Expression of HOXB7 molecule in colorectal cancer tissues and its clinical significance_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Yi ,  ZHAO Xuefeng

Department of General Surgery, The Affiliated Xinhua Hospital of Dalian University, Dalian, Liaoning 116021, P. R. China;

Corresponding author：

ZHAO Xuefeng, Email: zoserbong@163.com

Keywords：

colorectal cancer; HOXB7 molecule; survival analysis

DOI：

10.7507/1007-9424.201902044

Video：

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Objective To investigate the expression and clinical significance of HOXB7 mRNA and protein in colorectal cancer (CRC) tissues.Methods The expressions of HOXB7 mRNA were evaluated in 6 cases of adjacent colorectal mucosal (ACRM) tissues and 6 cases of CRC tissues by using RT-PCR. The HOXB7 protein expressions were evaluated in 30 cases of ACRM tissues and 98 cases of CRC tissues by using immunohistochemistry. The correlations between the expression of HOXB7 protein, and the clinicopathologic factors or the patient’ survival were analyzed.Results RT-PCR results showed that expression level of HOXB7 mRNA in CRC tissues was significantly higher than that of ACRM tissues (P=0.003). Immunohistochemistry results showed that significantly higher positive-expression rate of HOXB7 protein in CRC tissues compared with ACRM tissues (P<0.05). Positive expression of HOXB7 protein was associated with depth of tumor invasion, lymph node metastasis, and the TNM stage (P<0.05). Kaplan-Meier survival curves showed that positive expression of HOXB7 protein was not inversely correlated with survival of CRC patients (P=0.865).Conclusion Positive expression of HOXB7 protein is a novel biomarker for estimating the progression of CRC, but remains of textual research may be to confirm the significance of HOXB7 protein for prognosis evaluation.

Citation： WANG Yi, ZHAO Xuefeng. Expression of HOXB7 molecule in colorectal cancer tissues and its clinical significance. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2019, 26(6): 673-677. doi: 10.7507/1007-9424.201902044 Copy

1.	郑荣寿, 孙可欣, 张思维, 等. 2015年中国恶性肿瘤流行情况分析. 中华肿瘤杂志, 2019, 41(1): 19-28.
2.	王锡山. 中美结直肠癌流行病学特征对比及防控策略分析. 中华结直肠疾病电子杂志, 2019, 8(1): 1-5.
3.	康争春, 蔡慧, 韩一芳, 等. 结直肠癌的早期诊断及生物标志物现状. 国际外科学杂志, 2017, 44(8): 509-512.
4.	Komatsu H, Iguchi T, Masuda T, et al. HOXB7 expression is a novel biomarker for long-term prognosis after resection of hepatocellular carcinoma. Anticancer Res, 2016, 36(6): 2767-2773.
5.	Monterisi S, Lo Riso P, Russo K, et al. HOXB7 overexpression in lung cancer is a hallmark of acquired stem-like phenotype. Oncogene, 2018, 37(26): 3575-3588.
6.	Soret C, Martin E, Duluc I, et al. Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells. Cancer Lett, 2016, 374(2): 208-215.
7.	Stiegelbauer V, Vychytilova-Faltejskova P, Karbiener M, et al. miR-196b-5p regulates colorectal cancer cell migration and metastases through interaction with HOXB7 and GALNT5. Clin Cancer Res, 2017, 23(17): 5255-5266.
8.	罗云春, 易文, 姚宇宙, 等. 结直肠癌组织中同源异型盒基因B7蛋白的表达及临床意义. 重庆医学, 2018, 47(1): 60-62.
9.	原薇薇, 谭艳, 杜敏, 等. HOXB7基因在肺腺癌中的表达及其临床意义. 临床肿瘤学杂志, 2014, 19(11): 987-991.
10.	赵雪峰, 赵美兰, 许广大. TMPRSS4在胃癌中的表达及其临床意义. 中国医科大学学报, 2018, 47(11): 969-974.
11.	周总光, 杨烈. 结直肠癌外科实验研究进展与展望. 中华实验外科杂志, 2012, 29(2): 172-175.
12.	张海鑫, 苏琪. 精准医学下结直肠癌研究进展. 中国医师进修杂志, 2018, 41(9): 848-852.
13.	贺育华, 杨婕, 蒋理立. 结直肠癌术后患者生活质量的研究进展. 中国普外基础与临床杂志, 2019, [2019-03-05], http://www.gensurg.cn/article/10.7507/1007-9424.201812095.
14.	邓艳红. 结直肠癌的分子分型对临床个体化治疗至关重要. 中华胃肠外科杂志, 2015, 18(10): 994-997.
15.	卢海欣, 黄志辉, 陈佳雅, 等. 结直肠癌化疗增敏性研究进展. 国际外科学杂志, 2015, 42(11): 789-792.
16.	Jass JR. Classification of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology, 2007, 50(1): 113-130.
17.	Cantile M, Scognamiglio G, La Sala L, et al. Aberrant expression of posterior HOX genes in well differentiated histotypes of thyroid cancers. Int J Mol Sci, 2013, 14(11): 21727-21740.
18.	兰鸿波, 潘杰, 卢星榕, 等. miR-196b mRNA和HoxB8 mRNA在结直肠癌组织中的表达及其临床意义. 中国普外基础与临床杂志, 2013, 20(4): 400-405.
19.	周旋, 孔令平, 张仑. HOTAIR与肿瘤生物学行为的研究进展. 中国肿瘤临床, 2016, 43(16): 731-734.
20.	Jin K, Park S, Teo WW, et al. HOXB7 is an ERα cofactor in the activation of HER2 and multiple ER target genes leading to endocrine resistance. Cancer Discov, 2015, 5(9): 944-959.
21.	朱克祥, 袁得峰, 张正聪, 等. RNAi结肠癌HOXB7基因表达对癌细胞增殖及凋亡的机制研究. 中国免疫学志, 2018, 34(3): 371-375.
22.	王艺, 张晓微, 房爱春. HOXB7基因对裸鼠结肠癌肺转移模型的致癌机制研究. 海南医学, 2018, 29(20): 2816-2819.
23.	Liao WT, Jiang D, Yuan J, et al. HOXB7 as a prognostic factor and mediator of colorectal cancer progression. Clin Cancer Res, 2011, 17(11): 3569-3578.
24.	Iman M, Mostafavi SS, Arab SS, et al. HOXB7 and Hsa-miR-222 as the potential therapeutic candidates for metastatic colorectal cancer. Recent Pat Anticancer Drug Discov, 2016, 11(4): 434-443.
25.	肖海娟, 杨林, 徐鹏飞, 等. 结直肠癌侵袭转移过程中HOXB7介导Wnt/β-Catenin信号通路作用及机制研究. 中国临床研究, 2016, 29(11): 1453-1457.
26.	李婷婷. HOXB7激活WnT/β-Catenin信号通路促进结直肠癌侵袭转移的分子机制. 广州: 南方医科大学, 2013.
27.	陈翠敏. HOXB7激活Wnt/β-Catenin信号通路诱导结直肠癌转移. 广州: 南方医科大学, 2012.
28.	郭贞, 焦锋, 金子良, 等. 转录因子HOXB7在肿瘤及相关信号通路中的作用. 肿瘤防治研究, 2015, 42(2): 200-203.

1. 郑荣寿, 孙可欣, 张思维, 等. 2015年中国恶性肿瘤流行情况分析. 中华肿瘤杂志, 2019, 41(1): 19-28.
2. 王锡山. 中美结直肠癌流行病学特征对比及防控策略分析. 中华结直肠疾病电子杂志, 2019, 8(1): 1-5.
3. 康争春, 蔡慧, 韩一芳, 等. 结直肠癌的早期诊断及生物标志物现状. 国际外科学杂志, 2017, 44(8): 509-512.
4. Komatsu H, Iguchi T, Masuda T, et al. HOXB7 expression is a novel biomarker for long-term prognosis after resection of hepatocellular carcinoma. Anticancer Res, 2016, 36(6): 2767-2773.
5. Monterisi S, Lo Riso P, Russo K, et al. HOXB7 overexpression in lung cancer is a hallmark of acquired stem-like phenotype. Oncogene, 2018, 37(26): 3575-3588.
6. Soret C, Martin E, Duluc I, et al. Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells. Cancer Lett, 2016, 374(2): 208-215.
7. Stiegelbauer V, Vychytilova-Faltejskova P, Karbiener M, et al. miR-196b-5p regulates colorectal cancer cell migration and metastases through interaction with HOXB7 and GALNT5. Clin Cancer Res, 2017, 23(17): 5255-5266.
8. 罗云春, 易文, 姚宇宙, 等. 结直肠癌组织中同源异型盒基因B7蛋白的表达及临床意义. 重庆医学, 2018, 47(1): 60-62.
9. 原薇薇, 谭艳, 杜敏, 等. HOXB7基因在肺腺癌中的表达及其临床意义. 临床肿瘤学杂志, 2014, 19(11): 987-991.
10. 赵雪峰, 赵美兰, 许广大. TMPRSS4在胃癌中的表达及其临床意义. 中国医科大学学报, 2018, 47(11): 969-974.
11. 周总光, 杨烈. 结直肠癌外科实验研究进展与展望. 中华实验外科杂志, 2012, 29(2): 172-175.
12. 张海鑫, 苏琪. 精准医学下结直肠癌研究进展. 中国医师进修杂志, 2018, 41(9): 848-852.
13. 贺育华, 杨婕, 蒋理立. 结直肠癌术后患者生活质量的研究进展. 中国普外基础与临床杂志, 2019, [2019-03-05], http://www.gensurg.cn/article/10.7507/1007-9424.201812095.
14. 邓艳红. 结直肠癌的分子分型对临床个体化治疗至关重要. 中华胃肠外科杂志, 2015, 18(10): 994-997.
15. 卢海欣, 黄志辉, 陈佳雅, 等. 结直肠癌化疗增敏性研究进展. 国际外科学杂志, 2015, 42(11): 789-792.
16. Jass JR. Classification of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology, 2007, 50(1): 113-130.
17. Cantile M, Scognamiglio G, La Sala L, et al. Aberrant expression of posterior HOX genes in well differentiated histotypes of thyroid cancers. Int J Mol Sci, 2013, 14(11): 21727-21740.
18. 兰鸿波, 潘杰, 卢星榕, 等. miR-196b mRNA和HoxB8 mRNA在结直肠癌组织中的表达及其临床意义. 中国普外基础与临床杂志, 2013, 20(4): 400-405.
19. 周旋, 孔令平, 张仑. HOTAIR与肿瘤生物学行为的研究进展. 中国肿瘤临床, 2016, 43(16): 731-734.
20. Jin K, Park S, Teo WW, et al. HOXB7 is an ERα cofactor in the activation of HER2 and multiple ER target genes leading to endocrine resistance. Cancer Discov, 2015, 5(9): 944-959.
21. 朱克祥, 袁得峰, 张正聪, 等. RNAi结肠癌HOXB7基因表达对癌细胞增殖及凋亡的机制研究. 中国免疫学志, 2018, 34(3): 371-375.
22. 王艺, 张晓微, 房爱春. HOXB7基因对裸鼠结肠癌肺转移模型的致癌机制研究. 海南医学, 2018, 29(20): 2816-2819.
23. Liao WT, Jiang D, Yuan J, et al. HOXB7 as a prognostic factor and mediator of colorectal cancer progression. Clin Cancer Res, 2011, 17(11): 3569-3578.
24. Iman M, Mostafavi SS, Arab SS, et al. HOXB7 and Hsa-miR-222 as the potential therapeutic candidates for metastatic colorectal cancer. Recent Pat Anticancer Drug Discov, 2016, 11(4): 434-443.
25. 肖海娟, 杨林, 徐鹏飞, 等. 结直肠癌侵袭转移过程中HOXB7介导Wnt/β-Catenin信号通路作用及机制研究. 中国临床研究, 2016, 29(11): 1453-1457.
26. 李婷婷. HOXB7激活WnT/β-Catenin信号通路促进结直肠癌侵袭转移的分子机制. 广州: 南方医科大学, 2013.
27. 陈翠敏. HOXB7激活Wnt/β-Catenin信号通路诱导结直肠癌转移. 广州: 南方医科大学, 2012.
28. 郭贞, 焦锋, 金子良, 等. 转录因子HOXB7在肿瘤及相关信号通路中的作用. 肿瘤防治研究, 2015, 42(2): 200-203.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression of HOXB7 molecule in colorectal cancer tissues and its clinical significance

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