The management of a patient with primary pancreatic diffuse large B-cell lymphoma by muti-disciplinary term_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YANG Fan ¹ , FENG Huaguo ² ,  GONG Jianping ²

1. Department of General Surgery, People’s Hospital of Chishui, Chishui, Guizhou 564700, P. R. China;
2. Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P. R. China;

Corresponding author：

GONG Jianping, Email: gongjianping11@126.com

Keywords：

primary pancreatic diffuse large B-cell lymphoma; muti-disciplinary term

DOI：

10.7507/1007-9424.201901068

Video：

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Objective To summarize the individualized diagnosis and treatment experience in a patient with primary pancreatic diffuse large B-cell lymphoma.Methods By muti-disciplinary term (MDT) model, a patient with primary pancreatic diffuse large B-cell lymphoma admitted in the People’s Hospital of Chishui in Dec. 2016 was discussed. The diagnosis, perioperative period management, and operation scheme were carried out by the MDT.Results The patient’s general condition was good. After multidisciplinary discussion in the Department of Radiology, Oncology, Interventional, and Hepatobiliary and Pancreatic Surgery, the patient was considered to have surgical indications. After thorough communication with the patient and family, the patient was selected for surgical resection. The whole operation lasted for 5 hours, and the intraoperative blood loss was about 300 mL. The operation was successfully completed and no complications such as pancreatic fistula occurred after operation. Liquid drainage tube was drawn out at 10 days after opertion, and pancreatic tube stent and T tube were retained. The patient discharged on 13 days after surgery. Subsequently, the patient underwent adjuvant chemotherapy. At present, the patient has been followed up for 1 year, no signs of tumor recurrence and metastasis, and continued follow-up.Conclusions Primary pancreatic diffuse large B-cell lymphoma is rare and has a poor prognosis. The main treatment is mutli-mode treatment based on surgical resection combined with chemotherapy.

Citation： YANG Fan, FENG Huaguo, GONG Jianping. The management of a patient with primary pancreatic diffuse large B-cell lymphoma by muti-disciplinary term. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2019, 26(6): 723-727. doi: 10.7507/1007-9424.201901068 Copy

1.	王木森, 王新国, 郑金锋, 等. 原发性肝脏弥漫大B细胞淋巴瘤5例并文献复习. 重庆医科大学学报, 2016, 41(6): 605-608.
2.	王永超, 李强. 原发性胰腺淋巴瘤的临床分析及胰腺癌的鉴别. 中国肿瘤临床, 2014, 41(2): 113-116.
3.	曾纪权, 郑智, 王晓, 等. 原发胰腺淋巴瘤1例. 实用医学杂志, 2013, 29(1): 165-166.
4.	Behrns KE, Sarr MG, Strickler JG. Pancreatic lymphoma: is it a surgical disease? Pancreas, 1994, 9(5): 662-667.
5.	陈康, 陈家飞, 黄浩钊, 等. 原发性胰腺淋巴瘤CT特征及增强特点. 局解手术学杂志, 2016, 25(12): 905-908.
6.	李庆东, 余维倩, 邓和军, 等. 2例罕见的原发性胰腺淋巴瘤. 检验医学与临床, 2013, 10(19): 2640-2641.
7.	Fujinaga Y, Lall C, Patel A, et al. MR features of primary and secondary malignant lymphoma of the pancreas: a pictorial review. Insights Imaging, 2013, 4(3): 321-329.
8.	周建军, 丁建国, 周康荣, 等. 结外淋巴瘤: 影像学共性特征与病理的关系. 临床放射学杂志, 2007, 26(6): 618-622.
9.	王运韬, 陈韵彬, 陈英, 等. 原发性胰腺淋巴瘤的MSCT影像表现分析. 临床放射学杂志, 2015, 34(6): 924-928.
10.	Salvatore JR, Cooper B, Shah I, et al. Primary pancreatic lymphoma: a case report, literature review, and proposal for nomenclature. Med Oncol, 2000, 17(3): 237-247.
11.	Du X, Zhao Y, Zhang T, et al. Primary pancreatic lymphoma: a clinical quandary of diagnosis and treatment. Pancreas, 2011, 40(1): 30-36.
12.	姜鹏, 江勇, 吴宝强, 等. 原发性胰腺淋巴瘤诊疗体会. 临床肝胆病杂志, 2011, 27(11): 1190-1192.
13.	Arcari A, Anselmi E, Bernuzzi P, et al. Primary pancreatic lymphoma. A report of five cases. Haematologica, 2005, 90(1): ECR09.
14.	肖梦加, 欧阳取长, 胡哲煜, 等. 循环肿瘤DNA在晚期乳腺癌的临床应用进展. 临床肿瘤学杂志, 2018, 24(9): 855-860.
15.	李庞, 崔凯, 李朝华, 等. 原发性胰腺弥漫性大B细胞淋巴瘤2例报告. 世界华人消化杂志, 2017, 20(3): 303-306.
16.	谢家泰, 傅鸿亮, 曾志荣, 等. 原发性胰腺淋巴瘤26例诊疗分析. 海南医学, 2017, 14(1): 134-135.
17.	Rossi ED, Larghi A, Verna EC, et al. Endoscopic ultrasound-guided fine-needle aspiration with liquid-based cytologic preparation in the diagnosis of primary pancreatic lymphoma. Pancreas, 2010, 39(8): 1299-1302.
18.	Tuchek JM, De Jong SA, Pickleman J. Diagnosis, surgical intervention, and prognosis of primary pancreatic lymphoma. Am Surg, 1993, 59(8): 513-518.
19.	王艳芝, 杨云生, 蔡逢春, 等. 原发性胰腺淋巴瘤1例. 胃肠病学和肝病学杂志, 2013, 22(6): 591-592.
20.	徐梅梅, 高福来, 李莉, 等. 自身免疫性胰腺炎二例报道并文献分析. 中国全科医学, 2013, 16(29): 2760-2762.
21.	Hamano H, Kawa S, Horiuchi A, et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med, 2001, 344(10): 732-738.
22.	邓晓, 邱莎莎, 杨庆春. 原发性胰腺淋巴瘤诊治分析: 附2例报告. 中国普通外科杂志, 2011, 20(3): 314-316.
23.	郑天颖, 黄子星, 宋彬. 胰腺血液系统恶性肿瘤的影像学表现. 中国普外基础与临床杂志, 2017, 24(11): 1394-1399.
24.	何天霖, 胡先贵, 刘瑞, 等. 原发性胰腺淋巴瘤的诊断和治疗(附9例报告). 第二军医大学学报, 2005, 26(8): 875-876.

1. 王木森, 王新国, 郑金锋, 等. 原发性肝脏弥漫大B细胞淋巴瘤5例并文献复习. 重庆医科大学学报, 2016, 41(6): 605-608.
2. 王永超, 李强. 原发性胰腺淋巴瘤的临床分析及胰腺癌的鉴别. 中国肿瘤临床, 2014, 41(2): 113-116.
3. 曾纪权, 郑智, 王晓, 等. 原发胰腺淋巴瘤1例. 实用医学杂志, 2013, 29(1): 165-166.
4. Behrns KE, Sarr MG, Strickler JG. Pancreatic lymphoma: is it a surgical disease? Pancreas, 1994, 9(5): 662-667.
5. 陈康, 陈家飞, 黄浩钊, 等. 原发性胰腺淋巴瘤CT特征及增强特点. 局解手术学杂志, 2016, 25(12): 905-908.
6. 李庆东, 余维倩, 邓和军, 等. 2例罕见的原发性胰腺淋巴瘤. 检验医学与临床, 2013, 10(19): 2640-2641.
7. Fujinaga Y, Lall C, Patel A, et al. MR features of primary and secondary malignant lymphoma of the pancreas: a pictorial review. Insights Imaging, 2013, 4(3): 321-329.
8. 周建军, 丁建国, 周康荣, 等. 结外淋巴瘤: 影像学共性特征与病理的关系. 临床放射学杂志, 2007, 26(6): 618-622.
9. 王运韬, 陈韵彬, 陈英, 等. 原发性胰腺淋巴瘤的MSCT影像表现分析. 临床放射学杂志, 2015, 34(6): 924-928.
10. Salvatore JR, Cooper B, Shah I, et al. Primary pancreatic lymphoma: a case report, literature review, and proposal for nomenclature. Med Oncol, 2000, 17(3): 237-247.
11. Du X, Zhao Y, Zhang T, et al. Primary pancreatic lymphoma: a clinical quandary of diagnosis and treatment. Pancreas, 2011, 40(1): 30-36.
12. 姜鹏, 江勇, 吴宝强, 等. 原发性胰腺淋巴瘤诊疗体会. 临床肝胆病杂志, 2011, 27(11): 1190-1192.
13. Arcari A, Anselmi E, Bernuzzi P, et al. Primary pancreatic lymphoma. A report of five cases. Haematologica, 2005, 90(1): ECR09.
14. 肖梦加, 欧阳取长, 胡哲煜, 等. 循环肿瘤DNA在晚期乳腺癌的临床应用进展. 临床肿瘤学杂志, 2018, 24(9): 855-860.
15. 李庞, 崔凯, 李朝华, 等. 原发性胰腺弥漫性大B细胞淋巴瘤2例报告. 世界华人消化杂志, 2017, 20(3): 303-306.
16. 谢家泰, 傅鸿亮, 曾志荣, 等. 原发性胰腺淋巴瘤26例诊疗分析. 海南医学, 2017, 14(1): 134-135.
17. Rossi ED, Larghi A, Verna EC, et al. Endoscopic ultrasound-guided fine-needle aspiration with liquid-based cytologic preparation in the diagnosis of primary pancreatic lymphoma. Pancreas, 2010, 39(8): 1299-1302.
18. Tuchek JM, De Jong SA, Pickleman J. Diagnosis, surgical intervention, and prognosis of primary pancreatic lymphoma. Am Surg, 1993, 59(8): 513-518.
19. 王艳芝, 杨云生, 蔡逢春, 等. 原发性胰腺淋巴瘤1例. 胃肠病学和肝病学杂志, 2013, 22(6): 591-592.
20. 徐梅梅, 高福来, 李莉, 等. 自身免疫性胰腺炎二例报道并文献分析. 中国全科医学, 2013, 16(29): 2760-2762.
21. Hamano H, Kawa S, Horiuchi A, et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med, 2001, 344(10): 732-738.
22. 邓晓, 邱莎莎, 杨庆春. 原发性胰腺淋巴瘤诊治分析: 附2例报告. 中国普通外科杂志, 2011, 20(3): 314-316.
23. 郑天颖, 黄子星, 宋彬. 胰腺血液系统恶性肿瘤的影像学表现. 中国普外基础与临床杂志, 2017, 24(11): 1394-1399.
24. 何天霖, 胡先贵, 刘瑞, 等. 原发性胰腺淋巴瘤的诊断和治疗(附9例报告). 第二军医大学学报, 2005, 26(8): 875-876.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

The management of a patient with primary pancreatic diffuse large B-cell lymphoma by muti-disciplinary term

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