. MicroRNA biogenesis and function in plants. FEBS Lett, 2005, 579(26): 5923-5931.
23.	Duraisingh MT, Lodish HF. Sickle cell microRNAs inhibit the malaria parasite. Cell Host Microbe, 2012, 12(2): 127-128.
24.	Liang H, Zhang S, Fu Z, et al. Effective detection and quantification of dietetically absorbed plant microRNAs in human plasma. J Nutr Biochem, 2015, 26(5): 505-512.
25.	Liang H, Zen K, Zhang J, et al. New roles for microRNAs in cross-species communication. RNA Biol, 2013, 10(3): 367-370.
26.	Chin AR, Fong MY, Somlo G, et al. Cross-kingdom inhibition of breast cancer growth by plant miR159. Cell Res, 2016, 26(2): 217-228.
27.	Jayachandran B, Hussain M, Asgari S. An insect trypsin-like serine protease as a target of microRNA: utilization of microRNA mimics and inhibitors by oral feeding. Insect Biochem Mol Biol, 2013, 43(4): 398-406.
28.	Zhu K, Liu M, Fu Z, et al. Plant microRNAs in larval food regulate honeybee caste development. PLoS Genet, 2017, 13(8): e1006946.
29.	Wolschin F, Mutti NS, Amdam GV. Insulin receptor substrate influences female caste development in honeybees. Biol Lett, 2011, 7(1): 112-115.
30.	Du T, Zamore PD. microPrimer: the biogenesis and function of microRNA. Development, 2005, 132(21): 4645-4652.
31.	汪劼. 闯入动物王国的植物 miRNA. 生命的化学, 2016, 36(3): 404-408.
32.	Zhou Z, Li X, Liu J, et al. Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses. Cell Res, 2015, 25(1): 39-49.
33.	Shahid S, Kim G, Johnson NR, et al. MicroRNAs from the parasitic plant Cuscuta campestris target host messenger RNAs. Nature, 2018, 553(7686): 82-85.
34.	Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell, 2009, 136(2): 215-233.
35.	Scarpa ES, Ninfali P. Phytochemicals as innovative therapeutic tools against cancer stem cells. Int J Mol Sci, 2015, 16(7): 15727-15742.

1. 郭甜甜, 刘聪敏, 高肇妤, 等. 蔬菜水果中植物化学物质防治肺癌作用及机制研究现状. 中国肺癌杂志, 2017, 20(12): 841-846.
2. Chang SK, Alasalvar C, Shahidi F. Superfruits: Phytochemicals, antioxidant efficacies, and health effects—A comprehensive review. Crit Rev Food Sci Nutr, 2018: 1-25.
3. Howes MJ, Simmonds MS. The role of phytochemicals as micronutrients in health and disease. Curr Opin Clin Nutr Metab Care, 2014, 17(6): 558-566.
4. Zhang L, Hou D, Chen X, et al. Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res, 2012, 22(1): 107-126.
5. LaMonte G, Philip N, Reardon J, et al. Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance. Cell Host Microbe, 2012, 12(2): 187-199.
6. Alam MN, Almoyad M, Huq F. Polyphenols in colorectal cancer: current state of knowledge including clinical trials and molecular mechanism of action. Biomed Res Int, 2018, 2018: 4154185.
7. Khan M, Maryam A, Zhang H, et al. Killing cancer with platycodin D through multiple mechanisms. J Cell Mol Med, 2016, 20(3): 389-402.
8. Wang J, Hu S, Nie S, et al. Reviews on mechanisms of in vitro antioxidant activity of polysaccharides. Oxid Med Cell Longev, 2016, 2016: 5692852.
9. Ji X, Peng Q, Wang M. Anti-colon-cancer effects of polysaccharides: A mini-review of the mechanisms. Int J Biol Macromol, 2018, 114: 1127-1133.
10. 李国东, 金俊超, 张津宁, 等. 大肠可利用越橘成分抑制人结直肠癌细胞生长的机制研究. 中华结直肠疾病电子杂志, 2015, 4(2): 144-150.
11. 刘明. 结直肠癌多酚类植物化学预防剂的研究进展. 中华结直肠疾病电子杂志, 2014, 3(5): 8-11.
12. 李安国, 贺石林, 邓常清. 食用植物及其植物化学物质对慢性疾病的化学预防概述. 湖南中医药大学学报, 2018, 38(2): 228-234.
13. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 2004, 116(2): 281-297.
14. He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet, 2004, 5(7): 522-531.
15. Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell, 2005, 120(1): 15-20.
16. Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers. Nature, 2005, 435(7043): 834-838.
17. Xia T, Li J, Cheng H, et al. Small-molecule regulators of microRNAs in biomedicine. Drug Dev Res, 2015, 76(7): 375-381.
18. Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A, 2008, 105(30): 10513-10518.
19. Chen X, Ba Y, Ma L, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res, 2008, 18(10): 997-1006.
20. Kourembanas S. Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. Annu Rev Physiol, 2015, 77: 13-27.
21. Yu B, Yang Z, Li J, et al. Methylation as a crucial step in plant microRNA biogenesis. Science, 2005, 307(5711): 932-935.
22. Chen X. MicroRNA biogenesis and function in plants. FEBS Lett, 2005, 579(26): 5923-5931.
23. Duraisingh MT, Lodish HF. Sickle cell microRNAs inhibit the malaria parasite. Cell Host Microbe, 2012, 12(2): 127-128.
24. Liang H, Zhang S, Fu Z, et al. Effective detection and quantification of dietetically absorbed plant microRNAs in human plasma. J Nutr Biochem, 2015, 26(5): 505-512.
25. Liang H, Zen K, Zhang J, et al. New roles for microRNAs in cross-species communication. RNA Biol, 2013, 10(3): 367-370.
26. Chin AR, Fong MY, Somlo G, et al. Cross-kingdom inhibition of breast cancer growth by plant miR159. Cell Res, 2016, 26(2): 217-228.
27. Jayachandran B, Hussain M, Asgari S. An insect trypsin-like serine protease as a target of microRNA: utilization of microRNA mimics and inhibitors by oral feeding. Insect Biochem Mol Biol, 2013, 43(4): 398-406.
28. Zhu K, Liu M, Fu Z, et al. Plant microRNAs in larval food regulate honeybee caste development. PLoS Genet, 2017, 13(8): e1006946.
29. Wolschin F, Mutti NS, Amdam GV. Insulin receptor substrate influences female caste development in honeybees. Biol Lett, 2011, 7(1): 112-115.
30. Du T, Zamore PD. microPrimer: the biogenesis and function of microRNA. Development, 2005, 132(21): 4645-4652.
31. 汪劼. 闯入动物王国的植物 miRNA. 生命的化学, 2016, 36(3): 404-408.
32. Zhou Z, Li X, Liu J, et al. Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses. Cell Res, 2015, 25(1): 39-49.
33. Shahid S, Kim G, Johnson NR, et al. MicroRNAs from the parasitic plant Cuscuta campestris target host messenger RNAs. Nature, 2018, 553(7686): 82-85.
34. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell, 2009, 136(2): 215-233.
35. Scarpa ES, Ninfali P. Phytochemicals as innovative therapeutic tools against cancer stem cells. Int J Mol Sci, 2015, 16(7): 15727-15742.

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New mechanisms by which plants regulate human health and disease: cross-species regulation by plant microRNA

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