Research progress on significance of ABO blood group in colorectal cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YU Kaicong ^1,2 , YE Zi ^1,2 ,  WANG Xiaodong ¹ , LI Li ³

1. Division of Gastrointestinal Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. West China School of Medicine, Sichuan University, Chengdu 610041, P. R. China;
3. Colorectal Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

WANG Xiaodong, Email: wangxiaodong@wchscu.cn

Keywords：

ABO blood groups; colorectal cancer

DOI：

10.7507/1007-9424.202304034

Video：

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Objective To comprehend the role of ABO blood groups antigens in the occurrence, development, screening, treatment, and prognosis of colorectal cancer (CRC). Method The literature on the researches relevant to relation between ABO blood groups and CRC in recent years was reviewed and analyzed. Results There were two possible mechanisms relevant to the relation between the ABO blood groups antigens and the occurrence of CRC—Nucleotide polymorphisms in regulatory genes of the ABO blood groups antigens and lack of ABO blood groups antigens expression, and its abnormal expression in the cancer cells provided the clues for the screening of CRC. At present, it was found that the ABO blood groups were associated with the treatment and prognosis of the patients with CRC in the relatively fewer researches, but the detailed mechanism did not be clarified. Conclusions From the summary of the literature results, researchers have studied the role of ABO blood groups in CRC, and have obtained some conclusions with clinical significance in the occurrence, development, screening, treatment, and prognosis of patients with CRC, suggesting that it has certain research prospects. However, relevant to research is less, the conclusions need to be further verified.

Citation： YU Kaicong, YE Zi, WANG Xiaodong, LI Li. Research progress on significance of ABO blood group in colorectal cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2023, 30(7): 877-881. doi: 10.7507/1007-9424.202304034 Copy

1.	Zoratto F, Rossi L, Verrico M, et al. Focus on genetic and epigenetic events of colorectal cancer pathogenesis: implications for molecular diagnosis. Tumour Biol, 2014, 35(7): 6195-6206.
2.	Aird I, Bentall HH, Mehigan JA, et al. The blood groups in relation to peptic ulceration and carcinoma of colon, rectum, breast, and bronchus; an association between the ABO groups and peptic ulceration. Br Med J, 1954, 2(4883): 315-321.
3.	Yazer MH. What a difference 2 nucleotides make: a short review of ABO genetics. Transfus Med Rev, 2005, 19(3): 200-209.
4.	Labarrière N, Piau JP, Otry C, et al. H blood group antigen carried by CD44V modulates tumorigenicity of rat colon carcinoma cells. Cancer Res, 1994, 54(23): 6275-6281.
5.	Iwamoto S, Withers DA, Handa K, et al. Deletion of A-antigen in a human cancer cell line is associated with reduced promoter activity of CBF/NF-Y binding region, and possibly with enhanced DNA methylation of A transferase promoter. Glycoconj J, 1999, 16(10): 659-666.
6.	Broderick P, Carvajal-Carmona L, Pittman AM, et al. A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. Nat Genet, 2007, 39(11): 1315-1317.
7.	王志威, 于颖彦. ABO血型与消化系统肿瘤发生发展的关系. 诊断学理论与实践, 2011, 10(6): 567-570.
8.	Melzer D, Perry JR, Hernandez D, et al. A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet, 2008, 4(5): e1000072. doi: 10.1371/journal.pgen.1000072.
9.	Paré G, Chasman DI, Kellogg M, et al. Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6 578 women. PLoS Genet, 2008, 4(7): e1000118. doi: 10.1371/journal.pgen.1000118.
10.	Rieckmann P, Michel U, Albrecht M, et al. Soluble forms of intercellular adhesion molecule-1 (ICAM-1) block lymphocyte attachment to cerebral endothelial cells. J Neuroimmunol, 1995, 60(1-2): 9-15.
11.	Witkowska AM, Borawska MH. Soluble intercellular adhesion molecule-1 (sICAM-1): an overview. Eur Cytokine Netw, 2004, 15(2): 91-98.
12.	Van Alsten SC, Aversa JG, Santo L, et al. Association between ABO and Duffy blood types and circulating chemokines and cytokines. Genes Immun, 2021, 22(3): 161-171.
13.	Becker J, Pavlakovic H, Ludewig F, et al. Neuroblastoma progression correlates with downregulation of the lymphangiogenesis inhibitor sVEGFR-2. Clin Cancer Res, 2010, 16(5): 1431-1441.
14.	Shibata MA, Ambati J, Shibata E, et al. The endogenous soluble VEGF receptor-2 isoform suppresses lymph node metastasis in a mouse immunocompetent mammary cancer model. BMC Med, 2010, 8: 69. doi: 10.1186/1741-7015-8-69.
15.	Vasan SK, Hwang J, Rostgaard K, et al. ABO blood group and risk of cancer: a register-based cohort study of 1.6 million blood donors. Cancer Epidemiol, 2016, 44: 40-43.
16.	Yamamoto F, Clausen H, White T, et al. Molecular genetic basis of the histo-blood group ABO system. Nature, 1990, 345(6272): 229-233.
17.	Kominato Y, Hata Y, Takizawa H, et al. Expression of human histo-blood group ABO genes is dependent upon DNA methylation of the promoter region. J Biol Chem, 1999, 274(52): 37240-37250.
18.	Klutstein M, Nejman D, Greenfield R, et al. DNA methylation in cancer and aging. Cancer Res, 2016, 76(12): 3446-3450.
19.	Nakagoe T, Nanashima A, Sawai T, et al. Expression of blood group antigens A, B and H in carcinoma tissue correlates with a poor prognosis for colorectal cancer patients. J Cancer Res Clin Oncol, 2000, 126(7): 375-382.
20.	Watkins WM. The ABO blood group system: historical background. Transfus Med, 2001, 11(4): 243-265.
21.	Meng W, Cai SR, Zhou L, et al. Performance value of high risk factors in colorectal cancer screening in China. World J Gastroenterol, 2009, 15(48): 6111-6116.
22.	Ernst C, Thurin J, Atkinson B, et al. Monoclonal antibody localization of A and B isoantigens in normal and malignant fixed human tissues. Am J Pathol, 1984, 117(3): 451-461.
23.	Schoentag R, Primus FJ, Kuhns W. ABH and Lewis blood group expression in colorectal carcinoma. Cancer Res, 1987, 47(6): 1695-1700.
24.	Itzkowitz SH, Yuan M, Ferrell LD, et al. Cancer-associated alterations of blood group antigen expression in human colorectal polyps. Cancer Res, 1986, 46(11): 5976-5984.
25.	Yuan M, Itzkowitz SH, Palekar A, et al. Distribution of blood group antigens A, B, H, Lewisa, and Lewisb in human normal, fetal, and malignant colonic tissue. Cancer Res, 1985, 45(9): 4499-4511.
26.	Orntoft TF, Greenwell P, Clausen H, et al. Regulation of the oncodevelopmental expression of type 1 chain ABH and Lewis (b) blood group antigens in human colon by alpha-2-L-fucosylation. Gut, 1991, 32(3): 287-293.
27.	Tsuboi K, Asao T, Ide M, et al. Alpha1, 2fucosylation is a superior predictor of postoperative prognosis for colorectal cancer compared with blood group A, B, or sialyl Lewis X antigen generated within colorectal tumor tissues. Ann Surg Oncol, 2007, 14(6): 1880-1889.
28.	Yang JM, Byrd JC, Siddiki BB, et al. Alterations of O-glycan biosynthesis in human colon cancer tissues. Glycobiology, 1994, 4(6): 873-884.
29.	Yazawa S, Nakamura J, Asao T, et al. Aberrant alpha 1→2 fucosyltransferases found in human colorectal carcinoma involved in the accumulation of Leb and Y antigens in colorectal tumors. Jpn J Cancer Res, 1993, 84(9): 989-995.
30.	Pesec M, Sherertz T. Global health from a cancer care perspective. Future Oncol, 2015, 11(15): 2235-2245.
31.	Habibi M, Namimoghadam A, Korouni R, et al. Radiation-induced nausea and vomiting: is ABO blood group as important as radiation and patient-related factors? An observational study. Medicine (Baltimore), 2016, 95(31): e4334. doi: 10.1097/MD.0000000000004334.
32.	Luo Q, Pan M, Feng H, et al. ABO blood group antigen therapy: a potential new strategy against solid tumors. Sci Rep, 2021, 11(1): 16241. doi: 10.1038/s41598-021-95794-x.
33.	伊达(Jalayta RS). 结直肠癌患者ABO组织血型与肿瘤突变负荷的关系. 大连: 大连医科大学, 2021.
34.	Lee JS, Ro JY, Sahin AA, et al. Expression of blood-group antigen A—a favorable prognostic factor in non-small-cell lung cancer. N Engl J Med, 1991, 324(16): 1084-1090.
35.	Matsumoto H, Muramatsu H, Shimotakahara T, et al. Correlation of expression of ABH blood group carbohydrate antigens with metastatic potential in human lung carcinomas. Cancer, 1993, 72(1): 75-81.
36.	Nakagoe T, Fukushima K, Tuji T, et al. Immunohistochemical expression of ABH/Lewis-related antigens in primary breast carcinomas and metastatic lymph node lesions. Cancer Detect Prev, 1998, 22(6): 499-505.
37.	Fletcher RH. Carcinoembryonic antigen. Ann Intern Med, 1986, 104(1): 66-73.
38.	莫曾南. 广西复杂性疾病数量性状的全基因组扫描关联研究. 南宁: 广西医科大学, 2015.
39.	黄体强. ABH和Lewis组织-血型系统基因SNP与结直肠癌患者术前CEA水平相关性分析及其临床意义. 南宁: 广西医科大学, 2012.
40.	Ten Berg MJ, van den Bemt PM, Shantakumar S, et al. Thrombocytopenia in adult cancer patients receiving cytotoxic chemotherapy: results from a retrospective hospital-based cohort study. Drug Saf, 2011, 34(12): 1151-1160.
41.	Ogasawara K, Ueki J, Takenaka M, et al. Study on the expression of ABH antigens on platelets. Blood, 1993, 82(3): 993-999.
42.	Curtis BR, Edwards JT, Hessner MJ, et al. Blood group A and B antigens are strongly expressed on platelets of some individuals. Blood, 2000, 96(4): 1574-1581.
43.	Tanriverdi O. Is there a predictive significance of ABO blood group on chemotherapy-induced thrombocytopenia in patients with stage Ⅲ colon cancer?. Med Oncol, 2015, 32(1): 384. doi: 10.1007/s12032-014-0384-y.
44.	韦宇豪, 谢欣雨, 赵天浪, 等. 结直肠癌患者的ABO血型与手术类型及术后并发症的关系: 基于DACCA的真实世界数据研究. 中国普外基础与临床杂志, 2022, 29(9): 1226-1230.
45.	林容若, 张子为, 杜奕玲, 等. 结直肠癌患者血型对长期生存预后的影响: 基于DACCA数据库的真实世界分析. 中国普外基础与临床杂志, 2022, 29(11): 1506-1513.

1. Zoratto F, Rossi L, Verrico M, et al. Focus on genetic and epigenetic events of colorectal cancer pathogenesis: implications for molecular diagnosis. Tumour Biol, 2014, 35(7): 6195-6206.
2. Aird I, Bentall HH, Mehigan JA, et al. The blood groups in relation to peptic ulceration and carcinoma of colon, rectum, breast, and bronchus; an association between the ABO groups and peptic ulceration. Br Med J, 1954, 2(4883): 315-321.
3. Yazer MH. What a difference 2 nucleotides make: a short review of ABO genetics. Transfus Med Rev, 2005, 19(3): 200-209.
4. Labarrière N, Piau JP, Otry C, et al. H blood group antigen carried by CD44V modulates tumorigenicity of rat colon carcinoma cells. Cancer Res, 1994, 54(23): 6275-6281.
5. Iwamoto S, Withers DA, Handa K, et al. Deletion of A-antigen in a human cancer cell line is associated with reduced promoter activity of CBF/NF-Y binding region, and possibly with enhanced DNA methylation of A transferase promoter. Glycoconj J, 1999, 16(10): 659-666.
6. Broderick P, Carvajal-Carmona L, Pittman AM, et al. A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. Nat Genet, 2007, 39(11): 1315-1317.
7. 王志威, 于颖彦. ABO血型与消化系统肿瘤发生发展的关系. 诊断学理论与实践, 2011, 10(6): 567-570.
8. Melzer D, Perry JR, Hernandez D, et al. A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet, 2008, 4(5): e1000072. doi: 10.1371/journal.pgen.1000072.
9. Paré G, Chasman DI, Kellogg M, et al. Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6 578 women. PLoS Genet, 2008, 4(7): e1000118. doi: 10.1371/journal.pgen.1000118.
10. Rieckmann P, Michel U, Albrecht M, et al. Soluble forms of intercellular adhesion molecule-1 (ICAM-1) block lymphocyte attachment to cerebral endothelial cells. J Neuroimmunol, 1995, 60(1-2): 9-15.
11. Witkowska AM, Borawska MH. Soluble intercellular adhesion molecule-1 (sICAM-1): an overview. Eur Cytokine Netw, 2004, 15(2): 91-98.
12. Van Alsten SC, Aversa JG, Santo L, et al. Association between ABO and Duffy blood types and circulating chemokines and cytokines. Genes Immun, 2021, 22(3): 161-171.
13. Becker J, Pavlakovic H, Ludewig F, et al. Neuroblastoma progression correlates with downregulation of the lymphangiogenesis inhibitor sVEGFR-2. Clin Cancer Res, 2010, 16(5): 1431-1441.
14. Shibata MA, Ambati J, Shibata E, et al. The endogenous soluble VEGF receptor-2 isoform suppresses lymph node metastasis in a mouse immunocompetent mammary cancer model. BMC Med, 2010, 8: 69. doi: 10.1186/1741-7015-8-69.
15. Vasan SK, Hwang J, Rostgaard K, et al. ABO blood group and risk of cancer: a register-based cohort study of 1.6 million blood donors. Cancer Epidemiol, 2016, 44: 40-43.
16. Yamamoto F, Clausen H, White T, et al. Molecular genetic basis of the histo-blood group ABO system. Nature, 1990, 345(6272): 229-233.
17. Kominato Y, Hata Y, Takizawa H, et al. Expression of human histo-blood group ABO genes is dependent upon DNA methylation of the promoter region. J Biol Chem, 1999, 274(52): 37240-37250.
18. Klutstein M, Nejman D, Greenfield R, et al. DNA methylation in cancer and aging. Cancer Res, 2016, 76(12): 3446-3450.
19. Nakagoe T, Nanashima A, Sawai T, et al. Expression of blood group antigens A, B and H in carcinoma tissue correlates with a poor prognosis for colorectal cancer patients. J Cancer Res Clin Oncol, 2000, 126(7): 375-382.
20. Watkins WM. The ABO blood group system: historical background. Transfus Med, 2001, 11(4): 243-265.
21. Meng W, Cai SR, Zhou L, et al. Performance value of high risk factors in colorectal cancer screening in China. World J Gastroenterol, 2009, 15(48): 6111-6116.
22. Ernst C, Thurin J, Atkinson B, et al. Monoclonal antibody localization of A and B isoantigens in normal and malignant fixed human tissues. Am J Pathol, 1984, 117(3): 451-461.
23. Schoentag R, Primus FJ, Kuhns W. ABH and Lewis blood group expression in colorectal carcinoma. Cancer Res, 1987, 47(6): 1695-1700.
24. Itzkowitz SH, Yuan M, Ferrell LD, et al. Cancer-associated alterations of blood group antigen expression in human colorectal polyps. Cancer Res, 1986, 46(11): 5976-5984.
25. Yuan M, Itzkowitz SH, Palekar A, et al. Distribution of blood group antigens A, B, H, Lewisa, and Lewisb in human normal, fetal, and malignant colonic tissue. Cancer Res, 1985, 45(9): 4499-4511.
26. Orntoft TF, Greenwell P, Clausen H, et al. Regulation of the oncodevelopmental expression of type 1 chain ABH and Lewis (b) blood group antigens in human colon by alpha-2-L-fucosylation. Gut, 1991, 32(3): 287-293.
27. Tsuboi K, Asao T, Ide M, et al. Alpha1, 2fucosylation is a superior predictor of postoperative prognosis for colorectal cancer compared with blood group A, B, or sialyl Lewis X antigen generated within colorectal tumor tissues. Ann Surg Oncol, 2007, 14(6): 1880-1889.
28. Yang JM, Byrd JC, Siddiki BB, et al. Alterations of O-glycan biosynthesis in human colon cancer tissues. Glycobiology, 1994, 4(6): 873-884.
29. Yazawa S, Nakamura J, Asao T, et al. Aberrant alpha 1→2 fucosyltransferases found in human colorectal carcinoma involved in the accumulation of Leb and Y antigens in colorectal tumors. Jpn J Cancer Res, 1993, 84(9): 989-995.
30. Pesec M, Sherertz T. Global health from a cancer care perspective. Future Oncol, 2015, 11(15): 2235-2245.
31. Habibi M, Namimoghadam A, Korouni R, et al. Radiation-induced nausea and vomiting: is ABO blood group as important as radiation and patient-related factors? An observational study. Medicine (Baltimore), 2016, 95(31): e4334. doi: 10.1097/MD.0000000000004334.
32. Luo Q, Pan M, Feng H, et al. ABO blood group antigen therapy: a potential new strategy against solid tumors. Sci Rep, 2021, 11(1): 16241. doi: 10.1038/s41598-021-95794-x.
33. 伊达(Jalayta RS). 结直肠癌患者ABO组织血型与肿瘤突变负荷的关系. 大连: 大连医科大学, 2021.
34. Lee JS, Ro JY, Sahin AA, et al. Expression of blood-group antigen A—a favorable prognostic factor in non-small-cell lung cancer. N Engl J Med, 1991, 324(16): 1084-1090.
35. Matsumoto H, Muramatsu H, Shimotakahara T, et al. Correlation of expression of ABH blood group carbohydrate antigens with metastatic potential in human lung carcinomas. Cancer, 1993, 72(1): 75-81.
36. Nakagoe T, Fukushima K, Tuji T, et al. Immunohistochemical expression of ABH/Lewis-related antigens in primary breast carcinomas and metastatic lymph node lesions. Cancer Detect Prev, 1998, 22(6): 499-505.
37. Fletcher RH. Carcinoembryonic antigen. Ann Intern Med, 1986, 104(1): 66-73.
38. 莫曾南. 广西复杂性疾病数量性状的全基因组扫描关联研究. 南宁: 广西医科大学, 2015.
39. 黄体强. ABH和Lewis组织-血型系统基因SNP与结直肠癌患者术前CEA水平相关性分析及其临床意义. 南宁: 广西医科大学, 2012.
40. Ten Berg MJ, van den Bemt PM, Shantakumar S, et al. Thrombocytopenia in adult cancer patients receiving cytotoxic chemotherapy: results from a retrospective hospital-based cohort study. Drug Saf, 2011, 34(12): 1151-1160.
41. Ogasawara K, Ueki J, Takenaka M, et al. Study on the expression of ABH antigens on platelets. Blood, 1993, 82(3): 993-999.
42. Curtis BR, Edwards JT, Hessner MJ, et al. Blood group A and B antigens are strongly expressed on platelets of some individuals. Blood, 2000, 96(4): 1574-1581.
43. Tanriverdi O. Is there a predictive significance of ABO blood group on chemotherapy-induced thrombocytopenia in patients with stage Ⅲ colon cancer?. Med Oncol, 2015, 32(1): 384. doi: 10.1007/s12032-014-0384-y.
44. 韦宇豪, 谢欣雨, 赵天浪, 等. 结直肠癌患者的ABO血型与手术类型及术后并发症的关系: 基于DACCA的真实世界数据研究. 中国普外基础与临床杂志, 2022, 29(9): 1226-1230.
45. 林容若, 张子为, 杜奕玲, 等. 结直肠癌患者血型对长期生存预后的影响: 基于DACCA数据库的真实世界分析. 中国普外基础与临床杂志, 2022, 29(11): 1506-1513.

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Research progress on significance of ABO blood group in colorectal cancer

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