Value of preoperative inflammatory markers in diagnosis and prognosis of colorectal cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Shiyao , HU Huan , WANG Yayun , ZHANG Yong , ZHENG Pengfei ,  CHENG Zhibin

Department of Hepatobiliary Surgery, The Second Hospital of Lanzhou University, Lanzhou 730000, P. R. China;

Corresponding author：

CHENG Zhibin, Email: zhibin_cheng@hotmail.com

Keywords：

colorectal cancer; inflammation; diagnosis; prognosis

DOI：

10.7507/1007-9424.201903026

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To summarize value of preoperative inflammatory markers in diagnosis and prognosis of colorectal cancer.Method The literatures on the preoperative inflammatory markers in the diagnosis and prognosis prediction of colorectal cancer at home and abroad were searched and reviewed.Results The chronic inflammation might promote the occurrence and development of tumor, the tumor related inflammatory markers could be used for the auxiliary diagnosis and assessment of prognosis, such as the neutrophil to lymphocyte ratio, tumor-associated neutrophils, platelet to lymphocyte ratio, Glasgow prognostic score, and C-reactive protein/albumin ratio were obviously correlated with the prognosis of patients with colorectal cancer. What’s more, the D-dimer and fibrinogen to albumin or prealbumin ratio were valuable in the diagnosis and prognosis of colorectal cancer.Conclusions More and more inflammatory factors are applied in diagnosis and prognosis prediction of tumors. However, in general, specificity and sensitivity of a single indicator for tumor diagnosis are poor. In future, while studying new inflammatory indicators, diagnosis can be conducted in combination with various indicators, which is expected to improve specificity and sensitivity. Similarly, prognostic efficacy of a single indicator is low, so it can be combined with various indicators to improve prognostic efficacy of patients with colorectal cancer, and Nomogram model can be established to achieve individualized prediction and guide clinical work.

Citation： WANG Shiyao, HU Huan, WANG Yayun, ZHANG Yong, ZHENG Pengfei, CHENG Zhibin. Value of preoperative inflammatory markers in diagnosis and prognosis of colorectal cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2019, 26(10): 1248-1252. doi: 10.7507/1007-9424.201903026 Copy

1.	陈万青, 孙可欣, 郑荣寿, 等. 2014 年中国分地区恶性肿瘤发病和死亡分析. 中国肿瘤, 2018, 27(1): 1-14.
2.	Zhan X, Sun X, Hong Y, et al. Combined detection of preoperative neutrophil-to-lymphocyte ratio and CEA as an independent prognostic factor in nonmetastatic patients undergoing colorectal cancer resection is superior to NLR or CEA alone. Biomed Res Int, 2017, 2017: 3809464.
3.	Sun F, Tan YA, Gao QF, et al. Circulating fibrinogen to pre-albumin ratio is a promising biomarker for diagnosis of colorectal cancer. J Clin Lab Anal, 2019, 33(1): e22635.
4.	Watanabe A, Araki K, Harimoto N, et al. D-dimer predicts postoperative recurrence and prognosis in patients with liver metastasis of colorectal cancer. Int J Clin Oncol, 2018, 23(4): 689-697.
5.	Sun F, Peng HX, Gao QF, et al. Preoperative circulating FPR and CCF score are promising biomarkers for predicting clinical outcome of stage Ⅱ–Ⅲ colorectal cancer patients. Cancer Manag Res, 2018, 10: 2151-2161.
6.	陈辉, 卢明东, 陈昭屹, 等. 术前中性粒细胞与淋巴细胞比值对胃肠道间质瘤患者预后的预测价值. 中华普通外科杂志, 2017, 32(7): 557-560.
7.	Tanaka Y, Ito S, Isobe K. Vancomycin-sensitive bacteria trigger development of colitis-associated colon cancer by attracting neutrophils. Sci Rep, 2016, 6: 23920.
8.	Li SH, Wang QX, Yang ZY, et al. Prognostic value of the neutrophil-to-lymphocyte ratio for hepatocellular carcinoma patients with portal/hepatic vein tumor thrombosis. World J Gastroenterol, 2017, 23(17): 3122-3132.
9.	徐亚东, 张磊, 赵过超, 等. 术前 NLR 和 PLR 联合各共识在胰腺分支型导管内乳头状肿瘤手术决策中的价值. 中华普通外科杂志, 2017, 32(9): 733-737.
10.	Hurt B, Schulick R, Edil B, et al. Cancer-promoting mechanisms of tumor-associated neutrophils. Am J Surg, 2017, 214(5): 938-944.
11.	康争春, 鄂继福, 于恩达, 等. 中性粒细胞变化与结直肠癌患者预后的关系. 中华普通外科杂志, 2018, 33(10): 845-848.
12.	Zhang J, Zhang HY, Li J, et al. The elevated NLR, PLR and PLT may predict the prognosis of patients with colorectal cancer: a systematic review and meta-analysis. Oncotarget, 2017, 8(40): 68837-68846.
13.	全雄男, 朴美华, 刘兰. 术前 NLR 与 PLR 对结直肠癌预后的意义. 中国肿瘤外科杂志, 2016, 8(6): 369-372.
14.	曹祥龙, 余涛, 赵刚, 等. 格拉斯哥预后评分对腹腔镜结直肠癌根治术患者术后并发症及预后的预测价值. 中华胃肠外科杂志, 2016, 19(10): 1133-1138.
15.	Eren T, Burcu B, Tombalak E, et al. Clinical significance of the Glasgow prognostic score for survival after colorectal cancer surgery. J Gastrointest Surg, 2016, 20(6): 1231-1238.
16.	Okimoto S, Kobayashi T, Tashiro H, et al. Significance of the Glasgow prognostic score for patients with colorectal liver metastasis. Int J Surg, 2017, 42: 209-214.
17.	Liu Y, He X, Pan J, et al. Prognostic role of Glasgow prognostic score in patients with colorectal cancer: evidence from population studies. Sci Rep, 2017, 7(1): 6144.
18.	He L, Li H, Cai J, et al. Prognostic value of the Glasgow prognostic score or modified Glasgow prognostic score for patients with colorectal cancer receiving various treatments: a systematic review and meta-analysis. Cell Physiol Biochem, 2018, 51(3): 1237-1249.
19.	刘丹, 汪晓东, 邓磊, 等. Glasgow 预后分数与结直肠癌近期疗效. 中国普外基础与临床杂志, 2009, 16(12): 1037-1041.
20.	Kinoshita A, Onoda H, Imai N, et al. The C-reactive protein/albumin ratio, a novel inflammation-based prognostic score, predicts outcomes in patients with hepatocellular carcinoma. Ann Surg Oncol, 2015, 22(3): 803-810.
21.	Ni XF, Wu J, Ji M, et al. Effect of C-reactive protein/albumin ratio on prognosis in advanced non-small-cell lung cancer. Asia Pac J Clin Oncol, 2018, 14(6): 402-409.
22.	Wu M, Guo J, Guo L, et al. The C-reactive protein/albumin ratio predicts overall survival of patients with advanced pancreatic cancer. Tumour Biol, 2016, 37(9): 12525-12533.
23.	Liu Y, Chen S, Zheng C, et al. The prognostic value of the preoperative C-reactive protein/albumin ratio in ovarian cancer. BMC Cancer, 2017, 17(1): 285.
24.	刘丹, 汪晓东, 邓磊, 等. 术前炎症和营养预后指数与结直肠癌近期疗效. 中国普外基础与临床杂志, 2009, 16(11): 934-938.
25.	陈英英, 张佳和, 张湾, 等. C 反应蛋白/白蛋白比率预测结直肠癌病人预后关系. 南方医科大学学报, 2017, 37(5): 622-627.
26.	Shibutani M, Maeda K, Nagahara H, et al. Prognostic significance of the preoperative ratio of C-reactive protein to albumin in patients with colorectal cancer. Anticancer Res, 2016, 36(3): 995-1001.
27.	Ishizuka M, Nagata H, Takagi K, et al. Clinical significance of the C-reactive protein to albumin ratio for survival after surgery for colorectal cancer. Ann Surg Oncol, 2016, 23(3): 900-907.
28.	De Simone V, Franzè E, Ronchetti G, et al. Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene, 2015, 34(27): 3493-3503.
29.	谢健进, 邵春法. 术前炎症相关指标与结直肠癌根治术后预后的关系. 浙江临床医学, 2019, 21(2): 222-224.
30.	许柯青, 赵靖, 崔文贤. 术前炎性因子水平对 82 例行结直肠癌根治术患者预后影响研究. 肿瘤学杂志, 2016, 22(12): 1075-1077.
31.	Yu J, Li D, Lei D, et al. Tumor-specific D-dimer concentration ranges and influencing factors: a cross-sectional study. PLoS One, 2016, 11(11): e0165390.
32.	Go SI, Lee MJ, Lee WS, et al. D-dimer can serve as a prognostic and predictive biomarker for metastatic gastric cancer treated by chemotherapy. Medicine (Baltimore), 2015, 94(30): e951.
33.	Cui LN, Li N, Fu S, et al. Combination of preoperative D-dimer and mean platelet volume predicts postoperative deep venous thrombosis in breast cancer patients. Cancer Biomark, 2018, 21(4): 909-913.
34.	黄国飞, 陈玉祥, 李俊, 等. 联合检测 D-二聚体和 CEA 在结直肠癌诊断中的价值. 医药前沿, 2017, 7(15): 160-161.
35.	Motavaf E, Sunesen KG, Stender MT, et al. Prognostic value of preoperative D-dimer and carcinoembryonic antigen levels in patients undergoing intended curative resection for colorectal cancer: a prospective cohort study. Int J Colorectal Dis, 2014, 29(11): 1427-1432.
36.	Lu SL, Ye ZH, Ling T, et al. High pretreatment plasma D-dimer predicts poor survival of colorectal cancer: insight from a meta-analysis of observational studies. Oncotarget, 2017, 8(46): 81186-81194.
37.	Ghanim B, Hoda MA, Klikovits T, et al. Circulating fibrinogen is a prognostic and predictive biomarker in malignant pleural mesothelioma. Br J Cancer, 2014, 110(4): 984-990.
38.	Tang L, Liu K, Wang J, et al. High preoperative plasma fibrinogen levels are associated with distant metastases and impaired prognosis after curative resection in patients with colorectal cancer. J Surg Oncol, 2010, 102(5): 428-432.
39.	Son HJ, Park JW, Chang HJ, et al. Preoperative plasma hyperfibrinogenemia is predictive of poor prognosis in patients with nonmetastatic colon cancer. Ann Surg Oncol, 2013, 20(9): 2908-2913.
40.	陈小林, 姚国强, 刘剑荣. 术前外周血中 NLR、d-NLR、PLR 和 LMR 四种比值在结直肠癌患者预后诊断中的价值. 中国免疫学杂志, 2015, 31(10): 1389-1393.
41.	Erdogan S, Yilmaz FM, Yazici O, et al. Inflammation and chemerin in colorectal cancer. Tumour Biol, 2016, 37(5): 6337-6342.
42.	Martino MM, Briquez PS, Ranga A, et al. Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix. Proc Natl Acad Sci USA, 2013, 110(12): 4563-4568.
43.	Zheng S, Shen J, Jiao Y, et al. Platelets and fibrinogen facilitate each other in protecting tumor cells from natural killer cytotoxicity. Cancer Sci, 2009, 100(5): 859-865.
44.	Hong T, Shen D, Chen X, et al. Preoperative plasma fibrinogen, but not D-dimer might represent a prognostic factor in non-metastatic colorectal cancer: A prospective cohort study. Cancer Biomark, 2017, 19(1): 103-111.
45.	Ghanim B, Schweiger T, Jedamzik J, et al. Elevated inflammatory parameters and inflammation scores are associated with poor prognosis in patients undergoing pulmonary metastasectomy for colorectal cancer. Interact Cardiovasc Thorac Surg, 2015, 21(5): 616-623.
46.	Yamashita H, Kitayama J, Taguri M, et al. Effect of preoperative hyperfibrinogenemia on recurrence of colorectal cancer without a systemic inflammatory response. World J Surg, 2009, 33(6): 1298-1305.
47.	Kawai K, Kitayama J, Tsuno NH, et al. Hyperfibrinogenemia after preoperative chemoradiotherapy predicts poor response and poor prognosis in rectal cancer. Int J Colorectal Dis, 2011, 26(1): 45-51.

1. 陈万青, 孙可欣, 郑荣寿, 等. 2014 年中国分地区恶性肿瘤发病和死亡分析. 中国肿瘤, 2018, 27(1): 1-14.
2. Zhan X, Sun X, Hong Y, et al. Combined detection of preoperative neutrophil-to-lymphocyte ratio and CEA as an independent prognostic factor in nonmetastatic patients undergoing colorectal cancer resection is superior to NLR or CEA alone. Biomed Res Int, 2017, 2017: 3809464.
3. Sun F, Tan YA, Gao QF, et al. Circulating fibrinogen to pre-albumin ratio is a promising biomarker for diagnosis of colorectal cancer. J Clin Lab Anal, 2019, 33(1): e22635.
4. Watanabe A, Araki K, Harimoto N, et al. D-dimer predicts postoperative recurrence and prognosis in patients with liver metastasis of colorectal cancer. Int J Clin Oncol, 2018, 23(4): 689-697.
5. Sun F, Peng HX, Gao QF, et al. Preoperative circulating FPR and CCF score are promising biomarkers for predicting clinical outcome of stage Ⅱ–Ⅲ colorectal cancer patients. Cancer Manag Res, 2018, 10: 2151-2161.
6. 陈辉, 卢明东, 陈昭屹, 等. 术前中性粒细胞与淋巴细胞比值对胃肠道间质瘤患者预后的预测价值. 中华普通外科杂志, 2017, 32(7): 557-560.
7. Tanaka Y, Ito S, Isobe K. Vancomycin-sensitive bacteria trigger development of colitis-associated colon cancer by attracting neutrophils. Sci Rep, 2016, 6: 23920.
8. Li SH, Wang QX, Yang ZY, et al. Prognostic value of the neutrophil-to-lymphocyte ratio for hepatocellular carcinoma patients with portal/hepatic vein tumor thrombosis. World J Gastroenterol, 2017, 23(17): 3122-3132.
9. 徐亚东, 张磊, 赵过超, 等. 术前 NLR 和 PLR 联合各共识在胰腺分支型导管内乳头状肿瘤手术决策中的价值. 中华普通外科杂志, 2017, 32(9): 733-737.
10. Hurt B, Schulick R, Edil B, et al. Cancer-promoting mechanisms of tumor-associated neutrophils. Am J Surg, 2017, 214(5): 938-944.
11. 康争春, 鄂继福, 于恩达, 等. 中性粒细胞变化与结直肠癌患者预后的关系. 中华普通外科杂志, 2018, 33(10): 845-848.
12. Zhang J, Zhang HY, Li J, et al. The elevated NLR, PLR and PLT may predict the prognosis of patients with colorectal cancer: a systematic review and meta-analysis. Oncotarget, 2017, 8(40): 68837-68846.
13. 全雄男, 朴美华, 刘兰. 术前 NLR 与 PLR 对结直肠癌预后的意义. 中国肿瘤外科杂志, 2016, 8(6): 369-372.
14. 曹祥龙, 余涛, 赵刚, 等. 格拉斯哥预后评分对腹腔镜结直肠癌根治术患者术后并发症及预后的预测价值. 中华胃肠外科杂志, 2016, 19(10): 1133-1138.
15. Eren T, Burcu B, Tombalak E, et al. Clinical significance of the Glasgow prognostic score for survival after colorectal cancer surgery. J Gastrointest Surg, 2016, 20(6): 1231-1238.
16. Okimoto S, Kobayashi T, Tashiro H, et al. Significance of the Glasgow prognostic score for patients with colorectal liver metastasis. Int J Surg, 2017, 42: 209-214.
17. Liu Y, He X, Pan J, et al. Prognostic role of Glasgow prognostic score in patients with colorectal cancer: evidence from population studies. Sci Rep, 2017, 7(1): 6144.
18. He L, Li H, Cai J, et al. Prognostic value of the Glasgow prognostic score or modified Glasgow prognostic score for patients with colorectal cancer receiving various treatments: a systematic review and meta-analysis. Cell Physiol Biochem, 2018, 51(3): 1237-1249.
19. 刘丹, 汪晓东, 邓磊, 等. Glasgow 预后分数与结直肠癌近期疗效. 中国普外基础与临床杂志, 2009, 16(12): 1037-1041.
20. Kinoshita A, Onoda H, Imai N, et al. The C-reactive protein/albumin ratio, a novel inflammation-based prognostic score, predicts outcomes in patients with hepatocellular carcinoma. Ann Surg Oncol, 2015, 22(3): 803-810.
21. Ni XF, Wu J, Ji M, et al. Effect of C-reactive protein/albumin ratio on prognosis in advanced non-small-cell lung cancer. Asia Pac J Clin Oncol, 2018, 14(6): 402-409.
22. Wu M, Guo J, Guo L, et al. The C-reactive protein/albumin ratio predicts overall survival of patients with advanced pancreatic cancer. Tumour Biol, 2016, 37(9): 12525-12533.
23. Liu Y, Chen S, Zheng C, et al. The prognostic value of the preoperative C-reactive protein/albumin ratio in ovarian cancer. BMC Cancer, 2017, 17(1): 285.
24. 刘丹, 汪晓东, 邓磊, 等. 术前炎症和营养预后指数与结直肠癌近期疗效. 中国普外基础与临床杂志, 2009, 16(11): 934-938.
25. 陈英英, 张佳和, 张湾, 等. C 反应蛋白/白蛋白比率预测结直肠癌病人预后关系. 南方医科大学学报, 2017, 37(5): 622-627.
26. Shibutani M, Maeda K, Nagahara H, et al. Prognostic significance of the preoperative ratio of C-reactive protein to albumin in patients with colorectal cancer. Anticancer Res, 2016, 36(3): 995-1001.
27. Ishizuka M, Nagata H, Takagi K, et al. Clinical significance of the C-reactive protein to albumin ratio for survival after surgery for colorectal cancer. Ann Surg Oncol, 2016, 23(3): 900-907.
28. De Simone V, Franzè E, Ronchetti G, et al. Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene, 2015, 34(27): 3493-3503.
29. 谢健进, 邵春法. 术前炎症相关指标与结直肠癌根治术后预后的关系. 浙江临床医学, 2019, 21(2): 222-224.
30. 许柯青, 赵靖, 崔文贤. 术前炎性因子水平对 82 例行结直肠癌根治术患者预后影响研究. 肿瘤学杂志, 2016, 22(12): 1075-1077.
31. Yu J, Li D, Lei D, et al. Tumor-specific D-dimer concentration ranges and influencing factors: a cross-sectional study. PLoS One, 2016, 11(11): e0165390.
32. Go SI, Lee MJ, Lee WS, et al. D-dimer can serve as a prognostic and predictive biomarker for metastatic gastric cancer treated by chemotherapy. Medicine (Baltimore), 2015, 94(30): e951.
33. Cui LN, Li N, Fu S, et al. Combination of preoperative D-dimer and mean platelet volume predicts postoperative deep venous thrombosis in breast cancer patients. Cancer Biomark, 2018, 21(4): 909-913.
34. 黄国飞, 陈玉祥, 李俊, 等. 联合检测 D-二聚体和 CEA 在结直肠癌诊断中的价值. 医药前沿, 2017, 7(15): 160-161.
35. Motavaf E, Sunesen KG, Stender MT, et al. Prognostic value of preoperative D-dimer and carcinoembryonic antigen levels in patients undergoing intended curative resection for colorectal cancer: a prospective cohort study. Int J Colorectal Dis, 2014, 29(11): 1427-1432.
36. Lu SL, Ye ZH, Ling T, et al. High pretreatment plasma D-dimer predicts poor survival of colorectal cancer: insight from a meta-analysis of observational studies. Oncotarget, 2017, 8(46): 81186-81194.
37. Ghanim B, Hoda MA, Klikovits T, et al. Circulating fibrinogen is a prognostic and predictive biomarker in malignant pleural mesothelioma. Br J Cancer, 2014, 110(4): 984-990.
38. Tang L, Liu K, Wang J, et al. High preoperative plasma fibrinogen levels are associated with distant metastases and impaired prognosis after curative resection in patients with colorectal cancer. J Surg Oncol, 2010, 102(5): 428-432.
39. Son HJ, Park JW, Chang HJ, et al. Preoperative plasma hyperfibrinogenemia is predictive of poor prognosis in patients with nonmetastatic colon cancer. Ann Surg Oncol, 2013, 20(9): 2908-2913.
40. 陈小林, 姚国强, 刘剑荣. 术前外周血中 NLR、d-NLR、PLR 和 LMR 四种比值在结直肠癌患者预后诊断中的价值. 中国免疫学杂志, 2015, 31(10): 1389-1393.
41. Erdogan S, Yilmaz FM, Yazici O, et al. Inflammation and chemerin in colorectal cancer. Tumour Biol, 2016, 37(5): 6337-6342.
42. Martino MM, Briquez PS, Ranga A, et al. Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix. Proc Natl Acad Sci USA, 2013, 110(12): 4563-4568.
43. Zheng S, Shen J, Jiao Y, et al. Platelets and fibrinogen facilitate each other in protecting tumor cells from natural killer cytotoxicity. Cancer Sci, 2009, 100(5): 859-865.
44. Hong T, Shen D, Chen X, et al. Preoperative plasma fibrinogen, but not D-dimer might represent a prognostic factor in non-metastatic colorectal cancer: A prospective cohort study. Cancer Biomark, 2017, 19(1): 103-111.
45. Ghanim B, Schweiger T, Jedamzik J, et al. Elevated inflammatory parameters and inflammation scores are associated with poor prognosis in patients undergoing pulmonary metastasectomy for colorectal cancer. Interact Cardiovasc Thorac Surg, 2015, 21(5): 616-623.
46. Yamashita H, Kitayama J, Taguri M, et al. Effect of preoperative hyperfibrinogenemia on recurrence of colorectal cancer without a systemic inflammatory response. World J Surg, 2009, 33(6): 1298-1305.
47. Kawai K, Kitayama J, Tsuno NH, et al. Hyperfibrinogenemia after preoperative chemoradiotherapy predicts poor response and poor prognosis in rectal cancer. Int J Colorectal Dis, 2011, 26(1): 45-51.

Previous Article
Diagnostic value of LncRNAs for hepatocellular carcinoma
Next Article
Advances on clinical application of radiomics and colorectal cancer

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Value of preoperative inflammatory markers in diagnosis and prognosis of colorectal cancer

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content