单细胞转录组测序在腹主动脉瘤研究中的应用现状与展望_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

吴志远 ¹ , 刘声亮 ² , 高擎 ^1,3 ,  李拥军 ^1,3

1. ;
2. ;
3. ;

Corresponding author：

李拥军, Email: liyongjun4679@bjhmoh.cn

Keywords：

DOI：

10.7507/1007-9424.202110003

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Citation： 吴志远, 刘声亮, 高擎, 李拥军. 单细胞转录组测序在腹主动脉瘤研究中的应用现状与展望. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(11): 1405-1408. doi: 10.7507/1007-9424.202110003 Copy

1.	Wu ZY, Trenner M, Boon RA, et al. Long noncoding RNAs in key cellular processes involved in aortic aneurysms. Atherosclerosis, 2020, 292: 112-118.
2.	Eckstein HH, Maegdefessel L. Linking obesity with abdominal aortic aneurysm development. Eur Heart J, 2020, 41(26): 2469-2471.
3.	李拥军, 陈作观, 张玮. 腔内治疗时代腹主动脉瘤传统开放手术的地位和意义. 中华血管外科杂志, 2020, 5(1): 10-13.
4.	Wu ZY, Chen ZG, Diao YP, et al. Endovascular repair of complex aortoiliac aneurysm with the sandwich technique in sixteen patients. Ann Vasc Surg, 2019, 54: 233-239.
5.	Wu ZY, Chen ZG, Ma L, et al. Outcomes of chimney and/or periscope techniques in the endovascular management of complex aortic pathologies. Chin Med J (Engl), 2017, 130(17): 2095-2100.
6.	Chen ZG, Tan SP, Diao YP, et al. The long-term outcomes of open and endovascular repair for abdominal aortic aneurysm: A meta-analysis. Asian J Surg, 2019, 42(10): 899-906.
7.	Maegdefessel L, Spin JM, Adam M, et al. Micromanaging abdominal aortic aneurysms. Int J Mol Sci, 2013, 14(7): 14374-14394.
8.	Golledge J. Abdominal aortic aneurysm: update on pathogenesis and medical treatments. Nat Rev Cardiol, 2019, 16(4): 225-242.
9.	Stark R, Grzelak M, Hadfield J. RNA sequencing: the teenage years. Nat Rev Genet, 2019, 20(11): 631-656.
10.	Li DY, Busch A, Jin H, et al. H19 induces abdominal aortic aneurysm development and progression. Circulation, 2018, 138(15): 1551-1568.
11.	Vallejo J, Cochain C, Zernecke A, et al. Heterogeneity of immune cells in human atherosclerosis revealed by scRNA-seq. Cardiovasc Res, 2021: cvab260.
12.	Fernandez DM, Rahman AH, Fernandez NF, et al. Single-cell immune landscape of human atherosclerotic plaques. Nat Med, 2019, 25(10): 1576-1588.
13.	Yang H, Zhou T, Stranz A, et al. Single-cell RNA sequencing reveals heterogeneity of vascular cells in early stage murine abdominal aortic aneurysm-brief report. Arterioscler Thromb Vasc Biol, 2021, 41(3): 1158-1166.
14.	Zhao G, Lu H, Chang Z, et al. Single-cell RNA sequencing reveals the cellular heterogeneity of aneurysmal infrarenal abdominal aorta. Cardiovasc Res, 2021, 117(5): 1402-1416.
15.	Gao Q, Yu J, Chen Z, et al. The characteristics of peripheral blood mononuclear cells in takayasu arteritis by single cell RNA sequencing. Authorea, 2021.
16.	Lysgaard Poulsen J, Stubbe J, Lindholt JS. Animal models used to explore abdominal aortic aneurysms: A systematic review. Eur J Vasc Endovasc Surg, 2016, 52(4): 487-499.
17.	Hadi T, Boytard L, Silvestro M, et al. Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells. Nat Commun, 2018, 9(1): 5022.
18.	Boytard L, Hadi T, Silvestro M, et al. Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages. Nat Commun, 2020, 11(1): 4311.
19.	Kalluri AS, Vellarikkal SK, Edelman ER, et al. Single-cell analysis of the normal mouse aorta reveals functionally distinct endothelial cell populations. Circulation, 2019, 140(2): 147-163.
20.	李林, 狄长安, 李丽亚, 等. 腹主动脉瘤动物模型的建立. 腹腔镜外科杂志, 2014, 12(3): 225-228.
21.	Wu Z. Single-cell RNA sequencing analysis revealed cellular heterogeneity of human abdominal aortic aneurysm. München: Technische Universität München, 2021.
22.	Davis FM, Tsoi LC, Melvin WJ, et al. Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms. J Exp Med, 2021, 218(6): e20201839.
23.	Wirka RC, Wagh D, Paik DT, et al. Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis. Nat Med, 2019, 25(8): 1280-1289.
24.	Pan H, Xue C, Auerbach BJ, et al. Single-cell genomics reveals a novel cell state during smooth muscle cell phenotypic switching and potential therapeutic targets for atherosclerosis in mouse and human. Circulation, 2020, 142(21): 2060-2075.
25.	Pedroza AJ, Tashima Y, Shad R, et al. Single-cell transcriptomic profiling of vascular smooth muscle cell phenotype modulation in marfan syndrome aortic aneurysm. Arterioscler Thromb Vasc Biol, 2020, 40(9): 2195-2211.
26.	Chen Z, Zhang H, Bai Y, et al. Single cell transcriptomic analysis identifies novel vascular smooth muscle subsets under high hydrostatic pressure. Sci China Life Sci, 2021, 64(10): 1677-1690.
27.	Li F, Yan K, Wu L, et al. Single-cell RNA-seq reveals cellular heterogeneity of mouse carotid artery under disturbed flow. Cell Death Discov, 2021, 7(1): 180.
28.	Lähnemann D, Köster J, Szczurek E, et al. Eleven grand challenges in single-cell data science. Genome Biol, 2020, 21(1): 31.
29.	Regev A, Teichmann SA, Lander ES, et al. The human cell atlas. Elife, 2017, 6: e27041.
30.	Ståhl PL, Salmén F, Vickovic S, et al. Visualization and analysis of gene expression in tissue sections by spatial transcriptomics. Science, 2016, 353(6294): 78-82.
31.	Gyllborg D, Langseth CM, Qian X, et al. Hybridization-based in situ sequencing (HybISS) for spatially resolved transcriptomics in human and mouse brain tissue. Nucleic Acids Res, 2020, 48(19): e112.
32.	Burgess DJ. Spatial transcriptomics coming of age. Nat Rev Genet, 2019, 20(6): 317.
33.	Krausgruber T, Fortelny N, Fife-Gernedl V, et al. Structural cells are key regulators of organ-specific immune responses. Nature, 2020, 583(7815): 296-302.

1. Wu ZY, Trenner M, Boon RA, et al. Long noncoding RNAs in key cellular processes involved in aortic aneurysms. Atherosclerosis, 2020, 292: 112-118.
2. Eckstein HH, Maegdefessel L. Linking obesity with abdominal aortic aneurysm development. Eur Heart J, 2020, 41(26): 2469-2471.
3. 李拥军, 陈作观, 张玮. 腔内治疗时代腹主动脉瘤传统开放手术的地位和意义. 中华血管外科杂志, 2020, 5(1): 10-13.
4. Wu ZY, Chen ZG, Diao YP, et al. Endovascular repair of complex aortoiliac aneurysm with the sandwich technique in sixteen patients. Ann Vasc Surg, 2019, 54: 233-239.
5. Wu ZY, Chen ZG, Ma L, et al. Outcomes of chimney and/or periscope techniques in the endovascular management of complex aortic pathologies. Chin Med J (Engl), 2017, 130(17): 2095-2100.
6. Chen ZG, Tan SP, Diao YP, et al. The long-term outcomes of open and endovascular repair for abdominal aortic aneurysm: A meta-analysis. Asian J Surg, 2019, 42(10): 899-906.
7. Maegdefessel L, Spin JM, Adam M, et al. Micromanaging abdominal aortic aneurysms. Int J Mol Sci, 2013, 14(7): 14374-14394.
8. Golledge J. Abdominal aortic aneurysm: update on pathogenesis and medical treatments. Nat Rev Cardiol, 2019, 16(4): 225-242.
9. Stark R, Grzelak M, Hadfield J. RNA sequencing: the teenage years. Nat Rev Genet, 2019, 20(11): 631-656.
10. Li DY, Busch A, Jin H, et al. H19 induces abdominal aortic aneurysm development and progression. Circulation, 2018, 138(15): 1551-1568.
11. Vallejo J, Cochain C, Zernecke A, et al. Heterogeneity of immune cells in human atherosclerosis revealed by scRNA-seq. Cardiovasc Res, 2021: cvab260.
12. Fernandez DM, Rahman AH, Fernandez NF, et al. Single-cell immune landscape of human atherosclerotic plaques. Nat Med, 2019, 25(10): 1576-1588.
13. Yang H, Zhou T, Stranz A, et al. Single-cell RNA sequencing reveals heterogeneity of vascular cells in early stage murine abdominal aortic aneurysm-brief report. Arterioscler Thromb Vasc Biol, 2021, 41(3): 1158-1166.
14. Zhao G, Lu H, Chang Z, et al. Single-cell RNA sequencing reveals the cellular heterogeneity of aneurysmal infrarenal abdominal aorta. Cardiovasc Res, 2021, 117(5): 1402-1416.
15. Gao Q, Yu J, Chen Z, et al. The characteristics of peripheral blood mononuclear cells in takayasu arteritis by single cell RNA sequencing. Authorea, 2021.
16. Lysgaard Poulsen J, Stubbe J, Lindholt JS. Animal models used to explore abdominal aortic aneurysms: A systematic review. Eur J Vasc Endovasc Surg, 2016, 52(4): 487-499.
17. Hadi T, Boytard L, Silvestro M, et al. Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells. Nat Commun, 2018, 9(1): 5022.
18. Boytard L, Hadi T, Silvestro M, et al. Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages. Nat Commun, 2020, 11(1): 4311.
19. Kalluri AS, Vellarikkal SK, Edelman ER, et al. Single-cell analysis of the normal mouse aorta reveals functionally distinct endothelial cell populations. Circulation, 2019, 140(2): 147-163.
20. 李林, 狄长安, 李丽亚, 等. 腹主动脉瘤动物模型的建立. 腹腔镜外科杂志, 2014, 12(3): 225-228.
21. Wu Z. Single-cell RNA sequencing analysis revealed cellular heterogeneity of human abdominal aortic aneurysm. München: Technische Universität München, 2021.
22. Davis FM, Tsoi LC, Melvin WJ, et al. Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms. J Exp Med, 2021, 218(6): e20201839.
23. Wirka RC, Wagh D, Paik DT, et al. Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis. Nat Med, 2019, 25(8): 1280-1289.
24. Pan H, Xue C, Auerbach BJ, et al. Single-cell genomics reveals a novel cell state during smooth muscle cell phenotypic switching and potential therapeutic targets for atherosclerosis in mouse and human. Circulation, 2020, 142(21): 2060-2075.
25. Pedroza AJ, Tashima Y, Shad R, et al. Single-cell transcriptomic profiling of vascular smooth muscle cell phenotype modulation in marfan syndrome aortic aneurysm. Arterioscler Thromb Vasc Biol, 2020, 40(9): 2195-2211.
26. Chen Z, Zhang H, Bai Y, et al. Single cell transcriptomic analysis identifies novel vascular smooth muscle subsets under high hydrostatic pressure. Sci China Life Sci, 2021, 64(10): 1677-1690.
27. Li F, Yan K, Wu L, et al. Single-cell RNA-seq reveals cellular heterogeneity of mouse carotid artery under disturbed flow. Cell Death Discov, 2021, 7(1): 180.
28. Lähnemann D, Köster J, Szczurek E, et al. Eleven grand challenges in single-cell data science. Genome Biol, 2020, 21(1): 31.
29. Regev A, Teichmann SA, Lander ES, et al. The human cell atlas. Elife, 2017, 6: e27041.
30. Ståhl PL, Salmén F, Vickovic S, et al. Visualization and analysis of gene expression in tissue sections by spatial transcriptomics. Science, 2016, 353(6294): 78-82.
31. Gyllborg D, Langseth CM, Qian X, et al. Hybridization-based in situ sequencing (HybISS) for spatially resolved transcriptomics in human and mouse brain tissue. Nucleic Acids Res, 2020, 48(19): e112.
32. Burgess DJ. Spatial transcriptomics coming of age. Nat Rev Genet, 2019, 20(6): 317.
33. Krausgruber T, Fortelny N, Fife-Gernedl V, et al. Structural cells are key regulators of organ-specific immune responses. Nature, 2020, 583(7815): 296-302.

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