Association between IL-6 Gene Polymorphism and the Risk of Chronic Obstructive Pulmonary Disease: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 WEIJiang-tao ¹ , HOUMing-yong ¹ , HEBin ¹ , DENGLei ¹ ,  LIAOGa ²

1. Department of Anesthesiology, Affiliated Hospital/School Medicine, Chengdu University, Chengdu 610081, China;
2. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;

Corresponding author：

LIAOGa, Email: 401215068@qq.com

Keywords：

Chronic obstructive pulmonary disease; IL-6; Polymorphism; Meta-analysis; Case-control study

DOI：

10.7507/1672-2531.20140184

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To systematically review the association between-174G/C polymorphism in interleukin-6 (IL-6) gene and the risk of chronic obstructive pulmonary disease (COPD). Methods We electronically searched PubMed, EMbase, CBM, WanFang Data, CNKI and VIP for case-control studies on the correlation between IL-6 gene-174G/C polymorphism and the risk of COPD. Two reviewers independently screened the studies according to the inclusion and exclusion criteria and extracted data. Then meta-analysis was conducted using RevMan 5.2 software. Results A total of 5 studies involving 487 COPD cases and 786 controls were included. The results of meta-analysis showed that, there was no significant association between IL-6 gene SNP-174G/C and risks of COPD:GC+CC vs. GG:OR=1.01, 95%CI 0.76 to 1.34, P=0.95; CC vs. GC+GG:OR=1.04, 95%CI 0.70 to 1.54, P=0.85:CC vs. GG:OR=1.05, 95%CI 0.69 to 1.61, P=0.81; GC vs. GG:OR=1.00, 95%CI 0.74 to 1.35, P=0.99; C vs. G:OR=1.02, 95%CI 0.83 to 1.24, P=0.88. Conclusion IL-6-174G/C gene polymorphism may not be a risk factor that causes COPD.

Citation： WEIJiang-tao, HOUMing-yong, HEBin, DENGLei, LIAOGa. Association between IL-6 Gene Polymorphism and the Risk of Chronic Obstructive Pulmonary Disease: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2014, 14(9): 1131-1134. doi: 10.7507/1672-2531.20140184 Copy

1.	GOLD Executive Committee. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (Revised 2011). Available at:http:www.goldcopd.com.
2.	中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南(2013年修订版).中华结核和呼吸杂志, 2013, 4:255-264.
3.	WHO. The global burden of disease:2004 update. 2004; Available at: http://www.who.int/healthinfo/global_burden_disease/GBD_report_2004update_full.pdf?ua=1.
4.	Zhong NS, Wang C, Yao WZ, et al. Prevalence of chronic obstructive pulmonary disease in China:a large, population-based survey. Am J Respir Crit Care, 2007, 176 (8):753-760.
5.	Teramoto S. COPD pathogenesis from the viewpoint of risk factors.Intem Med, 2007, 46:77-79.
6.	Yanbaeva DG, Dentener MA, Creutzberg EC, et al. Systemic inflammation in COPD:is genetic susceptibility a key factor? COPD, 2006, 3(1):51-61.
7.	Ruwanpura SM, McLeod L, Miller A, et al. Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice. Am J Respir Cell Mol Biol, 2011, 45(4):720-730.
8.	Saxena M, Srivastava N, Banerjee M. Association of IL-6, TNF-α and IL-10 gene polymorphisms with type 2 diabetes mellitus. Mol Biol Rep, 2013, 40(11):6271-6279.
9.	Seifart C, Dempfle A, Plagens A, et al. TNF-α-, TNF-β-, IL-6-, and IL-10-promoter polymorphisms in patients with chronic obstructive pulmonary disease. Tissue Antigens, 2005, 65(1):93-100.
10.	Hsieh MH, Chong IW, Hwang JJ, et al. Lack of associations between several polymorphisms in cytokine genes and the risk of chronic obstructive pulmonary diseases in Taiwan. Kaohsiung J Med Sci, 2008, 24(3):126-137.
11.	Córdoba-Lanús E, de-Torres JP, López-Aguilar C, et al. Association of IL-6 gene polymorphisms and COPD in a Spanish population. Respir Med, 2008, 102(12):1805-1811.
12.	杨文昊.白细胞介素-6基因启动子多态性与慢性阻塞性肺病的相关性分析. 2011. Available at: http://d.wanfangdata.com.cn/Thesis_Y2013184.aspx.
13.	何琏.昆明地区汉族男性IL-6基因-174G/C多态性及IL-6、25(OH)D3水平与COPD合并OP的相关性研究. 2013. Available at: http://www.cnki.net/KCMS/detail/detail.aspx?QueryID=1&CurRec=1&recid=&filename=1013332553.nh&dbname=CMFDLAST2014&dbcode=CMFD&pr=&urlid=&yx=&uid=WEEvREcwSlJHSldTTGJhYlRjQ3p2OEcyUHh6WkJhTVlDeE9oYzluVThDWXlpTmp3MU5rTjdsUnpQc1BRMG1VRS9QMD0=$9A4hF_YAuvQ5obgVAqNKPCYcEjKensW4IQMovwHtwkF4VYPoHbKxJw!!&v=Mjc3NTMzcVRyV00xRnJDVVJMNmZidWR2RnlqblY3ckxWRjI2SGJDN0hOVEpySkViUElSOGVYMUx1eFlTN0RoMVQ=.

1. GOLD Executive Committee. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (Revised 2011). Available at:http:www.goldcopd.com.
2. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南(2013年修订版).中华结核和呼吸杂志, 2013, 4:255-264.
3. WHO. The global burden of disease:2004 update. 2004; Available at: http://www.who.int/healthinfo/global_burden_disease/GBD_report_2004update_full.pdf?ua=1.
4. Zhong NS, Wang C, Yao WZ, et al. Prevalence of chronic obstructive pulmonary disease in China:a large, population-based survey. Am J Respir Crit Care, 2007, 176 (8):753-760.
5. Teramoto S. COPD pathogenesis from the viewpoint of risk factors.Intem Med, 2007, 46:77-79.
6. Yanbaeva DG, Dentener MA, Creutzberg EC, et al. Systemic inflammation in COPD:is genetic susceptibility a key factor? COPD, 2006, 3(1):51-61.
7. Ruwanpura SM, McLeod L, Miller A, et al. Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice. Am J Respir Cell Mol Biol, 2011, 45(4):720-730.
8. Saxena M, Srivastava N, Banerjee M. Association of IL-6, TNF-α and IL-10 gene polymorphisms with type 2 diabetes mellitus. Mol Biol Rep, 2013, 40(11):6271-6279.
9. Seifart C, Dempfle A, Plagens A, et al. TNF-α-, TNF-β-, IL-6-, and IL-10-promoter polymorphisms in patients with chronic obstructive pulmonary disease. Tissue Antigens, 2005, 65(1):93-100.
10. Hsieh MH, Chong IW, Hwang JJ, et al. Lack of associations between several polymorphisms in cytokine genes and the risk of chronic obstructive pulmonary diseases in Taiwan. Kaohsiung J Med Sci, 2008, 24(3):126-137.
11. Córdoba-Lanús E, de-Torres JP, López-Aguilar C, et al. Association of IL-6 gene polymorphisms and COPD in a Spanish population. Respir Med, 2008, 102(12):1805-1811.
12. 杨文昊.白细胞介素-6基因启动子多态性与慢性阻塞性肺病的相关性分析. 2011. Available at: http://d.wanfangdata.com.cn/Thesis_Y2013184.aspx.
13. 何琏.昆明地区汉族男性IL-6基因-174G/C多态性及IL-6、25(OH)D3水平与COPD合并OP的相关性研究. 2013. Available at: http://www.cnki.net/KCMS/detail/detail.aspx?QueryID=1&CurRec=1&recid=&filename=1013332553.nh&dbname=CMFDLAST2014&dbcode=CMFD&pr=&urlid=&yx=&uid=WEEvREcwSlJHSldTTGJhYlRjQ3p2OEcyUHh6WkJhTVlDeE9oYzluVThDWXlpTmp3MU5rTjdsUnpQc1BRMG1VRS9QMD0=$9A4hF_YAuvQ5obgVAqNKPCYcEjKensW4IQMovwHtwkF4VYPoHbKxJw!!&v=Mjc3NTMzcVRyV00xRnJDVVJMNmZidWR2RnlqblY3ckxWRjI2SGJDN0hOVEpySkViUElSOGVYMUx1eFlTN0RoMVQ=.

Chinese Journal of Evidence-Based Medicine

Association between IL-6 Gene Polymorphism and the Risk of Chronic Obstructive Pulmonary Disease: A Meta-Analysis

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