Correlation between OSAHS and Hypertension: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

YAN Jingjiang ¹ ,  LI Ying ²

1. Graduate Department of Shanxi Medical University, Taiyuan 030001, China;2. Stomatology The Second Hospital of Shanxi Medical University, Taiyuan 030001, China;

Corresponding author：

LI Ying, Email: crystal.yan1984@gmail.com

Keywords：

Obstructive sleep apnea-hypopnea syndrome; Hypertension; Meta-analysis; Systematic review; Cohort study; Case-control study

DOI：

10.7507/1672-2531.20120090

Video：

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Objective 　To assess the correlation between obstructive sleep apnea-hypopnea syndrome (OSAHS) and hypertension.
Methods 　Such databases as MEDLINE (1950 to April 2011), EMbase (1989 to April 2011), VIP (1989 to April 2011), WANFANG (1977 to April 2011), CBM (1978 to April 2011) and CNKI (1979 to April 2011) were searched to collect literatures about the correlation between OSAHS and hypertension. The literatures in conference proceedings and some unpublicized articles were also retrieved. All cohort studies and case control studies were included. Two reviewers independently collected the data, assessed the quality, and conducted the Meta-analysis by using RevMan5.1 software.
Results 　Among the total 11 studies involving 4 019 participants were included, 1 was prospective cohort study and the other 10 were case control studies. The results of Meta-analyses showed that: a) the OSAHS was correlated with hypertension (P=0.16, RR=2.52, 95%CI 2.21 to 2.87); and b) the correlation between OSAHS and hypertension was related with the different grades of OSHAS (P=0.83, RR=1.84, 95%CI 1.53 to 2.22). The more severe grade the OSAHS, the greater possibility the hypertension.
Conclusion 　OSAHS is significantly related with hypertension, and they may be the mutual risk factor for each other. The correlation between OSAHS and hypertension may be related with different grades of OSAHS.

Citation： YAN Jingjiang,LI Ying. Correlation between OSAHS and Hypertension: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2012, 12(5): 557-562. doi: 10.7507/1672-2531.20120090 Copy

1.	中华医学会呼吸病学分会睡眠呼吸疾病学组. 阻塞性睡眠呼吸暂停低通气综合征诊治指南 (草案). 中华结核和呼吸杂志, 2002, 25(4): 195-198.
2.	Abu SMS, Bernard JG, Virend KS. Obstructive Sleep Apnea Implications for Cardiac and Vascular Disease. JAMA, 2003, 290(14): 1906-1914.
3.	Chobanian AV, Bakris GL, Black HR, et al. The seventh report of Joint National Committee on prevention, detectio, evaluation, and treatment of high blood pressure: the JNC 7report. JAMA, 2003, 289(19): 2560-2572.
4.	中国高血压防治指南修订委员会. 中国高血压防治指南(2005年修订版). 高血压杂志, 2005, 134(增刊): 2-41.
5.	中华医学会呼吸病学分会睡眠呼吸疾病学组. 睡眠呼吸暂停人群高血压患病率的多中心研究. 中华结核和呼吸杂志, 2007, 30(12): 894-897.
6.	樊利萍, 王蓓, 刘卓拉. 阻塞性睡眠呼吸暂停低通气综合征与高血压的关系. 临床医药实践, 2008, 17(6): 429-431.
7.	郭西梅, 林培英. 阻塞型睡眠呼吸暂停低通气综合征与心血管疾病关系的研究. 赣南医学院学报, 2004, 24(5): 532-533.
8.	李玉珊, 朱敏嘉. 阻塞性睡眠呼吸暂停低通气综合征与高血压. 广西医科大学学报, 2004, 21(5): 709-710.
9.	刘青, 李金国, 林挺岩, 等. 阻塞性睡眠呼吸暂停综合征患者的动态血压及心电图改变. 福建医科大学学报, 2007, 41(3): 254-256.
10.	Mohsenin V, Yaggi HK, Shah N, et al. The effect of gender on the prevalence of hypertension in obstructive sleep apnea. Sleep Med, 2009, 10(7): 759-762.
11.	Pradeep Kumar VG, Bhatia M, Tripathi M, et al.Obstructive sleep apnoea: a case-control study. Neurol India, 2003, 51(4): 497-499.
12.	苏梅, 张希龙, 殷凯生, 等. 成年鼾症者阻塞性睡眠呼吸暂停低通气综合征与心血管病变的相关性. 中国全科医学, 2008, 11(8A): 1326-1328.
13.	Yusoff MF, Baki MM, Mohamed N, et al. Obstructive sleep apnea among express bus drivers in Malaysia: important indicators for screening. Traffic Inj Prev, 2010, 11(6): 594-599.
14.	朱虹, 张雪青, 吴文俊, 等. 阻塞性睡眠呼吸暂停综合征患者代谢综合征的患病情况. 实用预防医学, 2008, 15(2): 317-319.
15.	林其昌, 黄瑞强, 黄建钗, 等. 阻塞性睡眠呼吸暂停低通气综合征与高血压关系的前瞻性研究. 国际呼吸杂志, 2010, 30(17): 1038-1041.
16.	Parish JM, Adam T, Facchiano L. Relationship of Metabolic syndrome and obstructive sleep apnea. J Clin Sleep Med, 2007, 3(5): 467-472.
17.	Cooper VL, Bowker CM, Pearson SB, et al. Effects of simulated obstructive sleep apnoea on the human carotid baroreceptor-vascular resistance reflex. J Physiol, 2004, 557 (Pt 3): 1055-1065.
18.	Niteo FJ, Young TB, Iind BK, et al. Association of sleep disorder breathing, sleep apnea, and hypertension in a large cornmunity based study. Sleep Heart Health Study. JAMA, 2000, 283(14): 1829-1836.
19.	Elmasry A, Janson C, Lindberg E, et al. The role of habitual snoring and obesity in the development of diabetes: a 10-year follow-up study in a male population. J Intern Med, 2000, 248(1): 13-20.
20.	Kwok KL, Ng DK, Chan CH. Cardiovascular changes in children with snoring and obstructive sleep apnoea. Ann Acad Med Singapore, 2008, 37(8): 715-721.
21.	Ng DK, Chan C, Chow AS, et al. Childhood sleep-disordered breathing and its implications for cardiac and vascular diseases. Paediatr Child Health, 2005, 41(12): 640-646.

1. 中华医学会呼吸病学分会睡眠呼吸疾病学组. 阻塞性睡眠呼吸暂停低通气综合征诊治指南 (草案). 中华结核和呼吸杂志, 2002, 25(4): 195-198.
2. Abu SMS, Bernard JG, Virend KS. Obstructive Sleep Apnea Implications for Cardiac and Vascular Disease. JAMA, 2003, 290(14): 1906-1914.
3. Chobanian AV, Bakris GL, Black HR, et al. The seventh report of Joint National Committee on prevention, detectio, evaluation, and treatment of high blood pressure: the JNC 7report. JAMA, 2003, 289(19): 2560-2572.
4. 中国高血压防治指南修订委员会. 中国高血压防治指南(2005年修订版). 高血压杂志, 2005, 134(增刊): 2-41.
5. 中华医学会呼吸病学分会睡眠呼吸疾病学组. 睡眠呼吸暂停人群高血压患病率的多中心研究. 中华结核和呼吸杂志, 2007, 30(12): 894-897.
6. 樊利萍, 王蓓, 刘卓拉. 阻塞性睡眠呼吸暂停低通气综合征与高血压的关系. 临床医药实践, 2008, 17(6): 429-431.
7. 郭西梅, 林培英. 阻塞型睡眠呼吸暂停低通气综合征与心血管疾病关系的研究. 赣南医学院学报, 2004, 24(5): 532-533.
8. 李玉珊, 朱敏嘉. 阻塞性睡眠呼吸暂停低通气综合征与高血压. 广西医科大学学报, 2004, 21(5): 709-710.
9. 刘青, 李金国, 林挺岩, 等. 阻塞性睡眠呼吸暂停综合征患者的动态血压及心电图改变. 福建医科大学学报, 2007, 41(3): 254-256.
10. Mohsenin V, Yaggi HK, Shah N, et al. The effect of gender on the prevalence of hypertension in obstructive sleep apnea. Sleep Med, 2009, 10(7): 759-762.
11. Pradeep Kumar VG, Bhatia M, Tripathi M, et al.Obstructive sleep apnoea: a case-control study. Neurol India, 2003, 51(4): 497-499.
12. 苏梅, 张希龙, 殷凯生, 等. 成年鼾症者阻塞性睡眠呼吸暂停低通气综合征与心血管病变的相关性. 中国全科医学, 2008, 11(8A): 1326-1328.
13. Yusoff MF, Baki MM, Mohamed N, et al. Obstructive sleep apnea among express bus drivers in Malaysia: important indicators for screening. Traffic Inj Prev, 2010, 11(6): 594-599.
14. 朱虹, 张雪青, 吴文俊, 等. 阻塞性睡眠呼吸暂停综合征患者代谢综合征的患病情况. 实用预防医学, 2008, 15(2): 317-319.
15. 林其昌, 黄瑞强, 黄建钗, 等. 阻塞性睡眠呼吸暂停低通气综合征与高血压关系的前瞻性研究. 国际呼吸杂志, 2010, 30(17): 1038-1041.
16. Parish JM, Adam T, Facchiano L. Relationship of Metabolic syndrome and obstructive sleep apnea. J Clin Sleep Med, 2007, 3(5): 467-472.
17. Cooper VL, Bowker CM, Pearson SB, et al. Effects of simulated obstructive sleep apnoea on the human carotid baroreceptor-vascular resistance reflex. J Physiol, 2004, 557 (Pt 3): 1055-1065.
18. Niteo FJ, Young TB, Iind BK, et al. Association of sleep disorder breathing, sleep apnea, and hypertension in a large cornmunity based study. Sleep Heart Health Study. JAMA, 2000, 283(14): 1829-1836.
19. Elmasry A, Janson C, Lindberg E, et al. The role of habitual snoring and obesity in the development of diabetes: a 10-year follow-up study in a male population. J Intern Med, 2000, 248(1): 13-20.
20. Kwok KL, Ng DK, Chan CH. Cardiovascular changes in children with snoring and obstructive sleep apnoea. Ann Acad Med Singapore, 2008, 37(8): 715-721.
21. Ng DK, Chan C, Chow AS, et al. Childhood sleep-disordered breathing and its implications for cardiac and vascular diseases. Paediatr Child Health, 2005, 41(12): 640-646.

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Correlation between OSAHS and Hypertension: A Systematic Review

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