Polymorphism of TGF on Genetic Susceptibility to Hypertension: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

LI Min ^1,2 ,  SHI Jingpu ^1,2

1. Department of Clinical Epidemiology, the First Affiliated Hospital, China Medical University, Shenyang 110001, China; 2. Evidence-Based Center of Liaoning Province, Shenyang 110001, China;

Corresponding author：

SHI Jingpu, Email: sjp56@yahoo.com

Keywords：

Transforming growth factor; Genetic polymorphism; Hypertension; Meta-analysis; Case control study

DOI：

10.7507/1672-2531.20110235

Video：

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Objective　 To explore whether the polymorphism of transforming growth factor β1 (TGF β1) gene at 869T/C and 915G/C loci contributes to the genetic susceptibility to hypertension.
Methods　 Assessed under the same criteria, all case control studies on relationship between the polymorphism of TGF β1 gene and hypertension were searched in both English and Chinese databases. All articles retrieved were screened and evaluated, and meta-analyses were conducted with RevMan 5.1 software.
Results　 A total of 14 case control studies were included. The results of meta-analyses showed TGF β1 gene C allele was related to hypertension (OR=1.37, 95%CI 1.21 to 1.54). It was noted that individuals with CC genotype and TT genotype had a significant increased risk of hypertension (OR=1.43, 95%CI 1.27 to 1.60; OR=0.64, 95%CI 0.53 to 0.78, respectively). And there was no b evidence showing that TGF β1 915G/C genetic polymorphism was related to hypertension. The results from meta-analyses of the studies based on Chinese population on the two loci were in consistent with the outcomes of overall meta-analyses. Sensitivity analyses indicated the results were stable. And publication bias was not present, reflected by P values from Egger’s regression asymmetry test and Begg’s adjusted rank correction test.
Conclusions 　869T/C polymorphism of TGF β1 gene is associated with hypertension. C allele is potentially one of the genetic risk factors for hypertension. Present studies do not support a direct relationship between 915G/C polymorphism TGF β1 gene and hypertension.

Citation： LI Min,SHI Jingpu. Polymorphism of TGF on Genetic Susceptibility to Hypertension: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2011, 11(12): 1384-1390. doi: 10.7507/1672-2531.20110235 Copy

1.	Golbang AP, Murthy M, Hamad A, et al. A new kindred with pseudohypoaldosteronism typeⅡand a novel mutation (564D>H) in the acidic motif of the WNK4 gene. Hypertension, 2005, 56(2): 295-300.
2.	Horwitz RI, Feinstein AR. Methodologic standards and contradictory result in case-control research. Am J Med, 1979, 66(4): 556-564.
3.	Colditz GA, Burdick E, Mosteller F. Heterogeneity in meta-analysis of data from epidemiologic studies: a commentary. Am J Epidemiol, 1995, 142(4): 371-382.
4.	DerSimonian R, Kacker R. Random-effects model for meta-analysis of clinical trials: an update. Contemp Clin Trials, 2007, 28(2): 105-114.
5.	Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50(4): 1088-1101.
6.	Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109): 629-634.
7.	He F, Zhao D, Deng F, et al. Association of TGF-beta 1 gene polymorphisms in exon1 and blood levels with essential hypertension. Blood Press, 2010, 19(4): 225-233.
8.	赵丹, 胡清华, 邓峰美, 等. 新疆哈萨克族转化生长因子β1基因多态性及其血浆水平与原发性高血压的关系. 中华医学遗传学杂志, 2010, 27(4): 463-468.
9.	唐任光, 韦叶生, 黄照河. 转化生长因子β1基因+869T/C多态性与原发性高血压的关系. 临床检验杂志, 2009, 27(4): 270-271.
10.	Argano C, Duro G, Corrao S, et al. Transforming growth factor beta1 T29C gene polymorphism and hypertension: relationship with cardiovascular and renal damage. Blood Press, 2008, 17(4): 220-226.
11.	Ivanov VP, Solodilova MA, Polonnikov AV, et al. Arg25Pro polymorphism of transforming growth factor-beta1 and its role in the pathogenesis of essential hypertension in Russian population of Central Chernozem Region. Bull Exp Biol Med, 2007, 114(1): 66-68.
12.	陈慧生, 张七一, 王云英. 转化生长因子β1基因多态性及其血清水平与高血压病肾脏损害的关系. 临床内科杂志, 2007, 24(1): 57-59.
13.	韦常丽, 吴延佳, 邱全, 等. 转化生长因子β1 基因多态性与原发性高血压关系的研究. 中国老年学杂志, 2007, 27(10): 962-964.
14.	呼邦传, 初少莉, 王继光, 等. 三个候选基因多态性与高血压病关联的研究. 中华内科杂志, 2006, 45(4): 281-284.
15.	张七一, 董海, 王云英, 等. 转化生长因子β1 基因多态性及血清水平与高血压左室肥厚的关系. 中华老年医学杂志, 2006, 25(5): 358-360.
16.	韦叶生, 李壮, 蓝景生. 转化生长因子β1基因多态性与广西壮族人原发性高血压的遗传易感性. 第四军医大学学报, 2005, 26(4): 341-344.
17.	Babel N, Cherepnev G, Kowalenko A, et al. Nonimmunologic complications and gene polymorphisms of immunoregulatory cytokines in long-term renal transplants. Kidney Int, 2004, 66(1): 428-432.
18.	Yamada Y, Fujisawa M, Ando F, et al. Association of a polymorphism of the transforming growth factor-beta1 gene with blood pressure in Japanese individuals. J Hum Genet, 2002, 4(5): 243-248.
19.	Frossard PM, Gupta A, Pravica V, et al. A study of five human cytokine genes in human essential hypertension. Mol Immunol, 2001, 38(12-13): 969-976.
20.	Li B, Khanna A, Sharma V, et al. TGF-beta1 DNA polymorphisms, protein levels, and blood pressure. Hypertension, 1999, 33(1Pt2): 271-275.
21.	Cusi D, Barlassina C, Azzani T, et al. Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. Lancet, 1997, 349(9062): 1353-1357.
22.	Stoll C, Mengsteab S, Stoll D, et al. Analysis of polymorphic TGFβ1 codons 10, 25, and 263 in a German patient group with non-syndromic cleft lip, alveolus, and palate compared with healthy adults. BMC Med Genet, 2004, 5: 15.
23.	Quarmby S, Fakhoury H, Levine E, et al. Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patients. Int J Radiat Biol, 2003, 79(2): 137-143.
24.	Antonipillai I, Le TH, Soceneantu L, et al. Transforming growth factor-beta is a renin secretagogue at picomolar concentrations. Am J Physiol, 1993, 265(4 Pt 2): F537-541.
25.	Kaizar EE. Metaanalyses are observational studies: how lack of randomization impacts analysis. Am J Gastroenterol, 2005, 100(6): 1233-1236.

1. Golbang AP, Murthy M, Hamad A, et al. A new kindred with pseudohypoaldosteronism typeⅡand a novel mutation (564D>H) in the acidic motif of the WNK4 gene. Hypertension, 2005, 56(2): 295-300.
2. Horwitz RI, Feinstein AR. Methodologic standards and contradictory result in case-control research. Am J Med, 1979, 66(4): 556-564.
3. Colditz GA, Burdick E, Mosteller F. Heterogeneity in meta-analysis of data from epidemiologic studies: a commentary. Am J Epidemiol, 1995, 142(4): 371-382.
4. DerSimonian R, Kacker R. Random-effects model for meta-analysis of clinical trials: an update. Contemp Clin Trials, 2007, 28(2): 105-114.
5. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50(4): 1088-1101.
6. Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109): 629-634.
7. He F, Zhao D, Deng F, et al. Association of TGF-beta 1 gene polymorphisms in exon1 and blood levels with essential hypertension. Blood Press, 2010, 19(4): 225-233.
8. 赵丹, 胡清华, 邓峰美, 等. 新疆哈萨克族转化生长因子β1基因多态性及其血浆水平与原发性高血压的关系. 中华医学遗传学杂志, 2010, 27(4): 463-468.
9. 唐任光, 韦叶生, 黄照河. 转化生长因子β1基因+869T/C多态性与原发性高血压的关系. 临床检验杂志, 2009, 27(4): 270-271.
10. Argano C, Duro G, Corrao S, et al. Transforming growth factor beta1 T29C gene polymorphism and hypertension: relationship with cardiovascular and renal damage. Blood Press, 2008, 17(4): 220-226.
11. Ivanov VP, Solodilova MA, Polonnikov AV, et al. Arg25Pro polymorphism of transforming growth factor-beta1 and its role in the pathogenesis of essential hypertension in Russian population of Central Chernozem Region. Bull Exp Biol Med, 2007, 114(1): 66-68.
12. 陈慧生, 张七一, 王云英. 转化生长因子β1基因多态性及其血清水平与高血压病肾脏损害的关系. 临床内科杂志, 2007, 24(1): 57-59.
13. 韦常丽, 吴延佳, 邱全, 等. 转化生长因子β1 基因多态性与原发性高血压关系的研究. 中国老年学杂志, 2007, 27(10): 962-964.
14. 呼邦传, 初少莉, 王继光, 等. 三个候选基因多态性与高血压病关联的研究. 中华内科杂志, 2006, 45(4): 281-284.
15. 张七一, 董海, 王云英, 等. 转化生长因子β1 基因多态性及血清水平与高血压左室肥厚的关系. 中华老年医学杂志, 2006, 25(5): 358-360.
16. 韦叶生, 李壮, 蓝景生. 转化生长因子β1基因多态性与广西壮族人原发性高血压的遗传易感性. 第四军医大学学报, 2005, 26(4): 341-344.
17. Babel N, Cherepnev G, Kowalenko A, et al. Nonimmunologic complications and gene polymorphisms of immunoregulatory cytokines in long-term renal transplants. Kidney Int, 2004, 66(1): 428-432.
18. Yamada Y, Fujisawa M, Ando F, et al. Association of a polymorphism of the transforming growth factor-beta1 gene with blood pressure in Japanese individuals. J Hum Genet, 2002, 4(5): 243-248.
19. Frossard PM, Gupta A, Pravica V, et al. A study of five human cytokine genes in human essential hypertension. Mol Immunol, 2001, 38(12-13): 969-976.
20. Li B, Khanna A, Sharma V, et al. TGF-beta1 DNA polymorphisms, protein levels, and blood pressure. Hypertension, 1999, 33(1Pt2): 271-275.
21. Cusi D, Barlassina C, Azzani T, et al. Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. Lancet, 1997, 349(9062): 1353-1357.
22. Stoll C, Mengsteab S, Stoll D, et al. Analysis of polymorphic TGFβ1 codons 10, 25, and 263 in a German patient group with non-syndromic cleft lip, alveolus, and palate compared with healthy adults. BMC Med Genet, 2004, 5: 15.
23. Quarmby S, Fakhoury H, Levine E, et al. Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patients. Int J Radiat Biol, 2003, 79(2): 137-143.
24. Antonipillai I, Le TH, Soceneantu L, et al. Transforming growth factor-beta is a renin secretagogue at picomolar concentrations. Am J Physiol, 1993, 265(4 Pt 2): F537-541.
25. Kaizar EE. Metaanalyses are observational studies: how lack of randomization impacts analysis. Am J Gastroenterol, 2005, 100(6): 1233-1236.

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