Research advances of tumor<b>-</b>associated neutrophils_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YUAN Jingsheng ^1,2 ,  YANG Jiayin ^1,2

1. Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. Liver Transplant Center, Transplant Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

YANG Jiayin, Email: docjackyang@163.com

Keywords：

tumour-associated neutrophil; heterogeneity; immunotherapy; phenotypic classification

DOI：

10.7507/1007-9424.202304046

Video：

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Abstract Full text Figures/Tables Video References Cited by

Neutrophils are the most abundant myeloid-derived eukaryotic cells in human blood with increasingly recognized as important regulators of cancer progression. However, the functional importance of tumor-associated neutrophils (TANs) is often overlooked due to their short-lived, terminally differentiated, non-proliferative properties. In recent years, a wealth of evidences obtained from experimental tumor models and cancer patients had indicated that TANs had obvious heterogeneity in morphology and function, and TANs had dual functions of pro- and anti-tumor in cancer patients. This review provides an adequate overview of the heterogeneity and distinct roles of neutrophils.

Citation： YUAN Jingsheng, YANG Jiayin. Research advances of tumor-associated neutrophils. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2023, 30(6): 650-652. doi: 10.7507/1007-9424.202304046 Copy

1.	Takasugi M, Yoshida Y, Ohtani N. Cellular senescence and the tumour microenvironment. Mol Oncol, 2022, 16(18): 3333-3351.
2.	Hinshaw DC, Shevde LA. The tumor microenvironment innately modulates cancer progression. Cancer Res. 2019; 79(18): 4557-4566.
3.	Masucci MT, Minopoli M, Del Vecchio S, et al. The emerging role of neutrophil extracellular traps (NETs) in tumor progression and metastasis. Front Immunol, 2020, 11: 1749. doi: 10.3389/fimmu.2020.01749.
4.	Xiong S, Dong L, Cheng L. Neutrophils in cancer carcinogenesis and metastasis. J Hematol Oncol, 2021, 14(1): 173. doi: 10.1186/s13045-021-01187-y.
5.	Sagiv JY, Michaeli J, Assi S, et al. Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer. Cell Rep, 2015, 10(4): 562-573.
6.	Brandau S, Trellakis S, Bruderek K, et al. Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties. J Leukoc Biol, 2011, 89(2): 311-317.
7.	Lang S, Bruderek K, Kaspar C, et al. Clinical relevance and suppressive capacity of human myeloid-derived suppressor cell subsets. Clin Cancer Res, 2018, 24(19): 4834-4844.
8.	Granot Z, Fridlender ZG. Plasticity beyond cancer cells and the “immunosuppressive switch”. Cancer Res, 2015, 75(21): 4441-4445.
9.	Sionov RV, Fridlender ZG, Granot Z. The multifaceted roles neutrophils play in the tumor microenvironment. Cancer Microenviron, 2015, 8(3): 125-158.
10.	Andzinski L, Kasnitz N, Stahnke S, et al. Type Ⅰ IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human. Int J Cancer, 2016, 138(8): 1982-1993.
11.	Wu CF, Andzinski L, Kasnitz N, et al. The lack of type Ⅰ interferon induces neutrophil-mediated pre-metastatic niche formation in the mouse lung. Int J Cancer, 2015, 137(4): 837-847.
12.	Mishalian I, Bayuh R, Eruslanov E, et al. Neutrophils recruit regulatory T-cells into tumors via secretion of CCL17-a new mechanism of impaired antitumor immunity. Int J Cancer, 2014, 135(5): 1178-1186.
13.	Demers M, Krause DS, Schatzberg D, et al. Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis. Proc Natl Acad Sci U S A, 2012, 109(32): 13076-13081.
14.	Que H, Fu Q, Lan T, et al. Tumor-associated neutrophils and neutrophil-targeted cancer therapies. Biochim Biophys Acta Rev Cancer, 2022, 1877(5): 188762. doi: 10.1016/j.bbcan.2022.188762.
15.	Yunna C, Mengru H, Lei W, et al. Macrophage M1/M2 polarization. Eur J Pharmacol, 2020, 877: 173090. doi: 10.1016/j.ejphar.2020.173090.
16.	Shaul ME, Fridlender ZG. Tumour-associated neutrophils in patients with cancer. Nat Rev Clin Oncol, 2019, 16(10): 601-620.
17.	Jaillon S, Ponzetta A, Di Mitri D, et al. Neutrophil diversity and plasticity in tumour progression and therapy. Nat Rev Cancer, 2020, 20(9): 485-503.
18.	Hedrick CC, Malanchi I. Neutrophils in cancer: heterogeneous and multifaceted. Nat Rev Immunol, 2022, 22(3): 173-187.

1. Takasugi M, Yoshida Y, Ohtani N. Cellular senescence and the tumour microenvironment. Mol Oncol, 2022, 16(18): 3333-3351.
2. Hinshaw DC, Shevde LA. The tumor microenvironment innately modulates cancer progression. Cancer Res. 2019; 79(18): 4557-4566.
3. Masucci MT, Minopoli M, Del Vecchio S, et al. The emerging role of neutrophil extracellular traps (NETs) in tumor progression and metastasis. Front Immunol, 2020, 11: 1749. doi: 10.3389/fimmu.2020.01749.
4. Xiong S, Dong L, Cheng L. Neutrophils in cancer carcinogenesis and metastasis. J Hematol Oncol, 2021, 14(1): 173. doi: 10.1186/s13045-021-01187-y.
5. Sagiv JY, Michaeli J, Assi S, et al. Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer. Cell Rep, 2015, 10(4): 562-573.
6. Brandau S, Trellakis S, Bruderek K, et al. Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties. J Leukoc Biol, 2011, 89(2): 311-317.
7. Lang S, Bruderek K, Kaspar C, et al. Clinical relevance and suppressive capacity of human myeloid-derived suppressor cell subsets. Clin Cancer Res, 2018, 24(19): 4834-4844.
8. Granot Z, Fridlender ZG. Plasticity beyond cancer cells and the “immunosuppressive switch”. Cancer Res, 2015, 75(21): 4441-4445.
9. Sionov RV, Fridlender ZG, Granot Z. The multifaceted roles neutrophils play in the tumor microenvironment. Cancer Microenviron, 2015, 8(3): 125-158.
10. Andzinski L, Kasnitz N, Stahnke S, et al. Type Ⅰ IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human. Int J Cancer, 2016, 138(8): 1982-1993.
11. Wu CF, Andzinski L, Kasnitz N, et al. The lack of type Ⅰ interferon induces neutrophil-mediated pre-metastatic niche formation in the mouse lung. Int J Cancer, 2015, 137(4): 837-847.
12. Mishalian I, Bayuh R, Eruslanov E, et al. Neutrophils recruit regulatory T-cells into tumors via secretion of CCL17-a new mechanism of impaired antitumor immunity. Int J Cancer, 2014, 135(5): 1178-1186.
13. Demers M, Krause DS, Schatzberg D, et al. Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis. Proc Natl Acad Sci U S A, 2012, 109(32): 13076-13081.
14. Que H, Fu Q, Lan T, et al. Tumor-associated neutrophils and neutrophil-targeted cancer therapies. Biochim Biophys Acta Rev Cancer, 2022, 1877(5): 188762. doi: 10.1016/j.bbcan.2022.188762.
15. Yunna C, Mengru H, Lei W, et al. Macrophage M1/M2 polarization. Eur J Pharmacol, 2020, 877: 173090. doi: 10.1016/j.ejphar.2020.173090.
16. Shaul ME, Fridlender ZG. Tumour-associated neutrophils in patients with cancer. Nat Rev Clin Oncol, 2019, 16(10): 601-620.
17. Jaillon S, Ponzetta A, Di Mitri D, et al. Neutrophil diversity and plasticity in tumour progression and therapy. Nat Rev Cancer, 2020, 20(9): 485-503.
18. Hedrick CC, Malanchi I. Neutrophils in cancer: heterogeneous and multifaceted. Nat Rev Immunol, 2022, 22(3): 173-187.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research advances of tumor-associated neutrophils

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