Research progress of DNA methylation change after bariatric surgery_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WENG Xiaoyu ,  LIU Chang

The Third Department of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, P. R. China;

Corresponding author：

LIU Chang, Email: changliu72@163.com

Keywords：

DNA methylation; bariatric surgery; epigenetics

DOI：

10.7507/1007-9424.202010013

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the difference of DNA methylation before and after bariatric surgery.Method The relevant literatures of the research on the changes of DNA methylation level and gene expression regulation in blood and tissues before and after bariatric surgery were retrieved and reviewed.Results DNA methylation was an important method of epigenetic regulation in organisms and its role in bariatric surgery had been paid more and more attention in recent years. Existing studies had found that there were changes of DNA methylation in blood and tissues before and after bariatric surgery. The degree of methylation varies with different follow-up time after bariatric surgery and the same gene had different degrees of methylation in different tissues, and some even had the opposite results.Conclusions DNA methylation levels before and after bariatric surgery are different in different tissues. And studies with larger sample size and longer follow-up time are needed, to further reveal relationship among DNA methylation, obesity, and bariatric surgery.

Citation： WENG Xiaoyu, LIU Chang. Research progress of DNA methylation change after bariatric surgery. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(8): 1103-1107. doi: 10.7507/1007-9424.202010013 Copy

1.	Gadde KM, Martin CK, Berthoud HR, et al. Obesity: Pathophysiology and management. J Am Coll Cardiol, 2018, 71(1): 69-84.
2.	Upadhyay J, Farr O, Perakakis N, et al. Obesity as a disease. Med Clin North Am, 2018, 102(1): 13-33.
3.	Heymsfield SB, Wadden TA. Mechanisms, pathophysiology, and management of obesity. N Engl J Med, 2017, 376(3): 254-266.
4.	Jakobsen GS, Småstuen MC, Sandbu R, et al. Association of bariatric surgery vs medical obesity treatment with long-term medical complications and obesity-related comorbidities. JAMA, 2018, 319(3): 291-301.
5.	Nicoletti CF, Cortes-Oliveira C, Pinhel MAS, et al. Bariatric surgery and precision nutrition. Nutrients, 2017, 9(9): 974.
6.	Frikke-Schmidt H, O’Rourke RW, Lumeng CN, et al. Does bariatric surgery improve adipose tissue function? Obes Rev, 2016, 17(9): 795-809.
7.	Wahl S, Drong A, Lehne B, et al. Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature, 2017, 541(7635): 81-86.
8.	Portela A, Esteller M. Epigenetic modifications and human disease. Nat Biotechnol, 2010, 28(10): 1057-1068.
9.	Crujeiras AB, Morcillo S, Diaz-Lagares A, et al. Identification of an episignature of human colorectal cancer associated with obesity by genome-wide DNA methylation analysis. Int J Obes (Lond), 2019, 43(1): 176-188.
10.	Raciti GA, Longo M, Parrillo L, et al. Understanding type 2 diabetes: from genetics to epigenetics. Acta Diabetol, 2015, 52(5): 821-827.
11.	Lister R, Pelizzola M, Dowen RH, et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature, 2009, 462(7271): 315-322.
12.	Bird A. Perceptions of epigenetics. Nature, 2007, 447(7143): 396-398.
13.	Sala P, de Miranda Torrinhas RSM, Fonseca DC, et al. Tissue-specific methylation profile in obese patients with type 2 diabetes before and after Roux-en-Y gastric bypass. Diabetol Metab Syndr, 2017, 9: 15.
14.	Nguyen CT, Gonzales FA, Jones PA. Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylation. Nucleic Acids Res, 2001, 29(22): 4598-4606.
15.	Yan J, Zierath JR, Barrès R. Evidence for non-CpG methylation in mammals. Exp Cell Res, 2011, 317(18): 2555-2561.
16.	Buchwald H, Estok R, Fahrbach K, et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med, 2009, 122(3): 248-256.
17.	Dayeh TA, Olsson AH, Volkov P, et al. Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets. Diabetologia, 2013, 56(5): 1036-1046.
18.	Berglind D, Müller P, Willmer M, et al. Differential methylation in inflammation and type 2 diabetes genes in siblings born before and after maternal bariatric surgery. Obesity (Silver Spring), 2016, 24(1): 250-261.
19.	Nicoletti CF, Nonino CB, de Oliveira BA, et al. DNA methylation and hydroxymethylation levels in relation to two weight loss strategies: energy-restricted diet or bariatric surgery. Obes Surg, 2016, 26(3): 603-611.
20.	Martín-Núñez GM, Cabrera-Mulero A, Alcaide-Torres J, et al. No effect of different bariatric surgery procedures on LINE-1 DNA methylation in diabetic and nondiabetic morbidly obese patients. Surg Obes Relat Dis, 2017, 13(3): 442-450.
21.	van Dijk SJ, Molloy PL, Varinli H, et al. Epigenetics and human obesity. Int J Obes (Lond), 2015, 39(1): 85-97.
22.	Nilsson EK, Ernst B, Voisin S, et al. Roux-en Y gastric bypass surgery induces genome-wide promoter-specific changes in DNA methylation in whole blood of obese patients. PLoS One, 2015, 10(2): e0115186.
23.	Multhaup ML, Seldin MM, Jaffe AE, et al. Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes. Cell Metab, 2015, 21(1): 138-149.
24.	Benton MC, Johnstone A, Eccles D, et al. An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss. Genome Biol, 2015, 16: 8.
25.	Dahlman I, Sinha I, Gao H, et al. The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes. Int J Obes (Lond), 2015, 39(6): 910-919.
26.	Barres R, Kirchner H, Rasmussen M, et al. Weight loss after gastric bypass surgery in human obesity remodels promoter methylation. Cell Rep, 2013, 3(4): 1020-1027.
27.	Donkin I, Versteyhe S, Ingerslev LR, et al. Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans. Cell Metab, 2016, 23(2): 369-378.
28.	Su L, Patti ME. Paternal nongenetic intergenerational transmission of metabolic disease risk. Curr Diab Rep, 2019, 19(7): 38.
29.	Festa A, Williams K, Tracy RP, et al. Progression of plasminogen activator inhibitor-1 and fibrinogen levels in relation to incident type 2 diabetes. Circulation, 2006, 113(14): 1753-1759.
30.	Nicoletti CF, Pinhel MS, Noronha NY, et al. Association of MFSD3 promoter methylation level and weight regain after gastric bypass: Assessment for 3 y after surgery. Nutrition, 2020, 70: 110499.
31.	Morcillo S, Martin-Nunez GM, Garcia-Serrano S, et al. Changes in SCD gene DNA methylation after bariatric surgery in morbidly obese patients are associated with free fatty acids. Sci Rep, 2017, 7: 46292.
32.	Macías-González M, Martín-Núñez GM, Garrido-Sánchez L, et al. Decreased blood pressure is related to changes in NF-κB promoter methylation levels after bariatric surgery. Surg Obes Relat Dis, 2018, 14(9): 1327-1334.
33.	Boström AE, Mwinyi J, Voisin S, et al. Longitudinal genome-wide methylation study of Roux-en-Y gastric bypass patients reveals novel CpG sites associated with essential hypertension. BMC Med Genomics, 2016, 9: 20.
34.	Pinhel MAS, Noronha NY, Nicoletti CF, et al. Changes in DNA methylation and gene expression of insulin and obesity-related gene PIK3R1 after Roux-en-Y gastric bypass. Int J Mol Sci, 2020, 21(12): 4476.
35.	Kirchner H, Nylen C, Laber S, et al. Altered promoter methylation of PDK4, IL1B, IL6, and TNF after Roux-en Y gastric bypass. Surg Obes Relat Dis, 2014, 10(4): 671-678.
36.	Day SE, Garcia LA, Coletta RL, et al. Alterations of sorbin and SH3 domain containing 3 (SORBS3) in human skeletal muscle following Roux-en-Y gastric bypass surgery. Clin Epigenetics, 2017, 9: 96.
37.	Huang Y, Zhang H, Wang C, et al. DNA methylation suppresses liver Hamp expression in response to iron deficiency after bariatric surgery. Surg Obes Relat Dis, 2020, 16(1): 109-118.
38.	Patti ME. Reducing maternal weight improves offspring metabolism and alters (or modulates) methylation. Proc Natl Acad Sci U S A, 2013, 110(32): 12859-12860.
39.	Ilhan ZE, DiBaise JK, Isern NG, et al. Distinctive microbiomes and metabolites linked with weight loss after gastric bypass, but not gastric banding. ISME J, 2017, 11(9): 2047-2058.

1. Gadde KM, Martin CK, Berthoud HR, et al. Obesity: Pathophysiology and management. J Am Coll Cardiol, 2018, 71(1): 69-84.
2. Upadhyay J, Farr O, Perakakis N, et al. Obesity as a disease. Med Clin North Am, 2018, 102(1): 13-33.
3. Heymsfield SB, Wadden TA. Mechanisms, pathophysiology, and management of obesity. N Engl J Med, 2017, 376(3): 254-266.
4. Jakobsen GS, Småstuen MC, Sandbu R, et al. Association of bariatric surgery vs medical obesity treatment with long-term medical complications and obesity-related comorbidities. JAMA, 2018, 319(3): 291-301.
5. Nicoletti CF, Cortes-Oliveira C, Pinhel MAS, et al. Bariatric surgery and precision nutrition. Nutrients, 2017, 9(9): 974.
6. Frikke-Schmidt H, O’Rourke RW, Lumeng CN, et al. Does bariatric surgery improve adipose tissue function? Obes Rev, 2016, 17(9): 795-809.
7. Wahl S, Drong A, Lehne B, et al. Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature, 2017, 541(7635): 81-86.
8. Portela A, Esteller M. Epigenetic modifications and human disease. Nat Biotechnol, 2010, 28(10): 1057-1068.
9. Crujeiras AB, Morcillo S, Diaz-Lagares A, et al. Identification of an episignature of human colorectal cancer associated with obesity by genome-wide DNA methylation analysis. Int J Obes (Lond), 2019, 43(1): 176-188.
10. Raciti GA, Longo M, Parrillo L, et al. Understanding type 2 diabetes: from genetics to epigenetics. Acta Diabetol, 2015, 52(5): 821-827.
11. Lister R, Pelizzola M, Dowen RH, et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature, 2009, 462(7271): 315-322.
12. Bird A. Perceptions of epigenetics. Nature, 2007, 447(7143): 396-398.
13. Sala P, de Miranda Torrinhas RSM, Fonseca DC, et al. Tissue-specific methylation profile in obese patients with type 2 diabetes before and after Roux-en-Y gastric bypass. Diabetol Metab Syndr, 2017, 9: 15.
14. Nguyen CT, Gonzales FA, Jones PA. Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylation. Nucleic Acids Res, 2001, 29(22): 4598-4606.
15. Yan J, Zierath JR, Barrès R. Evidence for non-CpG methylation in mammals. Exp Cell Res, 2011, 317(18): 2555-2561.
16. Buchwald H, Estok R, Fahrbach K, et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med, 2009, 122(3): 248-256.
17. Dayeh TA, Olsson AH, Volkov P, et al. Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets. Diabetologia, 2013, 56(5): 1036-1046.
18. Berglind D, Müller P, Willmer M, et al. Differential methylation in inflammation and type 2 diabetes genes in siblings born before and after maternal bariatric surgery. Obesity (Silver Spring), 2016, 24(1): 250-261.
19. Nicoletti CF, Nonino CB, de Oliveira BA, et al. DNA methylation and hydroxymethylation levels in relation to two weight loss strategies: energy-restricted diet or bariatric surgery. Obes Surg, 2016, 26(3): 603-611.
20. Martín-Núñez GM, Cabrera-Mulero A, Alcaide-Torres J, et al. No effect of different bariatric surgery procedures on LINE-1 DNA methylation in diabetic and nondiabetic morbidly obese patients. Surg Obes Relat Dis, 2017, 13(3): 442-450.
21. van Dijk SJ, Molloy PL, Varinli H, et al. Epigenetics and human obesity. Int J Obes (Lond), 2015, 39(1): 85-97.
22. Nilsson EK, Ernst B, Voisin S, et al. Roux-en Y gastric bypass surgery induces genome-wide promoter-specific changes in DNA methylation in whole blood of obese patients. PLoS One, 2015, 10(2): e0115186.
23. Multhaup ML, Seldin MM, Jaffe AE, et al. Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes. Cell Metab, 2015, 21(1): 138-149.
24. Benton MC, Johnstone A, Eccles D, et al. An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss. Genome Biol, 2015, 16: 8.
25. Dahlman I, Sinha I, Gao H, et al. The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes. Int J Obes (Lond), 2015, 39(6): 910-919.
26. Barres R, Kirchner H, Rasmussen M, et al. Weight loss after gastric bypass surgery in human obesity remodels promoter methylation. Cell Rep, 2013, 3(4): 1020-1027.
27. Donkin I, Versteyhe S, Ingerslev LR, et al. Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans. Cell Metab, 2016, 23(2): 369-378.
28. Su L, Patti ME. Paternal nongenetic intergenerational transmission of metabolic disease risk. Curr Diab Rep, 2019, 19(7): 38.
29. Festa A, Williams K, Tracy RP, et al. Progression of plasminogen activator inhibitor-1 and fibrinogen levels in relation to incident type 2 diabetes. Circulation, 2006, 113(14): 1753-1759.
30. Nicoletti CF, Pinhel MS, Noronha NY, et al. Association of MFSD3 promoter methylation level and weight regain after gastric bypass: Assessment for 3 y after surgery. Nutrition, 2020, 70: 110499.
31. Morcillo S, Martin-Nunez GM, Garcia-Serrano S, et al. Changes in SCD gene DNA methylation after bariatric surgery in morbidly obese patients are associated with free fatty acids. Sci Rep, 2017, 7: 46292.
32. Macías-González M, Martín-Núñez GM, Garrido-Sánchez L, et al. Decreased blood pressure is related to changes in NF-κB promoter methylation levels after bariatric surgery. Surg Obes Relat Dis, 2018, 14(9): 1327-1334.
33. Boström AE, Mwinyi J, Voisin S, et al. Longitudinal genome-wide methylation study of Roux-en-Y gastric bypass patients reveals novel CpG sites associated with essential hypertension. BMC Med Genomics, 2016, 9: 20.
34. Pinhel MAS, Noronha NY, Nicoletti CF, et al. Changes in DNA methylation and gene expression of insulin and obesity-related gene PIK3R1 after Roux-en-Y gastric bypass. Int J Mol Sci, 2020, 21(12): 4476.
35. Kirchner H, Nylen C, Laber S, et al. Altered promoter methylation of PDK4, IL1B, IL6, and TNF after Roux-en Y gastric bypass. Surg Obes Relat Dis, 2014, 10(4): 671-678.
36. Day SE, Garcia LA, Coletta RL, et al. Alterations of sorbin and SH3 domain containing 3 (SORBS3) in human skeletal muscle following Roux-en-Y gastric bypass surgery. Clin Epigenetics, 2017, 9: 96.
37. Huang Y, Zhang H, Wang C, et al. DNA methylation suppresses liver Hamp expression in response to iron deficiency after bariatric surgery. Surg Obes Relat Dis, 2020, 16(1): 109-118.
38. Patti ME. Reducing maternal weight improves offspring metabolism and alters (or modulates) methylation. Proc Natl Acad Sci U S A, 2013, 110(32): 12859-12860.
39. Ilhan ZE, DiBaise JK, Isern NG, et al. Distinctive microbiomes and metabolites linked with weight loss after gastric bypass, but not gastric banding. ISME J, 2017, 11(9): 2047-2058.

Previous Article
Research progress of laparoscopic sleeve gastrectomy in treatment of obesity and its comorbidities
Next Article
Recent advances of related biomarkers in early diagnosis of gastric cancer

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research progress of DNA methylation change after bariatric surgery

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content