• 1. School of Economics & Management, Tongji University, Shanghai 200092, P.R.China;
  • 2. General Practice Medicine, Dongfang Hospital of Tongji University, Shanghai 200092, P.R.China;
  • 3. School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai 200092, P.R.China;
  • 4. Yangpu Hospital, Tongji University School of Medicine, Shanghai 200092, P.R.China;
  • 5. Tongji University School of Medicine, Shanghai 200092, P.R.China;
WANG Chaoxin, Email: supercell@sina.com
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Objective To sort out the historical evolution of diagnostic screening methods for pancreatic cancer, and to explore how to achieve early diagnosis and treatment of pancreatic cancer in the context of China’s large population base and economic development.Methods Systematic review was performed. The computer was used to search databases inchuding CNKI, VIP, WanFang Data, Web of Science, PubMed and EMbase. Two researchers independently searched Baidu search engine to collect relevant reports on screening methods and effect evaluation of pancreatic cancer published before February 28, 2018, and a qualitative descroption was made.Results A total of 117 articles were included in the study. The exploration of screening methods for pancreatic cancer in China has experienced three stages: germination, enlightenment and growth. Current screening methods include clinical manifestations, imaging screening methods, serum tumor markers and molecular biology gene diagnosis, each of which had its advantages and disadvantages. Single method could not achieve higher specificity and sensitivity, and joint detection had become an inevitable trend. Considering the benefit of practical application, screening among high-risk groups could effectively reduce the population size and achieve accurate screening.Conclusion There was a big gap between domestic and foreign research in screening for pancreatic cancer. Screening methods are diverse, and joint detection is an inevitable trend. Screening for pancreatic cancer in high-risk population will become a breakthrough under the technical bottleneck.

Citation: XU Kangjie, JIANG Hua, SHI Jianwei, HUANG Jiaoling, LIU Nana, GONG Xin, BO Xiaojie, LIU Qian, CHEN Ning, YANG Yan, WANG Chaoxin. Systematic evaluation of the development of diagnosis and screening methods for pancreatic cancer. Chinese Journal of Evidence-Based Medicine, 2020, 20(2): 221-226. doi: 10.7507/1672-2531.201904056 Copy

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