DU Gongbo 1,2 , YIN Detao 1,2
  • 1. Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P. R. China;
  • 2. Key Discipline Laboratory of Clinical Medicine for Colleges and Universities in Henan, Zhengzhou 450052, P. R. China;
YIN Detao, Email: detaoyin@zzu.edu.cn
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Objective To summarize the role of circular RNA (circRNAs) in thyroid papillary carcinoma (PTC) and the emphasis of future research.Method Relevant literatures in recent years about the biological function of circRNA and its role in PTC were reviewed.Results circRNAs had abnormal expression in PTC tissues. Besides, by working as miRNA sponges or interacting with RNA-binding proteins, circRNAs regulated the expression of proteins that were associated with cell proliferation, apoptosis, invasion, and metastasis, which could affect the biological characteristics of tumor cells.Conclusion circRNAs are expected to be the biomarkers for early diagnosis of PTC or potential targets for PTC therapy and provid therapeutic bases to prevent PTC.

Citation: DU Gongbo, YIN Detao. Research progress of circRNAs in thyroid papillary carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2020, 27(7): 890-894. doi: 10.7507/1007-9424.201911087 Copy