Association of micronucleus and polycystic ovary syndrome: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

LI Xiaozhen ¹ , SONG Zeli ² , WANG Yefeng ³ , CAO Wenting ¹ ,  HUANG Hairong ¹

1. Department of Epidemiology, School of Public Health, Hainan Medical University, Haikou, 571199, P.R.China;
2. Department of Toxicology, College of Public Health, China Medical University, Shenyang, 110001, P.R.China;
3. School of Public Health and Management, NingXia Medical University, Yinchuan, 750004, P.R.China;

Corresponding author：

HUANG Hairong, Email: jialidog1@163.com

Keywords：

PCOS; Micronucleus; Oxidative stress; Meta-analysis; Systematic review; Case-control study

DOI：

10.7507/1672-2531.201906131

Video：

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Objective To systematically review the association of micronucleus and polycystic ovary syndrome (PCOS).Methods PubMed, OVID, Elsevier, CNKI, WanFang Data and CBM databases were electronically searched to collect case-control studies on the association of micronucleus and PCOS. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by using RevMan 5.3 software.Results A total of 5 case-control studies were included, in which 170 patients were in the case group and 148 in the control group. The results of meta-analysis showed: there were significant differences between the two groups for micronucleus frequency (MD=2.02%, 95%CI 1.63% to 2.41%, P<0.000 01) in peripheral blood lymphocytes and micro nucleated cells frequency (MD=2.43%, 95%CI 0.10% to 4.76%, P=0.04) in oral epithelial cells.Conclusion The current evidence shows that micronucleus is associated with PCOS. Due to limited quality and quantity of the included studies, more high quality studies are needed to verify above conclusion.

Citation： LI Xiaozhen, SONG Zeli, WANG Yefeng, CAO Wenting, HUANG Hairong. Association of micronucleus and polycystic ovary syndrome: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2020, 20(2): 181-185. doi: 10.7507/1672-2531.201906131 Copy

1.	Azziz R, Carmina E, Chen Z, et al. Polycystic ovary syndrome. Nat Rev Dis Primers, 2016, 2: 16057.
2.	张鸢, 蒋惠愈. 胰岛素抵抗与体质量指数对 PCOS 妇女脂代谢及性激素的影响. 中国妇幼健康研究, 2017, 28(11): 1412-1414.
3.	Azziz R. Polycystic ovary syndrome. Obstet Gynecol, 2018, 132(2): 321-336.
4.	Karataylı R, Gül Zamani A, Gezginç K, et al. Micronuclei frequencies in lymphocytes and cervical cells of women with polycystic ovarian syndrome. Turk J Obstet Gynecol, 2017, 14(3): 151-155.
5.	Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril, 2004, 81(1): 19-25.
6.	周月琴, 凌迎春, 沈群弟, 等. 中国女性血清瘦素与多囊卵巢综合征关系的 Meta 分析. 中国妇幼健康研究, 2019, 30(3): 385-388.
7.	陈咏, 于月新, 芦冬梅, 等. 维生素 D 受体基因多态性与多囊卵巢综合征 Meta 分析. 中国实用妇科与产科杂志, 2018, 34(1): 94-99.
8.	Deepika ML, Nalini S, Maruthi G, et al. Analysis of oxidative stress status through MN test and serum MDA levels in PCOS women. Pak J Biol Sci, 2014, 17(4): 574-577.
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12.	Rocha AL, Oliveira FR, Azevedo RC, et al. Recent advances in the understanding and management of polycystic ovary syndrome. F1000Res, 2019, 8: 1000-1565.
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14.	熊冬梅, 谷霞, 许良智, 等. 多囊卵巢综合征患者高雄激素的相关性研究. 实用医院临床杂志, 2013, 10(4): 56-58.
15.	朱茜, 倪郝, 全松. 多囊卵巢综合征高雄激素特征及管理. 中国实用妇科与产科杂志, 2019, 35(3): 274-278.
16.	曹娇娇. 中国人群 CYP17 基因多态性与多囊卵巢综合征关系的荟萃分析. 哈尔滨: 黑龙江中医药大学, 2011.
17.	董文娇, 王玉霞, 杨海婷. 雄激素受体基因(CAG)n 多态性对多囊卵巢综合征形成的影响. 国际生殖健康/计划生育杂志, 2017, 36(1): 70-73.
18.	左莉, 傅亚均. 多囊卵巢综合征病因及治疗进展. 重庆医学, 2018, 47(9): 1247-1250.
19.	Özer A, Bakacak M, Kıran H, et al. Increased oxidative stress is associated with insulin resistance and infertility in polycystic ovary syndrome. Ginekol Pol, 2016, 87(11): 733-738.
20.	Papalou O, Victor VM, Diamanti-Kandarakis E. Oxidative stress in polycystic ovary syndrome. Curr Pharm Des, 2016, 22(18): 2709-2722.
21.	Hintzsche H, Hemmann U, Poth A, et al. Fate of micronuclei and micronucleated cells. Mutat Res, 2017, 771: 85-98.
22.	Hyderali BN, Mala K. Oxidative stress and cardiovascular complications in polycystic ovarian syndrome. Eur J Obstet Gynecol Reprod Biol, 2015, 191: 15-22.
23.	高贵花, 曹云霞, 易龙, 等. 胆固醇侧链裂解酶 CYP11 A1 基因多态性与多囊卵巢综合征发病的相关性. 中华妇产科杂志, 2010, 45(3): 191-196.
24.	杨柳, 张磊, 李春辉, 等. 胆固醇侧链裂解酶基因微卫星多态性与多囊卵巢综合征发病风险的关联. 山东大学学报(医学版), 2013, 51(10): 85-89.
25.	Zuo T, Zhu M, Xu W. Roles of oxidative stress in polycystic ovary syndrome and cancers. Oxid Med Cell Longev, 2016, 2016: 8589318.

1. Azziz R, Carmina E, Chen Z, et al. Polycystic ovary syndrome. Nat Rev Dis Primers, 2016, 2: 16057.
2. 张鸢, 蒋惠愈. 胰岛素抵抗与体质量指数对 PCOS 妇女脂代谢及性激素的影响. 中国妇幼健康研究, 2017, 28(11): 1412-1414.
3. Azziz R. Polycystic ovary syndrome. Obstet Gynecol, 2018, 132(2): 321-336.
4. Karataylı R, Gül Zamani A, Gezginç K, et al. Micronuclei frequencies in lymphocytes and cervical cells of women with polycystic ovarian syndrome. Turk J Obstet Gynecol, 2017, 14(3): 151-155.
5. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril, 2004, 81(1): 19-25.
6. 周月琴, 凌迎春, 沈群弟, 等. 中国女性血清瘦素与多囊卵巢综合征关系的 Meta 分析. 中国妇幼健康研究, 2019, 30(3): 385-388.
7. 陈咏, 于月新, 芦冬梅, 等. 维生素 D 受体基因多态性与多囊卵巢综合征 Meta 分析. 中国实用妇科与产科杂志, 2018, 34(1): 94-99.
8. Deepika ML, Nalini S, Maruthi G, et al. Analysis of oxidative stress status through MN test and serum MDA levels in PCOS women. Pak J Biol Sci, 2014, 17(4): 574-577.
9. Hamurcu Z, Bayram F, Kahriman G, et al. Micronucleus frequency in lymphocytes and 8-hydroxydeoxyguanosine level in plasma of women with polycystic ovary syndrome. Gynecol Endocrinol, 2010, 26(8): 590-595.
10. Moran LJ, Noakes M, Clifton PM, et al. Genome instability is increased in lymphocytes of women with polycystic ovary syndrome and is correlated with insulin resistance. Mutat Res, 2008, 639(1-2): 55-63.
11. Nersesyan A, Chobanyan N. Micronuclei and other nuclear anomalies levels in exfoliated buccal cells and DNA damage in leukocytes of patients with polycystic ovary syndrome. J BUON, 2010, 15(2): 337-339.
12. Rocha AL, Oliveira FR, Azevedo RC, et al. Recent advances in the understanding and management of polycystic ovary syndrome. F1000Res, 2019, 8: 1000-1565.
13. Ortiz-Flores AE, Luque-Ramírez M, Escobar-Morreale HF. Polycystic ovary syndrome in adult women. Med Clin (Barc), 2019, 152(11): 450-457.
14. 熊冬梅, 谷霞, 许良智, 等. 多囊卵巢综合征患者高雄激素的相关性研究. 实用医院临床杂志, 2013, 10(4): 56-58.
15. 朱茜, 倪郝, 全松. 多囊卵巢综合征高雄激素特征及管理. 中国实用妇科与产科杂志, 2019, 35(3): 274-278.
16. 曹娇娇. 中国人群 CYP17 基因多态性与多囊卵巢综合征关系的荟萃分析. 哈尔滨: 黑龙江中医药大学, 2011.
17. 董文娇, 王玉霞, 杨海婷. 雄激素受体基因(CAG)n 多态性对多囊卵巢综合征形成的影响. 国际生殖健康/计划生育杂志, 2017, 36(1): 70-73.
18. 左莉, 傅亚均. 多囊卵巢综合征病因及治疗进展. 重庆医学, 2018, 47(9): 1247-1250.
19. Özer A, Bakacak M, Kıran H, et al. Increased oxidative stress is associated with insulin resistance and infertility in polycystic ovary syndrome. Ginekol Pol, 2016, 87(11): 733-738.
20. Papalou O, Victor VM, Diamanti-Kandarakis E. Oxidative stress in polycystic ovary syndrome. Curr Pharm Des, 2016, 22(18): 2709-2722.
21. Hintzsche H, Hemmann U, Poth A, et al. Fate of micronuclei and micronucleated cells. Mutat Res, 2017, 771: 85-98.
22. Hyderali BN, Mala K. Oxidative stress and cardiovascular complications in polycystic ovarian syndrome. Eur J Obstet Gynecol Reprod Biol, 2015, 191: 15-22.
23. 高贵花, 曹云霞, 易龙, 等. 胆固醇侧链裂解酶 CYP11 A1 基因多态性与多囊卵巢综合征发病的相关性. 中华妇产科杂志, 2010, 45(3): 191-196.
24. 杨柳, 张磊, 李春辉, 等. 胆固醇侧链裂解酶基因微卫星多态性与多囊卵巢综合征发病风险的关联. 山东大学学报(医学版), 2013, 51(10): 85-89.
25. Zuo T, Zhu M, Xu W. Roles of oxidative stress in polycystic ovary syndrome and cancers. Oxid Med Cell Longev, 2016, 2016: 8589318.

Chinese Journal of Evidence-Based Medicine

Association of micronucleus and polycystic ovary syndrome: a meta-analysis

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