乳腺癌的免疫治疗进展_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

陈洁 ¹ ,  彭榆富 ²

1. ;
2. ;

Corresponding author：

彭榆富, Email: pengyufu664920@163.com

Keywords：

DOI：

10.7507/1007-9424.201908046

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Citation： 陈洁, 彭榆富. 乳腺癌的免疫治疗进展. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2019, 26(12): 1403-1408. doi: 10.7507/1007-9424.201908046 Copy

1.	Coley WB. Ⅱ Contribution to the knowledge of sarcoma. Ann Surg, 1891, 14(3): 199-220.
2.	Gettinger S, Horn L, Jackman D, et al. Five-year follow-up of nivolumab in previously treated advanced non-small-cell lung cancer: results from the CA209-003 Study. J Clin Oncol, 2018, 36(17): 1675-1684.
3.	Thompson CB, Allison JP. The emerging role of CTLA-4 as an immune attenuator. Immunity, 1997, 7(4): 445-450.
4.	Nishimura H, Okazaki T, Tanaka Y, et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science, 2001, 291(5502): 319-322.
5.	Abril-Rodriguez G, Ribas A. SnapShot: immune checkpoint inhibitors. Cancer Cell, 2017, 31(6): 848-848.e841.
6.	Topalian SL, Drake CG, Pardoll DM. Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell, 2015, 27(4): 450-461.
7.	Granier C, De Guillebon E, Blanc C, et al. Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer. ESMO Open, 2017, 2(2): e000213.
8.	Solinas C, Gombos A, Latifyan S, et al. Targeting immune checkpoints in breast cancer: an update of early results. ESMO Open, 2017, 2(5): e000255.
9.	Salmaninejad A, Valilou SF, Shabgah AG, et al. PD-1/PD-L1 pathway: basic biology and role in cancer immunotherapy. J Cell Physiol, 2019, 234(10): 16824-16837.
10.	Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med, 2012, 366(26): 2455-2465.
11.	Okazaki T, Honjo T. PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol, 2007, 19(7): 813-824.
12.	Schmid P, Park YH, Munoz-Couselo E, et al. Pembrolizumab (pembro) plus chemotherapy (chemo) as neoadjuvant treatment for triple negative breast cancer (TNBC): preliminary results from KEYNOTE-173. http://apps.webofknowledge.com/Search.do?product=UA&SID=7EYfiA2D11IBlUT8WYO&search_mode=GeneralSearch&prID=088a2926-80f6-409a-a8be-ed0bc8fca996.
13.	Bertucci F, Gonçalves A. Immunotherapy in breast cancer: the emerging role of PD-1 and PD-L1. Curr Oncol Rep, 2017, 19(10): 64.
14.	Vonderheide RH, LoRusso PM, Khalil M, et al. Tremelimumab in combination with exemestane in patients with advanced breast cancer and treatment-associated modulation of inducible costimulator expression on patient T cells. Clin Cancer Res, 2010, 16(13): 3485-3494.
15.	Rotte A. Combination of CTLA-4 and PD-1 blockers for treatment of cancer. J Exp Clin Cancer Res, 2019, 38(1): 255.
16.	Brignone C, Gutierrez M, Mefti F, et al. First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321(LAG-3Ig) enhances immune responses and antitumor activity. J Transl Med, 2010, 8: 71.
17.	Dirix L, Triebel F. AIPAC: a phase Ⅱb study of eftilagimod alpha (IMP321 or LAG-3Ig) added to weekly paclitaxel in patients with metastatic breast cancer. Future Oncol, 2019, 15(17): 1963-1973.
18.	Senkus E, Cardoso F, Pagani O. Time for more optimism in metastatic breast cancer? Cancer Treat Rev, 2014, 40(2): 220-228.
19.	Rugo HS, Delord JP, Im SA, et al. Safety and antitumor activity of Pembrolizumab in patients with estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer. Clin Cancer Res, 2018, 24(12): 2804-2811.
20.	Holgado E, Perez-Garcia J, Gion M, et al. Is there a role for immunotherapy in HER2-positive breast cancer? NPJ Breast Cancer, 2018, 4: 21.
21.	Loi S. Tumor-infiltrating lymphocytes, breast cancer subtypes and therapeutic efficacy. Oncoimmunology, 2013, 2(7): e24720.
22.	Müller P, Kreuzaler M, Khan T, et al. Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible toCTLA-4/PD-1 blockade. Sci Transl Med, 2015, 7(315): 315ra188.
23.	Emens LA, Esteva F, Beresford M, et al. Results from KATE2, a randomized phase 2 study of atezolizumab (atezo) plus trastuzumab emtansine (T-DM1) vs placebo (pbo)+T-DM1 in previously treated HER2+ advanced breast cancer (BC). http://apps.webofknowledge.com/Search.do?product=UA&SID=7EYfiA2- D11IBlUT8WYO&search_mode=GeneralSearch&prID=ecb7443a-329b-4431-8e88-19db700cb296.
24.	Loi S, Giobbie-Hurder A, Gombos A, et al. Pembrolizumab plus trastuzumab in trastuzumab-resistant, advanced, HER2-positive breast cancer (PANACEA): a single-arm, multicentre, phase 1b-2 trial. Lancet Oncol, 2019, 20(3): 371-382.
25.	Hammond ME, Hayes DF, Dowsett M, et al. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version). Arch Pathol Lab Med, 2010, 134(7): e48-e72.
26.	Dent R, Trudeau M, Pritchard KI, et al. Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res, 2007, 13(15 Pt 1): 4429-4434.
27.	Liedtke C, Mazouni C, Hess KR, et al. Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. J Clin Oncol, 2008, 26(8): 1275-1281.
28.	Denkert C. The immunogenicity of breast cancer-molecular subtypes matter. Ann Oncol, 2014, 25(8): 1453-1455.
29.	Adams S, Loi S, Toppmeyer D, et al. Pembrolizumab monotherapy for previously untreated, PD-L1-positive, metastatic triple-negative breast cancer: cohort B of the phase Ⅱ KEYNOTE-086 study. Ann Oncol, 2019, 30(3): 405-411.
30.	Winer EP, Dang T, Karantza V, et al. KEYNOTE-119: A randomized phase Ⅲ study of single-agent pembrolizumab (MK-3475) vs single-agent chemotherapy per physician's choice for metastatic triple-negative breast cancer (mTNBC). http://apps.webofknowledge.com/Search.do?product=UA&SID=7EYfiA2D11I- BlUT8WYO&search_mode=GeneralSearch&prID=d76a5d7f-016b-4b40-8f9a-bcbda9acec83.
31.	Schmid P, Adams S, Rugo HS, et al. Atezolizumab and Nab-Paclitaxel in advanced triple-negative breast cancer. N Engl J Med, 2018, 379(22): 2108-2121.
32.	Schmid P, Adams S, Rugo HS, et al. IMpassion130: results from a global, randomised, double-blind, phase Ⅲ study of atezolizumab (atezo) plus nab-paclitaxel (nab-P) vs placebo plus nab-P in treatment-naive, locally advanced or metastatic triple-negative breast cancer (mTNBC). Ann Oncol, 2018, 29: 707-708.
33.	von Moos R, Emens LA, Loi S, et al. IMpassion130: efficacy in immune biomarker subgroups of atezolizumab plus nab-paclitaxel in patients with triple-negative BC. Swiss Medical Weekly, 2019, 149: 13S-14S.
34.	Adams S, Diamond JR, Hamilton E, et al. Atezolizumab plus nab-Paclitaxel in the treatment of metastatic triple-negative breast cancer with 2-year survival follow-up: a phase 1b clinical trial. JAMA Oncol, 2019, 5(3): 334-342.
35.	Page DB, Kim IK, Sanchez K, et al. Safety and efficacy of pembrolizumab (pembro) plus capecitabine (cape) in metastatic triple negative breast cancer (mTNBC). http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=16&SID=7EYfiA2D11IBlUT8WYO&page=1&doc=2.
36.	Cortés J, André F, Gonçalves A, et al. IMpassion132 phase Ⅲ trial: atezolizumab and chemotherapy in early relapsing metastatic triple-negative breast cancer. Future Oncol, 2019, 15(17): 1951-1961.
37.	Miles D, Kim SB, McNally V, et al. COLET: A multistage, phase 2 study evaluating the safety and efficacy of a doublet regimen of cobimetinib (C) in combination with paclitaxel (P) or triplet regimens of C in combination with atezolizumab (atezo) plus either P or nab-paclitaxel (nab-P) in metastatic triple-negative breast cancer (TNBC). http://apps.webofknowledge.com/Search.do?product=UA&SID=7EYfiA2D11IBlUT8WYO&search_mode=GeneralSearch&prID=450b237f-10de-46f3-8b8a-07bdc5fe36f1.
38.	Golden EB, Pellicciotta I, Demaria S, et al. The convergence of radiation and immunogenic cell death signaling pathways. Front Oncol, 2012, 2: 88.
39.	Deng L, Liang H, Xu M, et al. STING-dependent cytosolic DNA sensing promotes radiation-induced type i interferon-dependent antitumor immunity in immunogenic tumors. Immunity, 2014, 41(5): 843-852.
40.	Germano G, Lamba S, Rospo G, et al. Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth. Nature, 2017, 552(7683): 116-120.
41.	Matsumura S, Wang B, Kawashima N, et al. Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol, 2008, 181(5): 3099-3107.
42.	Sato H, Niimi A, Yasuhara T, et al. DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells. Nat Commun, 2017, 8(1): 1751.
43.	Reits EA, Hodge JW, Herberts CA, et al. Radiation modulates the peptide repertoire, enhances MHC class Ⅰ expression, and induces successful antitumor immunotherapy. J Exp Med, 2006, 203(5): 1259-1271.
44.	Deng L, Liang H, Burnette B, et al. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J Clin Invest, 2014, 124(2): 687-695.
45.	Loibl S, Untch M, Burchardi N, et al. Randomized phase Ⅱ neoadjuvant study (GeparNuevo) to investigate the addition of durvalumab to a taxane-anthracycline containing chemotherapy in triple negative breast cancer (TNBC). J Clin Oncol, 2018, 36(15_suppl): 104.
46.	Loibl S, Untch M, Burchardi N, et al. A randomised phase Ⅱ study investigating durvalumab in addition to an anthracycline taxane-based neoadjuvant therapy in early triple negative breast cancer - clinical results and biomarker analysis of GeparNuevo study. Ann Oncol, 2019, [Epub ahead of print].
47.	van’t Veer LJ, Wolf D, Yau C, et al. MammaPrint High1/High2 risk class as a pre-specified biomarker of response to nine different targeted agents plus standard neoadjuvant therapy for similar to 1 000 breast cancer patients in the I-SPY 2 TRIAL. Europ J Cancer, 2018, 103: E15.

1. Coley WB. Ⅱ Contribution to the knowledge of sarcoma. Ann Surg, 1891, 14(3): 199-220.
2. Gettinger S, Horn L, Jackman D, et al. Five-year follow-up of nivolumab in previously treated advanced non-small-cell lung cancer: results from the CA209-003 Study. J Clin Oncol, 2018, 36(17): 1675-1684.
3. Thompson CB, Allison JP. The emerging role of CTLA-4 as an immune attenuator. Immunity, 1997, 7(4): 445-450.
4. Nishimura H, Okazaki T, Tanaka Y, et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science, 2001, 291(5502): 319-322.
5. Abril-Rodriguez G, Ribas A. SnapShot: immune checkpoint inhibitors. Cancer Cell, 2017, 31(6): 848-848.e841.
6. Topalian SL, Drake CG, Pardoll DM. Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell, 2015, 27(4): 450-461.
7. Granier C, De Guillebon E, Blanc C, et al. Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer. ESMO Open, 2017, 2(2): e000213.
8. Solinas C, Gombos A, Latifyan S, et al. Targeting immune checkpoints in breast cancer: an update of early results. ESMO Open, 2017, 2(5): e000255.
9. Salmaninejad A, Valilou SF, Shabgah AG, et al. PD-1/PD-L1 pathway: basic biology and role in cancer immunotherapy. J Cell Physiol, 2019, 234(10): 16824-16837.
10. Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med, 2012, 366(26): 2455-2465.
11. Okazaki T, Honjo T. PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol, 2007, 19(7): 813-824.
12. Schmid P, Park YH, Munoz-Couselo E, et al. Pembrolizumab (pembro) plus chemotherapy (chemo) as neoadjuvant treatment for triple negative breast cancer (TNBC): preliminary results from KEYNOTE-173. http://apps.webofknowledge.com/Search.do?product=UA&SID=7EYfiA2D11IBlUT8WYO&search_mode=GeneralSearch&prID=088a2926-80f6-409a-a8be-ed0bc8fca996.
13. Bertucci F, Gonçalves A. Immunotherapy in breast cancer: the emerging role of PD-1 and PD-L1. Curr Oncol Rep, 2017, 19(10): 64.
14. Vonderheide RH, LoRusso PM, Khalil M, et al. Tremelimumab in combination with exemestane in patients with advanced breast cancer and treatment-associated modulation of inducible costimulator expression on patient T cells. Clin Cancer Res, 2010, 16(13): 3485-3494.
15. Rotte A. Combination of CTLA-4 and PD-1 blockers for treatment of cancer. J Exp Clin Cancer Res, 2019, 38(1): 255.
16. Brignone C, Gutierrez M, Mefti F, et al. First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321(LAG-3Ig) enhances immune responses and antitumor activity. J Transl Med, 2010, 8: 71.
17. Dirix L, Triebel F. AIPAC: a phase Ⅱb study of eftilagimod alpha (IMP321 or LAG-3Ig) added to weekly paclitaxel in patients with metastatic breast cancer. Future Oncol, 2019, 15(17): 1963-1973.
18. Senkus E, Cardoso F, Pagani O. Time for more optimism in metastatic breast cancer? Cancer Treat Rev, 2014, 40(2): 220-228.
19. Rugo HS, Delord JP, Im SA, et al. Safety and antitumor activity of Pembrolizumab in patients with estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer. Clin Cancer Res, 2018, 24(12): 2804-2811.
20. Holgado E, Perez-Garcia J, Gion M, et al. Is there a role for immunotherapy in HER2-positive breast cancer? NPJ Breast Cancer, 2018, 4: 21.
21. Loi S. Tumor-infiltrating lymphocytes, breast cancer subtypes and therapeutic efficacy. Oncoimmunology, 2013, 2(7): e24720.
22. Müller P, Kreuzaler M, Khan T, et al. Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible toCTLA-4/PD-1 blockade. Sci Transl Med, 2015, 7(315): 315ra188.
23. Emens LA, Esteva F, Beresford M, et al. Results from KATE2, a randomized phase 2 study of atezolizumab (atezo) plus trastuzumab emtansine (T-DM1) vs placebo (pbo)+T-DM1 in previously treated HER2+ advanced breast cancer (BC). http://apps.webofknowledge.com/Search.do?product=UA&SID=7EYfiA2- D11IBlUT8WYO&search_mode=GeneralSearch&prID=ecb7443a-329b-4431-8e88-19db700cb296.
24. Loi S, Giobbie-Hurder A, Gombos A, et al. Pembrolizumab plus trastuzumab in trastuzumab-resistant, advanced, HER2-positive breast cancer (PANACEA): a single-arm, multicentre, phase 1b-2 trial. Lancet Oncol, 2019, 20(3): 371-382.
25. Hammond ME, Hayes DF, Dowsett M, et al. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version). Arch Pathol Lab Med, 2010, 134(7): e48-e72.
26. Dent R, Trudeau M, Pritchard KI, et al. Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res, 2007, 13(15 Pt 1): 4429-4434.
27. Liedtke C, Mazouni C, Hess KR, et al. Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. J Clin Oncol, 2008, 26(8): 1275-1281.
28. Denkert C. The immunogenicity of breast cancer-molecular subtypes matter. Ann Oncol, 2014, 25(8): 1453-1455.
29. Adams S, Loi S, Toppmeyer D, et al. Pembrolizumab monotherapy for previously untreated, PD-L1-positive, metastatic triple-negative breast cancer: cohort B of the phase Ⅱ KEYNOTE-086 study. Ann Oncol, 2019, 30(3): 405-411.
30. Winer EP, Dang T, Karantza V, et al. KEYNOTE-119: A randomized phase Ⅲ study of single-agent pembrolizumab (MK-3475) vs single-agent chemotherapy per physician's choice for metastatic triple-negative breast cancer (mTNBC). http://apps.webofknowledge.com/Search.do?product=UA&SID=7EYfiA2D11I- BlUT8WYO&search_mode=GeneralSearch&prID=d76a5d7f-016b-4b40-8f9a-bcbda9acec83.
31. Schmid P, Adams S, Rugo HS, et al. Atezolizumab and Nab-Paclitaxel in advanced triple-negative breast cancer. N Engl J Med, 2018, 379(22): 2108-2121.
32. Schmid P, Adams S, Rugo HS, et al. IMpassion130: results from a global, randomised, double-blind, phase Ⅲ study of atezolizumab (atezo) plus nab-paclitaxel (nab-P) vs placebo plus nab-P in treatment-naive, locally advanced or metastatic triple-negative breast cancer (mTNBC). Ann Oncol, 2018, 29: 707-708.
33. von Moos R, Emens LA, Loi S, et al. IMpassion130: efficacy in immune biomarker subgroups of atezolizumab plus nab-paclitaxel in patients with triple-negative BC. Swiss Medical Weekly, 2019, 149: 13S-14S.
34. Adams S, Diamond JR, Hamilton E, et al. Atezolizumab plus nab-Paclitaxel in the treatment of metastatic triple-negative breast cancer with 2-year survival follow-up: a phase 1b clinical trial. JAMA Oncol, 2019, 5(3): 334-342.
35. Page DB, Kim IK, Sanchez K, et al. Safety and efficacy of pembrolizumab (pembro) plus capecitabine (cape) in metastatic triple negative breast cancer (mTNBC). http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=16&SID=7EYfiA2D11IBlUT8WYO&page=1&doc=2.
36. Cortés J, André F, Gonçalves A, et al. IMpassion132 phase Ⅲ trial: atezolizumab and chemotherapy in early relapsing metastatic triple-negative breast cancer. Future Oncol, 2019, 15(17): 1951-1961.
37. Miles D, Kim SB, McNally V, et al. COLET: A multistage, phase 2 study evaluating the safety and efficacy of a doublet regimen of cobimetinib (C) in combination with paclitaxel (P) or triplet regimens of C in combination with atezolizumab (atezo) plus either P or nab-paclitaxel (nab-P) in metastatic triple-negative breast cancer (TNBC). http://apps.webofknowledge.com/Search.do?product=UA&SID=7EYfiA2D11IBlUT8WYO&search_mode=GeneralSearch&prID=450b237f-10de-46f3-8b8a-07bdc5fe36f1.
38. Golden EB, Pellicciotta I, Demaria S, et al. The convergence of radiation and immunogenic cell death signaling pathways. Front Oncol, 2012, 2: 88.
39. Deng L, Liang H, Xu M, et al. STING-dependent cytosolic DNA sensing promotes radiation-induced type i interferon-dependent antitumor immunity in immunogenic tumors. Immunity, 2014, 41(5): 843-852.
40. Germano G, Lamba S, Rospo G, et al. Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth. Nature, 2017, 552(7683): 116-120.
41. Matsumura S, Wang B, Kawashima N, et al. Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol, 2008, 181(5): 3099-3107.
42. Sato H, Niimi A, Yasuhara T, et al. DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells. Nat Commun, 2017, 8(1): 1751.
43. Reits EA, Hodge JW, Herberts CA, et al. Radiation modulates the peptide repertoire, enhances MHC class Ⅰ expression, and induces successful antitumor immunotherapy. J Exp Med, 2006, 203(5): 1259-1271.
44. Deng L, Liang H, Burnette B, et al. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J Clin Invest, 2014, 124(2): 687-695.
45. Loibl S, Untch M, Burchardi N, et al. Randomized phase Ⅱ neoadjuvant study (GeparNuevo) to investigate the addition of durvalumab to a taxane-anthracycline containing chemotherapy in triple negative breast cancer (TNBC). J Clin Oncol, 2018, 36(15_suppl): 104.
46. Loibl S, Untch M, Burchardi N, et al. A randomised phase Ⅱ study investigating durvalumab in addition to an anthracycline taxane-based neoadjuvant therapy in early triple negative breast cancer - clinical results and biomarker analysis of GeparNuevo study. Ann Oncol, 2019, [Epub ahead of print].
47. van’t Veer LJ, Wolf D, Yau C, et al. MammaPrint High1/High2 risk class as a pre-specified biomarker of response to nine different targeted agents plus standard neoadjuvant therapy for similar to 1 000 breast cancer patients in the I-SPY 2 TRIAL. Europ J Cancer, 2018, 103: E15.

Previous Article
乳腺癌的区域外科治疗
Next Article
Clinical study of imaging and rapid pathology in diagnosis and treatment of pancreatic cystic neoplasm

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

乳腺癌的免疫治疗进展

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content