Study on application value of carbon nanoparticles during operation of differentiated thyroid cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Dasheng , ZHOU Yuteng , HUANG Xueyang ,  LIN Hongguo , CAI Bingqin

Department of Vascular and Thyroid Surgery, Guangdong Provincial Hospital of Chinese Medicine（The Second Affiliated Hospital of Guangzhou University of Chinese Medicine）, Guangzhou 510120, P. R. China;

Corresponding author：

LIN Hongguo, Email: linhongguodoctor@163.com

Keywords：

carbon nanoparticles; differentiated thyroid cancer; parathyroid; lymph node

DOI：

10.7507/1007-9424.202007020

Video：

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Objective To explore the application value of carbon nanoparticles during radical operation of differentiated thyroid cancer (DTC).Methods The DTC patients underwent total thyroidectomy plus neck lymph node (area Ⅳ) dissection from September 2017 to September 2019 in this hospital were retrospectively collected, who were divided into observation group and control group according to using carbon nanoparticles or not during the operation. The operation related informations [operation time, intraoperative blood loss, total drainage volume on day 3 after operation, postoperative hospitalization time, number of lymph nodes dissection (area Ⅳ), lymph node metastasis rate, and rate of parathyroid glands resected by mistake during operation] and blood calcium (Ca²⁺) level and parathyroid hormone (PTH) level before and after (24 h and 1 month) operation were compared between the two groups.Results A total of 134 patients with DTC were collected, including 76 patients in the observation group and 58 patients in the control group. There were no significant differences in baseline data such as gender, age, etc. between the two groups (P>0.05). Although there were no significant differences in terms of operation time, intraoperative blood loss, total drainage volume on day 3 after operation, postoperative hospitalization time, lymph node metastasis rate between the two groups (P>0.05), the numbers of lymph node dissection and metastasis (area Ⅳ) were more and rate of parathyroid glands resected by mistake during operation was lower in the observation group as compared with the control group (P<0.05). On hour 24 after operation, the levels of Ca²⁺ and PTH in the observation group were higher than those in the control group (P<0.05). On month 1 after operation, the PTH level in the observation group was still higher than that in the control group (P<0.05), but there was no significant difference in Ca²⁺ level between the two groups (P>0.05). Conclusion Carbon nanoparticles can better protect the function of parathyroid gland during radical operation of DTC and clean neck lymph nodes more thoroughly.

Citation： LIU Dasheng, ZHOU Yuteng, HUANG Xueyang, LIN Hongguo, CAI Bingqin. Study on application value of carbon nanoparticles during operation of differentiated thyroid cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(4): 457-460. doi: 10.7507/1007-9424.202007020 Copy

1.	Liao N, Zhuo Y, Chai YQ, et al. Reagentless electrochemiluminescent detection of protein biomarker using graphene-based magnetic nanoprobes and poly-L-lysine as co-reactant. Biosens Bioelectron, 2013, 45: 189-194.
2.	韩婧, 康骅. 甲状腺癌的发病现状及影响因素. 实用预防医学, 2018, 25(7): 894-897.
3.	Makita K, Hamamoto Y, Tsuruoka S, et al. Treatment intensity and control rates in combining external-beam radiotherapy and radioactive iodine therapy for metastatic or recurrent differentiated thyroid cancer. Int J Clin Oncol, 2020, 2(1): 1-7.
4.	姚京, 刘洋, 田文. 分化型甲状腺癌再次手术技巧的探讨. 中国普外基础与临床杂志, 2013, 20(9): 981-986.
5.	Liu J, Xu C, Wang R, et al. Do carbon nanoparticles really improve thyroid cancer surgery? A retrospective analysis of real-world data. World J Surg Oncol, 2020, 18(1): 84.
6.	Yang Z, Flores J, Katz S, et al. Comparison of survival outcomes following postsurgical radioactive iodine versus external beam radiation in stage Ⅳ differentiated thyroid carcinoma. Thyroid, 2017, 27(7): 944-952.
7.	Aschebrook-Kilfoy B, Ward MH, Sabra MM, et al. Thyroid cancer incidence patterns in the United States by histologic type, 1992–2006. Thyroid, 2011, 21(2): 125-134.
8.	孙辉, 刘晓莉. 甲状腺癌规范化诊治理念更新及其意义. 中华实用外科杂志, 2015, 35(1): 72-76.
9.	Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer. Thyroid, 2016, 26(1): 1-133.
10.	Yu W, Xu G, Sun J, et al. Carbon nanoparticles guide contralateral central neck dissection in patients with papillary thyroid cancer. Oncol Lett, 2018, 16(1): 447-452.
11.	Wang L, Yang D, Lv JY, et al. Application of carbon nanoparticles in lymph node dissection and parathyroid protection during thyroid cancer surgeries: a systematic review and meta-analysis. Onco Targets Ther, 2017, 10: 1247-1260.
12.	Liu FZ, Zhu Y, Qian YC, et al. Recognition of sentinel lymph nodes in patients with papillary thyroid cancer by nano-carbon and methylene blue. Pak J Med Sci, 2017, 33(6): 1485-1489.
13.	左倩, 王刚, 武林枫. 甲状腺手术中甲状旁腺辨识方法进展. 中国普外基础与临床杂志, 2020, 27(3): 358-362.
14.	Wang B, Su AP, Xing TF, et al. The function of carbon nanoparticles to improve lymph node dissection and identification of parathyroid glands during thyroid reoperation for carcinoma. Medicine (Baltimore), 2018, 97(32): e11778.
15.	张海艳, 陈娟. 纳米炭跟踪技术在甲状腺切除术中对癌旁组织的保护作用分析. 中华普外科手术学杂志(电子版), 2019, 13(6): 634-636.
16.	王桂林, 俸瑞发. 纳米炭在甲状腺癌手术中对甲状旁腺及喉返神经的保护作用. 中国肿瘤外科杂志, 2019, 11(6): 442-449.
17.	谢天皓, 哈思宁, 张景, 等. 甲状腺乳头状癌中应用纳米炭对甲状旁腺识别及原位保留的价值. 中华普通外科杂志, 2020, 35(3): 246-247.
18.	Chaojie Z, Shanshan L, Zhigong Z, et al. Evaluation of the clinical value of carbon nanoparticles as lymph node tracer in differentiated thyroid carcinoma requiring reoperation. Int J Clin Oncol, 2016, 21(1): 68-74.
19.	Delgado-Oliver E, Vidal-Sicart S, Martínez D, et al. Applicability of sentinel lymph node biopsy in papillary thyroid cancer. Q J Nucl Med Mol Imaging, 2018 Jul 9. doi: 0.23736/S1824-4785.18.03097-2.
20.	江国斌, 方红燕, 蔡建明. 纳米碳混悬液示踪前哨淋巴结在甲状腺乳头状癌中的应用. 中国癌症杂志, 2010, 20(12): 938-940.
21.	Xue S, Ren P, Wang P, et al. Short and long-term potential role of carbon nanoparticles in total thyroidectomy with central lymph node dissection. Sci Rep, 2018, 8(1): 11936.
22.	Yan S, Zhao W, Wang B, et al. Preoperative injection of carbon nanoparticles is beneficial to the patients with thyroid papillary carcinoma: From a prospective study of 102 cases. Medicine (Baltimore), 2018, 97(27): e11364.
23.	付浩, 张朝林, 唐振宁, 等. 纳米碳在甲状腺乳头状癌Ⅵ区淋巴结清扫术中应用的研究. 临床耳鼻咽喉头颈外科杂志, 2017, 31(14): 1089-1092.
24.	Haddad RI, Lydiatt WM, Ball DW, et al. Anaplastic thyroid carcinoma, version 2.2015. J Natl Compr Canc Netw, 2015, 13(9): 1140-1150.
25.	倪帮高, 费媛, 王彬, 等. 甲状腺手术中甲状旁腺误切的危险因素分析. 中国普外基础与临床杂志, 2020, 27(2): 152-157.

1. Liao N, Zhuo Y, Chai YQ, et al. Reagentless electrochemiluminescent detection of protein biomarker using graphene-based magnetic nanoprobes and poly-L-lysine as co-reactant. Biosens Bioelectron, 2013, 45: 189-194.
2. 韩婧, 康骅. 甲状腺癌的发病现状及影响因素. 实用预防医学, 2018, 25(7): 894-897.
3. Makita K, Hamamoto Y, Tsuruoka S, et al. Treatment intensity and control rates in combining external-beam radiotherapy and radioactive iodine therapy for metastatic or recurrent differentiated thyroid cancer. Int J Clin Oncol, 2020, 2(1): 1-7.
4. 姚京, 刘洋, 田文. 分化型甲状腺癌再次手术技巧的探讨. 中国普外基础与临床杂志, 2013, 20(9): 981-986.
5. Liu J, Xu C, Wang R, et al. Do carbon nanoparticles really improve thyroid cancer surgery? A retrospective analysis of real-world data. World J Surg Oncol, 2020, 18(1): 84.
6. Yang Z, Flores J, Katz S, et al. Comparison of survival outcomes following postsurgical radioactive iodine versus external beam radiation in stage Ⅳ differentiated thyroid carcinoma. Thyroid, 2017, 27(7): 944-952.
7. Aschebrook-Kilfoy B, Ward MH, Sabra MM, et al. Thyroid cancer incidence patterns in the United States by histologic type, 1992–2006. Thyroid, 2011, 21(2): 125-134.
8. 孙辉, 刘晓莉. 甲状腺癌规范化诊治理念更新及其意义. 中华实用外科杂志, 2015, 35(1): 72-76.
9. Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer. Thyroid, 2016, 26(1): 1-133.
10. Yu W, Xu G, Sun J, et al. Carbon nanoparticles guide contralateral central neck dissection in patients with papillary thyroid cancer. Oncol Lett, 2018, 16(1): 447-452.
11. Wang L, Yang D, Lv JY, et al. Application of carbon nanoparticles in lymph node dissection and parathyroid protection during thyroid cancer surgeries: a systematic review and meta-analysis. Onco Targets Ther, 2017, 10: 1247-1260.
12. Liu FZ, Zhu Y, Qian YC, et al. Recognition of sentinel lymph nodes in patients with papillary thyroid cancer by nano-carbon and methylene blue. Pak J Med Sci, 2017, 33(6): 1485-1489.
13. 左倩, 王刚, 武林枫. 甲状腺手术中甲状旁腺辨识方法进展. 中国普外基础与临床杂志, 2020, 27(3): 358-362.
14. Wang B, Su AP, Xing TF, et al. The function of carbon nanoparticles to improve lymph node dissection and identification of parathyroid glands during thyroid reoperation for carcinoma. Medicine (Baltimore), 2018, 97(32): e11778.
15. 张海艳, 陈娟. 纳米炭跟踪技术在甲状腺切除术中对癌旁组织的保护作用分析. 中华普外科手术学杂志(电子版), 2019, 13(6): 634-636.
16. 王桂林, 俸瑞发. 纳米炭在甲状腺癌手术中对甲状旁腺及喉返神经的保护作用. 中国肿瘤外科杂志, 2019, 11(6): 442-449.
17. 谢天皓, 哈思宁, 张景, 等. 甲状腺乳头状癌中应用纳米炭对甲状旁腺识别及原位保留的价值. 中华普通外科杂志, 2020, 35(3): 246-247.
18. Chaojie Z, Shanshan L, Zhigong Z, et al. Evaluation of the clinical value of carbon nanoparticles as lymph node tracer in differentiated thyroid carcinoma requiring reoperation. Int J Clin Oncol, 2016, 21(1): 68-74.
19. Delgado-Oliver E, Vidal-Sicart S, Martínez D, et al. Applicability of sentinel lymph node biopsy in papillary thyroid cancer. Q J Nucl Med Mol Imaging, 2018 Jul 9. doi: 0.23736/S1824-4785.18.03097-2.
20. 江国斌, 方红燕, 蔡建明. 纳米碳混悬液示踪前哨淋巴结在甲状腺乳头状癌中的应用. 中国癌症杂志, 2010, 20(12): 938-940.
21. Xue S, Ren P, Wang P, et al. Short and long-term potential role of carbon nanoparticles in total thyroidectomy with central lymph node dissection. Sci Rep, 2018, 8(1): 11936.
22. Yan S, Zhao W, Wang B, et al. Preoperative injection of carbon nanoparticles is beneficial to the patients with thyroid papillary carcinoma: From a prospective study of 102 cases. Medicine (Baltimore), 2018, 97(27): e11364.
23. 付浩, 张朝林, 唐振宁, 等. 纳米碳在甲状腺乳头状癌Ⅵ区淋巴结清扫术中应用的研究. 临床耳鼻咽喉头颈外科杂志, 2017, 31(14): 1089-1092.
24. Haddad RI, Lydiatt WM, Ball DW, et al. Anaplastic thyroid carcinoma, version 2.2015. J Natl Compr Canc Netw, 2015, 13(9): 1140-1150.
25. 倪帮高, 费媛, 王彬, 等. 甲状腺手术中甲状旁腺误切的危险因素分析. 中国普外基础与临床杂志, 2020, 27(2): 152-157.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Study on application value of carbon nanoparticles during operation of differentiated thyroid cancer

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