腹股沟富于细胞性血管纤维瘤1例报道并文献复习_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

陈嘉欣 ,  陈明 , 林满洲

广东医科大学附属医院疝和腹壁外科（广东湛江 524000）;

Corresponding author：

陈明, Email: cm641211@126.com

Keywords：

腹股沟; 富于细胞性血管纤维瘤; 间叶性肿瘤; 病理特征; 诊断; 治疗; 预后

DOI：

10.7507/1007-9424.202305057

Video：

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目的探讨富于细胞性血管纤维瘤（cellular angiofibroma，CAF）的影像学表现、病理特征、临床诊断、鉴别诊断以及治疗和预后。方法报道1例腹股沟区CAF的临床表现、病理特征及治疗情况，并结合国内外相关文献报道的142例病例资料进行分析。结果本例65岁男性患者，因发现左侧腹股沟区肿块5年且逐渐长大而入院行手术完整切除左侧腹股沟区肿物，肿物约7 cm×3 cm×5 cm大，质地较韧，边界清晰，术后病理学检查见肿物由大量短梭形细胞和小到中等大的血管组成，边界清晰，可见纤维性包膜。免疫组织化学示雌激素受体（部分 +）、平滑肌肌动蛋白（血管 +）、CD34（+）及CD117（+），Sox-10、S-100、Dog-1、结蛋白、P16、CDK4、mdm2、上皮膜抗原、孕激素受体、视网膜母细胞肿瘤抑制蛋白及神经营养因子络氨酸激酶均为（–）。最终诊断为CAF，术后随访3个月肿瘤无复发。复习国内外文献报道的142例CAF患者资料，肿瘤主要位于外阴（74例）和阴囊-腹股沟区（47例），21例位于其他部位，均接受手术治疗。CAF通常表现为触及无痛性肿块，肿瘤大体呈圆形、卵圆形或分叶状，镜下可见瘤体由大量梭形或短梭形细胞及丰富中小血管组成，间质胶原纤维化并伴有炎性细胞浸润，免疫组织化学特征表现为波形蛋白、CD34及平滑肌肌动蛋白阳性，部分表达雌激素受体和孕激素受体，结蛋白及S-100呈阴性。治疗以完整切除肿瘤为主，预后良好。结论 CAF为好发于两性生殖道远端的良性间叶性肿瘤，治疗以手术完整切除肿瘤为主，预后良好，术后需严密随访。

Citation： 陈嘉欣, 陈明, 林满洲. 腹股沟富于细胞性血管纤维瘤1例报道并文献复习. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2023, 30(11): 1367-1369. doi: 10.7507/1007-9424.202305057 Copy

1.	Nucci MR, Granter SR, Fletcher CD. Cellular angiofibroma: a benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma. Am J Surg Pathol, 1997, 21(6): 636-644.
2.	李祝庆, 张巍, 魏鹏. 右中指富于细胞性血管纤维瘤一例. 中华显微外科杂志, 2022, 45(1): 101-103.
3.	Bloom J, Jordan E, Baratta VM, et al. Cellular angiofibroma presenting as a subepithelial rectal mass. ACG Case Rep J, 2020, 7(11): e00471.
4.	Liu Y, Xu Y, Wang Q, et al. Cellular angiofibroma in the hypopharynx: a case report. Medicine (Baltimore), 2019. , 98(50): e18385.
5.	Lane JE, Walker AN, Mullis EN Jr, et al. Cellular angiofibroma of the vulva. Gynecol Oncol, 2001, 81(2): 326-329.
6.	Ahmadnia H, Kamalati A, Dolati M, et al. Angiofibroma of the vulva. J Cutan Med Surg, 2014, 18(3): 203-205.
7.	Mandato VD, Aguzzoli L, Cavazza A, et al. Coxalgia? Call the gynecologist. J Minim Invasive Gynecol, 2015, 22(4): 663-667.
8.	Flucke U, van Krieken JH, Mentzel T. Cellular angiofibroma: analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma. Mod Pathol, 2011, 24(1): 82-89.
9.	Maggiani F, Debiec-Rychter M, Vanbockrijck M, et al. Cellular angiofibroma: another mesenchymal tumour with 13q14 involvement, suggesting a link with spindle cell lipoma and (extra)-mammary myofibroblastoma. Histopathology, 2007, 51(3): 410-412.
10.	赵静, 牛惠萍, 任路平. 大阴唇富于细胞性血管纤维瘤超声表现1例. 中国超声医学杂志, 2021, 37(9): 985.
11.	Reder D, Kedan F, Garzon S, et al. Vulvar angiofibroma: a case report of a rare cause of huge vulvar mass. J Obstet Gynaecol, 2021, 41(6): 990-991.
12.	陈诺, 刘文飞, 常晓丹, 等. 腹股沟富于细胞性血管纤维瘤1例. 中国医学影像学杂志, 2022, 30(8): 814-815.
13.	Kamitani R, Matsumoto K, Fujiwara S, et al. A case of inguinal cellular angiofibroma. IJU Case Rep, 2020, 3(2): 69-71.
14.	龚智泉, 刘欣, 王力夫, 等. 富于细胞性血管纤维瘤3例临床病理分析. 临床与实验病理学杂志, 2017, 33(3): 318-320.
15.	Chen E, Fletcher CD. Cellular angiofibroma with atypia or sarcomatous transformation: clinicopathologic analysis of 13 cases. Am J Surg Pathol, 2010, 34(5): 707-714.
16.	McCluggage WG, Perenyei M, Irwin ST. Recurrent cellular angiofibroma of the vulva. J Clin Pathol, 2002, 55(6): 477-479.

1. Nucci MR, Granter SR, Fletcher CD. Cellular angiofibroma: a benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma. Am J Surg Pathol, 1997, 21(6): 636-644.
2. 李祝庆, 张巍, 魏鹏. 右中指富于细胞性血管纤维瘤一例. 中华显微外科杂志, 2022, 45(1): 101-103.
3. Bloom J, Jordan E, Baratta VM, et al. Cellular angiofibroma presenting as a subepithelial rectal mass. ACG Case Rep J, 2020, 7(11): e00471.
4. Liu Y, Xu Y, Wang Q, et al. Cellular angiofibroma in the hypopharynx: a case report. Medicine (Baltimore), 2019. , 98(50): e18385.
5. Lane JE, Walker AN, Mullis EN Jr, et al. Cellular angiofibroma of the vulva. Gynecol Oncol, 2001, 81(2): 326-329.
6. Ahmadnia H, Kamalati A, Dolati M, et al. Angiofibroma of the vulva. J Cutan Med Surg, 2014, 18(3): 203-205.
7. Mandato VD, Aguzzoli L, Cavazza A, et al. Coxalgia? Call the gynecologist. J Minim Invasive Gynecol, 2015, 22(4): 663-667.
8. Flucke U, van Krieken JH, Mentzel T. Cellular angiofibroma: analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma. Mod Pathol, 2011, 24(1): 82-89.
9. Maggiani F, Debiec-Rychter M, Vanbockrijck M, et al. Cellular angiofibroma: another mesenchymal tumour with 13q14 involvement, suggesting a link with spindle cell lipoma and (extra)-mammary myofibroblastoma. Histopathology, 2007, 51(3): 410-412.
10. 赵静, 牛惠萍, 任路平. 大阴唇富于细胞性血管纤维瘤超声表现1例. 中国超声医学杂志, 2021, 37(9): 985.
11. Reder D, Kedan F, Garzon S, et al. Vulvar angiofibroma: a case report of a rare cause of huge vulvar mass. J Obstet Gynaecol, 2021, 41(6): 990-991.
12. 陈诺, 刘文飞, 常晓丹, 等. 腹股沟富于细胞性血管纤维瘤1例. 中国医学影像学杂志, 2022, 30(8): 814-815.
13. Kamitani R, Matsumoto K, Fujiwara S, et al. A case of inguinal cellular angiofibroma. IJU Case Rep, 2020, 3(2): 69-71.
14. 龚智泉, 刘欣, 王力夫, 等. 富于细胞性血管纤维瘤3例临床病理分析. 临床与实验病理学杂志, 2017, 33(3): 318-320.
15. Chen E, Fletcher CD. Cellular angiofibroma with atypia or sarcomatous transformation: clinicopathologic analysis of 13 cases. Am J Surg Pathol, 2010, 34(5): 707-714.
16. McCluggage WG, Perenyei M, Irwin ST. Recurrent cellular angiofibroma of the vulva. J Clin Pathol, 2002, 55(6): 477-479.

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