NovaMin-containing Bioactive Toothpaste for Dentine Hypersensitivity: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 YANGZheng-yan ^1,2 , LIYue-heng ^1,2 , DUANYan-xia ^1,2 , ZHOUZhi ^1,2 ,  ZHOUHong ^1,2

1. Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing 401147, China;
2. Stomatology College, Chongqing Medical University, Chongqing 401147, China;

Corresponding author：

ZHOUHong, Email: zhouzhi_050918@hotmail.com

Keywords：

NovaMin-containing toothpaste; Dentine hypersensitivity; Systematic review; Meta-analysis; Randomized controlled trial

DOI：

10.7507/1672-2531.20140183

Video：

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Objective To review the effects of desensitizing toothpaste containing NovaMin for dentine hypersensitivity. Methods Such databases as CNKI, WanFang Data, CBM, VIP, PubMed, Web of Science and The Cochrane Library (Issue 11, 2013) were searched, and meanwhile Google Scholar was used for supplementary search up to December 2013. Randomized controlled trials (RCTs) on treating dentine hypersensitivity with NovaMin-containing toothpaste were retrieved. Literature screening, data extraction and quality assessment were completed independently by two reviewers. Meta-analysis was then performed using RevMan 5.2 software. Results Six RCTs involving 283 patients (experiment:140 patients; control:143 patients) were included. The results of meta-analysis showed that at 4 weeks, NovaMin-containing toothpaste was significantly better than potassium-containing toothpaste in alleviating patients' cold sensitivity (SMD=-1.60, 95%CI-2.14 to-1.05, P=0.01) and air blast (SMD=-1.12, 95%-1.64 to-0.60, P=0.02). Conclusion Current evidence shows that, NovaMin-containing toothpaste is effective in treating dentine hypersensitivity, compared with other toothpaste that has been proved to be effective in clinic. However, due to the limited quantity and quality of the included studies, more high quality and large-sample RCTs are needed to further verify the above conclusion.

Citation： YANGZheng-yan, LIYue-heng, DUANYan-xia, ZHOUZhi, ZHOUHong. NovaMin-containing Bioactive Toothpaste for Dentine Hypersensitivity: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2014, 14(9): 1126-1130. doi: 10.7507/1672-2531.20140183 Copy

1.	张举之, 主编.口腔内科学.第3版.北京:人民卫生出版社, 1997:108.
2.	中华口腔医学会牙本质敏感专家组.牙本质敏感的诊断和防治指南.中华口腔医学杂志, 2009, 44(3):132-134.
3.	Markowitz K, Pashley DH. Discovering new treatments for sensitive teeth:the long path from biology to therapy. J Oral Rehabil, 2008, 35(4):300-315.
4.	Orchardson R, Gillam DG. Managing dentin hypersensitivity. J Am Dent Assoc, 2006, 137(7):990-998.
5.	Brannstrom M. A hydrodynamic mechanism in the transmission of pain-produced stimuli through the dentine. In:Anderson DJ, ed. Sensory Mechanisms in Dentine. Oxford:Pergamon. 1962:73-79.
6.	Addy M. Dentine hypersensitivity:New perspectives on an old problem. Int Dent J, 2002, 52(Suppl):367-375.
7.	Brännström M, Johnson G. Movements of the dentine and pulp liquids on application of thermal stimuli. Acta Odontol Scand, 1970, 28(1):59-70.
8.	杜民权, 台保军, 江汉, 等.含NovaMin生物活性材料的牙膏抗牙本质过敏的临床试验.口腔医学研究, 2004, 20(6):641-643.
9.	Pradeep AR, Agarwal E, Naik SB, et al. Comparison of efficacy of three commercially available dentifrices on dentinal hypersensitivity:a randomized clinical trial. Australian Dental Journal, 2012, 57:429-434.
10.	Sharma N, Roy S, Kakar A, et al. A clinical study comparing oral formulations containing 7.5% calcium sodium phosphosilicate (NovaMin), 5% potassium nitrate, and 0.4% stannous fluoride for the management of dentin hypersensitivity. J Clin Dent, 2010, 21(Spec Iss):88-92.
11.	Salian S, Thakur S, Kulkarni S, et al. A randomized controlled clinical study evaluating the efficacy of two desensitizing dentifrices. J Clin Dent, 2010, 21(Spec Iss):82-87.
12.	Narongdej T, Sakoolnamarka R, Boonroung T. The effectiveness of a calcium sodium phosphosilicate desensitizer in reducing cervical dentin hypersensitivity:a pilot study. J Am Dent Assoc, 2010, 141:995-999.
13.	Acharya AB, Surve SM, Srinath L, et al. A clinical study of the effect of calcium sodium phosphosilicate on dentin hypersensitivity. J Clin Exp Dent, 2013, 5(1):e18-22.
14.	荣文笙, 胡德渝.牙本质敏感.中国实用口腔杂志, 2009, 2(9):516-519.
15.	Huskisson EC. Measurement of pain. Lancet, 1974(2):1127-1131.
16.	Higgins JP, Green S. Cochrane Handbook for Systematic Reviews of Interventions (Version 5.1.0).[cited 2012 Jan 5]. Available at: http://www.cochrane-handbook.org.
17.	李蓉, 王浙君, 蒋滔, 等. NovaMin在口腔医学中的应用.口腔医学研究, 2011, 27(10):930-932.
18.	Addy M. Dentine hypersensitivity:New perspectives on an old problem. Int Dent J, 2002, 52(Suppl):367-375.
19.	Brännström M, Johnson G. Movements of the dentine and pulp liquids on application of thermal stimuli. Acta Odontol Scand, 1970, 28(1):59-70.
20.	Canadian Advisory Board on Dentin Hypersensitivity. Consensus based recommendations for the diagnosis and management of dentin hypersensitivity. J Can Dent Assoc, 2003, 69(4):221-226.
21.	Blong MA, Volding B, Thrash WJ, et al. Effects of a gel containing 0.4 percent stannous fluoride on dentinal hypersensitivity. Dent Hyg (Chic), 1985, 59(11):489-492.
22.	Snyder RA, Beck FM, Horton JE. The efficacy of a 0.4% stannous fluoride gel on root surface hypersensitivity[abstract]. J Dent Res, 1983, 62(3):237.
23.	Thrash WJ, Dodds MW, Jones DL. The effect of stannous fluoride on dentinal hypersensitivity. Int Dent J, 1994, 44(Suppl 1):107-118.
24.	Schiff T, Saletta L, Baker RA, et al. Desensitizing effect of a stabilized stannous fluoride/sodium hexametaphosphate dentifrice. Compend Coutin Educ Dent, 2005, 26(Suppl 1):35-40.
25.	Miller S, Truong T, Heu R, et al. Recent advances in stannous fluoride technology:Antibacterial efficacy and mechanism of action towards hypersensitivity. Int Dent J, 1994, 44(Suppl 1):83-98.
26.	Walters PA. Dentinal hypersensitivity:A review. J Contemp Dent Pract, 2005, 6(2):107-117.
27.	Ayad F, Ayad N, Delgado E, et al. Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride, and to a control toothpaste with 1450 ppm fluoride:a three-day clinical study in Mississauga, Canada. J Clin Dent, 2009, 20(4):115-122.

1. 张举之, 主编.口腔内科学.第3版.北京:人民卫生出版社, 1997:108.
2. 中华口腔医学会牙本质敏感专家组.牙本质敏感的诊断和防治指南.中华口腔医学杂志, 2009, 44(3):132-134.
3. Markowitz K, Pashley DH. Discovering new treatments for sensitive teeth:the long path from biology to therapy. J Oral Rehabil, 2008, 35(4):300-315.
4. Orchardson R, Gillam DG. Managing dentin hypersensitivity. J Am Dent Assoc, 2006, 137(7):990-998.
5. Brannstrom M. A hydrodynamic mechanism in the transmission of pain-produced stimuli through the dentine. In:Anderson DJ, ed. Sensory Mechanisms in Dentine. Oxford:Pergamon. 1962:73-79.
6. Addy M. Dentine hypersensitivity:New perspectives on an old problem. Int Dent J, 2002, 52(Suppl):367-375.
7. Brännström M, Johnson G. Movements of the dentine and pulp liquids on application of thermal stimuli. Acta Odontol Scand, 1970, 28(1):59-70.
8. 杜民权, 台保军, 江汉, 等.含NovaMin生物活性材料的牙膏抗牙本质过敏的临床试验.口腔医学研究, 2004, 20(6):641-643.
9. Pradeep AR, Agarwal E, Naik SB, et al. Comparison of efficacy of three commercially available dentifrices on dentinal hypersensitivity:a randomized clinical trial. Australian Dental Journal, 2012, 57:429-434.
10. Sharma N, Roy S, Kakar A, et al. A clinical study comparing oral formulations containing 7.5% calcium sodium phosphosilicate (NovaMin), 5% potassium nitrate, and 0.4% stannous fluoride for the management of dentin hypersensitivity. J Clin Dent, 2010, 21(Spec Iss):88-92.
11. Salian S, Thakur S, Kulkarni S, et al. A randomized controlled clinical study evaluating the efficacy of two desensitizing dentifrices. J Clin Dent, 2010, 21(Spec Iss):82-87.
12. Narongdej T, Sakoolnamarka R, Boonroung T. The effectiveness of a calcium sodium phosphosilicate desensitizer in reducing cervical dentin hypersensitivity:a pilot study. J Am Dent Assoc, 2010, 141:995-999.
13. Acharya AB, Surve SM, Srinath L, et al. A clinical study of the effect of calcium sodium phosphosilicate on dentin hypersensitivity. J Clin Exp Dent, 2013, 5(1):e18-22.
14. 荣文笙, 胡德渝.牙本质敏感.中国实用口腔杂志, 2009, 2(9):516-519.
15. Huskisson EC. Measurement of pain. Lancet, 1974(2):1127-1131.
16. Higgins JP, Green S. Cochrane Handbook for Systematic Reviews of Interventions (Version 5.1.0).[cited 2012 Jan 5]. Available at: http://www.cochrane-handbook.org.
17. 李蓉, 王浙君, 蒋滔, 等. NovaMin在口腔医学中的应用.口腔医学研究, 2011, 27(10):930-932.
18. Addy M. Dentine hypersensitivity:New perspectives on an old problem. Int Dent J, 2002, 52(Suppl):367-375.
19. Brännström M, Johnson G. Movements of the dentine and pulp liquids on application of thermal stimuli. Acta Odontol Scand, 1970, 28(1):59-70.
20. Canadian Advisory Board on Dentin Hypersensitivity. Consensus based recommendations for the diagnosis and management of dentin hypersensitivity. J Can Dent Assoc, 2003, 69(4):221-226.
21. Blong MA, Volding B, Thrash WJ, et al. Effects of a gel containing 0.4 percent stannous fluoride on dentinal hypersensitivity. Dent Hyg (Chic), 1985, 59(11):489-492.
22. Snyder RA, Beck FM, Horton JE. The efficacy of a 0.4% stannous fluoride gel on root surface hypersensitivity[abstract]. J Dent Res, 1983, 62(3):237.
23. Thrash WJ, Dodds MW, Jones DL. The effect of stannous fluoride on dentinal hypersensitivity. Int Dent J, 1994, 44(Suppl 1):107-118.
24. Schiff T, Saletta L, Baker RA, et al. Desensitizing effect of a stabilized stannous fluoride/sodium hexametaphosphate dentifrice. Compend Coutin Educ Dent, 2005, 26(Suppl 1):35-40.
25. Miller S, Truong T, Heu R, et al. Recent advances in stannous fluoride technology:Antibacterial efficacy and mechanism of action towards hypersensitivity. Int Dent J, 1994, 44(Suppl 1):83-98.
26. Walters PA. Dentinal hypersensitivity:A review. J Contemp Dent Pract, 2005, 6(2):107-117.
27. Ayad F, Ayad N, Delgado E, et al. Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride, and to a control toothpaste with 1450 ppm fluoride:a three-day clinical study in Mississauga, Canada. J Clin Dent, 2009, 20(4):115-122.

Chinese Journal of Evidence-Based Medicine

NovaMin-containing Bioactive Toothpaste for Dentine Hypersensitivity: A Meta-Analysis

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