Body mass index of patients with colorectal cancer will affect tumor characteristics: a real world study based on DACCA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHAN Wenyi ^1,2 , LIU Guina ^1,2 , LIU Ying ^1,2 , ZHAO Tianlang ^1,2 ,  WANG Xiaodong ¹ , LI Li ¹

1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. West China School of Medicine in Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

WANG Xiaodong, Email: wangxiaodong@wchscu.cn

Keywords：

colorectal cancer; tumor feature; database; big data; the label; structured

DOI：

10.7507/1007-9424.202201001

Video：

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Objective To analyze the impact of body mass index (BMI) on tumor characteristics of colorectal patients served by West China Hospital as a regional center in the current version of Database from Colorectal Cancer (DACCA). Methods The data of DACCA was updated on October 16, 2021. All data items included BMI, precancerous lesions, cancer family, tumor site, tumor morphology, location, differentiation, pathological properties of tumor, obstruction, overlap, perforation, pain, edema, and bleeding. The patients were divided into lean (BMI<18.5 kg/m²), normal (BMI 18.5–23.9 kg/m²), overweight (BMI 24.0–27.9 kg/m²) and obesity (BMI≥28.0 kg/m²) by Chinese classification methods. Results After scanning, 5 761 data rows were analyzed. Chi-square test showed that there was significant difference in the type composition ratio of tumor location in colorectal cancer patients under different BMI groups (χ²=31.477, P<0.001). Rank sum test showed that there was significant difference in the degree of obstruction (H=42.490, P<0.001), intussusception (H=8.179, P=0.042), edema (H=14.795, P=0.002), and bleeding (H=9.884, P=0.020) among different BMI groups. Conclusions The BMI classification of colorectal cancer patients is related to the location of tumor and the occurrence of some tumor complications. Patients with tumor involving intestinal lumens for one week are more likely to have low BMI. The patients with low BMI are more likely to have severe bleeding, obstruction, intestinal intussusception, and severe intestinal wall edema.

Citation： ZHAN Wenyi, LIU Guina, LIU Ying, ZHAO Tianlang, WANG Xiaodong, LI Li. Body mass index of patients with colorectal cancer will affect tumor characteristics: a real world study based on DACCA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(2): 232-238. doi: 10.7507/1007-9424.202201001 Copy

1.	汪晓东, 刘健博, 李立. 数据库建设第五部分: 结直肠癌的肿瘤特征—模块的设计 (一). 中国普外基础与临床杂志, 2020, 27(3): 345-349.
2.	汪晓东, 刘健博, 李立. 数据库建设第五部分·结直肠癌的肿瘤特征—模块的设计 (二). 中国普外基础与临床杂志, 2020, 27(4): 483-488.
3.	Ochs-Balcom HM, Kanth P, Farnham JM, et al. Colorectal cancer risk based on extended family history and body mass index. Genet Epidemiol, 2020, 44(7): 778-784.
4.	Hanyuda A, Cao Y, Hamada T, et al. Body mass index and risk of colorectal carcinoma subtypes classified by tumor differentiation status. Eur J Epidemiol, 2017, 32(5): 393-407.
5.	国际生命科学学会中国办事处中国肥胖问题工作组联合数据汇总分析协作组. 中国成人体质指数分类的推荐意见简介. 中华预防医学杂志, 2001, 35(5): 349-350.
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7.	Micu SI, Oraiopoulou I, Manea ME, et al. Five years retrospective review of colorectal cancer risk factors in the black sea coast population. Revista de Chimie, 2020, 71(1): 355-359.
8.	Bou-abboud C, Cooper G. The increasing incidence of young-onset colorectal cancer: risk factors and presentation. Am J Gastroenterol, 2016, 111: S125-S126.
9.	任建松, 石菊芳, 张洪召, 等. 2012–2013年中国城市人群大肠癌筛查结果初步分析. 中华预防医学杂志, 2015, 49(5): 441-443.
10.	张敏, 刘思达, 刁敏, 等. 体质量指数对腹腔镜结直肠癌手术结果的影响. 腹部外科, 2020, 33(3): 223-226.
11.	赵世栋, 申占龙, 叶颖江. 肥胖结直肠癌患者腹腔镜手术要点. 结直肠肛门外科, 2021, 27(3): 300-303.
12.	van den Berg I, Coebergh van den Braak RRJ, van Vugt JLA, et al. Actual survival after resection of primary colorectal cancer: results from a prospective multicenter study. World J Surg Oncol, 2021, 19(1): 96. doi: 10.1186/s12957-021-02207-4.
13.	Fransgaard T, Caspar Thygesen L, Gögenur I. The impact of postoperative complications and delay of adjuvant chemotherapy on oncological outcomes in patients with colorectal cancer. Colorectal Dis, 2021, 23(5): 1132-1140.
14.	Mualla NM, Hussain MR, Akrmah M, et al. The impact of postoperative complications on long-term oncological outcomes following curative resection of colorectal cancer (Stage Ⅰ-Ⅲ): a systematic review and meta-analysis. Cureus, 2021, 13(1): e12837. doi: 10.7759/cureus.12837.
15.	Robsahm TE, Aagnes B, Hjartåker A, et al. Body mass index, physical activity, and colorectal cancer by anatomical subsites: a systematic review and meta-analysis of cohort studies. Eur J Cancer Prev, 2013, 22(6): 492-505.

1. 汪晓东, 刘健博, 李立. 数据库建设第五部分: 结直肠癌的肿瘤特征—模块的设计 (一). 中国普外基础与临床杂志, 2020, 27(3): 345-349.
2. 汪晓东, 刘健博, 李立. 数据库建设第五部分·结直肠癌的肿瘤特征—模块的设计 (二). 中国普外基础与临床杂志, 2020, 27(4): 483-488.
3. Ochs-Balcom HM, Kanth P, Farnham JM, et al. Colorectal cancer risk based on extended family history and body mass index. Genet Epidemiol, 2020, 44(7): 778-784.
4. Hanyuda A, Cao Y, Hamada T, et al. Body mass index and risk of colorectal carcinoma subtypes classified by tumor differentiation status. Eur J Epidemiol, 2017, 32(5): 393-407.
5. 国际生命科学学会中国办事处中国肥胖问题工作组联合数据汇总分析协作组. 中国成人体质指数分类的推荐意见简介. 中华预防医学杂志, 2001, 35(5): 349-350.
6. Song EY, Swanson J, Patel A, et al. Colorectal cancer risk factors and screening among the uninsured of tampa bay: a free clinic study. Prev Chronic Dis, 2021, 18: E16. doi: 10.5888/pcd18.200496.
7. Micu SI, Oraiopoulou I, Manea ME, et al. Five years retrospective review of colorectal cancer risk factors in the black sea coast population. Revista de Chimie, 2020, 71(1): 355-359.
8. Bou-abboud C, Cooper G. The increasing incidence of young-onset colorectal cancer: risk factors and presentation. Am J Gastroenterol, 2016, 111: S125-S126.
9. 任建松, 石菊芳, 张洪召, 等. 2012–2013年中国城市人群大肠癌筛查结果初步分析. 中华预防医学杂志, 2015, 49(5): 441-443.
10. 张敏, 刘思达, 刁敏, 等. 体质量指数对腹腔镜结直肠癌手术结果的影响. 腹部外科, 2020, 33(3): 223-226.
11. 赵世栋, 申占龙, 叶颖江. 肥胖结直肠癌患者腹腔镜手术要点. 结直肠肛门外科, 2021, 27(3): 300-303.
12. van den Berg I, Coebergh van den Braak RRJ, van Vugt JLA, et al. Actual survival after resection of primary colorectal cancer: results from a prospective multicenter study. World J Surg Oncol, 2021, 19(1): 96. doi: 10.1186/s12957-021-02207-4.
13. Fransgaard T, Caspar Thygesen L, Gögenur I. The impact of postoperative complications and delay of adjuvant chemotherapy on oncological outcomes in patients with colorectal cancer. Colorectal Dis, 2021, 23(5): 1132-1140.
14. Mualla NM, Hussain MR, Akrmah M, et al. The impact of postoperative complications on long-term oncological outcomes following curative resection of colorectal cancer (Stage Ⅰ-Ⅲ): a systematic review and meta-analysis. Cureus, 2021, 13(1): e12837. doi: 10.7759/cureus.12837.
15. Robsahm TE, Aagnes B, Hjartåker A, et al. Body mass index, physical activity, and colorectal cancer by anatomical subsites: a systematic review and meta-analysis of cohort studies. Eur J Cancer Prev, 2013, 22(6): 492-505.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Body mass index of patients with colorectal cancer will affect tumor characteristics: a real world study based on DACCA

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