毒蕈碱样胆碱能受体在慢性阻塞性肺疾病防治中的研究进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

黄晓芬 , 李金田 , 张毅 , 孙少伯 ,  李娟 , 余森豪

甘肃中医药大学敦煌医学与转化教育部重点实验室中药药理与毒理学省级重点实验室（甘肃兰州 730000）;

Corresponding author：

李娟, Email: gansulijuan@sina.com

Keywords：

DOI：

10.7507/1671-6205.2016024

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Citation： 黄晓芬, 李金田, 张毅, 孙少伯, 李娟, 余森豪. 毒蕈碱样胆碱能受体在慢性阻塞性肺疾病防治中的研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2016, 15(1): 95-98. doi: 10.7507/1671-6205.2016024 Copy

1.	Kistemaker LE, Oenema TA, Meurs H, et al. Regulation of airway inflammation and remodeling by muscarinic receptors:perspectives on anticholinergic therapy in asthma and COPD. Life Sciences, 2012, 91:1126-1133.
2.	Hu J, Thor D, Zhou Y, et al.Structural aspect of M3 muscarinic acetylcholine receptor dimer formation and activation. FASEB J, 2012, 2:604-616.
3.	孙科.M受体-G蛋白信号转导途径研究进展.国际药学研究杂志, 2008, 35:87-90.
4.	Ikeda T, Anisuzzaman AS, Yoshiki H, et al. Regional quantification of muscarinic acetylcholine receptors andβ-adrenoceptors in human airways. Br J Pharmacol, 2012, 166:1804-1814.
5.	王海波, 张海鹏.毒蕈碱乙酰胆碱受体表达和功能的调节及其介导新的信号途径.国外医学(生理、病理科学与临床分册), 2003, 23:76-78.
6.	Jiang ST, Li YF, Zhang CL.et al.M1 muscarinic acetylcholine receptor in Alzheimer's disease. Neurosci Bull, 2014, 30:295-307.
7.	姚婉贞, 王国扬.慢性阻塞性肺疾病的气道毒蕈碱M受体变化与抗胆碱治疗的研究.中华结核和呼吸杂志, 2005, 28:484-485.
8.	Lammers JW, Minette P, McCusker M, et al. The role of prinzepine-sensitive (M1) muscarinic receptors in vagally mediated bronchoconstriction in humans. Am Rev Respir Dis, 1989, 139:446-449.
9.	Fisher JT, Vincent SG, Gomeza J, et al. Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors. FASEB J, 2010, 18:711-713.
10.	Milara J, Serrano A, Peiró T, et al.Aclidinium inhibits human lung fibroblast to myofibroblast transition. Thorax, 2012, 67:229-237.
11.	Billington CK, Penn RB.M3 muscarinic acetylcholine receptor regulation in the airway. Am Respir Cell Mol Biol, 2002, 26:269-272.
12.	Cao R, Dong XW, Jiang JX, et al. M3 muscarinic receptor antagonist bencycloquidium bromide attenuates allergic airway inflammation, hyperresponsiveness and remodeling in mice. Eur J Pharmacol, 2011, 655:83-90.
13.	Selivanova PA, Kulikov ES, Kozina OV, et al. Differential expression of theβ, 2-adrenoreceptor and M3-cholinoreceptor genes in bronchial mucosa of patients with asthma and chronic obstructive pulmonary disease. Ann Allergy Asthma Immunol, 2012, 108:39-43.
14.	董广锋, 刘瑞娟, 郭兴华.噻托溴铵抑制慢性阻塞性肺疾病气道重塑及炎症反应机制的研究进展.山东医药, 2014, 54:106-107.
15.	Rogers DF. Motor control of airway goblet cells and glands. Respir Physiol, 2001, 125:129-144.
16.	Kelly EA, Jarjour NN. Role of matrix metalloproteinases in asthma. Curr Opin Pulm Med, 2003, 9:28-33.
17.	Grainge CL, Lau LC, Ward JA, et al. Effect of bronchoconstriction on airway remodeling in asthma. N Engl J Med, 2011, 364:2006-2015.
18.	Oenema TA, Smit, Smedinga L, et al. Muscarinicreceptor stimulation augments TGF-β1-induced contractile protein expression by airway smooth muscle cells. Am J Physiol, 2012, 303:L589-L597.
19.	Bos IS, Gosens R, Zuidhof AB, et al. Inhibition of allergen-induced airway remodelling by tiotropium and budesonide:a comparison. Eur Respir J, 2007, 30:653-661.
20.	Pera T, Zuidhof A, Valadas J, et al. Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD. Eur Respir J, 2011, 38:789-796.
21.	白新会.噻托溴铵治疗稳定期慢阻肺临床研究.当代医学, 2011, 17:25-26.
22.	陈利, 陶玉坚, 林郁, 等.噻托溴铵粉吸入剂治疗稳定期中重度COPD患者的临床疗效观察.现代生物医学进展, 2012, 27:5319-5321.
23.	黄锦伦.噻托溴铵粉吸入剂治疗慢性阻塞性肺疾病的治疗体会.中国医学工程, 2015, 23:135.

1. Kistemaker LE, Oenema TA, Meurs H, et al. Regulation of airway inflammation and remodeling by muscarinic receptors:perspectives on anticholinergic therapy in asthma and COPD. Life Sciences, 2012, 91:1126-1133.
2. Hu J, Thor D, Zhou Y, et al.Structural aspect of M3 muscarinic acetylcholine receptor dimer formation and activation. FASEB J, 2012, 2:604-616.
3. 孙科.M受体-G蛋白信号转导途径研究进展.国际药学研究杂志, 2008, 35:87-90.
4. Ikeda T, Anisuzzaman AS, Yoshiki H, et al. Regional quantification of muscarinic acetylcholine receptors andβ-adrenoceptors in human airways. Br J Pharmacol, 2012, 166:1804-1814.
5. 王海波, 张海鹏.毒蕈碱乙酰胆碱受体表达和功能的调节及其介导新的信号途径.国外医学(生理、病理科学与临床分册), 2003, 23:76-78.
6. Jiang ST, Li YF, Zhang CL.et al.M1 muscarinic acetylcholine receptor in Alzheimer's disease. Neurosci Bull, 2014, 30:295-307.
7. 姚婉贞, 王国扬.慢性阻塞性肺疾病的气道毒蕈碱M受体变化与抗胆碱治疗的研究.中华结核和呼吸杂志, 2005, 28:484-485.
8. Lammers JW, Minette P, McCusker M, et al. The role of prinzepine-sensitive (M1) muscarinic receptors in vagally mediated bronchoconstriction in humans. Am Rev Respir Dis, 1989, 139:446-449.
9. Fisher JT, Vincent SG, Gomeza J, et al. Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors. FASEB J, 2010, 18:711-713.
10. Milara J, Serrano A, Peiró T, et al.Aclidinium inhibits human lung fibroblast to myofibroblast transition. Thorax, 2012, 67:229-237.
11. Billington CK, Penn RB.M3 muscarinic acetylcholine receptor regulation in the airway. Am Respir Cell Mol Biol, 2002, 26:269-272.
12. Cao R, Dong XW, Jiang JX, et al. M3 muscarinic receptor antagonist bencycloquidium bromide attenuates allergic airway inflammation, hyperresponsiveness and remodeling in mice. Eur J Pharmacol, 2011, 655:83-90.
13. Selivanova PA, Kulikov ES, Kozina OV, et al. Differential expression of theβ, 2-adrenoreceptor and M3-cholinoreceptor genes in bronchial mucosa of patients with asthma and chronic obstructive pulmonary disease. Ann Allergy Asthma Immunol, 2012, 108:39-43.
14. 董广锋, 刘瑞娟, 郭兴华.噻托溴铵抑制慢性阻塞性肺疾病气道重塑及炎症反应机制的研究进展.山东医药, 2014, 54:106-107.
15. Rogers DF. Motor control of airway goblet cells and glands. Respir Physiol, 2001, 125:129-144.
16. Kelly EA, Jarjour NN. Role of matrix metalloproteinases in asthma. Curr Opin Pulm Med, 2003, 9:28-33.
17. Grainge CL, Lau LC, Ward JA, et al. Effect of bronchoconstriction on airway remodeling in asthma. N Engl J Med, 2011, 364:2006-2015.
18. Oenema TA, Smit, Smedinga L, et al. Muscarinicreceptor stimulation augments TGF-β1-induced contractile protein expression by airway smooth muscle cells. Am J Physiol, 2012, 303:L589-L597.
19. Bos IS, Gosens R, Zuidhof AB, et al. Inhibition of allergen-induced airway remodelling by tiotropium and budesonide:a comparison. Eur Respir J, 2007, 30:653-661.
20. Pera T, Zuidhof A, Valadas J, et al. Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD. Eur Respir J, 2011, 38:789-796.
21. 白新会.噻托溴铵治疗稳定期慢阻肺临床研究.当代医学, 2011, 17:25-26.
22. 陈利, 陶玉坚, 林郁, 等.噻托溴铵粉吸入剂治疗稳定期中重度COPD患者的临床疗效观察.现代生物医学进展, 2012, 27:5319-5321.
23. 黄锦伦.噻托溴铵粉吸入剂治疗慢性阻塞性肺疾病的治疗体会.中国医学工程, 2015, 23:135.

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毒蕈碱样胆碱能受体在慢性阻塞性肺疾病防治中的研究进展

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