支气管镜介入治疗在肺移植术后气道并发症的应用研究进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

叶泽慧 ,  王健

重庆医科大学附属儿童医院呼吸科，国家儿童健康与疾病临床医学研究中心，儿童发育疾病研究教育部重点实验室，儿童代谢与炎症性疾病重庆市重点实验室（重庆 400014）;

Corresponding author：

王健, Email: dawangjiannihao@163.com

Keywords：

DOI：

10.7507/1671-6205.202405116

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Citation： 叶泽慧, 王健. 支气管镜介入治疗在肺移植术后气道并发症的应用研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2025, 24(1): 71-75. doi: 10.7507/1671-6205.202405116 Copy

1.	岳冰清, 陈静瑜. 儿童肺移植治疗. 中国实用儿科杂志, 2023, 38(3): 215-217.
2.	Cheng GS, Madtes DK, Edelman J, et al. Outcomes of lung transplantation after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant, 2014, 20(8): 1169-1175.
3.	高霏, 卫栋, 吴波, 等. 双肺移植治疗骨髓移植术后闭塞性细支气管炎一例报告并文献复习. 中华血液学杂志, 2013, 34(8): 669-672.
4.	Iguidbashian J, Cotton J, King RW, et al. Survival following lung transplantation: A population-based nested case-control study. J Card Surg, 2022, 37(5): 1153-1160.
5.	Chambers DC, Perch M, Zuckermann A, et al. International Society for Heart and Lung Transplantation. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult lung transplantation report - 2021; Focus on recipient characteristics. J Heart Lung Transplant, 2021, 40(10): 1060-1072.
6.	Delbove A, Senage T, Gazengel P, et al. Incidence and risk factors of anastomotic complications after lung transplantation. Ther Adv Respir Dis, 2022, 16: 17534666221110354.
7.	Awori Hayanga JW, Aboagye JK, Shigemura N, et al. Airway complications after lung transplantation: Contemporary survival and outcomes. J Heart Lung Transplant, 2016, 35(10): 1206-1211.
8.	Olland A, Reeb J, Puyraveau M, et al. Bronchial complications after lung transplantation are associated with primary lung graft dysfunction and surgical technique. J Heart Lung Transplant, 2017, 36(2): 157-165.
9.	Patoir A, Luchez A, Tiffet O, et al. Airway complications after lung transplantation: benefit of a conservative bronchoscopy strategy. J Thorac Dis, 2020, 12(5): 2625-2634.
10.	吴波, 张稷, 朱艳红, 等. 肺移植术后气道并发症临床分析. 南京医科大学学报(自然科学版), 2009, 29(12): 1736-1738.
11.	Mahajan AK, Folch E, Khandhar SJ, et al. The diagnosis and management of airway complications following lung transplantation. Chest, 2017, 152(3): 627-638.
12.	Frye L, Machuzak M. Airway Complications After Lung Transplantation. Clin Chest Med, 2017, 38(4): 693-706.
13.	Crespo MM, McCarthy DP, Hopkins PM, et al. ISHLT Consensus Statement on adult and pediatric airway complications after lung transplantation: Definitions, grading system, and therapeutics. J Heart Lung Transplant, 2018, 37(5): 548-563.
14.	Santacruz JF, Mehta AC. Airway complications and management after lung transplantation: ischemia, dehiscence, and stenosis. Proc Am Thorac Soc, 2009, 6(1): 79-93.
15.	Debray MP, Dauriat G, Khalil A, et al. Diagnostic accuracy of low-mA chest CT reconstructed with Model Based Iterative Reconstruction in the detection of early pleuro-pulmonary complications following a lung transplantation. Eur Radiol, 2016, 26(9): 3138-3146.
16.	吴波, 郑明锋, 张稷, 等. 肺移植术后气道狭窄并发症的诊断和治疗. 中华器官移植杂志, 2012, 33(7): 422-425.
17.	史灵芝, 黄桁, 刘明昭, 等. 肺移植术后需要临床干预的气道狭窄患者生存结局的影响因素. 器官移植, 2024, 15(2): 236-243.
18.	Douros K, Kremmydas G, Grammeniatis V, et al. Helical multi-detector CT scan as a tool for diagnosing tracheomalacia in children. Pediatr Pulmonol, 2019, 54(1): 47-52.
19.	Tendulkar RD, Fleming PA, Reddy CA, et al. High-dose-rate endobronchial brachytherapy for recurrent airway obstruction from hyperplastic granulation tissue. Int J Radiat Oncol Biol Phys, 2008, 70(3): 701-706.
20.	Walters DM, Kuckelman JP, Mulligan MS. Electromagnetic navigational bronchoscopic airway recanalization in patients with vanishing bronchus. J Surg Res, 2018, 231: 154-160.
21.	王婷, 张杰, 邱小建, 等. 气管镜下介入治疗瘢痕性气道狭窄的有效性及影响因素分析. 中华结核和呼吸杂志, 2020, 43(9): 784-790.
22.	Mora-Cuesta VM, Tello-Mena S, Izquierdo-Cuervo S, et al. Bronchial stenosis after lung transplantation from cDCD donors using simultaneous abdominal normothermic regional perfusion: a single-center experience. Transplantation, 2023, 107(11): 2415-2423.
23.	Liang W, Hu P, Guo W, et al. Appropriate treatment sessions of flexible bronchoscopic balloon dilation for patients with nonmalignant central airway stenosis. Ther Adv Respir Dis, 2019, 13: 1753466619831966.
24.	丁银锋, 李付琦, 黄海东, 等. 支气管镜介入治疗肺移植术后中心气道狭窄的疗效分析. 中国呼吸与危重监护杂志, 2020, 19(3): 276-280.
25.	Greer M, Fuehner T, Warnecke G, et al. Paclitaxel-coated balloons in refractory nonanastomostic airway stenosis following lung transplantation. Am J Transplant, 2014, 14(10): 2400-2405.
26.	Davidson KR, Elmasri M, Wahidi MM, et al. Management of lung transplant bronchial stenosis with mitomycin C. J Bronchology Interv Pulmonol, 2019, 26(2): 124-128.
27.	倪彩云, 刘霞, 马静, 等. 支气管镜下冷冻治疗儿童肉芽及瘢痕组织导致的下气道狭窄及阻塞22例. 中华儿科杂志, 2012, 50(1): 45-49.
28.	许煊, 刘玺诚, 祝彬, 等. 支气管镜下氩等离子体凝固联合二氧化碳冷冻技术治疗小儿气道支架置入术后肉芽组织增生八例. 中华儿科杂志, 2014, 52(5): 368-372.
29.	姚志刚, 吴波, 李宾, 等. 支气管内型错构瘤临床病理学特征及气管镜下热消融联合冷冻治疗. 国际呼吸杂志, 2014, 34(14): 1084-1087.
30.	谢宝松, 叶玲, 李国平, 等. 不同冷冻消融时间对兔气管创伤性肉芽组织增生的影响及其作用机制. 中华医学杂志, 2018, 98(44): 3587-3591.
31.	Daggett C, Daggett A, McBurney E, et al. Laser safety: the need for protocols. Cutis, 2020, 106(2): 87-92.
32.	徐翠容, 贾坤林, 龙苗, 等. 电子支气管镜下支架植入联合氩气刀治疗恶性肿瘤引起中央气道狭窄的临床观察. 临床肺科杂志, 2016, 21(8): 1482-1485.
33.	李一诗, 杨丽, 郭述良. 呼吸介入消融技术的临床应用. 中国实用内科杂志, 2022, 42(9): 712-716.
34.	王洪武, 金发光, 张楠. 气道内金属支架临床应用中国专家共识. 中华肺部疾病杂志(电子版), 2021, 14(1): 5-10.
35.	Gottlieb J, Fuehner T, Dierich M, et al. Are metallic stents really safe? A long-term analysis in lung transplant recipients. Eur Respir J, 2009, 34(6): 1417-1422.
36.	Bottero S, Meucci D, Trozzi M, et al. Dehiscence of bronchial anastomosis after lung transplantation: a successful unconventional treatment. Ann Thorac Surg, 2018, 106(2): e81-e83.
37.	Duvvuri M, Motz K, Tsai HW, et al. Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal stenosis. J Vis Exp, 2020, 155: 10.3791/60483.
38.	耿玉梅, 王苏网, 陈丹萍, 等. 西罗莫司洗脱支架对气管支架内再狭窄的作用. 中山大学学报(医学科学版), 2016, 37(1): 54-60.
39.	刘伟, 傅恩清, 谢永宏, 等. 气管镜介入治疗支气管内膜结核方法的探讨. 中华肺部疾病杂志电子版, 2011, 4(3): 183-186.
40.	Mei-Sheng Riley M. Invasive Fungal infections among immunocompromised patients in critical care settings: infection prevention risk mitigation. Crit Care Nurs Clin North Am, 2021, 33(4): 395-405.
41.	Soetanto V, Grewal US, Mehta AC, et al. Early postoperative complications in lung transplant recipients. Indian J Thorac Cardiovasc Surg, 2022, 38(Suppl 2): 260-270.
42.	Gebremariam T, Gu Y, Alkhazraji S, et al. The Combination treatment of fosmanogepix and liposomal amphotericin B is superior to monotherapy in treating experimental invasive mold infections. Antimicrob Agents Chemother, 2022, 66(7): e0038022.
43.	Randhawa SK, Yang Z, Morkan DB, et al. One-year survival worse for lung retransplants relative to primary lung transplants. Ann Thorac Surg, 2022, 113(4): 1265-1273.
44.	Polastri M, Reed RM. Rehabilitative goals for patients undergoing lung retransplantation. J Yeungnam Med Sci, 2024, 41(2): 134-138.
45.	Yang J, Pan X, Fu S, et al. Pulmonary retransplantation. J Thorac Dis, 2018, 10(7): 4632-4636.

1. 岳冰清, 陈静瑜. 儿童肺移植治疗. 中国实用儿科杂志, 2023, 38(3): 215-217.
2. Cheng GS, Madtes DK, Edelman J, et al. Outcomes of lung transplantation after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant, 2014, 20(8): 1169-1175.
3. 高霏, 卫栋, 吴波, 等. 双肺移植治疗骨髓移植术后闭塞性细支气管炎一例报告并文献复习. 中华血液学杂志, 2013, 34(8): 669-672.
4. Iguidbashian J, Cotton J, King RW, et al. Survival following lung transplantation: A population-based nested case-control study. J Card Surg, 2022, 37(5): 1153-1160.
5. Chambers DC, Perch M, Zuckermann A, et al. International Society for Heart and Lung Transplantation. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult lung transplantation report - 2021; Focus on recipient characteristics. J Heart Lung Transplant, 2021, 40(10): 1060-1072.
6. Delbove A, Senage T, Gazengel P, et al. Incidence and risk factors of anastomotic complications after lung transplantation. Ther Adv Respir Dis, 2022, 16: 17534666221110354.
7. Awori Hayanga JW, Aboagye JK, Shigemura N, et al. Airway complications after lung transplantation: Contemporary survival and outcomes. J Heart Lung Transplant, 2016, 35(10): 1206-1211.
8. Olland A, Reeb J, Puyraveau M, et al. Bronchial complications after lung transplantation are associated with primary lung graft dysfunction and surgical technique. J Heart Lung Transplant, 2017, 36(2): 157-165.
9. Patoir A, Luchez A, Tiffet O, et al. Airway complications after lung transplantation: benefit of a conservative bronchoscopy strategy. J Thorac Dis, 2020, 12(5): 2625-2634.
10. 吴波, 张稷, 朱艳红, 等. 肺移植术后气道并发症临床分析. 南京医科大学学报(自然科学版), 2009, 29(12): 1736-1738.
11. Mahajan AK, Folch E, Khandhar SJ, et al. The diagnosis and management of airway complications following lung transplantation. Chest, 2017, 152(3): 627-638.
12. Frye L, Machuzak M. Airway Complications After Lung Transplantation. Clin Chest Med, 2017, 38(4): 693-706.
13. Crespo MM, McCarthy DP, Hopkins PM, et al. ISHLT Consensus Statement on adult and pediatric airway complications after lung transplantation: Definitions, grading system, and therapeutics. J Heart Lung Transplant, 2018, 37(5): 548-563.
14. Santacruz JF, Mehta AC. Airway complications and management after lung transplantation: ischemia, dehiscence, and stenosis. Proc Am Thorac Soc, 2009, 6(1): 79-93.
15. Debray MP, Dauriat G, Khalil A, et al. Diagnostic accuracy of low-mA chest CT reconstructed with Model Based Iterative Reconstruction in the detection of early pleuro-pulmonary complications following a lung transplantation. Eur Radiol, 2016, 26(9): 3138-3146.
16. 吴波, 郑明锋, 张稷, 等. 肺移植术后气道狭窄并发症的诊断和治疗. 中华器官移植杂志, 2012, 33(7): 422-425.
17. 史灵芝, 黄桁, 刘明昭, 等. 肺移植术后需要临床干预的气道狭窄患者生存结局的影响因素. 器官移植, 2024, 15(2): 236-243.
18. Douros K, Kremmydas G, Grammeniatis V, et al. Helical multi-detector CT scan as a tool for diagnosing tracheomalacia in children. Pediatr Pulmonol, 2019, 54(1): 47-52.
19. Tendulkar RD, Fleming PA, Reddy CA, et al. High-dose-rate endobronchial brachytherapy for recurrent airway obstruction from hyperplastic granulation tissue. Int J Radiat Oncol Biol Phys, 2008, 70(3): 701-706.
20. Walters DM, Kuckelman JP, Mulligan MS. Electromagnetic navigational bronchoscopic airway recanalization in patients with vanishing bronchus. J Surg Res, 2018, 231: 154-160.
21. 王婷, 张杰, 邱小建, 等. 气管镜下介入治疗瘢痕性气道狭窄的有效性及影响因素分析. 中华结核和呼吸杂志, 2020, 43(9): 784-790.
22. Mora-Cuesta VM, Tello-Mena S, Izquierdo-Cuervo S, et al. Bronchial stenosis after lung transplantation from cDCD donors using simultaneous abdominal normothermic regional perfusion: a single-center experience. Transplantation, 2023, 107(11): 2415-2423.
23. Liang W, Hu P, Guo W, et al. Appropriate treatment sessions of flexible bronchoscopic balloon dilation for patients with nonmalignant central airway stenosis. Ther Adv Respir Dis, 2019, 13: 1753466619831966.
24. 丁银锋, 李付琦, 黄海东, 等. 支气管镜介入治疗肺移植术后中心气道狭窄的疗效分析. 中国呼吸与危重监护杂志, 2020, 19(3): 276-280.
25. Greer M, Fuehner T, Warnecke G, et al. Paclitaxel-coated balloons in refractory nonanastomostic airway stenosis following lung transplantation. Am J Transplant, 2014, 14(10): 2400-2405.
26. Davidson KR, Elmasri M, Wahidi MM, et al. Management of lung transplant bronchial stenosis with mitomycin C. J Bronchology Interv Pulmonol, 2019, 26(2): 124-128.
27. 倪彩云, 刘霞, 马静, 等. 支气管镜下冷冻治疗儿童肉芽及瘢痕组织导致的下气道狭窄及阻塞22例. 中华儿科杂志, 2012, 50(1): 45-49.
28. 许煊, 刘玺诚, 祝彬, 等. 支气管镜下氩等离子体凝固联合二氧化碳冷冻技术治疗小儿气道支架置入术后肉芽组织增生八例. 中华儿科杂志, 2014, 52(5): 368-372.
29. 姚志刚, 吴波, 李宾, 等. 支气管内型错构瘤临床病理学特征及气管镜下热消融联合冷冻治疗. 国际呼吸杂志, 2014, 34(14): 1084-1087.
30. 谢宝松, 叶玲, 李国平, 等. 不同冷冻消融时间对兔气管创伤性肉芽组织增生的影响及其作用机制. 中华医学杂志, 2018, 98(44): 3587-3591.
31. Daggett C, Daggett A, McBurney E, et al. Laser safety: the need for protocols. Cutis, 2020, 106(2): 87-92.
32. 徐翠容, 贾坤林, 龙苗, 等. 电子支气管镜下支架植入联合氩气刀治疗恶性肿瘤引起中央气道狭窄的临床观察. 临床肺科杂志, 2016, 21(8): 1482-1485.
33. 李一诗, 杨丽, 郭述良. 呼吸介入消融技术的临床应用. 中国实用内科杂志, 2022, 42(9): 712-716.
34. 王洪武, 金发光, 张楠. 气道内金属支架临床应用中国专家共识. 中华肺部疾病杂志(电子版), 2021, 14(1): 5-10.
35. Gottlieb J, Fuehner T, Dierich M, et al. Are metallic stents really safe? A long-term analysis in lung transplant recipients. Eur Respir J, 2009, 34(6): 1417-1422.
36. Bottero S, Meucci D, Trozzi M, et al. Dehiscence of bronchial anastomosis after lung transplantation: a successful unconventional treatment. Ann Thorac Surg, 2018, 106(2): e81-e83.
37. Duvvuri M, Motz K, Tsai HW, et al. Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal stenosis. J Vis Exp, 2020, 155: 10.3791/60483.
38. 耿玉梅, 王苏网, 陈丹萍, 等. 西罗莫司洗脱支架对气管支架内再狭窄的作用. 中山大学学报(医学科学版), 2016, 37(1): 54-60.
39. 刘伟, 傅恩清, 谢永宏, 等. 气管镜介入治疗支气管内膜结核方法的探讨. 中华肺部疾病杂志电子版, 2011, 4(3): 183-186.
40. Mei-Sheng Riley M. Invasive Fungal infections among immunocompromised patients in critical care settings: infection prevention risk mitigation. Crit Care Nurs Clin North Am, 2021, 33(4): 395-405.
41. Soetanto V, Grewal US, Mehta AC, et al. Early postoperative complications in lung transplant recipients. Indian J Thorac Cardiovasc Surg, 2022, 38(Suppl 2): 260-270.
42. Gebremariam T, Gu Y, Alkhazraji S, et al. The Combination treatment of fosmanogepix and liposomal amphotericin B is superior to monotherapy in treating experimental invasive mold infections. Antimicrob Agents Chemother, 2022, 66(7): e0038022.
43. Randhawa SK, Yang Z, Morkan DB, et al. One-year survival worse for lung retransplants relative to primary lung transplants. Ann Thorac Surg, 2022, 113(4): 1265-1273.
44. Polastri M, Reed RM. Rehabilitative goals for patients undergoing lung retransplantation. J Yeungnam Med Sci, 2024, 41(2): 134-138.
45. Yang J, Pan X, Fu S, et al. Pulmonary retransplantation. J Thorac Dis, 2018, 10(7): 4632-4636.

Chinese Journal of Respiratory and Critical Care Medicine

支气管镜介入治疗在肺移植术后气道并发症的应用研究进展

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