Situation of application and funding of evidenced-based research projects on traditional Chinese medicine (TCM) of National Natural Science Foundation of China in 2019_Chinese Journal of Evidence-Based Medicine

Authors：

JIANG Jing ¹ , SHEN Li ² , LI Weidong ³ , YAN Qianhua ⁴ , LIU Qi ⁵ , CUI Shuna ⁶ ,  BI Minggang ⁷

1. Beijing University of Chinese Medicine, Beijing 100029, P.R.China;
2. Institue of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100070, P.R.China;
3. Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, P.R.China;
4. Affiliated Hospital of Nanjing Chinese Medicine University, Nanjing 210023, P.R.China;
5. Shanxi University of Chinese Medicine, Shanxi 712046, P.R.China;
6. Yangzhou University, Yangzhou 225000, P.R.China;
7. National Natural Science Foundation of China, Beijing 100081, P.R.China;

Corresponding author：

BI Minggang, Email: bimg@nsfc.gov.cn

Keywords：

traditional Chinese medicine; Evidence-based research; National Natural Science Foundation of China; Project application; Project funding

DOI：

10.7507/1672-2531.201912044

Video：

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This paper introduces the application and funding of evidence-based research projects on traditional Chinese medicine (TCM) of the National Natural Science Foundation of China (NSFC) in 2019 in terms of clinical research and methodology research, summarizes the primary problems existing in evidence-based research on TCM, discusses the quality of evidence-based research on TCM in clinical research, highlights the characteristics of TCM and reveals the evidence-based methodology on TCM.

Citation： JIANG Jing, SHEN Li, LI Weidong, YAN Qianhua, LIU Qi, CUI Shuna, BI Minggang. Situation of application and funding of evidenced-based research projects on traditional Chinese medicine (TCM) of National Natural Science Foundation of China in 2019. Chinese Journal of Evidence-Based Medicine, 2020, 20(6): 628-633. doi: 10.7507/1672-2531.201912044 Copy

1.	Djulbegovic B, Guyatt GH. Progress in evidence-based medicine: a quarter century on. Lancet, 2017, 390(10092): 415-423.
2.	Tenny S, Varacallo M. Evidence Based Medicine. Treasure Island: StatPearls Publishing, 2020.
3.	张俊华, 李幼平, 张伯礼. 循证中医药学: 理论与实践. 中国中药杂志, 2018, 43(1): 1-7.
4.	张俊华, 孙鑫, 李幼平, 等. 循证中医药学的现在和未来. 中国循证医学杂志, 2019, 19(5): 515-520.
5.	荀杨芹, 成鹏, 李秀霞, 等. 中国临床路径的证据来源调查. 中国循证医学杂志, 2018, 18(10): 1032-1036.
6.	刘建平. 循证中医药临床研究方法. 北京: 人民卫生出版社, 2015.
7.	《2019 年度国家自然科学基金项目指南》编辑委员会. 2019 年度国家自然科学基金项目指南. Aaviable from: http://www.nsfc.gov.cn/nsfc/cen/xmzn/2019xmzn/index.html.
8.	de Vet HC, Verhagen AP, Logghe I, et al. Literature research: aims and design of systematic reviews. Aust J Physiother, 2005, 51(2): 125-128.
9.	张俊华, 孙鑫. 循证中医药学. 上海: 上海科学技术出版社, 2018.
10.	胡嘉元, 赵晨, 田然, 等. 中医药临床研究报告规范体系研究. 中国循证医学杂志, 2018, 18(11): 1151-1157.
11.	张晓雨, 陈诗琪, 李承羽, 等. 循证中医药学理论研究与应用实践. 中国循证医学杂志, 2018, 18(1): 86-91.
12.	费菲, 刘姗姗. 张伯礼: 以循证医学的方法学推动中医药研究国际化. 中国医药科学, 2015, 5(17): 1-3.
13.	Whitehead AL, Sully BG, Campbell MJ. Pilot and feasibility studies: is there a difference from each other and from a randomised controlled trial? Contemp Clin Trials, 2014, 38(1): 130-133.
14.	张泽, 李博. 基于循证医学谈中医药临床试验的现状和对策. 广州中医药大学学报, 2015, 32(5): 946-948+959.
15.	Hróbjartsson A, Emanuelsson F, Skou TAS, et al. Bias due to lack of patient blinding in clinical trials. A systematic review of trials randomizing patients to blind and nonblind sub-studies. Int J Epidemiol, 2014, 43(4): 1272-1283.
16.	Page SJ, Persch AC. Recruitment, retention, and blinding in clinical trials. Am J Occup Ther, 2013, 67(2): 154-161.
17.	张颖, 贾丽燕, 邵建柱, 等. 中医药临床研究中实施盲法的原则, 问题和评价. 北京中医药, 2018, 37(12): 1159-1162.
18.	王丽琼, 李青, 苏春香, 等. 中医药随机对照试验中盲法的应用与评价. 中医杂志, 2014, 55(1): 28-33.
19.	Kube T, Rief W. Are placebo and drug-specific effects additive? Questioning basic assumptions of double-blinded randomized clinical trials and presenting novel study designs. Drug Discov Today, 2017, 22(4): 729-735.
20.	韩春雯, 李海昌, 温成平, 等. 中医药随机对照临床试验安慰剂选择的探讨. 中华中医药杂志, 2014, 29(4): 1165-1167.
21.	黄珊珊. 安慰剂在中医药临床研究中的应用原则探讨. 北京: 北京中医药大学, 2018.
22.	刘丽辉, 李国信. 中医药临床疗效评价方法研究进展. 实用中医内科杂志, 2013, 27(1): 151-152.
23.	Porcino AJ, Punja S, Chan AW, et al. Protocol for a systematic review of N-of-1 trial protocol guidelines and protocol reporting guidelines. Syst Rev, 2017, 6(1): 132.
24.	井含光, 孟庆刚. 单病例随机对照试验在中医药临床疗效评价中的应用与思考. 北京中医药大学学报, 2018, 41(10): 842-847.
25.	朱文慧, 孟庆刚. 单病例随机对照试验的周期设计在中医药临床疗效评价中的应用研究. 中华中医药学刊, 2018, 36(10): 2509-2512.
26.	薛晶晶, 杨佩兰, 王洁, 等. 评价中医个体化治疗: 单病例随机对照试验的初步研究. 循证医学, 2016, 16(2): 103-108.
27.	Margolis A, Giuliano C. Making the switch: From case studies to N-of-1 trials. Epilepsy Behav Rep, 2019, 12: 100336.
28.	岗卫娟, 孟醒, 景向红. 临床试验中针刺方案充分性评价: 现状与建议. 中国针灸, 2019, 39(3): 229-233.
29.	丁乐, 杨人泽. 中医药疗效评价的特殊性及建议. 中华中医药杂志, 2016, 31(11): 4399-4401.
30.	陶立元, 刘珏, 商洪才. 中医药疗效评价研究热点的双向聚类计量学分析. 世界中医药, 2019, 14(10): 2568-2572.
31.	赵鑫, 王阶, 陈光. 循证医学理论与传统中医临床疗效评价. 中华中医药杂志, 2019, 34(8): 3362-3365.
32.	陈智慧, 裴宇鹏, 关红阳, 等. 中医药临床疗效评价量表临床疗效判定阈值研究的构想. 中华中医药学刊, 2019, 37(6): 1342-1344.

1. Djulbegovic B, Guyatt GH. Progress in evidence-based medicine: a quarter century on. Lancet, 2017, 390(10092): 415-423.
2. Tenny S, Varacallo M. Evidence Based Medicine. Treasure Island: StatPearls Publishing, 2020.
3. 张俊华, 李幼平, 张伯礼. 循证中医药学: 理论与实践. 中国中药杂志, 2018, 43(1): 1-7.
4. 张俊华, 孙鑫, 李幼平, 等. 循证中医药学的现在和未来. 中国循证医学杂志, 2019, 19(5): 515-520.
5. 荀杨芹, 成鹏, 李秀霞, 等. 中国临床路径的证据来源调查. 中国循证医学杂志, 2018, 18(10): 1032-1036.
6. 刘建平. 循证中医药临床研究方法. 北京: 人民卫生出版社, 2015.
7. 《2019 年度国家自然科学基金项目指南》编辑委员会. 2019 年度国家自然科学基金项目指南. Aaviable from: http://www.nsfc.gov.cn/nsfc/cen/xmzn/2019xmzn/index.html.
8. de Vet HC, Verhagen AP, Logghe I, et al. Literature research: aims and design of systematic reviews. Aust J Physiother, 2005, 51(2): 125-128.
9. 张俊华, 孙鑫. 循证中医药学. 上海: 上海科学技术出版社, 2018.
10. 胡嘉元, 赵晨, 田然, 等. 中医药临床研究报告规范体系研究. 中国循证医学杂志, 2018, 18(11): 1151-1157.
11. 张晓雨, 陈诗琪, 李承羽, 等. 循证中医药学理论研究与应用实践. 中国循证医学杂志, 2018, 18(1): 86-91.
12. 费菲, 刘姗姗. 张伯礼: 以循证医学的方法学推动中医药研究国际化. 中国医药科学, 2015, 5(17): 1-3.
13. Whitehead AL, Sully BG, Campbell MJ. Pilot and feasibility studies: is there a difference from each other and from a randomised controlled trial? Contemp Clin Trials, 2014, 38(1): 130-133.
14. 张泽, 李博. 基于循证医学谈中医药临床试验的现状和对策. 广州中医药大学学报, 2015, 32(5): 946-948+959.
15. Hróbjartsson A, Emanuelsson F, Skou TAS, et al. Bias due to lack of patient blinding in clinical trials. A systematic review of trials randomizing patients to blind and nonblind sub-studies. Int J Epidemiol, 2014, 43(4): 1272-1283.
16. Page SJ, Persch AC. Recruitment, retention, and blinding in clinical trials. Am J Occup Ther, 2013, 67(2): 154-161.
17. 张颖, 贾丽燕, 邵建柱, 等. 中医药临床研究中实施盲法的原则, 问题和评价. 北京中医药, 2018, 37(12): 1159-1162.
18. 王丽琼, 李青, 苏春香, 等. 中医药随机对照试验中盲法的应用与评价. 中医杂志, 2014, 55(1): 28-33.
19. Kube T, Rief W. Are placebo and drug-specific effects additive? Questioning basic assumptions of double-blinded randomized clinical trials and presenting novel study designs. Drug Discov Today, 2017, 22(4): 729-735.
20. 韩春雯, 李海昌, 温成平, 等. 中医药随机对照临床试验安慰剂选择的探讨. 中华中医药杂志, 2014, 29(4): 1165-1167.
21. 黄珊珊. 安慰剂在中医药临床研究中的应用原则探讨. 北京: 北京中医药大学, 2018.
22. 刘丽辉, 李国信. 中医药临床疗效评价方法研究进展. 实用中医内科杂志, 2013, 27(1): 151-152.
23. Porcino AJ, Punja S, Chan AW, et al. Protocol for a systematic review of N-of-1 trial protocol guidelines and protocol reporting guidelines. Syst Rev, 2017, 6(1): 132.
24. 井含光, 孟庆刚. 单病例随机对照试验在中医药临床疗效评价中的应用与思考. 北京中医药大学学报, 2018, 41(10): 842-847.
25. 朱文慧, 孟庆刚. 单病例随机对照试验的周期设计在中医药临床疗效评价中的应用研究. 中华中医药学刊, 2018, 36(10): 2509-2512.
26. 薛晶晶, 杨佩兰, 王洁, 等. 评价中医个体化治疗: 单病例随机对照试验的初步研究. 循证医学, 2016, 16(2): 103-108.
27. Margolis A, Giuliano C. Making the switch: From case studies to N-of-1 trials. Epilepsy Behav Rep, 2019, 12: 100336.
28. 岗卫娟, 孟醒, 景向红. 临床试验中针刺方案充分性评价: 现状与建议. 中国针灸, 2019, 39(3): 229-233.
29. 丁乐, 杨人泽. 中医药疗效评价的特殊性及建议. 中华中医药杂志, 2016, 31(11): 4399-4401.
30. 陶立元, 刘珏, 商洪才. 中医药疗效评价研究热点的双向聚类计量学分析. 世界中医药, 2019, 14(10): 2568-2572.
31. 赵鑫, 王阶, 陈光. 循证医学理论与传统中医临床疗效评价. 中华中医药杂志, 2019, 34(8): 3362-3365.
32. 陈智慧, 裴宇鹏, 关红阳, 等. 中医药临床疗效评价量表临床疗效判定阈值研究的构想. 中华中医药学刊, 2019, 37(6): 1342-1344.

Chinese Journal of Evidence-Based Medicine

Situation of application and funding of evidenced-based research projects on traditional Chinese medicine (TCM) of National Natural Science Foundation of China in 2019

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