MDT discussion of a case of giant gastrointestinal stromal tumor_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Kaimin , QIAN Shidong ,  CHEN Gang

The Second Department of Hepatopancreatobiliary Surgery, The First Hospital of Kunming, Kunming 650011, P. R. China;

Corresponding author：

CHEN Gang, Email: kmcg123@163.com

Keywords：

gastrointestinal stromal tumor; multidisciplinary diagnosis and treatment

DOI：

10.7507/1007-9424.201906097

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the clinical characteristics, diagnosis, and treatment norms of gastrointestinal stromal tumor, so as to deepen clinicians’ understanding of the gastrointestinal stromal tumor and avoid misdiagnosis.Methods The clinical data of a patient with gastrointestinal stromal tumor who treated in March 2019 in The First Hospital of Kunming was retrospectively analyzed, and determining the methods of the treatment through MDT mode.Results This patient was generally in good condition. After MDT discussions among the imaging department, cardiothoracic surgery department, oncology department, and anesthesia department, it was considered that surgical treatment was the best treatment scheme. The operation time was 120 min, intraoperative bleeding was about 100 mL, and no blood transfusion was performed. No bleeding, abdominal infection, gastroesophageal reflux, and other complications occurred after the operation, and the patient was discharged successfully on the 10^th day after the operation. Postoperative treatment was assisted by imatinib. Follow-up was conducted for more than 4 months, with no obvious complication occurred after discharge, so continued to follow-up.Conclusion Gastrointestinal stromal tumor can be diagnosed and treated by multidisciplinary approach, and surgical resection is still the most important and effective treatment.

Citation： LIU Kaimin, QIAN Shidong, CHEN Gang. MDT discussion of a case of giant gastrointestinal stromal tumor. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2020, 27(2): 192-195. doi: 10.7507/1007-9424.201906097 Copy

1.	中国胃肠道间质瘤专家组. 中国胃肠道间质瘤诊断治疗共识(2008 年版). 临床肿瘤学杂志, 2009, 14(8): 746.
2.	Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol, 2002, 33(5): 459-465.
3.	侯英勇, 王坚, 朱雄增, 等. 胃肠道间质瘤 76例的临床病理及免疫组织化学特征. 中华病理学杂志, 2002, 31(1): 20-25.
4.	Miettinen M, Lasota J. KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation. Appl Immunohistochem Mol Morphol, 2005, 13(3): 205-220.
5.	贺慧颖, 方伟岗, 钟镐镐, 等. 165例胃肠道间质瘤中 c-kit和PDGFRA基因突变的检测及临床诊断意义. 中华病理学杂志, 2006, 35(5): 262-266.
6.	Wada N, Kurokawa Y, Takahashi T, et al. Detecting secondary cKIT mutations in the peripheral blood of patients with imatinibresistant gastrointestinal stromal tumor. Oncology, 2016, 90(2): 112-117.
7.	Gao J, Li J, Li Y, et al. Intratumoral KIT mutational heterogeneity and recurrent KIT/PDGFRA mutations in KIT/PDGFRAwild-type gastrointestinal stromal tumors. Oncotarget, 2016, 7(21): 30241-30249.
8.	曹晖, 高志冬, 何裕隆, 等. 胃肠间质瘤规范化外科治疗中国专家共识(2018版). 中国实用外科杂志, 2018, 38(9): 965-973.
9.	徐泽宽, 徐皓, 李沣员. 腹腔镜技术在胃肠间质瘤手术中的应用价值与争议. 中国实用外科杂志, 2018, 38(5): 501-504.
10.	Bischof DA, Kim Y, Dodson R, et al. Open versus minimally invasive resection of gastric GIST : a multi-institutional analysis of short- and long- term outcomes. Ann Surg Oncol, 2014, 21(9): 2941-2948.
11.	Honda M, Hiki N, Nunobe S, et al. Long-term and surgical outcomes of laparoscopic surgery for gastric gastrointestinal stromal tumors. Surg Endosc, 2014, 28(8): 2317-2322.
12.	Shoji Y, Takeuchi H, Goto O, et al. Optimal minimally invasive surgical procedure for gastric submucosal tumors. Gastric Cancer, 2018, 21(3): 508-515.
13.	Yin Y, Xiang J, Tang S, et al. A lower dosage of imatinib in patients with gastrointestinal stromal tumors with toxicity of the treatment. Medicine (Baltimore), 2016, 95(49): e5488.
14.	徐皓, 马利林, 徐为, 等. 胃肠间质瘤病人服药前后监测伊马替尼血浆浓度意义的中国多中心研究. 中华胃肠外科杂志, 2016, 19(11): 1271-1276.

1. 中国胃肠道间质瘤专家组. 中国胃肠道间质瘤诊断治疗共识(2008 年版). 临床肿瘤学杂志, 2009, 14(8): 746.
2. Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol, 2002, 33(5): 459-465.
3. 侯英勇, 王坚, 朱雄增, 等. 胃肠道间质瘤 76例的临床病理及免疫组织化学特征. 中华病理学杂志, 2002, 31(1): 20-25.
4. Miettinen M, Lasota J. KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation. Appl Immunohistochem Mol Morphol, 2005, 13(3): 205-220.
5. 贺慧颖, 方伟岗, 钟镐镐, 等. 165例胃肠道间质瘤中 c-kit和PDGFRA基因突变的检测及临床诊断意义. 中华病理学杂志, 2006, 35(5): 262-266.
6. Wada N, Kurokawa Y, Takahashi T, et al. Detecting secondary cKIT mutations in the peripheral blood of patients with imatinibresistant gastrointestinal stromal tumor. Oncology, 2016, 90(2): 112-117.
7. Gao J, Li J, Li Y, et al. Intratumoral KIT mutational heterogeneity and recurrent KIT/PDGFRA mutations in KIT/PDGFRAwild-type gastrointestinal stromal tumors. Oncotarget, 2016, 7(21): 30241-30249.
8. 曹晖, 高志冬, 何裕隆, 等. 胃肠间质瘤规范化外科治疗中国专家共识(2018版). 中国实用外科杂志, 2018, 38(9): 965-973.
9. 徐泽宽, 徐皓, 李沣员. 腹腔镜技术在胃肠间质瘤手术中的应用价值与争议. 中国实用外科杂志, 2018, 38(5): 501-504.
10. Bischof DA, Kim Y, Dodson R, et al. Open versus minimally invasive resection of gastric GIST : a multi-institutional analysis of short- and long- term outcomes. Ann Surg Oncol, 2014, 21(9): 2941-2948.
11. Honda M, Hiki N, Nunobe S, et al. Long-term and surgical outcomes of laparoscopic surgery for gastric gastrointestinal stromal tumors. Surg Endosc, 2014, 28(8): 2317-2322.
12. Shoji Y, Takeuchi H, Goto O, et al. Optimal minimally invasive surgical procedure for gastric submucosal tumors. Gastric Cancer, 2018, 21(3): 508-515.
13. Yin Y, Xiang J, Tang S, et al. A lower dosage of imatinib in patients with gastrointestinal stromal tumors with toxicity of the treatment. Medicine (Baltimore), 2016, 95(49): e5488.
14. 徐皓, 马利林, 徐为, 等. 胃肠间质瘤病人服药前后监测伊马替尼血浆浓度意义的中国多中心研究. 中华胃肠外科杂志, 2016, 19(11): 1271-1276.

Previous Article
Feasibility and quality control of robotic sleeve lobectomy and bronchoplasty
Next Article
Analysis of risk factors of myasthenia crisis after thymectomy in patients with myasthenia gravis

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

MDT discussion of a case of giant gastrointestinal stromal tumor

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content