Research progress of circRNA in gastric cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LU Yixun ,  CHEN Lin

Department of General Surgery, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, P. R. China;

Corresponding author：

CHEN Lin, Email: chenlin@301hospital.com.cn

Keywords：

gastric cancer; circRNA; biomarker; therapeutic target

DOI：

10.7507/1007-9424.202103089

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the recent research progress of circRNA in gastric cancer, and to explore the clinical value of circRNA as new therapeutic target and diagnostic or prognostic biomarker for gastric cancer.Method The studies on circRNA and related literatures in gastric cancer were reviewed.Results As a new member of the non-coding RNA family, circRNA played a key role in regulating the proliferation, invasion, migration, apoptosis, and therapeutic resistance of gastric cancer cells. At the same time, based on the stability and tissue-specific characteristics, circRNA possessed great potential as biomarker for early diagnosis or prognosis evaluation of gastric cancer.Conclusions circRNA plays an important role in the initiation and progression of gastric cancer. As a diagnostic and prognostic biomarker and a new therapeutic target for gastric cancer, circRNA has great potential for clinical transformation.

Citation： LU Yixun, CHEN Lin. Research progress of circRNA in gastric cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(2): 255-263. doi: 10.7507/1007-9424.202103089 Copy

1.	Sanger HL, Klotz G, Riesner D, et al. Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci U S A, 1976, 73(11): 3852-3856.
2.	Cocquerelle C, Mascrez B, Hétuin D, et al. Mis-splicing yields circular RNA molecules. FASEB J, 1993, 7(1): 155-160.
3.	Tang X, Ren H, Guo M, et al. Review on circular RNAs and new insights into their roles in cancer. Comput Struct Biotechnol J, 2021, 19: 910-928.
4.	Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2021, 71(3): 209-249.
5.	Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
6.	Memczak S, Jens M, Elefsinioti A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature, 2013, 495(7441): 333-338.
7.	Schmidt CA, Giusto JD, Bao A, et al. Molecular determinants of metazoan tricRNA biogenesis. Nucleic Acids Res, 2019, 47(12): 6452-6465.
8.	Jeck WR, Sharpless NE. Detecting and characterizing circular RNAs. Nat Biotechnol, 2014, 32(5): 453-461.
9.	Jeck WR, Sorrentino JA, Wang K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA, 2013, 19(2): 141-157.
10.	Lu Z, Filonov GS, Noto JJ, et al. Metazoan tRNA introns generate stable circular RNAs in vivo. RNA, 2015, 21(9): 1554-1565.
11.	Zhang XO, Wang HB, Zhang Y, et al. Complementary sequence-mediated exon circularization. Cell, 2014, 159(1): 134-147.
12.	Suzuki H, Zuo Y, Wang J, et al. Characterization of RNaseR-digested cellular RNA source that consists of lariat and circular RNAs from pre-mRNA splicing. Nucleic Acids Res, 2006, 34(8): e63. doi: 10.1093/nar/gkl151.
13.	Salzman J, Chen RE, Olsen MN, et al. Cell-type specific features of circular RNA expression. PLoS Genet, 2013, 9(9): e1003777. doi: 10.1371/journal.pgen.1003777.
14.	Glažar P, Papavasileiou P, Rajewsky N. circBase: a database for circular RNAs. RNA, 2014, 20(11): 1666-1670.
15.	Wang X, Li H, Lu Y, et al. Circular RNAs in human cancer. Front Oncol, 2021, 10: 577118.
16.	Guo H, Ingolia NT, Weissman JS, et al. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature, 2010, 466(7308): 835-840.
17.	Chen LL. The biogenesis and emerging roles of circular RNAs. Nat Rev Mol Cell Biol, 2016, 17(4): 205-211.
18.	Hansen TB, Jensen TI, Clausen BH, et al. Natural RNA circles function as efficient microRNA sponges. Nature, 2013, 495(7441): 384-388.
19.	Hansen TB, Kjems J, Damgaard CK. Circular RNA and miR-7 in cancer. Cancer Res, 2013, 73(18): 5609-5612.
20.	Wen J, Liao J, Liang J, et al. Circular RNA HIPK3: A key circular RNA in a variety of human cancers. Front Oncol, 2020, 10: 773. doi: 10.3389/fonc.2020.00773.
21.	Ashwal-Fluss R, Meyer M, Pamudurti NR, et al. circRNA biogenesis competes with pre-mRNA splicing. Mol Cell, 2014, 56(1): 55-66.
22.	Abdelmohsen K, Panda AC, Munk R, et al. Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. RNA Biol, 2017, 14(3): 361-369.
23.	Du WW, Yang W, Chen Y, et al. Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses. Eur Heart J, 2017, 38(18): 1402-1412.
24.	Guo JU, Agarwal V, Guo H, et al. Expanded identification and characterization of mammalian circular RNAs. Genome Biol, 2014, 15(7): 409. doi: 10.1186/s13059-014-0409-z.
25.	Legnini I, Di Timoteo G, Rossi F, et al. Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis. Mol Cell, 2017, 66(1): 22-37.
26.	Pamudurti NR, Bartok O, Jens M, et al. Translation of circRNAs. Mol Cell, 2017, 66(1): 9-21.
27.	Chen CY, Sarnow P. Initiation of protein synthesis by the eukaryotic translational apparatus on circular RNAs. Science, 1995, 268(5209): 415-417.
28.	Lei M, Zheng G, Ning Q, et al. Translation and functional roles of circular RNAs in human cancer. Mol Cancer, 2020, 19(1): 30. doi: 10.1186/s12943-020-1135-7.
29.	Li Z, Huang C, Bao C, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol, 2015, 22(3): 256-264.
30.	Conn VM, Hugouvieux V, Nayak A, et al. A circRNA from SEPALLATA3 regulates splicing of its cognate mRNA throughR-loop formation. Nat Plants, 2017, 3: 17053. doi: 10.1038/nplants.2017.53.
31.	Dong R, Zhang XO, Zhang Y, et al. CircRNA-derived pseudogenes. Cell Res, 2016, 26(6): 747-750.
32.	Kalyana-Sundaram S, Kumar-Sinha C, Shankar S, et al. Expressed pseudogenes in the transcriptional landscape of human cancers. Cell, 2012, 149(7): 1622-1634.
33.	Du WW, Zhang C, Yang W, et al. Identifying and characterizing circRNA-protein interaction. Theranostics, 2017, 7(17): 4183-4191.
34.	Jie M, Wu Y, Gao M, et al. CircMRPS35 suppresses gastric cancer progression via recruiting KAT7 to govern histone modification. Mol Cancer, 2020, 19(1): 56. doi: 10.1186/s12943-020-01160-2.
35.	Mathieu M, Martin-Jaular L, Lavieu G, et al. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat Cell Biol, 2019, 21(1): 9-17.
36.	Enuka Y, Lauriola M, Feldman ME, et al. Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor. Nucleic Acids Res, 2016, 44(3): 1370-1383.
37.	Hansen TB, Wiklund ED, Bramsen JB, et al. miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA. EMBO J, 2011, 30(21): 4414-4422.
38.	Park OH, Ha H, Lee Y, et al. Endoribonucleolytic cleavage of m6A-containing RNAs by RNase P/MRP complex. Mol Cell, 2019, 74(3): 494-507.
39.	Shi X, Wang B, Feng X, et al. circRNAs and exosomes: A mysterious frontier for human cancer. Mol Ther Nucleic Acids, 2020, 19: 384-392.
40.	Allemani C, Weir HK, Carreira H, et al. Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887patients from 279 population-based registries in 67 countries (CONCORD-2). Lancet, 2015, 385(9972): 977-1010.
41.	Chen J, Li Y, Zheng Q, et al. Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Cancer Lett, 2017, 388: 208-219.
42.	Huang X, Li Z, Zhang Q, et al. Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression. Mol Cancer, 2019, 18(1): 71. doi: 10.1186/s12943-019-0969-3.
43.	Ouyang Y, Li Y, Huang Y, et al. CircRNA circPDSS1 promotes the gastric cancer progression by sponging miR-186-5p and modulating NEK2. J Cell Physiol, 2019, 234(7): 10458-10469.
44.	Ding L, Zhao Y, Dang S, et al. Circular RNA circ-DONSON facilitates gastric cancer growth and invasion via NURF complex dependent activation of transcription factor SOX4. Mol Cancer, 2019, 18(1): 45. doi: 10.1186/s12943-019-1006-2.
45.	Wang S, Tang D, Wang W, et al. circLMTK2 acts as a sponge of miR-150-5p and promotes proliferation and metastasis in gastric cancer. Mol Cancer, 2019, 18(1): 162. doi: 10.1186/s12943-019-1081-4.
46.	Zhang J, Hou L, Liang R, et al. CircDLST promotes the tumorigenesis and metastasis of gastric cancer by sponging miR-502-5p and activating the NRAS/MEK1/ERK1/2 signaling. Mol Cancer, 2019, 18(1): 80. doi: 10.1186/s12943-019-1015-1.
47.	Liu J, Song S, Lin S, et al. Circ-SERPINE2 promotes the development of gastric carcinoma by sponging miR-375 and modulating YWHAZ. Cell Prolif, 2019, 52(4): e12648. doi: 10.1111/cpr.12648.
48.	Yang D, Hu Z, Zhang Y, et al. CircHIPK3 promotes the tumorigenesis and development of gastric cancer through miR-637/AKT1 pathway. Front Oncol, 2021, 11: 637761. doi: 10.3389/fonc.2021.637761.
49.	Wang L, Li B, Yi X, et al. Circ_SMAD4 promotes gastric carcinogenesis by activating wnt/β-catenin pathway. Cell Prolif, 2021, 54(3): e12981. doi: 10.1111/cpr.12981.
50.	Cao J, Zhang X, Xu P, et al. Circular RNA circLMO7 acts as a microRNA-30a-3p sponge to promote gastric cancer progression via the WNT2/β-catenin pathway. J Exp Clin Cancer Res, 2021, 40(1): 6. doi: 10.1186/s13046-020-01791-9.
51.	Xie M, Yu T, Jing X, et al. Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation. Mol Cancer, 2020, 19(1): 112. doi: 10.1186/s12943-020-01208-3.
52.	Zhang Z, Wang C, Zhang Y, et al. CircDUSP16 promotes the tumorigenesis and invasion of gastric cancer by sponging miR-145-5p. Gastric Cancer, 2020, 23(3): 437-448.
53.	Wang S, Zhang X, Li Z, et al. Circular RNA profile identifies circOSBPL10 as an oncogenic factor and prognostic marker in gastric cancer. Oncogene, 2019, 38(44): 6985-7001.
54.	Cai J, Chen Z, Wang J, et al. circHECTD1 facilitates glutaminolysis to promote gastric cancer progression by targeting miR-1256 and activating β-catenin/c-Myc signaling. Cell Death Dis, 2019, 10(8): 576. doi: 10.1038/s41419-019-1814-8.
55.	Zhang H, Zhu L, Bai M, et al. Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR-133/PRDM16 pathway. Int J Cancer, 2019, 144(10): 2501-2515.
56.	Hong Y, Qin H, Li Y, et al. FNDC3B circular RNA promotes the migration and invasion of gastric cancer cells via the regulation of E-cadherin and CD44 expression. J Cell Physiol, 2019, 234(11): 19895-19910.
57.	Zhang L, Song X, Chen X, et al. Circular RNA circCACTIN promotes gastric cancer progression by sponging miR-331-3p and regulating TGFBR1 expression. Int J Biol Sci, 2019, 15(5): 1091-1103.
58.	Chen Y, Yang F, Fang E, et al. Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes. Cell Death Differ, 2019, 26(7): 1346-1364.
59.	Xue M, Li G, Fang X, et al. hsa_circ_0081143 promotes cisplatin resistance in gastric cancer by targeting miR-646/CDK6 pathway. Cancer Cell Int, 2019, 19: 25. doi: 10.1186/s12935-019-0737-x.
60.	Yang F, Hu A, Li D, et al. Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation. Mol Cancer, 2019, 18(1): 158. doi: 10.1186/s12943-019-1094-z.
61.	Sun G, Li Z, He Z, et al. Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer by miR-99a-5p-mediated induction of MTMR3 expression. J Exp Clin Cancer Res, 2020, 39(1): 246. doi: 10.1186/s13046-020-01758-w.
62.	Guo X, Dai X, Liu J, et al. Circular RNA circREPS2 acts as a sponge of miR-558 to suppress gastric cancer progression by regulating RUNX3/β-catenin signaling. Mol Ther Nucleic Acids, 2020, 21: 577-591.
63.	Luo Z, Rong Z, Zhang J, et al. Circular RNA circCCDC9 acts as a miR-6792-3p sponge to suppress the progression of gastric cancer through regulating CAV1 expression. Mol Cancer, 2020, 19(1): 86. doi: 10.1186/s12943-020-01203-8.
64.	Deng G, Mou T, He J, et al. Circular RNA circRHOBTB3 acts as a sponge for miR-654-3p inhibiting gastric cancer growth. J Exp Clin Cancer Res, 2020, 39(1): 1. doi: 10.1186/s13046-019-1487-2.
65.	Rong D, Lu C, Zhang B, et al. CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p. Mol Cancer, 2019, 18(1): 25. doi: 10.1186/s12943-019-0958-6.
66.	Peng L, Sang H, Wei S, et al. circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2. Mol Cancer, 2020, 19(1): 156. doi: 10.1186/s12943-020-01270-x.
67.	Fang J, Hong H, Xue X, et al. A novel circular RNA, circFAT1(e2), inhibits gastric cancer progression by targeting miR-548g in the cytoplasm and interacting with YBX1 in the nucleus. Cancer Lett, 2019, 442: 222-232.
68.	Liu H, Liu Y, Bian Z, et al. Circular RNA YAP1 inhibits the proliferation and invasion of gastric cancer cells by regulating the miR-367-5p/p27 Kip1 axis. Mol Cancer, 2018, 17(1): 151. doi: 10.1186/s12943-018-0902-1.
69.	Zhang J, Liu H, Hou L, et al. Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression. Mol Cancer, 2017, 16(1): 151. doi: 10.1186/s12943-017-0719-3.
70.	Zhang Y, Liu H, Li W, et al. CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630. Aging (Albany NY), 2017, 9(6): 1585-1594.
71.	Ma C, Wang X, Yang F, et al. Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit. Mol Cancer, 2020, 19(1): 157. doi: 10.1186/s12943-020-01268-5.
72.	Wei J, Wei W, Xu H, et al. Circular RNA hsa_circRNA_102958 may serve as a diagnostic marker for gastric cancer. Cancer Biomark, 2020, 27(2): 139-145.
73.	Tang W, Fu K, Sun H, et al. CircRNA microarray profiling identifies a novel circulating biomarker for detection of gastric cancer. Mol Cancer, 2018, 17(1): 137. doi: 10.1186/s12943-018-0888-8.
74.	Li T, Shao Y, Fu L, et al. Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection. J Mol Med (Berl), 2018, 96(1): 85-96.
75.	Wang F, Li X, Zhao X, et al. Detection of a 5-circRNA signature to improve prognostic prediction in gastric cancer. J Investig Med, 2020, 68(3): 762-769.
76.	Ma S, Kong S, Gu X, et al. As a biomarker for gastric cancer, circPTPN22 regulates the progression of gastric cancer through the EMT pathway. Cancer Cell Int, 2021, 21(1): 44. doi: 10.1186/s12935-020-01701-1.
77.	Li P, Chen H, Chen S, et al. Circular RNA 0000096 affects cell growth and migration in gastric cancer. Br J Cancer, 2017, 116(5): 626-633.
78.	Zhao Q, Chen S, Li T, et al. Clinical values of circular RNA 0000181 in the screening of gastric cancer. J Clin Lab Anal, 2018, 32(4): e22333. doi: 10.1002/jcla.22333.
79.	Sun H, Tang W, Rong D, et al. Hsa_circ_0000520, a potential new circular RNA biomarker, is involved in gastric carcinoma. Cancer Biomark, 2018, 21(2): 299-306.
80.	Rong D, Dong C, Fu K, et al. Upregulation of circ_0066444 promotes the proliferation, invasion, and migration of gastric cancer cells. Onco Targets Ther, 2018, 11: 2753-2761.
81.	Lasda E, Parker R. Circular RNAs: diversity of form and function. RNA, 2014, 20(12): 1829-1842.
82.	Dodbele S, Mutlu N, Wilusz JE. Best practices to ensure robust investigation of circular RNAs: pitfalls and tips. EMBO Rep, 2021, 22(3): e52072. doi: 10.15252/embr.202052072.
83.	Liu X, Abraham JM, Cheng Y, et al. Synthetic circular RNA functions as a miR-21 sponge to suppress gastric carcinoma cell proliferation. Mol Ther Nucleic Acids, 2018, 13: 312-321.

1. Sanger HL, Klotz G, Riesner D, et al. Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci U S A, 1976, 73(11): 3852-3856.
2. Cocquerelle C, Mascrez B, Hétuin D, et al. Mis-splicing yields circular RNA molecules. FASEB J, 1993, 7(1): 155-160.
3. Tang X, Ren H, Guo M, et al. Review on circular RNAs and new insights into their roles in cancer. Comput Struct Biotechnol J, 2021, 19: 910-928.
4. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2021, 71(3): 209-249.
5. Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
6. Memczak S, Jens M, Elefsinioti A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature, 2013, 495(7441): 333-338.
7. Schmidt CA, Giusto JD, Bao A, et al. Molecular determinants of metazoan tricRNA biogenesis. Nucleic Acids Res, 2019, 47(12): 6452-6465.
8. Jeck WR, Sharpless NE. Detecting and characterizing circular RNAs. Nat Biotechnol, 2014, 32(5): 453-461.
9. Jeck WR, Sorrentino JA, Wang K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA, 2013, 19(2): 141-157.
10. Lu Z, Filonov GS, Noto JJ, et al. Metazoan tRNA introns generate stable circular RNAs in vivo. RNA, 2015, 21(9): 1554-1565.
11. Zhang XO, Wang HB, Zhang Y, et al. Complementary sequence-mediated exon circularization. Cell, 2014, 159(1): 134-147.
12. Suzuki H, Zuo Y, Wang J, et al. Characterization of RNaseR-digested cellular RNA source that consists of lariat and circular RNAs from pre-mRNA splicing. Nucleic Acids Res, 2006, 34(8): e63. doi: 10.1093/nar/gkl151.
13. Salzman J, Chen RE, Olsen MN, et al. Cell-type specific features of circular RNA expression. PLoS Genet, 2013, 9(9): e1003777. doi: 10.1371/journal.pgen.1003777.
14. Glažar P, Papavasileiou P, Rajewsky N. circBase: a database for circular RNAs. RNA, 2014, 20(11): 1666-1670.
15. Wang X, Li H, Lu Y, et al. Circular RNAs in human cancer. Front Oncol, 2021, 10: 577118.
16. Guo H, Ingolia NT, Weissman JS, et al. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature, 2010, 466(7308): 835-840.
17. Chen LL. The biogenesis and emerging roles of circular RNAs. Nat Rev Mol Cell Biol, 2016, 17(4): 205-211.
18. Hansen TB, Jensen TI, Clausen BH, et al. Natural RNA circles function as efficient microRNA sponges. Nature, 2013, 495(7441): 384-388.
19. Hansen TB, Kjems J, Damgaard CK. Circular RNA and miR-7 in cancer. Cancer Res, 2013, 73(18): 5609-5612.
20. Wen J, Liao J, Liang J, et al. Circular RNA HIPK3: A key circular RNA in a variety of human cancers. Front Oncol, 2020, 10: 773. doi: 10.3389/fonc.2020.00773.
21. Ashwal-Fluss R, Meyer M, Pamudurti NR, et al. circRNA biogenesis competes with pre-mRNA splicing. Mol Cell, 2014, 56(1): 55-66.
22. Abdelmohsen K, Panda AC, Munk R, et al. Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. RNA Biol, 2017, 14(3): 361-369.
23. Du WW, Yang W, Chen Y, et al. Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses. Eur Heart J, 2017, 38(18): 1402-1412.
24. Guo JU, Agarwal V, Guo H, et al. Expanded identification and characterization of mammalian circular RNAs. Genome Biol, 2014, 15(7): 409. doi: 10.1186/s13059-014-0409-z.
25. Legnini I, Di Timoteo G, Rossi F, et al. Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis. Mol Cell, 2017, 66(1): 22-37.
26. Pamudurti NR, Bartok O, Jens M, et al. Translation of circRNAs. Mol Cell, 2017, 66(1): 9-21.
27. Chen CY, Sarnow P. Initiation of protein synthesis by the eukaryotic translational apparatus on circular RNAs. Science, 1995, 268(5209): 415-417.
28. Lei M, Zheng G, Ning Q, et al. Translation and functional roles of circular RNAs in human cancer. Mol Cancer, 2020, 19(1): 30. doi: 10.1186/s12943-020-1135-7.
29. Li Z, Huang C, Bao C, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol, 2015, 22(3): 256-264.
30. Conn VM, Hugouvieux V, Nayak A, et al. A circRNA from SEPALLATA3 regulates splicing of its cognate mRNA throughR-loop formation. Nat Plants, 2017, 3: 17053. doi: 10.1038/nplants.2017.53.
31. Dong R, Zhang XO, Zhang Y, et al. CircRNA-derived pseudogenes. Cell Res, 2016, 26(6): 747-750.
32. Kalyana-Sundaram S, Kumar-Sinha C, Shankar S, et al. Expressed pseudogenes in the transcriptional landscape of human cancers. Cell, 2012, 149(7): 1622-1634.
33. Du WW, Zhang C, Yang W, et al. Identifying and characterizing circRNA-protein interaction. Theranostics, 2017, 7(17): 4183-4191.
34. Jie M, Wu Y, Gao M, et al. CircMRPS35 suppresses gastric cancer progression via recruiting KAT7 to govern histone modification. Mol Cancer, 2020, 19(1): 56. doi: 10.1186/s12943-020-01160-2.
35. Mathieu M, Martin-Jaular L, Lavieu G, et al. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat Cell Biol, 2019, 21(1): 9-17.
36. Enuka Y, Lauriola M, Feldman ME, et al. Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor. Nucleic Acids Res, 2016, 44(3): 1370-1383.
37. Hansen TB, Wiklund ED, Bramsen JB, et al. miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA. EMBO J, 2011, 30(21): 4414-4422.
38. Park OH, Ha H, Lee Y, et al. Endoribonucleolytic cleavage of m6A-containing RNAs by RNase P/MRP complex. Mol Cell, 2019, 74(3): 494-507.
39. Shi X, Wang B, Feng X, et al. circRNAs and exosomes: A mysterious frontier for human cancer. Mol Ther Nucleic Acids, 2020, 19: 384-392.
40. Allemani C, Weir HK, Carreira H, et al. Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887patients from 279 population-based registries in 67 countries (CONCORD-2). Lancet, 2015, 385(9972): 977-1010.
41. Chen J, Li Y, Zheng Q, et al. Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Cancer Lett, 2017, 388: 208-219.
42. Huang X, Li Z, Zhang Q, et al. Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression. Mol Cancer, 2019, 18(1): 71. doi: 10.1186/s12943-019-0969-3.
43. Ouyang Y, Li Y, Huang Y, et al. CircRNA circPDSS1 promotes the gastric cancer progression by sponging miR-186-5p and modulating NEK2. J Cell Physiol, 2019, 234(7): 10458-10469.
44. Ding L, Zhao Y, Dang S, et al. Circular RNA circ-DONSON facilitates gastric cancer growth and invasion via NURF complex dependent activation of transcription factor SOX4. Mol Cancer, 2019, 18(1): 45. doi: 10.1186/s12943-019-1006-2.
45. Wang S, Tang D, Wang W, et al. circLMTK2 acts as a sponge of miR-150-5p and promotes proliferation and metastasis in gastric cancer. Mol Cancer, 2019, 18(1): 162. doi: 10.1186/s12943-019-1081-4.
46. Zhang J, Hou L, Liang R, et al. CircDLST promotes the tumorigenesis and metastasis of gastric cancer by sponging miR-502-5p and activating the NRAS/MEK1/ERK1/2 signaling. Mol Cancer, 2019, 18(1): 80. doi: 10.1186/s12943-019-1015-1.
47. Liu J, Song S, Lin S, et al. Circ-SERPINE2 promotes the development of gastric carcinoma by sponging miR-375 and modulating YWHAZ. Cell Prolif, 2019, 52(4): e12648. doi: 10.1111/cpr.12648.
48. Yang D, Hu Z, Zhang Y, et al. CircHIPK3 promotes the tumorigenesis and development of gastric cancer through miR-637/AKT1 pathway. Front Oncol, 2021, 11: 637761. doi: 10.3389/fonc.2021.637761.
49. Wang L, Li B, Yi X, et al. Circ_SMAD4 promotes gastric carcinogenesis by activating wnt/β-catenin pathway. Cell Prolif, 2021, 54(3): e12981. doi: 10.1111/cpr.12981.
50. Cao J, Zhang X, Xu P, et al. Circular RNA circLMO7 acts as a microRNA-30a-3p sponge to promote gastric cancer progression via the WNT2/β-catenin pathway. J Exp Clin Cancer Res, 2021, 40(1): 6. doi: 10.1186/s13046-020-01791-9.
51. Xie M, Yu T, Jing X, et al. Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation. Mol Cancer, 2020, 19(1): 112. doi: 10.1186/s12943-020-01208-3.
52. Zhang Z, Wang C, Zhang Y, et al. CircDUSP16 promotes the tumorigenesis and invasion of gastric cancer by sponging miR-145-5p. Gastric Cancer, 2020, 23(3): 437-448.
53. Wang S, Zhang X, Li Z, et al. Circular RNA profile identifies circOSBPL10 as an oncogenic factor and prognostic marker in gastric cancer. Oncogene, 2019, 38(44): 6985-7001.
54. Cai J, Chen Z, Wang J, et al. circHECTD1 facilitates glutaminolysis to promote gastric cancer progression by targeting miR-1256 and activating β-catenin/c-Myc signaling. Cell Death Dis, 2019, 10(8): 576. doi: 10.1038/s41419-019-1814-8.
55. Zhang H, Zhu L, Bai M, et al. Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR-133/PRDM16 pathway. Int J Cancer, 2019, 144(10): 2501-2515.
56. Hong Y, Qin H, Li Y, et al. FNDC3B circular RNA promotes the migration and invasion of gastric cancer cells via the regulation of E-cadherin and CD44 expression. J Cell Physiol, 2019, 234(11): 19895-19910.
57. Zhang L, Song X, Chen X, et al. Circular RNA circCACTIN promotes gastric cancer progression by sponging miR-331-3p and regulating TGFBR1 expression. Int J Biol Sci, 2019, 15(5): 1091-1103.
58. Chen Y, Yang F, Fang E, et al. Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes. Cell Death Differ, 2019, 26(7): 1346-1364.
59. Xue M, Li G, Fang X, et al. hsa_circ_0081143 promotes cisplatin resistance in gastric cancer by targeting miR-646/CDK6 pathway. Cancer Cell Int, 2019, 19: 25. doi: 10.1186/s12935-019-0737-x.
60. Yang F, Hu A, Li D, et al. Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation. Mol Cancer, 2019, 18(1): 158. doi: 10.1186/s12943-019-1094-z.
61. Sun G, Li Z, He Z, et al. Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer by miR-99a-5p-mediated induction of MTMR3 expression. J Exp Clin Cancer Res, 2020, 39(1): 246. doi: 10.1186/s13046-020-01758-w.
62. Guo X, Dai X, Liu J, et al. Circular RNA circREPS2 acts as a sponge of miR-558 to suppress gastric cancer progression by regulating RUNX3/β-catenin signaling. Mol Ther Nucleic Acids, 2020, 21: 577-591.
63. Luo Z, Rong Z, Zhang J, et al. Circular RNA circCCDC9 acts as a miR-6792-3p sponge to suppress the progression of gastric cancer through regulating CAV1 expression. Mol Cancer, 2020, 19(1): 86. doi: 10.1186/s12943-020-01203-8.
64. Deng G, Mou T, He J, et al. Circular RNA circRHOBTB3 acts as a sponge for miR-654-3p inhibiting gastric cancer growth. J Exp Clin Cancer Res, 2020, 39(1): 1. doi: 10.1186/s13046-019-1487-2.
65. Rong D, Lu C, Zhang B, et al. CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p. Mol Cancer, 2019, 18(1): 25. doi: 10.1186/s12943-019-0958-6.
66. Peng L, Sang H, Wei S, et al. circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2. Mol Cancer, 2020, 19(1): 156. doi: 10.1186/s12943-020-01270-x.
67. Fang J, Hong H, Xue X, et al. A novel circular RNA, circFAT1(e2), inhibits gastric cancer progression by targeting miR-548g in the cytoplasm and interacting with YBX1 in the nucleus. Cancer Lett, 2019, 442: 222-232.
68. Liu H, Liu Y, Bian Z, et al. Circular RNA YAP1 inhibits the proliferation and invasion of gastric cancer cells by regulating the miR-367-5p/p27 Kip1 axis. Mol Cancer, 2018, 17(1): 151. doi: 10.1186/s12943-018-0902-1.
69. Zhang J, Liu H, Hou L, et al. Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression. Mol Cancer, 2017, 16(1): 151. doi: 10.1186/s12943-017-0719-3.
70. Zhang Y, Liu H, Li W, et al. CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630. Aging (Albany NY), 2017, 9(6): 1585-1594.
71. Ma C, Wang X, Yang F, et al. Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit. Mol Cancer, 2020, 19(1): 157. doi: 10.1186/s12943-020-01268-5.
72. Wei J, Wei W, Xu H, et al. Circular RNA hsa_circRNA_102958 may serve as a diagnostic marker for gastric cancer. Cancer Biomark, 2020, 27(2): 139-145.
73. Tang W, Fu K, Sun H, et al. CircRNA microarray profiling identifies a novel circulating biomarker for detection of gastric cancer. Mol Cancer, 2018, 17(1): 137. doi: 10.1186/s12943-018-0888-8.
74. Li T, Shao Y, Fu L, et al. Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection. J Mol Med (Berl), 2018, 96(1): 85-96.
75. Wang F, Li X, Zhao X, et al. Detection of a 5-circRNA signature to improve prognostic prediction in gastric cancer. J Investig Med, 2020, 68(3): 762-769.
76. Ma S, Kong S, Gu X, et al. As a biomarker for gastric cancer, circPTPN22 regulates the progression of gastric cancer through the EMT pathway. Cancer Cell Int, 2021, 21(1): 44. doi: 10.1186/s12935-020-01701-1.
77. Li P, Chen H, Chen S, et al. Circular RNA 0000096 affects cell growth and migration in gastric cancer. Br J Cancer, 2017, 116(5): 626-633.
78. Zhao Q, Chen S, Li T, et al. Clinical values of circular RNA 0000181 in the screening of gastric cancer. J Clin Lab Anal, 2018, 32(4): e22333. doi: 10.1002/jcla.22333.
79. Sun H, Tang W, Rong D, et al. Hsa_circ_0000520, a potential new circular RNA biomarker, is involved in gastric carcinoma. Cancer Biomark, 2018, 21(2): 299-306.
80. Rong D, Dong C, Fu K, et al. Upregulation of circ_0066444 promotes the proliferation, invasion, and migration of gastric cancer cells. Onco Targets Ther, 2018, 11: 2753-2761.
81. Lasda E, Parker R. Circular RNAs: diversity of form and function. RNA, 2014, 20(12): 1829-1842.
82. Dodbele S, Mutlu N, Wilusz JE. Best practices to ensure robust investigation of circular RNAs: pitfalls and tips. EMBO Rep, 2021, 22(3): e52072. doi: 10.15252/embr.202052072.
83. Liu X, Abraham JM, Cheng Y, et al. Synthetic circular RNA functions as a miR-21 sponge to suppress gastric carcinoma cell proliferation. Mol Ther Nucleic Acids, 2018, 13: 312-321.

Previous Article
Progress on integrated treatment of adenocarcinoma of esophagogastric junction
Next Article
Advantages and application of restricted fluid therapy after resection of esophageal carcinoma

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research progress of circRNA in gastric cancer

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content