Association of preoperative systemic immune-inflammation index with early allograft dysfunction in liver transplant recipients: a single-center retrospective study_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIAO Xiaojun ¹ , WANG Siying ¹ , YANG Jiayin ² ,  YU Hai ¹

1. Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. Department of Liver Surgery/Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

YU Hai, Email: yuhaishan117@yahoo.com

Keywords：

systemic immune-inflammatory index; early allograft dysfunction; liver transplantation; generalized propensity score weighting

DOI：

10.7507/1007-9424.202201012

Video：

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Objective To investigate the association between preoperative systemic immune-inflammation index (SII) and early allograft dysfunction (EAD) in liver transplant recipients. Methods The patients underwent liver transplantation who met the inclusion and exclusion criteria in the West China Hospital of Sichuan University from January 2015 to December 2019 were collected. The postoperative EAD was analyzed. The generalized propensity score weighting (GPSW) were used to balance the confounding factors affecting the occurrence of EAD. Results A total of 390 patients who met the inclusion and exclusion criteria were enrolled in this study, 93 cases of EAD occurred, the incidence of EAD was 23.8%. The recipient’s model for endstage liver disease score and Child-Pugh grade, the donor’s body mass index, age, and graft weight, and the intraoperative cold ischemia time, liver transplantation time, intraoperative blood loss, total infusion, red blood cell transfusion, autologous blood reinfusion, fresh frozen plasma transfusion, concentrated platelet transfusion, total red blood cell and autologous blood transfusions were balanced by GPSW, then the overall mean correlation coefficient of the 14 covariables and SII decreased from 0.049 to 0.039, and each covariable reached the standard of less than 0.1. The binary logistic regression analysis based on GPSW showed that there was no significant association between SII and EAD (P=0.371). Conclusion From preliminary result of this study, it is not found that preoperative SII of liver transplantation patients is related to occurrence of postoperative EAD.

Citation： LIAO Xiaojun, WANG Siying, YANG Jiayin, YU Hai. Association of preoperative systemic immune-inflammation index with early allograft dysfunction in liver transplant recipients: a single-center retrospective study. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(5): 613-617. doi: 10.7507/1007-9424.202201012 Copy

1.	Song JL, Yang J, Yan LN, et al. A new index predicts early allograft dysfunction following living donor liver transplantation: a propensity score analysis. Dig Liver Dis, 2017, 49(11): 1225-1232.
2.	Jochmans I, Fieuws S, Monbaliu D, et al. “Model for Early Allograft Function” outperforms “Early Allograft Dysfunction” as a predictor of transplant survival. Transplantation, 2017, 101(8): e258-e264. doi: 10.1097/TP.0000000000001833.
3.	Lee DD, Singh A, Burns JM, et al. Early allograft dysfunction in liver transplantation with donation after cardiac death donors results in inferior survival. Liver Transpl, 2014, 20(12): 1447-1453.
4.	Hudcova J, Scopa C, Rashid J, et al. Effect of early allograft dysfunction on outcomes following liver transplantation. Clin Transplant, 2017, 31(2): e12887. doi: 10.1111/ctr.12887.
5.	Zhang Y, Chen B, Wang L, et al. Systemic immune-inflammation index is a promising noninvasive marker to predict survival of lung cancer: a meta-analysis. Medicine (Baltimore), 2019, 98(3): e13788. doi: 10.1097/MD.0000000000013788.
6.	Hu X, Shao YX, Yang ZQ, et al. Preoperative systemic immune-inflammation index predicts prognosis of patients with non-metastatic renal cell carcinoma: a propensity score-matched analysis. Cancer Cell Int, 2020, 20: 222. doi: 10.1186/s12935-020-01320-w.
7.	Hua X, Long ZQ, Zhang YL, et al. Prognostic value of preoperative systemic immune-inflammation index in breast cancer: a propensity score-matching study. Front Oncol, 2020, 10: 580. doi: 10.3389/fonc.2020.00580.
8.	Li J, Shao J, Zhang X, et al. Prognostic value of the pretreatment systemic immune-inflammation index in patients with colorectal cancer. Gastroenterol Res Pract, 2020, 2020: 8781674. doi: 10.1155/2020/8781674.
9.	Chen H, Huang Z, Sun B, et al. The predictive value of systemic immune inflammation index for postoperative survival of gallbladder carcinoma patients. J Surg Oncol, 2021, 124(1): 59-66.
10.	Kurtul A, Ornek E. Platelet to lymphocyte ratio in cardiovascular diseases: a systematic review. Angiology, 2019, 70(9): 802-818.
11.	Yang YL, Wu CH, Hsu PF, et al. Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease. Eur J Clin Invest, 2020, 50(5): e13230. doi: 10.1111/eci.13230.
12.	Trifan G, Testai FD. Systemic immune-inflammation (SII) index predicts poor outcome after spontaneous supratentorial intracerebral hemorrhage. J Stroke Cerebrovasc Dis, 2020, 29(9): 105057. doi: 10.1016/j.jstrokecerebrovasdis.2020.105057.
13.	Li S, Liu K, Gao Y, et al. Prognostic value of systemic immune-inflammation index in acute/subacute patients with cerebral venous sinus thrombosis. Stroke Vasc Neurol, 2020, 5(4): 368-373.
14.	Kim JW, Jung JY, Suh CH, et al. Systemic immune-inflammation index combined with ferritin can serve as a reliable assessment score for adult-onset Still’s disease. Clin Rheumatol, 2021, 40(2): 661-668.
15.	Fu H, Zheng J, Cai J, et al. Systemic immune-inflammation index (SII) is useful to predict survival outcomes in patients after liver transplantation for hepatocellular carcinoma within Hangzhou criteria. Cell Physiol Biochem, 2018, 47(1): 293-301.
16.	Ren A, Li Z, Cheng P, et al. Systemic immune-inflammation index is a prognostic predictor in patients with intrahepatic cholangiocarcinoma undergoing liver transplantation. Mediators Inflamm, 2021, 2021: 6656996. doi: 10.1155/2021/6656996.
17.	Halpern SE, Moris D, Shaw BI, et al. The systemic immune-inflammation index predicts clinical outcomes in kidney transplant recipients. In Vivo, 2020, 34(6): 3349-3360.
18.	von Elm E, Altman DG, Egger M, et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Int J Surg, 2014, 12(12): 1495-1499.
19.	王再莉, 李雪霏, 玉红, 等. 全身免疫炎症指数对腹部手术患者术后肺部并发症的影响: 回顾性观察性研究. 中国普外基础与临床杂志, 2021, 28(5): 625-630.
20.	Olthoff KM, Kulik L, Samstein B, et al. Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors. Liver Transpl, 2010, 16(8): 943-949.
21.	Pomposelli JJ, Goodrich NP, Emond JC, et al. Patterns of early allograft dysfunction in adult live donor liver transplantation: the A2ALL experience. Transplantation, 2016, 100(7): 1490-1499.
22.	Zhou J, Chen J, Wei Q, et al. The role of ischemia/reperfusion injury in early hepatic allograft dysfunction. Liver Transpl, 2020, 26(8): 1034-1048.
23.	Jiménez-Castro MB, Cornide-Petronio ME, Gracia-Sancho J, et al. Inflammasome-mediated inflammation in liver ischemia-reperfusion injury. Cells, 2019, 8(10): 1131. doi: 10.3390/cells8101131.
24.	Ringelhan M, Pfister D, O’Connor T, et al. The immunology of hepatocellular carcinoma. Nat Immunol, 2018, 19(3): 222-232.
25.	Quesnelle KM, Bystrom PV, Toledo-Pereyra LH. Molecular responses to ischemia and reperfusion in the liver. Arch Toxicol, 2015, 89(5): 651-657.

1. Song JL, Yang J, Yan LN, et al. A new index predicts early allograft dysfunction following living donor liver transplantation: a propensity score analysis. Dig Liver Dis, 2017, 49(11): 1225-1232.
2. Jochmans I, Fieuws S, Monbaliu D, et al. “Model for Early Allograft Function” outperforms “Early Allograft Dysfunction” as a predictor of transplant survival. Transplantation, 2017, 101(8): e258-e264. doi: 10.1097/TP.0000000000001833.
3. Lee DD, Singh A, Burns JM, et al. Early allograft dysfunction in liver transplantation with donation after cardiac death donors results in inferior survival. Liver Transpl, 2014, 20(12): 1447-1453.
4. Hudcova J, Scopa C, Rashid J, et al. Effect of early allograft dysfunction on outcomes following liver transplantation. Clin Transplant, 2017, 31(2): e12887. doi: 10.1111/ctr.12887.
5. Zhang Y, Chen B, Wang L, et al. Systemic immune-inflammation index is a promising noninvasive marker to predict survival of lung cancer: a meta-analysis. Medicine (Baltimore), 2019, 98(3): e13788. doi: 10.1097/MD.0000000000013788.
6. Hu X, Shao YX, Yang ZQ, et al. Preoperative systemic immune-inflammation index predicts prognosis of patients with non-metastatic renal cell carcinoma: a propensity score-matched analysis. Cancer Cell Int, 2020, 20: 222. doi: 10.1186/s12935-020-01320-w.
7. Hua X, Long ZQ, Zhang YL, et al. Prognostic value of preoperative systemic immune-inflammation index in breast cancer: a propensity score-matching study. Front Oncol, 2020, 10: 580. doi: 10.3389/fonc.2020.00580.
8. Li J, Shao J, Zhang X, et al. Prognostic value of the pretreatment systemic immune-inflammation index in patients with colorectal cancer. Gastroenterol Res Pract, 2020, 2020: 8781674. doi: 10.1155/2020/8781674.
9. Chen H, Huang Z, Sun B, et al. The predictive value of systemic immune inflammation index for postoperative survival of gallbladder carcinoma patients. J Surg Oncol, 2021, 124(1): 59-66.
10. Kurtul A, Ornek E. Platelet to lymphocyte ratio in cardiovascular diseases: a systematic review. Angiology, 2019, 70(9): 802-818.
11. Yang YL, Wu CH, Hsu PF, et al. Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease. Eur J Clin Invest, 2020, 50(5): e13230. doi: 10.1111/eci.13230.
12. Trifan G, Testai FD. Systemic immune-inflammation (SII) index predicts poor outcome after spontaneous supratentorial intracerebral hemorrhage. J Stroke Cerebrovasc Dis, 2020, 29(9): 105057. doi: 10.1016/j.jstrokecerebrovasdis.2020.105057.
13. Li S, Liu K, Gao Y, et al. Prognostic value of systemic immune-inflammation index in acute/subacute patients with cerebral venous sinus thrombosis. Stroke Vasc Neurol, 2020, 5(4): 368-373.
14. Kim JW, Jung JY, Suh CH, et al. Systemic immune-inflammation index combined with ferritin can serve as a reliable assessment score for adult-onset Still’s disease. Clin Rheumatol, 2021, 40(2): 661-668.
15. Fu H, Zheng J, Cai J, et al. Systemic immune-inflammation index (SII) is useful to predict survival outcomes in patients after liver transplantation for hepatocellular carcinoma within Hangzhou criteria. Cell Physiol Biochem, 2018, 47(1): 293-301.
16. Ren A, Li Z, Cheng P, et al. Systemic immune-inflammation index is a prognostic predictor in patients with intrahepatic cholangiocarcinoma undergoing liver transplantation. Mediators Inflamm, 2021, 2021: 6656996. doi: 10.1155/2021/6656996.
17. Halpern SE, Moris D, Shaw BI, et al. The systemic immune-inflammation index predicts clinical outcomes in kidney transplant recipients. In Vivo, 2020, 34(6): 3349-3360.
18. von Elm E, Altman DG, Egger M, et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Int J Surg, 2014, 12(12): 1495-1499.
19. 王再莉, 李雪霏, 玉红, 等. 全身免疫炎症指数对腹部手术患者术后肺部并发症的影响: 回顾性观察性研究. 中国普外基础与临床杂志, 2021, 28(5): 625-630.
20. Olthoff KM, Kulik L, Samstein B, et al. Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors. Liver Transpl, 2010, 16(8): 943-949.
21. Pomposelli JJ, Goodrich NP, Emond JC, et al. Patterns of early allograft dysfunction in adult live donor liver transplantation: the A2ALL experience. Transplantation, 2016, 100(7): 1490-1499.
22. Zhou J, Chen J, Wei Q, et al. The role of ischemia/reperfusion injury in early hepatic allograft dysfunction. Liver Transpl, 2020, 26(8): 1034-1048.
23. Jiménez-Castro MB, Cornide-Petronio ME, Gracia-Sancho J, et al. Inflammasome-mediated inflammation in liver ischemia-reperfusion injury. Cells, 2019, 8(10): 1131. doi: 10.3390/cells8101131.
24. Ringelhan M, Pfister D, O’Connor T, et al. The immunology of hepatocellular carcinoma. Nat Immunol, 2018, 19(3): 222-232.
25. Quesnelle KM, Bystrom PV, Toledo-Pereyra LH. Molecular responses to ischemia and reperfusion in the liver. Arch Toxicol, 2015, 89(5): 651-657.

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Association of preoperative systemic immune-inflammation index with early allograft dysfunction in liver transplant recipients: a single-center retrospective study

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