Association between IL-1β Gene-511C/T Polymorphisms and Chronic Obstructive Pulmonary Disease Risk: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 ZENGLing-jun , LILi , BIYu-ling

Department of Respiratory, First People Hospital of Ziyang City, Ziyang 641300, China;

Corresponding author：

Keywords：

Chronic obstructive pulmonary disease; Gene; Polymorphism; IL-1β; Meta-analysis

DOI：

10.7507/1672-2531.20140212

Video：

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Objective To investigate the association between IL-1β gene-511C/T polymorphisms and the risk of chronic obstructive pulmonary disease (COPD). Methods Such databases as PubMed, EMbase, CNKI, CBM, VIP and WanFang Data were searched for the studies on the association between IL-1β gene-511C/T polymorphisms and the risk of COPD up to May 2014. According to inclusion and exclusion criteria, two reviewers independently screened literature, extracted data, and assessed methodological quality of included studies. Then meta-analysis was performed using RevMan 5.0 software. Results A total of 10 case-control studies from 9 articles involving 1 171 cases and 1 268 controls were included. The results of meta-analysis showed that, no significant association was found between IL-1β gene-511C/T polymorphisms and the risk of COPD:TT+CT vs. CC:OR=1.06, 95%CI 0.66 to 1.70, P=0.82; TT vs. CT+CC:OR=0.87, 95%CI 0.60 to 1.26, P=0.32; TT vs. CC:OR=0.95, 95%CI 0.51 to 1.75, P=0.86; CT vs. CC:OR=1.10, 95%CI 0.71 to 1.70, P=0.15; T vs. C:OR=0.97, 95%CI=0.72 to 1.30, P=0.84. The results of subgroup analysis by ethnicity showed that, no significant association was found between IL-1β gene-511C/T polymorphisms and the risk of COPD among Caucasians and Asians. Conclusion IL-1β gene-511C/T polymorphisms might not contribute to the risk of COPD.

Citation： ZENGLing-jun, LILi, BIYu-ling. Association between IL-1β Gene-511C/T Polymorphisms and Chronic Obstructive Pulmonary Disease Risk: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2014, 14(11): 1304-1310. doi: 10.7507/1672-2531.20140212 Copy

1.	vestbo J, Hurd SS, Agusti AG, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease:GOLD executive summary. Am J Respir Crit Care Med, 2013, 187(4):347-365.
2.	Ferkol T, Schraufnagel D. The global burden of respiratory disease. Ann Am Thorac Soc, 2014, 11(3):404-406.
3.	Zhong N, Wang C, Yao W, et al. Prevalence of chronic obstructive pulmonary disease in China:a large, population-based survey. Am J Respir Crit Care Med, 2007, 176(8):753-760.
4.	Kim H, Cha SI, Shin KM, et al. Clinical relevance of bronchial anthracofibrosis in patients with chronic obstructive pulmonary disease exacerbation. Tuberc Respir Dis (Seoul), 2014, 77(3):124-131.
5.	Zhang XF, Zhu J, Geng WY, et al. Electroacupuncture at Feishu (BL13) and Zusanli (ST36) down-regulates the expression of orexins and their receptors in rats with chronic obstructive pulmonary disease. J Integr Med, 2014, 12(5):417-424.
6.	Davidsen PK, Herbert JM, Antczak P, et al. A systems biology approach reveals a link between systemic cytokines and skeletal muscle energy metabolism in a rodent smoking model and human COPD. Genome Med, 2014, 6(8):59.
7.	Bascom R. Differential susceptibility to tobacco smoke:possible mechanisms. Pharmacogenetics, 1991, 1(2):102-106.
8.	Hegab AE, Sakamoto T, Saitoh W, et al. Polymorphisms of TNFalpha, IL1beta, and IL1RN genes in chronic obstructive pulmonary disease. Biochem Biophys Res Commun, 2005, 329(4):1246-1252.
9.	Guo Y, Gong Y, Pan C, et al. Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population:a case-control study. BMC Med Genomics, 2012, 5:64.
10.	Wang EY, Liang WB, Zhang L. Association between single-nucleotide polymorphisms in interleukin-12A and risk of chronic obstructive pulmonary disease. DNA Cell Biol, 2012, 31(9):1475-1479.
11.	Lee JM, Kang YR, Park SH, et al. Polymorphisms in interleukin-1B and its receptor antagonist genes and the risk of chronic obstructive pulmonary disease in a Korean population:a case-control study. Respir Med, 2008, 102(9):1311-1320.
12.	Le J, Vilcek J. Tumor necrosis factor and interleukin 1:cytokines with multiple overlapping biological activities. Lab Invest, 1987, 56(3):234-248.
13.	Shukla RK, Kant S, Bhattacharya S, et al. Association of cytokine gene polymorphisms in patients with chronic obstructive pulmonary disease. Oman Med J, 2012, 27(4):285-290.
14.	von Elm E, Moher D, Little J, et al. Reporting genetic association studies:the STREGA statement. Lancet, 2009, 374(9684):98-100.
15.	郝旻置. TNF-α、IL-1β和IL-10启动子区基因多态性与慢性阻塞性肺疾病和肺癌的易感性研究, 2008, 学位论文, 东华大学.
16.	Issac MS, Ashur W, Mousa H. Genetic polymorphisms of surfactant protein D rs2243639, Interleukin (IL)-1beta rs16944 and IL-1RN rs2234663 in chronic obstructive pulmonary disease, healthy smokers, and non-smokers. Mol Diagn Ther, 2014, 18(3):343-354.
17.	Broekhuizen R, Grimble RF, Howell WM, et al. Pulmonary cachexia, systemic inflammatory profile, and the interleukin 1beta-511 single nucleotide polymorphism. Am J Clin Nutr, 2005, 82(5):1059-1064.
18.	Ishii T, Matsuse T, Teramoto S, et al. Neither IL-1beta, IL-1 receptor antagonist, nor TNF-alpha polymorphisms are associated with susceptibility to COPD. Respir Med, 2000, 94(9):847-851.
19.	孙丽蓉, 王海龙, 高扬, 等. IL-1、IL-6基因多态性与慢性阻塞性肺疾病肺动脉高压相关性研究.医学研究杂志, 2013, 42(11):80-84.
20.	石玉枝, 刘豹, 霍建民, 等.慢性阻塞性肺疾病易感性与白细胞介素1基因的多态性.中国临床康复, 2006, 10(16):67-69.
21.	Chen L, Shen Y, Liu L, et al. Interleukin-13-1112 C/T promoter polymorphism confers risk for COPD:a meta-analysis. PLoS One, 2013, 8(7):e68222.
22.	Zhang S, Wang C, Xi B, et al. Association between the tumour necrosis factor-alpha-308G/A polymorphism and chronic obstructive pulmonary disease:an update. Respirology, 2011, 16(1):107-115.
23.	Kuschner WG, D'Alessandro A, Wong H, et al. Dose-dependent cigarette smoking-related inflammatory responses in healthy adults. Eur Respir J, 1996, 9(10):1989-1994.
24.	Kim JO, Lee WS, Lee BE, et al. Interleukin-1beta-511T>C genetic variant contributes to recurrent pregnancy loss risk and peripheral natural killer cell proportion. Fertil Steril, 2014, 102(1):206-212 e205.
25.	Lakhanpal M, Yadav DS, Devi TR, et al. Association of interleukin-1beta-511 C/T polymorphism with tobacco-associated cancer in northeast India:a study on oral and gastric cancer. Cancer Genet, 2014, 207(1-2):1-11.
26.	Bo Y, Liu S, Yin Y, et al. Association study between IL-1beta-511 C/T polymorphism and obsessive-compulsive disorder (OCD) in Chinese Han population. Int J Psychiatry Med, 2013, 46(2):145-152.
27.	Szewczyk J, Koszowski R, Juzwiak R, et al. A radiographic assessment of the regeneration process in post-operative alveolar bone defects in patients with different IL-1B-511 genotypes. Adv Clin Exp Med, 2013, 22(6):847-854.

1. vestbo J, Hurd SS, Agusti AG, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease:GOLD executive summary. Am J Respir Crit Care Med, 2013, 187(4):347-365.
2. Ferkol T, Schraufnagel D. The global burden of respiratory disease. Ann Am Thorac Soc, 2014, 11(3):404-406.
3. Zhong N, Wang C, Yao W, et al. Prevalence of chronic obstructive pulmonary disease in China:a large, population-based survey. Am J Respir Crit Care Med, 2007, 176(8):753-760.
4. Kim H, Cha SI, Shin KM, et al. Clinical relevance of bronchial anthracofibrosis in patients with chronic obstructive pulmonary disease exacerbation. Tuberc Respir Dis (Seoul), 2014, 77(3):124-131.
5. Zhang XF, Zhu J, Geng WY, et al. Electroacupuncture at Feishu (BL13) and Zusanli (ST36) down-regulates the expression of orexins and their receptors in rats with chronic obstructive pulmonary disease. J Integr Med, 2014, 12(5):417-424.
6. Davidsen PK, Herbert JM, Antczak P, et al. A systems biology approach reveals a link between systemic cytokines and skeletal muscle energy metabolism in a rodent smoking model and human COPD. Genome Med, 2014, 6(8):59.
7. Bascom R. Differential susceptibility to tobacco smoke:possible mechanisms. Pharmacogenetics, 1991, 1(2):102-106.
8. Hegab AE, Sakamoto T, Saitoh W, et al. Polymorphisms of TNFalpha, IL1beta, and IL1RN genes in chronic obstructive pulmonary disease. Biochem Biophys Res Commun, 2005, 329(4):1246-1252.
9. Guo Y, Gong Y, Pan C, et al. Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population:a case-control study. BMC Med Genomics, 2012, 5:64.
10. Wang EY, Liang WB, Zhang L. Association between single-nucleotide polymorphisms in interleukin-12A and risk of chronic obstructive pulmonary disease. DNA Cell Biol, 2012, 31(9):1475-1479.
11. Lee JM, Kang YR, Park SH, et al. Polymorphisms in interleukin-1B and its receptor antagonist genes and the risk of chronic obstructive pulmonary disease in a Korean population:a case-control study. Respir Med, 2008, 102(9):1311-1320.
12. Le J, Vilcek J. Tumor necrosis factor and interleukin 1:cytokines with multiple overlapping biological activities. Lab Invest, 1987, 56(3):234-248.
13. Shukla RK, Kant S, Bhattacharya S, et al. Association of cytokine gene polymorphisms in patients with chronic obstructive pulmonary disease. Oman Med J, 2012, 27(4):285-290.
14. von Elm E, Moher D, Little J, et al. Reporting genetic association studies:the STREGA statement. Lancet, 2009, 374(9684):98-100.
15. 郝旻置. TNF-α、IL-1β和IL-10启动子区基因多态性与慢性阻塞性肺疾病和肺癌的易感性研究, 2008, 学位论文, 东华大学.
16. Issac MS, Ashur W, Mousa H. Genetic polymorphisms of surfactant protein D rs2243639, Interleukin (IL)-1beta rs16944 and IL-1RN rs2234663 in chronic obstructive pulmonary disease, healthy smokers, and non-smokers. Mol Diagn Ther, 2014, 18(3):343-354.
17. Broekhuizen R, Grimble RF, Howell WM, et al. Pulmonary cachexia, systemic inflammatory profile, and the interleukin 1beta-511 single nucleotide polymorphism. Am J Clin Nutr, 2005, 82(5):1059-1064.
18. Ishii T, Matsuse T, Teramoto S, et al. Neither IL-1beta, IL-1 receptor antagonist, nor TNF-alpha polymorphisms are associated with susceptibility to COPD. Respir Med, 2000, 94(9):847-851.
19. 孙丽蓉, 王海龙, 高扬, 等. IL-1、IL-6基因多态性与慢性阻塞性肺疾病肺动脉高压相关性研究.医学研究杂志, 2013, 42(11):80-84.
20. 石玉枝, 刘豹, 霍建民, 等.慢性阻塞性肺疾病易感性与白细胞介素1基因的多态性.中国临床康复, 2006, 10(16):67-69.
21. Chen L, Shen Y, Liu L, et al. Interleukin-13-1112 C/T promoter polymorphism confers risk for COPD:a meta-analysis. PLoS One, 2013, 8(7):e68222.
22. Zhang S, Wang C, Xi B, et al. Association between the tumour necrosis factor-alpha-308G/A polymorphism and chronic obstructive pulmonary disease:an update. Respirology, 2011, 16(1):107-115.
23. Kuschner WG, D'Alessandro A, Wong H, et al. Dose-dependent cigarette smoking-related inflammatory responses in healthy adults. Eur Respir J, 1996, 9(10):1989-1994.
24. Kim JO, Lee WS, Lee BE, et al. Interleukin-1beta-511T>C genetic variant contributes to recurrent pregnancy loss risk and peripheral natural killer cell proportion. Fertil Steril, 2014, 102(1):206-212 e205.
25. Lakhanpal M, Yadav DS, Devi TR, et al. Association of interleukin-1beta-511 C/T polymorphism with tobacco-associated cancer in northeast India:a study on oral and gastric cancer. Cancer Genet, 2014, 207(1-2):1-11.
26. Bo Y, Liu S, Yin Y, et al. Association study between IL-1beta-511 C/T polymorphism and obsessive-compulsive disorder (OCD) in Chinese Han population. Int J Psychiatry Med, 2013, 46(2):145-152.
27. Szewczyk J, Koszowski R, Juzwiak R, et al. A radiographic assessment of the regeneration process in post-operative alveolar bone defects in patients with different IL-1B-511 genotypes. Adv Clin Exp Med, 2013, 22(6):847-854.

Chinese Journal of Evidence-Based Medicine

Association between IL-1β Gene-511C/T Polymorphisms and Chronic Obstructive Pulmonary Disease Risk: A Meta-Analysis

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