Part <b>Ⅴ</b> of database building: design of tumor characteristics module of colorectal cancer <b>Ⅱ</b>_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Xiaodong ¹ , LIU Jianbo ^1,2 ,  LI Li ¹

1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. West China School of Medicine, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

LI Li, Email: drlili116@126.com

Keywords：

colorectal cancer; tumor characteristics; database; bigdata; tag; structure

DOI：

10.7507/1007-9424.202002045

Video：

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Objective To elaborate constitute, definition, and interpretation of tumor characteristics module of colorectal cancer in the Database from Colorectal Cancer (DACCA) in the West China Hospital.Method The article was described in the words.Results The tumor features module of colorectal cancer in the DACCA included the precancerous lesion, cancer family, location of tumor, distance to the dentate line, morphology of tumor, size, position, happening and origination, differentiation, pathology of tumor, Ki-67 protein, obstruction, intussusception, perforation, pain, edema, and hemorrhage. The exact definitions of morphology of tumor, size, position, differentiation, pathology of tumor, Ki-67 protein and complication (included obstruction, intussusception, perforation, pain, edema, and hemorrhage), tag and structure, corrective precautions and update of these columns, and how to use these tumor characteristics in the DACCA when analysis was carried out were described in detail.Conclusion Through detailed description and specification of current tumor characteristics module of colorectal cancer in DACCA in West China Hospital, it can provide a reference for standardized treatment of colorectal cancer and also provide experiences for the peers who wish to build a colorectal cancer database.

Citation： WANG Xiaodong, LIU Jianbo, LI Li. Part Ⅴ of database building: design of tumor characteristics module of colorectal cancer Ⅱ. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2020, 27(4): 483-488. doi: 10.7507/1007-9424.202002045 Copy

1.	刘健博, 吕炘沂, 邹雨恒, 等. 多周期新辅助化疗联合阿帕替尼对进展期直肠癌的疗效评价: 基于 DACCA 数据库的辅助研究. 中国普外基础与临床杂志, 2019, 26(6): 728-734.
2.	刘健博, 由屹先, 邹雨恒, 等. 数据库辅助研究: 结直肠癌新辅助治疗的应用—基于 DACCA 的华西真实世界数据报道. 中国普外基础与临床杂志, 2019, 26(12): 1467-1475.
3.	汪晓东, 安丽珉, 李立. 数据库研究第二部分: 结直肠癌的住院流程管理. 中国普外基础与临床杂志, 2019, 26(4): 469-475.
4.	汪晓东, 李立. 数据库建设第一部分: 个人数据的标签与结构化. 中国普外基础与临床杂志, 2019, 26(3): 335-342.
5.	汪晓东, 李立. 真实场景与大数据下的整体微创理念, 大幅提高结直肠癌远期生存率. 中国普外基础与临床杂志, 2019, 26(1): 92-95.
6.	汪晓东, 李希, 何欣林, 等. 数据库研究第一部分: 区域性医疗中心的结直肠癌与人群特征. 中国普外基础与临床杂志, 2019, 26(2): 212-220.
7.	汪晓东, 刘健博, 安丽珉, 等. 数据库建设第四部分: 结直肠癌的术前专科检查与评估的标签与结构化. 中国普外基础与临床杂志, 2019, 26(11): 1337-1341.
8.	汪晓东, 刘健博, 安丽珉, 等. 数据库研究第四部分: 结直肠癌的术前专科检查与评估. 中国普外基础与临床杂志, 2019, 26(10): 1230-1238.
9.	汪晓东, 刘健博, 李立. 数据库建设第三部分: 结直肠癌内外科合并症及术前体质状态的标签与结构化. 中国普外基础与临床杂志, 2019, 26(9): 1110-1115.
10.	汪晓东, 刘健博, 张诗, 等. 数据库研究第三部分: 结直肠癌的内外科合并症及术前体质状态. 中国普外基础与临床杂志, 2019, 26(8): 985-991.
11.	汪晓东, 吕炘沂, 黄明君, 等. 数据库建设第二部分: 结直肠癌住院流程管理的标签与结构化. 中国普外基础与临床杂志, 2019, 26(7): 852-855.
12.	于瑞璇, 何欣林, 张秋露, 等. 华西 DACCA 的辅助研究: 单独的新辅助化疗不会影响直肠癌术后近期的肛门功能. 中国普外基础与临床杂志, 2019, 26(5): 595-601.
13.	汪晓东, 刘健博, 李立. 数据库建设第五部分: 结直肠癌的肿瘤特征—模块的设计(一). 中国普外基础与临床杂志, 2020, 27(3): 345-349.
14.	Su MY, Ho YP, Hsu CM, et al. How can colorectal neoplasms be treated during colonoscopy? World J Gastroenterol, 2005, 11(18): 2806-2810.
15.	Wang YP, Guo PT, Zhu Z, et al. Macroscopic serosal classification of colorectal cancer and its clinical significance. Int J Clin Exp Med, 2015, 8(11): 20123-20134.
16.	Suenaga M, Fujimoto Y, Matsusaka S, et al. Perioperative FOLFOX4 plus bevacizumab for initially unresectable advanced colorectal cancer (NAVIGATE-CRC-01). Onco Targets Ther, 2015, 8: 1111-1118.
17.	Granero-Castro P, Muñoz E, Frasson M, et al. Evaluation of mesorectal fascia in mid and low anterior rectal cancer using endorectal ultrasound is feasible and reliable: a comparison with MRI findings. Dis Colon Rectum, 2014, 57(6): 709-714.
18.	Issa N, Fenig Y, Khatib M, et al. Transanal endoscopic microsurgery combined with laparoscopic colectomy for synchronous colorectal tumors: a word of caution. J Laparoendosc Adv Surg Tech A, 2017, 27(6): 605-610.
19.	Nemanqani DM, Aftab K, Al-Malki SH, et al. Expression of epidermal growth factor receptor in colorectal adenocarcinoma and its correlation with clinicopathological factors. J Coll Physicians Surg Pak, 2018, 28(7): 527-531.
20.	Wei XB, Gao XH, Wang H, et al. More advanced or aggressive colorectal cancer is associated with a higher incidence of “high-grade intraepithelial neoplasia” on biopsy-based pathological examination. Tech Coloproctol, 2012, 16(4): 277-283.
21.	Li LT, Jiang G, Chen Q, et al. Ki67 is a promising molecular target in the diagnosis of cancer (review). Mol Med Rep, 2015, 11(3): 1566-1572.
22.	Dudley JC, Lin MT, Le DT, et al. Microsatellite instability as a biomarker for PD-1 blockade. Clin Cancer Res, 2016, 22(4): 813-820.
23.	Li X, Yao X, Wang Y, et al. MLH1 promoter methylation frequency in colorectal cancer patients and related clinicopathological and molecular features. PLoS One, 2013, 8(3): e59064.
24.	Goodenberger ML, Thomas BC, Riegert-Johnson D, et al. PMS2 monoallelic mutation carriers: the known unknown. Genet Med, 2016, 18(1): 13-19.

1. 刘健博, 吕炘沂, 邹雨恒, 等. 多周期新辅助化疗联合阿帕替尼对进展期直肠癌的疗效评价: 基于 DACCA 数据库的辅助研究. 中国普外基础与临床杂志, 2019, 26(6): 728-734.
2. 刘健博, 由屹先, 邹雨恒, 等. 数据库辅助研究: 结直肠癌新辅助治疗的应用—基于 DACCA 的华西真实世界数据报道. 中国普外基础与临床杂志, 2019, 26(12): 1467-1475.
3. 汪晓东, 安丽珉, 李立. 数据库研究第二部分: 结直肠癌的住院流程管理. 中国普外基础与临床杂志, 2019, 26(4): 469-475.
4. 汪晓东, 李立. 数据库建设第一部分: 个人数据的标签与结构化. 中国普外基础与临床杂志, 2019, 26(3): 335-342.
5. 汪晓东, 李立. 真实场景与大数据下的整体微创理念, 大幅提高结直肠癌远期生存率. 中国普外基础与临床杂志, 2019, 26(1): 92-95.
6. 汪晓东, 李希, 何欣林, 等. 数据库研究第一部分: 区域性医疗中心的结直肠癌与人群特征. 中国普外基础与临床杂志, 2019, 26(2): 212-220.
7. 汪晓东, 刘健博, 安丽珉, 等. 数据库建设第四部分: 结直肠癌的术前专科检查与评估的标签与结构化. 中国普外基础与临床杂志, 2019, 26(11): 1337-1341.
8. 汪晓东, 刘健博, 安丽珉, 等. 数据库研究第四部分: 结直肠癌的术前专科检查与评估. 中国普外基础与临床杂志, 2019, 26(10): 1230-1238.
9. 汪晓东, 刘健博, 李立. 数据库建设第三部分: 结直肠癌内外科合并症及术前体质状态的标签与结构化. 中国普外基础与临床杂志, 2019, 26(9): 1110-1115.
10. 汪晓东, 刘健博, 张诗, 等. 数据库研究第三部分: 结直肠癌的内外科合并症及术前体质状态. 中国普外基础与临床杂志, 2019, 26(8): 985-991.
11. 汪晓东, 吕炘沂, 黄明君, 等. 数据库建设第二部分: 结直肠癌住院流程管理的标签与结构化. 中国普外基础与临床杂志, 2019, 26(7): 852-855.
12. 于瑞璇, 何欣林, 张秋露, 等. 华西 DACCA 的辅助研究: 单独的新辅助化疗不会影响直肠癌术后近期的肛门功能. 中国普外基础与临床杂志, 2019, 26(5): 595-601.
13. 汪晓东, 刘健博, 李立. 数据库建设第五部分: 结直肠癌的肿瘤特征—模块的设计(一). 中国普外基础与临床杂志, 2020, 27(3): 345-349.
14. Su MY, Ho YP, Hsu CM, et al. How can colorectal neoplasms be treated during colonoscopy? World J Gastroenterol, 2005, 11(18): 2806-2810.
15. Wang YP, Guo PT, Zhu Z, et al. Macroscopic serosal classification of colorectal cancer and its clinical significance. Int J Clin Exp Med, 2015, 8(11): 20123-20134.
16. Suenaga M, Fujimoto Y, Matsusaka S, et al. Perioperative FOLFOX4 plus bevacizumab for initially unresectable advanced colorectal cancer (NAVIGATE-CRC-01). Onco Targets Ther, 2015, 8: 1111-1118.
17. Granero-Castro P, Muñoz E, Frasson M, et al. Evaluation of mesorectal fascia in mid and low anterior rectal cancer using endorectal ultrasound is feasible and reliable: a comparison with MRI findings. Dis Colon Rectum, 2014, 57(6): 709-714.
18. Issa N, Fenig Y, Khatib M, et al. Transanal endoscopic microsurgery combined with laparoscopic colectomy for synchronous colorectal tumors: a word of caution. J Laparoendosc Adv Surg Tech A, 2017, 27(6): 605-610.
19. Nemanqani DM, Aftab K, Al-Malki SH, et al. Expression of epidermal growth factor receptor in colorectal adenocarcinoma and its correlation with clinicopathological factors. J Coll Physicians Surg Pak, 2018, 28(7): 527-531.
20. Wei XB, Gao XH, Wang H, et al. More advanced or aggressive colorectal cancer is associated with a higher incidence of “high-grade intraepithelial neoplasia” on biopsy-based pathological examination. Tech Coloproctol, 2012, 16(4): 277-283.
21. Li LT, Jiang G, Chen Q, et al. Ki67 is a promising molecular target in the diagnosis of cancer (review). Mol Med Rep, 2015, 11(3): 1566-1572.
22. Dudley JC, Lin MT, Le DT, et al. Microsatellite instability as a biomarker for PD-1 blockade. Clin Cancer Res, 2016, 22(4): 813-820.
23. Li X, Yao X, Wang Y, et al. MLH1 promoter methylation frequency in colorectal cancer patients and related clinicopathological and molecular features. PLoS One, 2013, 8(3): e59064.
24. Goodenberger ML, Thomas BC, Riegert-Johnson D, et al. PMS2 monoallelic mutation carriers: the known unknown. Genet Med, 2016, 18(1): 13-19.

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Part Ⅴ of database building: design of tumor characteristics module of colorectal cancer Ⅱ

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