Advances in studies on potential related proteins of thyroid papillary carcinoma metastasis and its mechanisms_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHAO Yu ¹ , YU Linna ² , GAO Qingjun ³ ,  ZHAO Daiwei ⁴

1. Guizhou Medical University, Guiyang 550004, P. R. China;
2. School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, P. R. China;
3. Department of Thyroid Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, P. R. China;
4. Department of Thyroid Surgery, The Second Affiliated Hospital of Guizhou Medical University, Kaili, Guizhou 556000, P. R. China;

Corresponding author：

ZHAO Daiwei, Email: zhaodw@hotmail.com

Keywords：

papillary thyroid carcinoma; metastasis; protein; mechanism

DOI：

10.7507/1007-9424.201809070

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To summarize potential related proteins in thyroid papillary carcinoma metastasis and explore its mechanism.Method The relevant literatures on the potential related proteins of papillary thyroid carcinoma metastasis at home and abroad were reviewed.Results The previous studies had shown that many biological indicators might be associated with the metastasis of papillary thyroid carcinoma, such as the interleukin-13 receptor alpha 2, chemokine receptor 7, low-density lipoprotein receptor-related protein 4, cytokine receptor-like factor 1, Rho-related protein kinase 1, and astrocyte up-regulated gene-1 were involved in the proliferation, migration, and metastasis of papillary thyroid carcinoma, which might be the potential therapeutic target for the papillary thyroid carcinoma.Conclusions Thyroid papillary carcinoma metastasis-associated proteins play an important role in tumor metastasis. Some progress has been made in study of metastasis mechanisms, its role and mechanism in lymphatic metastasis should be further studied.

Citation： ZHAO Yu, YU Linna, GAO Qingjun, ZHAO Daiwei. Advances in studies on potential related proteins of thyroid papillary carcinoma metastasis and its mechanisms. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2019, 26(4): 503-507. doi: 10.7507/1007-9424.201809070 Copy

1.	Lim H, Devesa SS, Sosa JA, et al. Trends in thyroid cancer incidence and mortality in the united states, 1974-2013. JAMA, 2017, 317(13): 1338-1348.
2.	Bychkov A, Hirokawa M, Jung CK, et al. Low rate of noninvasive follicular thyroid neoplasm with papillary-like nuclear features in asian practice. Thyroid, 2017, 27(7): 983-984.
3.	Chen L, Zhu Y, Zheng K, et al. The presence of cancerous nodules in lymph nodes is a novel indicator of distant metastasis and poor survival in patients with papillary thyroid carcinoma. J Cancer Res Clin Oncol, 2017, 143(6): 1035-1042.
4.	Rahaman SO, Sharma P, Harbor PC, et al. IL-13Rα2, a decoy receptor for IL-13 acts as an inhibitor of IL-4-dependent signal transduction in glioblastoma cells. Cancer Res, 2002, 62(4): 1103-1109.
5.	Fichtner-Feigl S, Strober W, Kawakami K, et al. IL-13 signaling through the IL-13α2 receptor is involved in induction of TGF-β1 production and fibrosis. Nat Med, 2006, 12(1): 99-106.
6.	Han J, Puri RK. Analysis of the cancer genome atlas (TCGA) database identifies an inverse relationship between interleukin-13 receptor α1 and α2 gene expression and poor prognosis and drug resistance in subjects with glioblastoma multiforme. J Neurooncol, 2018, 136(3): 463-474.
7.	Newman JP, Wang GY, Arima K, et al. Interleukin-13 receptor alpha 2 cooperates with EGFRvⅢ signaling to promote glioblastoma multiforme. Nat Commun, 2017, 8(1): 1913.
8.	Meng M, Liao H, Zhang B, et al. Cigarette smoke extracts induce overexpression of the proto-oncogenic gene interleukin-13 receptor α2 through activation of the PKA-CREB signaling pathway to trigger malignant transformation of lung vascular endothelial cells and angiogenesis. Cell Signal, 2017, 31: 15-25.
9.	Kwon HJ, Choi JE, Bae YK. Interleukin-13 receptor alpha 2 expression in tumor cells is associated with reduced disease-free survival in patients with luminal subtype invasive breast cancer. Tumour Biol, 2018, 40(6): 1010428318783657.
10.	Bartolomé RA, Jaén M, Casal JI. An IL13Rα2 peptide exhibits therapeutic activity against metastatic colorectal cancer. Br J Cancer, 2018, 119(8): 940-949.
11.	Wanibuchi M, Kataoka-Sasaki Y, Sasaki M, et al. Interleukin-13 receptor alpha 2 as a marker of poorer prognosis in high-grade astrocytomas. J Neurosurg Sci, 2018, 62(3): 239-244.
12.	Gu M. IL13Rα2 siRNA inhibited cell proliferation, induced cell apoptosis, and suppressed cell invasion in papillary thyroid carcinoma cells. Onco Targets Ther, 2018, 11: 1345-1352.
13.	Burns JM, Summers BC, Wang Y, et al. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med, 2006, 203(9): 2201-2213.
14.	Boldajipour B, Mahabaleshwar H, Kardash E, et al. Control of chemokine-guided cell migration by ligand sequestration. Cell, 2008, 132(3): 463-473.
15.	Gu HQ, Zhang ZB, Zhang JW, et al. The role of the SDF-1/CXCR7 axis on the growth and invasion ability of endometrial cancer cells. Arch Gynecol Obstet, 2017, 295(4): 987-995.
16.	Yuan CL, Liu ZH, Zou N, et al. Relationship between expression of CXCR7 and NF-κB in breast cancer tissue and occurrence of breast cancer and lymphatic metastasis. Saudi J Biol Sci, 2017, 24(8): 1767-1770.
17.	Xue TC, Han D, Chen RX, et al. High expression of CXCR7 combined with alpha fetoprotein in hepatocellular carcinoma correlates with extra-hepatic metastasis to lung after hepatectomy. Asian Pac J Cancer Prev, 2011, 12(3): 657-663.
18.	Benhadjeba S, Edjekouane L, Sauvé K, et al. Feedback control of the CXCR7/CXCL11 chemokine axis by estrogen receptor α in ovarian cancer. Mol Oncol, 2018, 12(10): 1689-1705.
19.	Li XX, Zheng HT, Huang LY, et al. Silencing of CXCR7 gene represses growth and invasion and induces apoptosis in colorectal cancer through ERK and β-arrestin pathways. Int J Oncol, 2014, 45(4): 1649-1657.
20.	Wu Y, Tian L, Xu Y, et al. CXCR7 silencing inhibits the migration and invasion of human tumor endothelial cells derived from hepatocellular carcinoma by suppressing STAT3. Mol Med Rep, 2018, 18(2): 1644-1650.
21.	Singh RK, Lokeshwar BL. The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate cancer growth. Cancer Res, 2011, 71(9): 3268-3277.
22.	Hao M, Zheng J, Hou K, et al. Role of chemokine receptor CXCR7 in bladder cancer progression. Biochem Pharmacol, 2012, 84(2): 204-214.
23.	Liu Z, Sun DX, Teng XY, et al. Expression of stromal cell-derived factor 1 and CXCR7 in papillary thyroid carcinoma. Endocr Pathol, 2012, 23(4): 247-253.
24.	Liu Z, Yang L, Teng X, et al. The involvement of CXCR7 in modulating the progression of papillary thyroid carcinoma. J Surg Res, 2014, 191(2): 379-388.
25.	Zhang H, Yang L, Teng X, et al. The chemokine receptor CXCR7 is a critical regulator for the tumorigenesis and development of papillary thyroid carcinoma by inducing angiogenesis in vitro and in vivo. Tumour Biol, 2016, 37(2): 2415-2423.
26.	Lin Y, Ma Q, Li L, et al. The CXCL12-CXCR4 axis promotes migration, invasiveness, and EMT in human papillary thyroid carcinoma B-CPAP cells via NF-κB signaling. Biochem Cell Biol, 2018, 96(5): 619-626.
27.	Zhang H, Yang L, Liu Z, et al. iTRAQ-coupled 2D LC/MS-MS analysis of CXCR7-transfected papillary thyroid carcinoma cells: A new insight into CXCR7 regulation of papillary thyroid carcinoma progression and identification of potential biomarkers. Oncol Lett, 2017, 14(3): 3734-3740.
28.	Ye XC, Hu JX, Li L, et al. Astrocytic Lrp4 (low-density lipoprotein receptor-related protein 4) contributes to ischemia-induced brain injury by regulating atp release and adenosine-A stroke, 2018, 49(1): 165-174.
29.	Weatherbee SD, Anderson KV, Niswander LA. LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction. Development, 2006, 133(24): 4993-5000.
30.	Ohno K, Ohkawara B, Ito M. Agrin-LRP4-MuSK signaling as a therapeutic target for myasthenia gravis and other neuromuscular disorders. Expert Opin Ther Targets, 2017, 21(10): 949-958.
31.	Karakatsani A, Marichal N, Urban S, et al. Neuronal LRP4 regulates synapse formation in the developing CNS. Development, 2017, 144(24): 4604-4615.
32.	Chakraborty S, Lakshmanan M, Swa HL, et al. An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma. Nat Commun, 2015, 6: 6184.
33.	Hucz J, Kowalska M, Jarzab M, et al. Gene expression of meta-lloproteinase 11, claudin 1 and selected adhesion related genes in papillary thyroid cancer. Endokrynol Pol, 2006, 57 Suppl A: 18-25.
34.	Zhou X, Xia E, Bhandari A, et al. LRP4 promotes proliferation, migration, and invasion in papillary thyroid cancer. Biochem Biophys Res Commun, 2018, 503(1): 257-263.
35.	Fischer P, Hilfiker-Kleiner D. Role of gp130-mediated signalling pathways in the heart and its impact on potential therapeutic aspects. Br J Pharmacol, 2008, 153 Suppl 1: S414-S427.
36.	Elson GC, Lelièvre E, Guillet C, et al. CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex. Nat Neurosci, 2000, 3(9): 867-872.
37.	Knappskog PM, Majewski J, Livneh A, et al. Cold-induced sweating syndrome is caused by mutations in the CRLF1 gene. Am J Hum Genet, 2003, 72(2): 375-383.
38.	Stearman RS, Dwyer-Nield L, Zerbe L, et al. Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model. Am J Pathol, 2005, 167(6): 1763-1775.
39.	Yu ST, Zhong Q, Chen RH, et al. CRLF1 promotes malignant phenotypes of papillary thyroid carcinoma by activating the MAPK/ERK and PI3K/AKT pathways. Cell Death Dis, 2018, 9(3): 371.
40.	Saito K, Ozawa Y, Hibino K, et al. FilGAP, a Rho/Rho-associated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migration. Mol Biol Cell, 2012, 23(24): 4739-4750.
41.	Morgan-Fisher M, Wewer UM, Yoneda A. Regulation of ROCK activity in cancer. J Histochem Cytochem, 2013, 61(3): 185-198.
42.	Luo D, Chen H, Li X, et al. Activation of the ROCK1/MMP-9 pathway is associated with the invasion and poor prognosis in papillary thyroid carcinoma. Int J Oncol, 2017, 51(4): 1209-1218.
43.	Su ZZ, Kang DC, Chen Y, et al. Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH. Oncogene, 2002, 21(22): 3592-3602.
44.	Kang DC, Su ZZ, Sarkar D, et al. Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene, 2005, 353(1): 8-15.
45.	Yoo BK, Emdad L, Lee SG, et al. Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology. Pharmacol Ther, 2011, 130(1): 1-8.
46.	Luo Y, Zhang X, Tan Z, et al. Astrocyte elevated gene-1 as a novel clinicopathological and prognostic biomarker for gastrointestinal cancers: a meta-analysis with 2 999 patients. PLoS One, 2015, 10(12): e0145659.
47.	Emdad L, Das SK, Dasgupta S, et al. AEG-1/MTDH/LYRIC: signaling pathways, downstream genes, interacting proteins, and regulation of tumor angiogenesis. Adv Cancer Res, 2013, 120: 75-111.
48.	Huang LL, Wang Z, Cao CJ, et al. AEG-1 associates with metastasis in papillary thyroid cancer through upregulation of MMP2/9. Int J Oncol, 2017, 51(3): 812-822.

1. Lim H, Devesa SS, Sosa JA, et al. Trends in thyroid cancer incidence and mortality in the united states, 1974-2013. JAMA, 2017, 317(13): 1338-1348.
2. Bychkov A, Hirokawa M, Jung CK, et al. Low rate of noninvasive follicular thyroid neoplasm with papillary-like nuclear features in asian practice. Thyroid, 2017, 27(7): 983-984.
3. Chen L, Zhu Y, Zheng K, et al. The presence of cancerous nodules in lymph nodes is a novel indicator of distant metastasis and poor survival in patients with papillary thyroid carcinoma. J Cancer Res Clin Oncol, 2017, 143(6): 1035-1042.
4. Rahaman SO, Sharma P, Harbor PC, et al. IL-13Rα2, a decoy receptor for IL-13 acts as an inhibitor of IL-4-dependent signal transduction in glioblastoma cells. Cancer Res, 2002, 62(4): 1103-1109.
5. Fichtner-Feigl S, Strober W, Kawakami K, et al. IL-13 signaling through the IL-13α2 receptor is involved in induction of TGF-β1 production and fibrosis. Nat Med, 2006, 12(1): 99-106.
6. Han J, Puri RK. Analysis of the cancer genome atlas (TCGA) database identifies an inverse relationship between interleukin-13 receptor α1 and α2 gene expression and poor prognosis and drug resistance in subjects with glioblastoma multiforme. J Neurooncol, 2018, 136(3): 463-474.
7. Newman JP, Wang GY, Arima K, et al. Interleukin-13 receptor alpha 2 cooperates with EGFRvⅢ signaling to promote glioblastoma multiforme. Nat Commun, 2017, 8(1): 1913.
8. Meng M, Liao H, Zhang B, et al. Cigarette smoke extracts induce overexpression of the proto-oncogenic gene interleukin-13 receptor α2 through activation of the PKA-CREB signaling pathway to trigger malignant transformation of lung vascular endothelial cells and angiogenesis. Cell Signal, 2017, 31: 15-25.
9. Kwon HJ, Choi JE, Bae YK. Interleukin-13 receptor alpha 2 expression in tumor cells is associated with reduced disease-free survival in patients with luminal subtype invasive breast cancer. Tumour Biol, 2018, 40(6): 1010428318783657.
10. Bartolomé RA, Jaén M, Casal JI. An IL13Rα2 peptide exhibits therapeutic activity against metastatic colorectal cancer. Br J Cancer, 2018, 119(8): 940-949.
11. Wanibuchi M, Kataoka-Sasaki Y, Sasaki M, et al. Interleukin-13 receptor alpha 2 as a marker of poorer prognosis in high-grade astrocytomas. J Neurosurg Sci, 2018, 62(3): 239-244.
12. Gu M. IL13Rα2 siRNA inhibited cell proliferation, induced cell apoptosis, and suppressed cell invasion in papillary thyroid carcinoma cells. Onco Targets Ther, 2018, 11: 1345-1352.
13. Burns JM, Summers BC, Wang Y, et al. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med, 2006, 203(9): 2201-2213.
14. Boldajipour B, Mahabaleshwar H, Kardash E, et al. Control of chemokine-guided cell migration by ligand sequestration. Cell, 2008, 132(3): 463-473.
15. Gu HQ, Zhang ZB, Zhang JW, et al. The role of the SDF-1/CXCR7 axis on the growth and invasion ability of endometrial cancer cells. Arch Gynecol Obstet, 2017, 295(4): 987-995.
16. Yuan CL, Liu ZH, Zou N, et al. Relationship between expression of CXCR7 and NF-κB in breast cancer tissue and occurrence of breast cancer and lymphatic metastasis. Saudi J Biol Sci, 2017, 24(8): 1767-1770.
17. Xue TC, Han D, Chen RX, et al. High expression of CXCR7 combined with alpha fetoprotein in hepatocellular carcinoma correlates with extra-hepatic metastasis to lung after hepatectomy. Asian Pac J Cancer Prev, 2011, 12(3): 657-663.
18. Benhadjeba S, Edjekouane L, Sauvé K, et al. Feedback control of the CXCR7/CXCL11 chemokine axis by estrogen receptor α in ovarian cancer. Mol Oncol, 2018, 12(10): 1689-1705.
19. Li XX, Zheng HT, Huang LY, et al. Silencing of CXCR7 gene represses growth and invasion and induces apoptosis in colorectal cancer through ERK and β-arrestin pathways. Int J Oncol, 2014, 45(4): 1649-1657.
20. Wu Y, Tian L, Xu Y, et al. CXCR7 silencing inhibits the migration and invasion of human tumor endothelial cells derived from hepatocellular carcinoma by suppressing STAT3. Mol Med Rep, 2018, 18(2): 1644-1650.
21. Singh RK, Lokeshwar BL. The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate cancer growth. Cancer Res, 2011, 71(9): 3268-3277.
22. Hao M, Zheng J, Hou K, et al. Role of chemokine receptor CXCR7 in bladder cancer progression. Biochem Pharmacol, 2012, 84(2): 204-214.
23. Liu Z, Sun DX, Teng XY, et al. Expression of stromal cell-derived factor 1 and CXCR7 in papillary thyroid carcinoma. Endocr Pathol, 2012, 23(4): 247-253.
24. Liu Z, Yang L, Teng X, et al. The involvement of CXCR7 in modulating the progression of papillary thyroid carcinoma. J Surg Res, 2014, 191(2): 379-388.
25. Zhang H, Yang L, Teng X, et al. The chemokine receptor CXCR7 is a critical regulator for the tumorigenesis and development of papillary thyroid carcinoma by inducing angiogenesis in vitro and in vivo. Tumour Biol, 2016, 37(2): 2415-2423.
26. Lin Y, Ma Q, Li L, et al. The CXCL12-CXCR4 axis promotes migration, invasiveness, and EMT in human papillary thyroid carcinoma B-CPAP cells via NF-κB signaling. Biochem Cell Biol, 2018, 96(5): 619-626.
27. Zhang H, Yang L, Liu Z, et al. iTRAQ-coupled 2D LC/MS-MS analysis of CXCR7-transfected papillary thyroid carcinoma cells: A new insight into CXCR7 regulation of papillary thyroid carcinoma progression and identification of potential biomarkers. Oncol Lett, 2017, 14(3): 3734-3740.
28. Ye XC, Hu JX, Li L, et al. Astrocytic Lrp4 (low-density lipoprotein receptor-related protein 4) contributes to ischemia-induced brain injury by regulating atp release and adenosine-A stroke, 2018, 49(1): 165-174.
29. Weatherbee SD, Anderson KV, Niswander LA. LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction. Development, 2006, 133(24): 4993-5000.
30. Ohno K, Ohkawara B, Ito M. Agrin-LRP4-MuSK signaling as a therapeutic target for myasthenia gravis and other neuromuscular disorders. Expert Opin Ther Targets, 2017, 21(10): 949-958.
31. Karakatsani A, Marichal N, Urban S, et al. Neuronal LRP4 regulates synapse formation in the developing CNS. Development, 2017, 144(24): 4604-4615.
32. Chakraborty S, Lakshmanan M, Swa HL, et al. An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma. Nat Commun, 2015, 6: 6184.
33. Hucz J, Kowalska M, Jarzab M, et al. Gene expression of meta-lloproteinase 11, claudin 1 and selected adhesion related genes in papillary thyroid cancer. Endokrynol Pol, 2006, 57 Suppl A: 18-25.
34. Zhou X, Xia E, Bhandari A, et al. LRP4 promotes proliferation, migration, and invasion in papillary thyroid cancer. Biochem Biophys Res Commun, 2018, 503(1): 257-263.
35. Fischer P, Hilfiker-Kleiner D. Role of gp130-mediated signalling pathways in the heart and its impact on potential therapeutic aspects. Br J Pharmacol, 2008, 153 Suppl 1: S414-S427.
36. Elson GC, Lelièvre E, Guillet C, et al. CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex. Nat Neurosci, 2000, 3(9): 867-872.
37. Knappskog PM, Majewski J, Livneh A, et al. Cold-induced sweating syndrome is caused by mutations in the CRLF1 gene. Am J Hum Genet, 2003, 72(2): 375-383.
38. Stearman RS, Dwyer-Nield L, Zerbe L, et al. Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model. Am J Pathol, 2005, 167(6): 1763-1775.
39. Yu ST, Zhong Q, Chen RH, et al. CRLF1 promotes malignant phenotypes of papillary thyroid carcinoma by activating the MAPK/ERK and PI3K/AKT pathways. Cell Death Dis, 2018, 9(3): 371.
40. Saito K, Ozawa Y, Hibino K, et al. FilGAP, a Rho/Rho-associated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migration. Mol Biol Cell, 2012, 23(24): 4739-4750.
41. Morgan-Fisher M, Wewer UM, Yoneda A. Regulation of ROCK activity in cancer. J Histochem Cytochem, 2013, 61(3): 185-198.
42. Luo D, Chen H, Li X, et al. Activation of the ROCK1/MMP-9 pathway is associated with the invasion and poor prognosis in papillary thyroid carcinoma. Int J Oncol, 2017, 51(4): 1209-1218.
43. Su ZZ, Kang DC, Chen Y, et al. Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH. Oncogene, 2002, 21(22): 3592-3602.
44. Kang DC, Su ZZ, Sarkar D, et al. Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene, 2005, 353(1): 8-15.
45. Yoo BK, Emdad L, Lee SG, et al. Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology. Pharmacol Ther, 2011, 130(1): 1-8.
46. Luo Y, Zhang X, Tan Z, et al. Astrocyte elevated gene-1 as a novel clinicopathological and prognostic biomarker for gastrointestinal cancers: a meta-analysis with 2 999 patients. PLoS One, 2015, 10(12): e0145659.
47. Emdad L, Das SK, Dasgupta S, et al. AEG-1/MTDH/LYRIC: signaling pathways, downstream genes, interacting proteins, and regulation of tumor angiogenesis. Adv Cancer Res, 2013, 120: 75-111.
48. Huang LL, Wang Z, Cao CJ, et al. AEG-1 associates with metastasis in papillary thyroid cancer through upregulation of MMP2/9. Int J Oncol, 2017, 51(3): 812-822.

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Advances in studies on potential related proteins of thyroid papillary carcinoma metastasis and its mechanisms

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