LI Binghui 1,2,3 , MENG Jiming 1,2,3 , WANG Chaoyang 1,2,3 , ZHENG Zhongli 1,2,3 , ZI Hao 2,3,4 , CHEN Shaohua 2,3 , ZENG Xiantao 2,3,5,6,7,8 , REN Xuequn 1,2,3
  • 1. Department of General Surgery, Huaihe Hospital of Henan University, Kaifeng, 475000, P.R.China;
  • 2. Center for Evidence-Based Medicine, Huaihe Hospital of Henan University, Kaifeng, 475000, P.R.China;
  • 3. Center for Evidence-Based Medicine, Henan University, Kaifeng, 475000, P.R.China;
  • 4. Department of Urology, Huaihe Hospital of Henan University, Kaifeng, 475000, P.R.China;
  • 5. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, P.R.China;
  • 6. Center for Evidence-Based and Translational Medicine, Wuhan University, Wuhan, 430071, P.R.China;
  • 7. Department of Evidence-Based Medicine and Clinical Epidemiology, The Second Clinical Medical College, Wuhan University, Wuhan, 430071, P.R.China;
  • 8. Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, P.R.China;
REN Xuequn, Email: renxuequn001@163.com
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Objective  To systematically review the relationship between periodontal disease and gastric cancer risk. Methods  We retrieved PubMed, EMbase, CNKI, WanFang Data, VIP, and CBM databases to collect studies about the correlation between periodontal disease and gastric cancer from inception to January 31st, 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.3 software. Results  Five studies were included. The results of meta-analysis showed that there was no significant correlation between periodontal disease and gastric cancer (RR=0.99, 95%CI 0.83 to 1.19, P=0.93). Sensitivity analysis showed good stability. Subgroup analysis showed that the type of study, race and type of effect size have no statistically impact on the outcome, there was no significant correlation between periodontal disease and gastric cancer. Conclusion  According to the current evidence, periodontal disease probably is not a risk factor of gastric cancer. Due to limited quality and quantity of the included studies, more high quality studies are needed to verify above conclusion.

Citation: LI Binghui, MENG Jiming, WANG Chaoyang, ZHENG Zhongli, ZI Hao, CHEN Shaohua, ZENG Xiantao, REN Xuequn. Association between periodontal disease and gastric cancer risk: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2017, 17(10): 1183-1187. doi: 10.7507/1672-2531.201703145 Copy

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