Research progress of circRNAs in thyroid papillary carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

DU Gongbo ^1,2 ,  YIN Detao ^1,2

1. Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P. R. China;
2. Key Discipline Laboratory of Clinical Medicine for Colleges and Universities in Henan, Zhengzhou 450052, P. R. China;

Corresponding author：

YIN Detao, Email: detaoyin@zzu.edu.cn

Keywords：

circRNA; papillary thyroid carcinoma; biomarker; therapy target; review

DOI：

10.7507/1007-9424.201911087

Video：

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Objective To summarize the role of circular RNA (circRNAs) in thyroid papillary carcinoma (PTC) and the emphasis of future research.Method Relevant literatures in recent years about the biological function of circRNA and its role in PTC were reviewed.Results circRNAs had abnormal expression in PTC tissues. Besides, by working as miRNA sponges or interacting with RNA-binding proteins, circRNAs regulated the expression of proteins that were associated with cell proliferation, apoptosis, invasion, and metastasis, which could affect the biological characteristics of tumor cells.Conclusion circRNAs are expected to be the biomarkers for early diagnosis of PTC or potential targets for PTC therapy and provid therapeutic bases to prevent PTC.

Citation： DU Gongbo, YIN Detao. Research progress of circRNAs in thyroid papillary carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2020, 27(7): 890-894. doi: 10.7507/1007-9424.201911087 Copy

1.	Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin, 2017, 67(1): 7-30.
2.	Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid, 2016, 26(1): 1-133.
3.	Vriens MR, Weng J, Suh I, et al. MicroRNA expression profiling is a potential diagnostic tool for thyroid cancer. Cancer, 2012, 118(13): 3426-3432.
4.	Ling H, Fabbri M, Calin GA. MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat Rev Drug Discov, 2013, 12(11): 847-865.
5.	Chen Y, Li C, Tan C, et al. Circular RNAs: a new frontier in the study of human diseases. J Med Genet, 2016, 53(6): 359-365.
6.	Hsu MT, Coca-Prados M. Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells. Nature, 1979, 280(5720): 339-340.
7.	Wang X, Fang L. Advances in circular RNAs and their roles in breast cancer. J Exp Clin Cancer Res, 2018, 37(1): 206.
8.	Jeck WR, Sorrentino JA, Wang K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA, 2013, 19(2): 141-157.
9.	Chen LL, Yang L. Regulation of circRNA biogenesis. RNA Biol, 2015, 12(4): 381-388.
10.	Li Z, Chen Z, Hu G, et al. Roles of circular RNA in breast cancer: present and future. Am J Transl Res, 2019, 11(7): 3945-3954.
11.	Ren H, Liu Z, Liu S, et al. Profile and clinical implication of circular RNAs in human papillary thyroid carcinoma. PeerJ, 2018, 6: e5363.
12.	Hentze MW, Preiss T. Circular RNAs: splicing’s enigma variations. EMBO J, 2013, 32(7): 923-925.
13.	Li Z, Huang C, Bao C, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol, 2015, 22(3): 256-264.
14.	Pamudurti NR, Bartok O, Jens M, et al. Translation of circRNAs. Mol Cell, 2017, 66(1): 9-21.e7.
15.	Bolha L, Ravnik-Glavač M, Glavač D. Circular RNAs: biogenesis, function, and a role as possible cancer biomarkers. Int J Genomics, 2017, 2017: 6218353.
16.	Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell, 2009, 136(2): 215-233.
17.	Tay FC, Lim JK, Zhu H, et al. Using artificial microRNA sponges to achieve microRNA loss-of-function in cancer cells. Adv Drug Deliv Rev, 2015, 81: 117-127.
18.	You X, Vlatkovic I, Babic A, et al. Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. Nat Neurosci, 2015, 18(4): 603-610.
19.	Conn SJ, Pillman KA, Toubia J, et al. The RNA binding protein quaking regulates formation of circRNAs. Cell, 2015, 160(6): 1125-1134.
20.	Ashwal-Fluss R, Meyer M, Pamudurti NR, et al. circRNA biogenesis competes with pre-mRNA splicing. Mol Cell, 2014, 56(1): 55-66.
21.	Zhang Y, Zhang XO, Chen T, et al. Circular intronic long noncoding RNAs. Mol Cell, 2013, 51(6): 792-806.
22.	Perriman R, Ares M Jr. Circular mRNA can direct translation of extremely long repeating-sequence proteins in vivo. RNA, 1998, 4(9): 1047-1054.
23.	Yao Y, Chen X, Yang H, et al. Hsa_circ_0058124 promotes papillary thyroid cancer tumorigenesis and invasiveness through the NOTCH3/GATAD2A axis. J Exp Clin Cancer Res, 2019, 38(1): 318.
24.	Pan Y, Xu T, Liu Y, et al. Upregulated circular RNA circ_0025033 promotes papillary thyroid cancer cell proliferation and invasion via sponging miR-1231 and miR-1304. Biochem Biophys Res Commun, 2019, 510(2): 334-338.
25.	Cai X, Zhao Z, Dong J, et al. Circular RNA circBACH2 plays a role in papillary thyroid carcinoma by sponging miR-139-5p and regulating LMO4 expression. Cell Death Dis, 2019, 10(3): 184.
26.	Liu W, Zhao J, Jin M, et al. circRAPGEF5 contributes to papillary thyroid proliferation and metastatis by regulation miR-198/FGFR1. Mol Ther Nucleic Acids, 2019, 14: 609-616.
27.	Wei H, Pan L, Tao D, et al. Circular RNA circZFR contributes to papillary thyroid cancer cell proliferation and invasion by sponging miR-1261 and facilitating C8orf4 expression. Biochem Biophys Res Commun, 2018, 503(1): 56-61.
28.	Wang M, Chen B, Ru Z, et al. CircRNA circ-ITCH suppresses papillary thyroid cancer progression through miR-22-3p/CBL/β-catenin pathway. Biochem Biophys Res Commun, 2018, 504(1): 283-288.
29.	Flores AN, McDermott N, Meunier A, et al. NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer. Nat Rev Urol, 2014, 11(9): 499-507.
30.	Shen K, Liang Q, Xu K, et al. MiR-139 inhibits invasion and metastasis of colorectal cancer by targeting the type Ⅰ insulin-like growth factor receptor. Biochem Pharmacol, 2012, 84(3): 320-330.
31.	Wong CC, Wong CM, Tung EK, et al. The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2. Gastroenterology, 2011, 140(1): 322-331.
32.	Bi W, Huang J, Nie C, et al. CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of β-catenin pathway. J Exp Clin Cancer Res, 2018, 37(1): 275.
33.	Lan X, Xu J, Chen C, et al. The landscape of circular RNA expression profiles in papillary thyroid carcinoma based on RNA sequencing. Cell Physiol Biochem, 2018, 47(3): 1122-1132.
34.	Yang C, Wei Y, Yu L, et al. Identification of altered circular RNA expression in serum exosomes from patients with papillary thyroid carcinoma by high-throughput sequencing. Med Sci Monit, 2019, 25: 2785-2791.
35.	Peng N, Shi L, Zhang Q, et al. Microarray profiling of circular RNAs in human papillary thyroid carcinoma. PLoS One, 2017, 12(3): e0170287.

1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin, 2017, 67(1): 7-30.
2. Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid, 2016, 26(1): 1-133.
3. Vriens MR, Weng J, Suh I, et al. MicroRNA expression profiling is a potential diagnostic tool for thyroid cancer. Cancer, 2012, 118(13): 3426-3432.
4. Ling H, Fabbri M, Calin GA. MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat Rev Drug Discov, 2013, 12(11): 847-865.
5. Chen Y, Li C, Tan C, et al. Circular RNAs: a new frontier in the study of human diseases. J Med Genet, 2016, 53(6): 359-365.
6. Hsu MT, Coca-Prados M. Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells. Nature, 1979, 280(5720): 339-340.
7. Wang X, Fang L. Advances in circular RNAs and their roles in breast cancer. J Exp Clin Cancer Res, 2018, 37(1): 206.
8. Jeck WR, Sorrentino JA, Wang K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA, 2013, 19(2): 141-157.
9. Chen LL, Yang L. Regulation of circRNA biogenesis. RNA Biol, 2015, 12(4): 381-388.
10. Li Z, Chen Z, Hu G, et al. Roles of circular RNA in breast cancer: present and future. Am J Transl Res, 2019, 11(7): 3945-3954.
11. Ren H, Liu Z, Liu S, et al. Profile and clinical implication of circular RNAs in human papillary thyroid carcinoma. PeerJ, 2018, 6: e5363.
12. Hentze MW, Preiss T. Circular RNAs: splicing’s enigma variations. EMBO J, 2013, 32(7): 923-925.
13. Li Z, Huang C, Bao C, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol, 2015, 22(3): 256-264.
14. Pamudurti NR, Bartok O, Jens M, et al. Translation of circRNAs. Mol Cell, 2017, 66(1): 9-21.e7.
15. Bolha L, Ravnik-Glavač M, Glavač D. Circular RNAs: biogenesis, function, and a role as possible cancer biomarkers. Int J Genomics, 2017, 2017: 6218353.
16. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell, 2009, 136(2): 215-233.
17. Tay FC, Lim JK, Zhu H, et al. Using artificial microRNA sponges to achieve microRNA loss-of-function in cancer cells. Adv Drug Deliv Rev, 2015, 81: 117-127.
18. You X, Vlatkovic I, Babic A, et al. Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. Nat Neurosci, 2015, 18(4): 603-610.
19. Conn SJ, Pillman KA, Toubia J, et al. The RNA binding protein quaking regulates formation of circRNAs. Cell, 2015, 160(6): 1125-1134.
20. Ashwal-Fluss R, Meyer M, Pamudurti NR, et al. circRNA biogenesis competes with pre-mRNA splicing. Mol Cell, 2014, 56(1): 55-66.
21. Zhang Y, Zhang XO, Chen T, et al. Circular intronic long noncoding RNAs. Mol Cell, 2013, 51(6): 792-806.
22. Perriman R, Ares M Jr. Circular mRNA can direct translation of extremely long repeating-sequence proteins in vivo. RNA, 1998, 4(9): 1047-1054.
23. Yao Y, Chen X, Yang H, et al. Hsa_circ_0058124 promotes papillary thyroid cancer tumorigenesis and invasiveness through the NOTCH3/GATAD2A axis. J Exp Clin Cancer Res, 2019, 38(1): 318.
24. Pan Y, Xu T, Liu Y, et al. Upregulated circular RNA circ_0025033 promotes papillary thyroid cancer cell proliferation and invasion via sponging miR-1231 and miR-1304. Biochem Biophys Res Commun, 2019, 510(2): 334-338.
25. Cai X, Zhao Z, Dong J, et al. Circular RNA circBACH2 plays a role in papillary thyroid carcinoma by sponging miR-139-5p and regulating LMO4 expression. Cell Death Dis, 2019, 10(3): 184.
26. Liu W, Zhao J, Jin M, et al. circRAPGEF5 contributes to papillary thyroid proliferation and metastatis by regulation miR-198/FGFR1. Mol Ther Nucleic Acids, 2019, 14: 609-616.
27. Wei H, Pan L, Tao D, et al. Circular RNA circZFR contributes to papillary thyroid cancer cell proliferation and invasion by sponging miR-1261 and facilitating C8orf4 expression. Biochem Biophys Res Commun, 2018, 503(1): 56-61.
28. Wang M, Chen B, Ru Z, et al. CircRNA circ-ITCH suppresses papillary thyroid cancer progression through miR-22-3p/CBL/β-catenin pathway. Biochem Biophys Res Commun, 2018, 504(1): 283-288.
29. Flores AN, McDermott N, Meunier A, et al. NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer. Nat Rev Urol, 2014, 11(9): 499-507.
30. Shen K, Liang Q, Xu K, et al. MiR-139 inhibits invasion and metastasis of colorectal cancer by targeting the type Ⅰ insulin-like growth factor receptor. Biochem Pharmacol, 2012, 84(3): 320-330.
31. Wong CC, Wong CM, Tung EK, et al. The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2. Gastroenterology, 2011, 140(1): 322-331.
32. Bi W, Huang J, Nie C, et al. CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of β-catenin pathway. J Exp Clin Cancer Res, 2018, 37(1): 275.
33. Lan X, Xu J, Chen C, et al. The landscape of circular RNA expression profiles in papillary thyroid carcinoma based on RNA sequencing. Cell Physiol Biochem, 2018, 47(3): 1122-1132.
34. Yang C, Wei Y, Yu L, et al. Identification of altered circular RNA expression in serum exosomes from patients with papillary thyroid carcinoma by high-throughput sequencing. Med Sci Monit, 2019, 25: 2785-2791.
35. Peng N, Shi L, Zhang Q, et al. Microarray profiling of circular RNAs in human papillary thyroid carcinoma. PLoS One, 2017, 12(3): e0170287.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research progress of circRNAs in thyroid papillary carcinoma

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