The regularity of prescriptions of traditional Chinese medicine in the treatment of syndrome of Shi-Re-Huo-Du based on complex network analyses_Chinese Journal of Evidence-Based Medicine

Authors：

HU Haiyin ¹ , JI Zhaochen ¹ , WANG Hucheng ¹ , JIN Xinyao ¹ , LI Nan ¹ , WANG Keyi ¹ , YANG Fengwen ¹ , PANG Wentai ¹ , WANG hui ¹ , LI Xiantao ² ,  ZHANG Junhua ¹

1. Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 300361, P.R.China;
2. The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, 510000, P.R.China;

Corresponding author：

ZHANG Junhua, Email: zjhtcm@foxmail.com

Keywords：

Syndrome of intense fire and heat; Syndrome of Shi-Re-Huo-Du; Complex network; The regularity of prescription

DOI：

10.7507/1672-2531.201812091

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Objective To analysis the regularity of prescriptions of Chinese Medicine for syndrome of intense fire and heat (syndrome of Shi-Re-Huo-Du), and to provide evidences for the clinical treatment.Methods CNKI, Sinomed, WanFang Data, VIP and Chinese medical databases were electronically searched to collect literatures about traditional Chinese Medicine for syndrome of Shi-Re-Huo-Du from inception to October, 2018. Two reviewers independently screened literature and extracted data. Then BICOMS 2 software was used to generate the co-occurrence matrix, NetDraw software was used to draw network maps.Results A total of 381 literatures involving 335 patients were included. There were 716 prescriptions of Shi-Re-Huo-Du (390 Chinese medicinal herbs), in which the frequently used herb included radix glycyrrhizae (346), Scutellariae Radix (255), Fructus Gardeniae (241), Rehmanniae Radix (239), Moutan Cortex (218), etc. The classification was performed according to traditional efficacy, Qing-re herbs (73), Bu-xu herbs (47), and Hua-tan-zhi-ke-ping-chuan herbs (39), accounted for 40.77% of the total herbs. The results of the analysis showed that the top herbs in Degree and Betweenness were consistent with high-frequency herbs. Among them, Rehmanniae Radix, Fructus Gardeniae, Scutellariae Radix, Moutan Cortex are the most important traditional Chinese herbs. High-frequency herbs are mainly based on Qing-re herbs, and the highest frequency of the herbs combination is Scutellariae Radix-Fructus Gardeniae.Conclusion Although there are kinds of herbs for syndrome of Shi-Re-Huo-Du, the commonly used herbs are relatively concentrated, and there is obvious interaction between high-frequency herbs, which is in line with the principle of compatibility of Chinese medicine. The high-frequency Chinese herbs and herb pairs were main components of the Chinese patent medicines and classic prescription. It reflected the rule of medicine used and essence in the treatment of syndrome of Shi-Re-Huo-Du.

Citation： HU Haiyin, JI Zhaochen, WANG Hucheng, JIN Xinyao, LI Nan, WANG Keyi, YANG Fengwen, PANG Wentai, WANG hui, LI Xiantao, ZHANG Junhua. The regularity of prescriptions of traditional Chinese medicine in the treatment of syndrome of Shi-Re-Huo-Du based on complex network analyses. Chinese Journal of Evidence-Based Medicine, 2020, 20(2): 186-190. doi: 10.7507/1672-2531.201812091 Copy

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1. 中华人民共和国卫生部. GB/T 16751.2-1997 中医临床诊疗术语证候部分(修订版). 北京: 中国标准出版社, 1997.
2. 谢伟, 刘晓芳, 徐晨希, 等. 《神农本草经》治疗火热证药物特点浅析. 时珍国医国药, 2018, 29(6): 1415-1418.
3. 王伟杰, 谢冠群, 范永升. 中医八法治疗火热证探微. 中华中医药杂志, 2017, 32(5): 1918-1920.
4. Gonz LMC, Barab SAL. complex networks: from data to models. Nature Physics, 2007, 3(4): 224-225.
5. 杨铭, 田雨, 陈佳蕾, 等. BK 算法在中医方剂“基本方”发现中的应用. 中国中药杂志, 2012, 37(21): 3323-3328.
6. 周雪忠, 刘保延, 王映辉, 等. 复方药物配伍的复杂网络方法研究. 中国中医药信息杂志, 2008, (11): 98-100.
7. Li S, Zhang B, Jiang D, et al. Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae. BMC Bioinformatics, 2010, 11: S6.
8. Zhou X, Zhang R, Wang Y, et al. Network analysis for core herbal combination knowledge discovery from clinical chinese medical formulae. Proceedings-20091st International Workshop on database technology and applications, 2009.
9. 季昭臣, 郭雨驰, 胡海殷, 等. 基于复杂网络分析中医药自拟方治疗缓慢性心率失常用药规律. 环球中医药, 2018, 11(6): 801-806.
10. 赵晔, 张俊华, 李伦, 等. 全球网状 Meta 分析研究主题的可视化分析. 中国药物评价, 2017, 34(1): 18-21.

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Chinese Journal of Evidence-Based Medicine

The regularity of prescriptions of traditional Chinese medicine in the treatment of syndrome of Shi-Re-Huo-Du based on complex network analyses

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