Review on the application of omega-3 polyunsaturated fatty acids in patients with gastric cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Xingxia ,  LI Ka

West China School of Nursing, Sichuan University/West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

LI Ka, Email: lika127@126.com

Keywords：

gastric cancer; omega-3 polyunsaturated fatty acids; review

DOI：

10.7507/1007-9424.202008056

Video：

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Objective To review the application of omega-3 polyunsaturated fatty acids (Ω-3PUFAs) in patients with gastric cancer.Method The related literatures about the application of Ω-3PUFAs in patients with gastric cancer were reviewed by searching domestic and international databases.Results Ω-3PUFAs didn’t only improve the perioperative immune function and inflammatory response in patients with gastric cancer, but also prevent the occurrence of gastric cancer, inhibit the proliferation and promote the apoptosis of gastric cancer cells, increase the sensitivity of chemotherapy, and reduce the occurrence of chemotherapy-related adverse events.Conclusions Ω-3PUFAsis an immunological nutrition, which can provide energy and also has functions of anti-inflammatory, anti-cancer, immunity regulation. It has been widely used in patients with gastric cancer, but the relevant mechanism needs further to be investigated.

Citation： ZHANG Xingxia, LI Ka. Review on the application of omega-3 polyunsaturated fatty acids in patients with gastric cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(5): 678-682. doi: 10.7507/1007-9424.202008056 Copy

1.	Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
2.	Feng RM, Zong YN, Cao SM, et al. Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics? Cancer Commun (Lond), 2019, 39(1): 22.
3.	卫生健康委员会. 胃癌诊疗规范(2018 年版). 中华消化病与影像杂志(电子版), 2019, 9(3): 118-144.
4.	Bang HO, Dyerberg J, Nielsen AB. Plasma lipid and lipoprotein pattern in Greenlandic West-coast Eskimos. Lancet, 1971, 1(7710): 1143-1145.
5.	Dyerberg J, Bang HO. Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet, 1979, 2(8140): 433-435.
6.	Shahidi F, Ambigaipalan P. Omega-3 polyunsaturated fatty acids and their health benefits. Annu Rev Food Sci Technol, 2018, 9: 345-381.
7.	Department of Health and Human Services US. Dietary Guidelines for Americans 2015–2020. Eight Edition [Internet]. Available from: http://health.gov/ietaryguidelines/2015/guidelines/.
8.	中国营养学会. 中国居民膳食指南(2016). 北京: 人民卫生出版社, 2016.
9.	Klek S. Omega-3 fatty acids in modern parenteral nutrition: A review of the current evidence. J Clin Med, 2016, 5(3): 34.
10.	Mocellin MC, Fernandes R, Chagas TR, et al. A meta-analysis of n-3 polyunsaturated fatty acids effects on circulating acute-phase protein and cytokines in gastric cancer. Clin Nutr, 2018, 37(3): 840-850.
11.	Zhao Y, Wang C. Effect of ω-3 polyunsaturated fatty acid-supplemented parenteral nutrition on inflammatory and immune function in postoperative patients with gastrointestinal malignancy: A meta-analysis of randomized control trials in China. Medicine (Baltimore), 2018, 97(16): e0472.
12.	何纪恩, 李晓花. ω-3 多不饱和脂肪酸(ω-3 PUFA)对存在营养风险的胃癌患者术后炎性反应的影响. 实用癌症杂志, 2017, 32(3): 405-407.
13.	Wu DY, Lewis ED, Pae M, et al. Nutritional modulation of immune function: analysis of evidence, mechanisms, and clinical relevance. Front Immunol, 2019, 9: 3160.
14.	Calder PC. Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochem Soc Trans, 2017, 45(5): 1105-1115.
15.	高俊, 王静东, 王琦三. 含 ω-3 多不饱和脂肪酸的肠外营养对胃癌病人免疫功能影响的 Meta 分析. 肠外与肠内营养, 2015, 22(2): 107-111.
16.	Lin MT, Yeh SL, Yeh CL, et al. Parenteral N-3 fatty acids modulate inflammatory and immune response in rats undergoing total gastrectomy. Shock, 2006, 25(1): 56-60.
17.	Gurzell EA, Teague H, Harris M, et al. DHA-enriched fish oil targets B cell lipid microdomains and enhances ex vivo and in vivo B cell function. J Leukoc Biol, 2013, 93(4): 463-470.
18.	Weimann A, Braga M, Carli F, et al. ESPEN guideline: Clinical nutrition in surgery. Clin Nutr, 2017, 36(3): 623-650.
19.	Ida S, Hiki N, Cho H, et al. Randomized clinical trial comparing standard diet with perioperative oral immunonutrition in total gastrectomy for gastric cancer. Br J Surg, 2017, 104(4): 377-383.
20.	潘敦, 陈辉, 李良庆. 添加 ω-3 鱼油脂肪乳的围术期肠外营养支持对老年胃癌患者营养状况、免疫功能及术后并发症的影响. 中国老年学杂志, 2016, 36(19): 4792-4794.
21.	程康文, 王贵和, 束宽山, 等. 添加 ω-3 鱼油脂肪乳的肠外营养对胃癌术后患者营养、应激及肝功能的影响. 中国普外基础与临床杂志, 2020, 27(8): 964-969.
22.	Wei Z, Wang W, Chen J, et al. A prospective, randomized, controlled study of ω-3 fish oil fat emulsion-based parenteral nutrition for patients following surgical resection of gastric tumors. Nutr J, 2014, 13: 25.
23.	Ma CJ, Wu JM, Tsai HL, et al. Prospective double-blind randomized study on the efficacy and safety of an n-3 fatty acid enriched intravenous fat emulsion in postsurgical gastric and colorectal cancer patients. Nutr J, 2015, 14: 9.
24.	Wang J, Yu JC, Kang WM, et al. Superiority of a fish oil-enriched emulsion to medium-chain triacylglycerols/long-chain triacylglycerols in gastrointestinal surgery patients: a randomized clinical trial. Nutrition, 2012, 28(6): 623-629.
25.	Park HW, Lee NM, Kim JH, et al. Parenteral fish oil-containing lipid emulsions may reverse parenteral nutrition-associated cholestasis in neonates: a systematic review and meta-analysis. J Nutr, 2015, 145(2): 277-283.
26.	秦龙, 李婷, 任明扬, 等. 围手术期应用 ω-3 多不饱和脂肪酸对胃癌根治术患者术后恢复及生活质量的影响. 现代生物医学进展, 2019, 19(2): 346-349.
27.	梁涛, 伍晓汀. ω-3 多不饱和脂肪酸对老年胃癌患者术后谵妄的预防作用. 中国普外基础与临床杂志, 2019, 26(2): 174-179.
28.	Lee S, Lee J, Choi IJ, et al. Dietary n-3 and n-6 polyunsaturated fatty acids, the FADS gene, and the risk of gastric cancer in a Korean population. Sci Rep, 2018, 8(1): 3823.
29.	Kuriki K, Wakai K, Matsuo K, et al. Gastric cancer risk and erythrocyte composition of docosahexaenoic acid with anti-inflammatory effects. Cancer Epidemiol Biomarkers Prev, 2007, 16(11): 2406-2415.
30.	Caro Y, Petit T, Grondin I, et al. Chemical characterization of unconventional palm oils from Hyophorbe indica and two other endemic Arecaceae species from Reunion Island. Nat Prod Res, 2020, 34(1): 93-101.
31.	Sugano K. Effect of Helicobacter pylori eradication on the incidence of gastric cancer: a systematic review and meta-analysis. Gastric Cancer, 2019, 22(3): 435-445.
32.	Correia M, Michel V, Matos AA, et al. Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization. PLoS One, 2012, 7(4): e35072.
33.	Han YM, Kim KJ, Jeong M, et al. Suppressed Helicobacter pylori-associated gastric tumorigenesis in Fat-1 transgenic mice producing endogenous ω-3 polyunsaturated fatty acids. Oncotarget, 2016, 7(41): 66606-66622.
34.	马家驰, 郭天康, 陈泉, 等. 多不饱和脂肪酸 ω-3 和 ω-6 影响胃癌新生血管的机制. 中华胃肠外科杂志, 2017, 20(1): 84-89.
35.	史浩, 郭天康. 多不饱和脂肪酸 ω-3 和 ω-6 对胃癌细胞侵袭影响的研究. 银川: 宁夏医科大学, 2013.
36.	巩涛, 李勇, 郭建文, 等. ω-3 多不饱和脂肪酸对人胃癌 BGC823 细胞周期及凋亡的影响. 中国临床营养杂志, 2006, 14(2): 77-81, 141.
37.	盛虹, 吴丹. ω-3 多不饱和脂肪酸对胃癌细胞生长的影响及其机制研究. 上海: 上海交通大学, 2012.
38.	蒋亦燕, 蒋亦雯, 楼哲丰, 等. ω-3 多不饱和脂肪酸对胃癌生长及 RHO -ROCK1 信号通路相关基因表达的影响. 中国医师杂志, 2018, 20(11): 1641-1646.
39.	王宝贵, 张晖, 丁学伟, 等. ω-3 多不饱和脂肪酸对胃癌细胞系生长抑制作用及其机制的研究. 中华肿瘤防治杂志, 2011, 18(5): 336-338.
40.	Hosseinzadeh A, Ardebili SM. Efficacy of omega fatty acid supplementation on mRNA expression level of tumor necrosis factor alpha in patients with gastric adenocarcinoma. J Gastrointest Cancer, 2016, 47(3): 287-293.
41.	Shekari N, Javadian M, Ghasemi M, et al. Synergistic beneficial effect of docosahexaenoic acid (DHA) and docetaxel on the expression level of matrix metalloproteinase-2 (MMP-2) and microRNA-106b in gastric cancer. J Gastrointest Cancer, 2020, 51(1): 70-75.
42.	柳欣欣, 于健春. ω-3 多不饱和脂肪酸对胃癌治疗作用机制研究. 北京: 中国协和医科大学, 2010.
43.	Eltweri AM, Thomas AL, Chung WY, et al. The effect of supplementary omegaven® on the clinical outcome of patients with advanced esophagogastric adenocarcinoma receiving palliative epirubicin, oxaliplatin, and capecitabine chemotherapy: A phase Ⅱ clinical trial. Anticancer Res, 2019, 39(2): 853-861.

1. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
2. Feng RM, Zong YN, Cao SM, et al. Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics? Cancer Commun (Lond), 2019, 39(1): 22.
3. 卫生健康委员会. 胃癌诊疗规范(2018 年版). 中华消化病与影像杂志(电子版), 2019, 9(3): 118-144.
4. Bang HO, Dyerberg J, Nielsen AB. Plasma lipid and lipoprotein pattern in Greenlandic West-coast Eskimos. Lancet, 1971, 1(7710): 1143-1145.
5. Dyerberg J, Bang HO. Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet, 1979, 2(8140): 433-435.
6. Shahidi F, Ambigaipalan P. Omega-3 polyunsaturated fatty acids and their health benefits. Annu Rev Food Sci Technol, 2018, 9: 345-381.
7. Department of Health and Human Services US. Dietary Guidelines for Americans 2015–2020. Eight Edition [Internet]. Available from: http://health.gov/ietaryguidelines/2015/guidelines/.
8. 中国营养学会. 中国居民膳食指南(2016). 北京: 人民卫生出版社, 2016.
9. Klek S. Omega-3 fatty acids in modern parenteral nutrition: A review of the current evidence. J Clin Med, 2016, 5(3): 34.
10. Mocellin MC, Fernandes R, Chagas TR, et al. A meta-analysis of n-3 polyunsaturated fatty acids effects on circulating acute-phase protein and cytokines in gastric cancer. Clin Nutr, 2018, 37(3): 840-850.
11. Zhao Y, Wang C. Effect of ω-3 polyunsaturated fatty acid-supplemented parenteral nutrition on inflammatory and immune function in postoperative patients with gastrointestinal malignancy: A meta-analysis of randomized control trials in China. Medicine (Baltimore), 2018, 97(16): e0472.
12. 何纪恩, 李晓花. ω-3 多不饱和脂肪酸(ω-3 PUFA)对存在营养风险的胃癌患者术后炎性反应的影响. 实用癌症杂志, 2017, 32(3): 405-407.
13. Wu DY, Lewis ED, Pae M, et al. Nutritional modulation of immune function: analysis of evidence, mechanisms, and clinical relevance. Front Immunol, 2019, 9: 3160.
14. Calder PC. Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochem Soc Trans, 2017, 45(5): 1105-1115.
15. 高俊, 王静东, 王琦三. 含 ω-3 多不饱和脂肪酸的肠外营养对胃癌病人免疫功能影响的 Meta 分析. 肠外与肠内营养, 2015, 22(2): 107-111.
16. Lin MT, Yeh SL, Yeh CL, et al. Parenteral N-3 fatty acids modulate inflammatory and immune response in rats undergoing total gastrectomy. Shock, 2006, 25(1): 56-60.
17. Gurzell EA, Teague H, Harris M, et al. DHA-enriched fish oil targets B cell lipid microdomains and enhances ex vivo and in vivo B cell function. J Leukoc Biol, 2013, 93(4): 463-470.
18. Weimann A, Braga M, Carli F, et al. ESPEN guideline: Clinical nutrition in surgery. Clin Nutr, 2017, 36(3): 623-650.
19. Ida S, Hiki N, Cho H, et al. Randomized clinical trial comparing standard diet with perioperative oral immunonutrition in total gastrectomy for gastric cancer. Br J Surg, 2017, 104(4): 377-383.
20. 潘敦, 陈辉, 李良庆. 添加 ω-3 鱼油脂肪乳的围术期肠外营养支持对老年胃癌患者营养状况、免疫功能及术后并发症的影响. 中国老年学杂志, 2016, 36(19): 4792-4794.
21. 程康文, 王贵和, 束宽山, 等. 添加 ω-3 鱼油脂肪乳的肠外营养对胃癌术后患者营养、应激及肝功能的影响. 中国普外基础与临床杂志, 2020, 27(8): 964-969.
22. Wei Z, Wang W, Chen J, et al. A prospective, randomized, controlled study of ω-3 fish oil fat emulsion-based parenteral nutrition for patients following surgical resection of gastric tumors. Nutr J, 2014, 13: 25.
23. Ma CJ, Wu JM, Tsai HL, et al. Prospective double-blind randomized study on the efficacy and safety of an n-3 fatty acid enriched intravenous fat emulsion in postsurgical gastric and colorectal cancer patients. Nutr J, 2015, 14: 9.
24. Wang J, Yu JC, Kang WM, et al. Superiority of a fish oil-enriched emulsion to medium-chain triacylglycerols/long-chain triacylglycerols in gastrointestinal surgery patients: a randomized clinical trial. Nutrition, 2012, 28(6): 623-629.
25. Park HW, Lee NM, Kim JH, et al. Parenteral fish oil-containing lipid emulsions may reverse parenteral nutrition-associated cholestasis in neonates: a systematic review and meta-analysis. J Nutr, 2015, 145(2): 277-283.
26. 秦龙, 李婷, 任明扬, 等. 围手术期应用 ω-3 多不饱和脂肪酸对胃癌根治术患者术后恢复及生活质量的影响. 现代生物医学进展, 2019, 19(2): 346-349.
27. 梁涛, 伍晓汀. ω-3 多不饱和脂肪酸对老年胃癌患者术后谵妄的预防作用. 中国普外基础与临床杂志, 2019, 26(2): 174-179.
28. Lee S, Lee J, Choi IJ, et al. Dietary n-3 and n-6 polyunsaturated fatty acids, the FADS gene, and the risk of gastric cancer in a Korean population. Sci Rep, 2018, 8(1): 3823.
29. Kuriki K, Wakai K, Matsuo K, et al. Gastric cancer risk and erythrocyte composition of docosahexaenoic acid with anti-inflammatory effects. Cancer Epidemiol Biomarkers Prev, 2007, 16(11): 2406-2415.
30. Caro Y, Petit T, Grondin I, et al. Chemical characterization of unconventional palm oils from Hyophorbe indica and two other endemic Arecaceae species from Reunion Island. Nat Prod Res, 2020, 34(1): 93-101.
31. Sugano K. Effect of Helicobacter pylori eradication on the incidence of gastric cancer: a systematic review and meta-analysis. Gastric Cancer, 2019, 22(3): 435-445.
32. Correia M, Michel V, Matos AA, et al. Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization. PLoS One, 2012, 7(4): e35072.
33. Han YM, Kim KJ, Jeong M, et al. Suppressed Helicobacter pylori-associated gastric tumorigenesis in Fat-1 transgenic mice producing endogenous ω-3 polyunsaturated fatty acids. Oncotarget, 2016, 7(41): 66606-66622.
34. 马家驰, 郭天康, 陈泉, 等. 多不饱和脂肪酸 ω-3 和 ω-6 影响胃癌新生血管的机制. 中华胃肠外科杂志, 2017, 20(1): 84-89.
35. 史浩, 郭天康. 多不饱和脂肪酸 ω-3 和 ω-6 对胃癌细胞侵袭影响的研究. 银川: 宁夏医科大学, 2013.
36. 巩涛, 李勇, 郭建文, 等. ω-3 多不饱和脂肪酸对人胃癌 BGC823 细胞周期及凋亡的影响. 中国临床营养杂志, 2006, 14(2): 77-81, 141.
37. 盛虹, 吴丹. ω-3 多不饱和脂肪酸对胃癌细胞生长的影响及其机制研究. 上海: 上海交通大学, 2012.
38. 蒋亦燕, 蒋亦雯, 楼哲丰, 等. ω-3 多不饱和脂肪酸对胃癌生长及 RHO -ROCK1 信号通路相关基因表达的影响. 中国医师杂志, 2018, 20(11): 1641-1646.
39. 王宝贵, 张晖, 丁学伟, 等. ω-3 多不饱和脂肪酸对胃癌细胞系生长抑制作用及其机制的研究. 中华肿瘤防治杂志, 2011, 18(5): 336-338.
40. Hosseinzadeh A, Ardebili SM. Efficacy of omega fatty acid supplementation on mRNA expression level of tumor necrosis factor alpha in patients with gastric adenocarcinoma. J Gastrointest Cancer, 2016, 47(3): 287-293.
41. Shekari N, Javadian M, Ghasemi M, et al. Synergistic beneficial effect of docosahexaenoic acid (DHA) and docetaxel on the expression level of matrix metalloproteinase-2 (MMP-2) and microRNA-106b in gastric cancer. J Gastrointest Cancer, 2020, 51(1): 70-75.
42. 柳欣欣, 于健春. ω-3 多不饱和脂肪酸对胃癌治疗作用机制研究. 北京: 中国协和医科大学, 2010.
43. Eltweri AM, Thomas AL, Chung WY, et al. The effect of supplementary omegaven® on the clinical outcome of patients with advanced esophagogastric adenocarcinoma receiving palliative epirubicin, oxaliplatin, and capecitabine chemotherapy: A phase Ⅱ clinical trial. Anticancer Res, 2019, 39(2): 853-861.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Review on the application of omega-3 polyunsaturated fatty acids in patients with gastric cancer

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