Observation on the effect of <i>pseudomonas aeruginosa</i> preparation in treating refractory seroma after breast cancer surgery_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

FENG Xiaojuan ¹ , ZHONG Shanqiong ¹ , ZENG Yuanyuan ¹ , LÜ Qing ¹ ,  LI Ka ²

1. Department of Breast Surgery, West China Hospital of Sichuan University, Chengdu 610041, P. R. China;
2. West China Nursing School of Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

LI Ka, Email: likalika127127@163.com

Keywords：

refractory seroma; pseudomonas aeruginosa preparation; breast cancer

DOI：

10.7507/1007-9424.201909126

Video：

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Objective To observe the effectiveness and safety of pseudomonas aeruginosa preparation in treating refractory seroma after breast cancer surgery.Methods A total of 76 patients with refractory seroma after breast cancer surgery who underwent surgery from October 2018 to August 2019 in our hospital were selected. The subjects were randomly divided into two groups. The patients in the control group (n=36) adopted negative pressure drainage connected with indwelling needle in the lower position of the seroma chamber; on the basis, patients in the experimental group (n=400) were injected with pseudomonas aeruginosa preparation into the seroma chamber. The drainage time, total drainage volume, recurrence rate, and incidence of complications of the two groups were compared.Results There were 4 cases in the experimental group and 3 cases in the control group were lost followed-up, so only 69 cases enrolled in data analysis. The drainage time, total drainage volume, and the recurrence rate of the experimental group were all shorter or less than those of the control group (P<0.05). But there was no significant difference in the incidence of complications between the experimental group and the control group (P>0.05), such as fever, inflamed skin, and infection of incision.Conclusion Pseudomonas aeruginosa preparation is an effective treatment for refractory seroma after breast cancer surgery, which can shorten the drainage time and promote wound healing.

Citation： FENG Xiaojuan, ZHONG Shanqiong, ZENG Yuanyuan, LÜ Qing, LI Ka. Observation on the effect of pseudomonas aeruginosa preparation in treating refractory seroma after breast cancer surgery. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2020, 27(3): 304-308. doi: 10.7507/1007-9424.201909126 Copy

1.	Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
2.	曹欣华, 吕建鑫, 胡浩霖, 等. 不同手术方式对早期乳腺癌患者的术后恢复及并发症的影响. 东南大学学报: 医学版, 2018, 37(1): 45-49.
3.	吕淑贞, 李艳萍, 赵霞, 等. 静脉留置针持续负压引流治疗乳腺癌术后皮下积液. 癌症进展, 2018, 16(1): 120-122.
4.	van Bastelaar J, Theunissen LLB, Snoeijs MGJ, et al. Flap fixation using tissue glue or sutures appears to reduce seroma aspiration after mastectomy for breast cancer. Clin Breast Cancer, 2017, 17(4): 316-321.
5.	徐青. 乳腺癌术后皮下积液研究现状及进展. 国际外科学杂志, 2017, 44(3): 195-197.
6.	郭智慧, 罗道蕴, 周庆, 等. 常规处理方案联合铜绿假单胞菌制剂治疗乳腺癌疗效的 Meta 分析. 中国普通外科杂志, 2015, 24(5): 669-676.
7.	喻满成, 王伟, 范威, 等. 皮瓣点式缝合联合万特普安防治乳腺癌术后皮下积液疗效观察. 肿瘤防治研究, 2018, 45(3): 163-166.
8.	宋爱琳, 曹农. 铜绿假单胞菌注射液防治乳腺癌术后皮下积液的临床研究. 辽宁医学杂志, 2012, 26(2): 57-60.
9.	马富懿, 王礼泉, 王昌亮, 等. 铜绿假单胞菌注射液在乳腺癌切除术后皮下积液中的临床应用. 中华肿瘤防治杂志, 2009, 16(14): 1111-1112, 1119.
10.	Isozaki H, Yamamoto Y, Murakami S, et al. Impact of the surgical modality for axillary lymph node dissection on postoperative drainage and seroma formation after total mastectomy. Patient Saf Surg, 2019, 13(1): 20.
11.	Dalberg K, Johansson H, Signomklao T, et al. A randomised study of axillary drainage and pectoral fascia preservation after mastectomy for breast cancer. Eur J Surg Oncol, 2004, 30(6): 602-609.
12.	许言, 许贵勤, 胡少锋. 多点缝合术治疗乳腺癌术后顽固性皮下积液 17 例体会. 实用中西医结合临床, 2019, 19(1): 150-151.
13.	张祥运. 负压封闭引流技术在乳且癌术后重度皮下积液中的应用. 中华妇幼临床医学杂志: 电子版, 2018, 14(2): 147-150.
14.	van Bastelaar J, Granzier R, van Roozendaal LM, et al. Analysis of TNF-α and interleukin-6 in seroma of patients undergoing mastectomy with or without flap fixation: is there a predictive value for seroma formation and its sequelae? Surg Oncol, 2019, 28: 36-41.
15.	Srivastava V, Basu S, Shukla VK. Seroma formation after breast cancer surgery: what we have learned in the last two decades. J Breast Cancer, 2012, 15(4): 373-380.
16.	Woodworth PA, McBoyle MF, Helmer SD, et al. Seroma formation after breast cancer surgery: incidence and predicting factors. Am Surg, 2000, 66(5): 444-451.
17.	郝凯峰. 乳腺癌改良根治术后皮下积液产生的高危因素及预防措施. 实用癌症杂志, 2018, 33(4): 686-689.
18.	巫泓生, 廖碧玲, 曹天生, 等. 金葡素治疗乳腺癌改良根治术后皮下积液的效果. 临床医学, 2019, 39(4): 107-109.
19.	李磊, 阿迪力江•买买提明, 地力木拉提•艾斯木吐拉. 乳腺癌改良根治术后皮下积液与皮瓣坏死的原因及防治探讨. 中国普外基础与临床杂志, 2015, 26(6): 725-728.
20.	于永政, 胡晓川, 赵辉, 等. 滑石粉悬液治疗乳腺癌术后顽固性皮下积液的临床研究. 临床外科杂志, 2013, 21(6): 485.
21.	Yang Y, Gao E, Liu X, et al. Effectiveness of OK-432(Sapylin) to reduce seroma formation after axillary lymphadenectomy for breast cancer. Ann Surg Oncol, 2013, 20(5): 1500-1504.
22.	刘鹏熙, 刘晓雁, 欧阳慧英, 等. 生物蛋白胶对乳腺癌术后顽固性皮下积液的治疗作用. 中华普通外科杂志, 2004, 19(8): 510.
23.	吕晶. 网格划痕术用于乳腺癌根治术后顽固性皮下积液的处理. 医药论坛杂志, 2011, 32(6): 47-48.
24.	Liu Z, Hou Y, Dong M, et al. 0015 PA-MSHA inhibits proliferation and induces apoptosis through the up-regulation and activation of caspases in the human breast cancer cell lines. Breast, 2009, 108(1): 195-206.
25.	Liu ZB, Hou YF, Zhu J, et al. Inhibition of EGFR pathway signaling and the metastatic potential of breast cancer cells by PA-MSHA mediated by type 1 fimbriae via a mannose-dependent manner. Oncogene, 2010, 29(20): 2996-3009.
26.	Li T, Yang L, Fu SJ, et al. Subcutaneous injections of the mannose-sensitive hemagglutination pilus strain of pseudomonas aeruginosa stimulate host immunity, reduce bladder cancer size and improve tumor survival in mice. Cell Biochem Biophys, 2015, 73(1): 245-252.
27.	Chang J, Liu Y, Han B, et al. Pseudomonas aeruginosa preparation plus chemotherapy for advanced non-small-cell lung cancer: a randomized, multicenter, double-blind phase Ⅲ study. Med Oncol, 2015, 32(5): 139.
28.	Kong D, Liu Y, Li Z, et al. OK-432(Sapylin) reduces seroma formation after axillary lymphadenectomy in breast cancer. J Invest Surg, 2017, 30(1): 1-5.

1. Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
2. 曹欣华, 吕建鑫, 胡浩霖, 等. 不同手术方式对早期乳腺癌患者的术后恢复及并发症的影响. 东南大学学报: 医学版, 2018, 37(1): 45-49.
3. 吕淑贞, 李艳萍, 赵霞, 等. 静脉留置针持续负压引流治疗乳腺癌术后皮下积液. 癌症进展, 2018, 16(1): 120-122.
4. van Bastelaar J, Theunissen LLB, Snoeijs MGJ, et al. Flap fixation using tissue glue or sutures appears to reduce seroma aspiration after mastectomy for breast cancer. Clin Breast Cancer, 2017, 17(4): 316-321.
5. 徐青. 乳腺癌术后皮下积液研究现状及进展. 国际外科学杂志, 2017, 44(3): 195-197.
6. 郭智慧, 罗道蕴, 周庆, 等. 常规处理方案联合铜绿假单胞菌制剂治疗乳腺癌疗效的 Meta 分析. 中国普通外科杂志, 2015, 24(5): 669-676.
7. 喻满成, 王伟, 范威, 等. 皮瓣点式缝合联合万特普安防治乳腺癌术后皮下积液疗效观察. 肿瘤防治研究, 2018, 45(3): 163-166.
8. 宋爱琳, 曹农. 铜绿假单胞菌注射液防治乳腺癌术后皮下积液的临床研究. 辽宁医学杂志, 2012, 26(2): 57-60.
9. 马富懿, 王礼泉, 王昌亮, 等. 铜绿假单胞菌注射液在乳腺癌切除术后皮下积液中的临床应用. 中华肿瘤防治杂志, 2009, 16(14): 1111-1112, 1119.
10. Isozaki H, Yamamoto Y, Murakami S, et al. Impact of the surgical modality for axillary lymph node dissection on postoperative drainage and seroma formation after total mastectomy. Patient Saf Surg, 2019, 13(1): 20.
11. Dalberg K, Johansson H, Signomklao T, et al. A randomised study of axillary drainage and pectoral fascia preservation after mastectomy for breast cancer. Eur J Surg Oncol, 2004, 30(6): 602-609.
12. 许言, 许贵勤, 胡少锋. 多点缝合术治疗乳腺癌术后顽固性皮下积液 17 例体会. 实用中西医结合临床, 2019, 19(1): 150-151.
13. 张祥运. 负压封闭引流技术在乳且癌术后重度皮下积液中的应用. 中华妇幼临床医学杂志: 电子版, 2018, 14(2): 147-150.
14. van Bastelaar J, Granzier R, van Roozendaal LM, et al. Analysis of TNF-α and interleukin-6 in seroma of patients undergoing mastectomy with or without flap fixation: is there a predictive value for seroma formation and its sequelae? Surg Oncol, 2019, 28: 36-41.
15. Srivastava V, Basu S, Shukla VK. Seroma formation after breast cancer surgery: what we have learned in the last two decades. J Breast Cancer, 2012, 15(4): 373-380.
16. Woodworth PA, McBoyle MF, Helmer SD, et al. Seroma formation after breast cancer surgery: incidence and predicting factors. Am Surg, 2000, 66(5): 444-451.
17. 郝凯峰. 乳腺癌改良根治术后皮下积液产生的高危因素及预防措施. 实用癌症杂志, 2018, 33(4): 686-689.
18. 巫泓生, 廖碧玲, 曹天生, 等. 金葡素治疗乳腺癌改良根治术后皮下积液的效果. 临床医学, 2019, 39(4): 107-109.
19. 李磊, 阿迪力江•买买提明, 地力木拉提•艾斯木吐拉. 乳腺癌改良根治术后皮下积液与皮瓣坏死的原因及防治探讨. 中国普外基础与临床杂志, 2015, 26(6): 725-728.
20. 于永政, 胡晓川, 赵辉, 等. 滑石粉悬液治疗乳腺癌术后顽固性皮下积液的临床研究. 临床外科杂志, 2013, 21(6): 485.
21. Yang Y, Gao E, Liu X, et al. Effectiveness of OK-432(Sapylin) to reduce seroma formation after axillary lymphadenectomy for breast cancer. Ann Surg Oncol, 2013, 20(5): 1500-1504.
22. 刘鹏熙, 刘晓雁, 欧阳慧英, 等. 生物蛋白胶对乳腺癌术后顽固性皮下积液的治疗作用. 中华普通外科杂志, 2004, 19(8): 510.
23. 吕晶. 网格划痕术用于乳腺癌根治术后顽固性皮下积液的处理. 医药论坛杂志, 2011, 32(6): 47-48.
24. Liu Z, Hou Y, Dong M, et al. 0015 PA-MSHA inhibits proliferation and induces apoptosis through the up-regulation and activation of caspases in the human breast cancer cell lines. Breast, 2009, 108(1): 195-206.
25. Liu ZB, Hou YF, Zhu J, et al. Inhibition of EGFR pathway signaling and the metastatic potential of breast cancer cells by PA-MSHA mediated by type 1 fimbriae via a mannose-dependent manner. Oncogene, 2010, 29(20): 2996-3009.
26. Li T, Yang L, Fu SJ, et al. Subcutaneous injections of the mannose-sensitive hemagglutination pilus strain of pseudomonas aeruginosa stimulate host immunity, reduce bladder cancer size and improve tumor survival in mice. Cell Biochem Biophys, 2015, 73(1): 245-252.
27. Chang J, Liu Y, Han B, et al. Pseudomonas aeruginosa preparation plus chemotherapy for advanced non-small-cell lung cancer: a randomized, multicenter, double-blind phase Ⅲ study. Med Oncol, 2015, 32(5): 139.
28. Kong D, Liu Y, Li Z, et al. OK-432(Sapylin) reduces seroma formation after axillary lymphadenectomy in breast cancer. J Invest Surg, 2017, 30(1): 1-5.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Observation on the effect of pseudomonas aeruginosa preparation in treating refractory seroma after breast cancer surgery

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