Progress and prospects of organoid research_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHOU Yongjie ,  SHI Yujun

Institute of Clinical Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, Laboratory of Liver Transplantation, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

SHI Yujun, Email: shiyujun@scu.edu.cn

Keywords：

organoids; 3D culture; stem cells; precise medicine

DOI：

10.7507/1007-9424.202205011

Video：

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As one of the most breakthrough cutting-edge technologies in the biomedical field in recent years, organoid culture technology can use cells derived from, either (pluripotent) stem cells or tissue-derived differentiated/progenitor cells (foetal, neonatal, or adult) to form 3D multicellular structure organoids with self-organizing and recapitulating at least some features of the organ including tissue architecture or function abilities. Recently, organoids have been widely used in disease model construction, anti-cancer drug screening, gene or cell therapy, etc., providing an ideal model for basic biomedical research, drug development and clinical precision medicine, and has shown an important role in regenerative medicine.

Citation： ZHOU Yongjie, SHI Yujun. Progress and prospects of organoid research. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(6): 716-718. doi: 10.7507/1007-9424.202205011 Copy

1.	Kaluthantrige Don F, Huch M. Organoids, Where We Stand and Where We Go. Trends Mol Med. 2021;27(5): 416-418.
2.	Sato T, Vries RG, Snippert HJ, et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature, 2009, 459(7244): 262-265.
3.	Rossi G, Manfrin A, Lutolf MP. Progress and potential in organoid research. Nat Rev Genet. 2018;19(11): 671-687.
4.	Veninga V, Voest EE. Tumor organoids: Opportunities and challenges to guide precision medicine. Cancer Cell. 2021;39(9): 1190-1201.
5.	Heo I, Dutta D, Schaefer DA, et al. Modelling Cryptosporidium infection in human small intestinal and lung organoids. Nat Microbiol, 2018, 3(7): 814-823.
6.	Zhao B, Ni C, Gao R, et al. Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids. Protein Cell, 2020, 11(10): 771-775.
7.	Takahashi T. Organoids for drug discovery and personalized medicine. Annu Rev Pharmacol Toxicol, 2019, 59: 447-462.
8.	Nishinakamura R. Human kidney organoids: progress and remaining challenges. Nat Rev Nephrol, 2019, 15(10): 613-624.
9.	Drost J, Clevers H. Organoids in cancer research. Nat Rev Cancer, 2018, 18(7): 407-418.
10.	LeSavage BL, Suhar RA, Broguiere N, et al. Next-generation cancer organoids. Nat Mater, 2022, 21(2): 143-159.
11.	Aboulkheyr Es H, Montazeri L, Aref AR, et al. Personalized cancer medicine: an organoid approach. Trends Biotechnol, 2018, 36(4): 358-371.
12.	Sugimoto S, Kobayashi E, Fujii M, et al. An organoid-based organ-repurposing approach to treat short bowel syndrome. Nature, 2021, 592(7852): 99-104.
13.	Sampaziotis F, Muraro D, Tysoe OC, et al. Cholangiocyte organoids can repair bile ducts after transplantation in the human liver. Science, 2021, 371(6531): 839-846.
14.	Shiota J, Samuelson LC, Razumilava N. Hepatobiliary Organoids and Their Applications for Studies of Liver Health and Disease: Are We There Yet? Hepatology. 2021;74(4): 2251-2263.
15.	Marsee A, Roos FJM, Verstegen MMA, et al. Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids. Cell Stem Cell. 2021;28(5): 816-832.

1. Kaluthantrige Don F, Huch M. Organoids, Where We Stand and Where We Go. Trends Mol Med. 2021;27(5): 416-418.
2. Sato T, Vries RG, Snippert HJ, et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature, 2009, 459(7244): 262-265.
3. Rossi G, Manfrin A, Lutolf MP. Progress and potential in organoid research. Nat Rev Genet. 2018;19(11): 671-687.
4. Veninga V, Voest EE. Tumor organoids: Opportunities and challenges to guide precision medicine. Cancer Cell. 2021;39(9): 1190-1201.
5. Heo I, Dutta D, Schaefer DA, et al. Modelling Cryptosporidium infection in human small intestinal and lung organoids. Nat Microbiol, 2018, 3(7): 814-823.
6. Zhao B, Ni C, Gao R, et al. Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids. Protein Cell, 2020, 11(10): 771-775.
7. Takahashi T. Organoids for drug discovery and personalized medicine. Annu Rev Pharmacol Toxicol, 2019, 59: 447-462.
8. Nishinakamura R. Human kidney organoids: progress and remaining challenges. Nat Rev Nephrol, 2019, 15(10): 613-624.
9. Drost J, Clevers H. Organoids in cancer research. Nat Rev Cancer, 2018, 18(7): 407-418.
10. LeSavage BL, Suhar RA, Broguiere N, et al. Next-generation cancer organoids. Nat Mater, 2022, 21(2): 143-159.
11. Aboulkheyr Es H, Montazeri L, Aref AR, et al. Personalized cancer medicine: an organoid approach. Trends Biotechnol, 2018, 36(4): 358-371.
12. Sugimoto S, Kobayashi E, Fujii M, et al. An organoid-based organ-repurposing approach to treat short bowel syndrome. Nature, 2021, 592(7852): 99-104.
13. Sampaziotis F, Muraro D, Tysoe OC, et al. Cholangiocyte organoids can repair bile ducts after transplantation in the human liver. Science, 2021, 371(6531): 839-846.
14. Shiota J, Samuelson LC, Razumilava N. Hepatobiliary Organoids and Their Applications for Studies of Liver Health and Disease: Are We There Yet? Hepatology. 2021;74(4): 2251-2263.
15. Marsee A, Roos FJM, Verstegen MMA, et al. Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids. Cell Stem Cell. 2021;28(5): 816-832.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Progress and prospects of organoid research

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