难治性癫痫合并语言障碍的生酮饮食治疗_Journal of Epilepsy

Authors：

 查剑 , 曾兴颖 ,  钟建民

江西省儿童医院神经内科(南昌, 330006);

Corresponding author：

钟建民, Email: zhongjm@163.com

Keywords：

难治性癫痫; 语言障碍; 生酮饮食

DOI：

10.7507/2096-0247.20160077

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

生酮饮食(Ketogenic diet, KD)疗法有近100多年的历史, 是一种高脂肪, 低碳水化合物, 合适的蛋白及营养素的配方饮食疗法, 目前被广泛运用到难治性癫痫的治疗当中, 取得了一定的疗效。越来越多的研究证据表明KD对难治性癫痫患者的认知功能的改善有一定的促进作用; 甚至有些病例癫痫发作控制不理想, 患者的语言功能和(或)运动功能也能得到一定的改善。KD治疗难治性癫痫的机制尚未完全明确, 但其疗效已被大量的研究证实; 对于癫痫所致语言障碍方面的生酮饮食治疗方面文献较少, 目前尚缺乏共识性的诊断和疗效判断标准。现就难治性癫痫合并语言障碍的定义及评价标准、癫痫和语言障碍的关系, 以及近年来KD对癫痫伴发语言障碍的治疗作用进展作一综述。

Citation： 查剑, 曾兴颖, 钟建民. 难治性癫痫合并语言障碍的生酮饮食治疗. Journal of Epilepsy, 2016, 2(5): 429-432. doi: 10.7507/2096-0247.20160077 Copy

1.	梁卫兰.儿童言语和语言障碍的诊断与治疗.中国儿童保健杂志, 2011, 19(10):876-877.
2.	章依文.语言与言语障碍的发病机理、诊断与防治.中国儿童保健杂志, 2011, 19(10):878-880.
3.	陈敏, 华丽, 郝燕, 等. MRI在儿童语言发育迟缓中的应用.放射学实践, 2014, 29(12):1468-1470.
4.	梁巍.语言障碍的分类与界定.中国听力语言康复科学杂志, 2011, 9(1):59-61.
5.	Myklebust H. Minimal Brain Damage in Children:Final Report. Neurological and Sensory Disease Control Program.Washington DC:Department of Health, Education, and Welfare, 1969.
6.	王贞, 李胜利.不同儿童语言障碍特点及主要相关因素.中国康复理论与实践, 2013, 19(6):536-540.
7.	刘巧云, 张艳丽, 黄昭鸣.儿童词汇语义发展特点及其对听障儿童康复的启示.中国听力语言康复科学杂志, 2015, 13(3):226-229.
8.	刘晓, 金星明.婴幼儿语言发育研究进展.临床儿科杂志, 2006, 24(3):234-235.
9.	章依文, 金星明, 沈晓明, 等.2~3岁儿童词汇和语法发展的多因素研究.中华儿科杂志, 2002, 40(11):646-649.
10.	潘虹地, 赵亚茹.儿童发育性语言障碍的研究现状.国际儿科学杂志, 2012, 39(4):387-389.
11.	Shriberg LD, Tomblin JB, McSweeny JL. Prevalence of speech delay in 6-year old children and comorbidity with language impairment. J Speech Lang Hear Res, 1999, 42(6):1461-1481.
12.	Allen DA, Rapin I, Wizhitzer M. Communication disorders of preschool children:the physician's responsibility. J Dev Behav Peds, 1998, 9(3):164-170.
13.	Parry-Fielder B, Nolan TM, Collins KJ, et al. Developmental language disorders and epilepsy. J Paediatr Child Health, 1997, 33(4):277-280.
14.	Bartha-Doering L, Trinka E.The interictal language profile in adult epilepsy. Epilepsia, 2014, 55(10):1512-1525.
15.	Caplan R, Siddarth P, Vona P, et al. Language in pediatric epilepsy. Epilepsia, 2009, 50(11):2397-2407.
16.	Hermann B, Seidenberg M, Bell B, et al. The neurodevelopmental impact of childhood-onset temporal lobe epilepsy on brain structure and function. Epilepsia, 2002, 43(9):1062-1071.
17.	Helmstaedter C, Reuber M, Elger CC. Interaction of cognitive aging and memory deficits related to epilepsy surgery. AnnNeurol, 2002, 52(1):89-94.
18.	于萍.儿童言语和语言障碍的研究现状.中华耳科学杂志, 2013, 11(3):408-512.
19.	Sepeta LN, Croft LJ, Zimmaro LA, et al. Reduced language connectivity in pediatric epilepsy. Epilepsia, 2015, 56(2):273-282.
20.	Debiais S, Tuller L, Barthez MA, et al. Epilepsy and language development:the continuous spike-waves during slow sleep syndrome. Epilepsia, 2007, 48(6):1104-1110.
21.	Turner SJ, Morgan AT, Perez ER, et al. New genes for focal epilepsies with speech and language disorders. Curr Neurol Neurosci Rep, 2015, 15(6):35-47.
22.	Wheless JW. History and Origin of the Ketogenic Diet In Stafstrom CE, Rho JM.Epilepsy and the Ketogenic Diet. Totowa:Humana Press, 2004:31-50.
23.	Danial NN, Hartman AL, Stafstrom CE, et al. How does the ketogenic diet work? Four potential mechanisms. Journal of Child Neurology, 2013, 28(8):1027-1033.
24.	Kossoff EH, Pyzik PL, Mcgrogan JR, et al. Efficacy of the ketogenic diet for infantile spasms. Pediatrics, 2002, 109(5):780-783.
25.	费凌霞, 李花, 胡湘蜀, 等. 22例难治性癫痫患儿生酮饮食治疗前后的脑电图分析.癫痫与神经电生理学杂志, 2012, 21(4):220-223.
26.	Lambrechts DA, Bovens MJ, de la Parra NM, et al. Ketogenic diet effects on cognition, mood, and psychosocial adjustment in children. Acta Neurologica Scandinavica, 2013, 127(2):103-108.
27.	郭超凡, 陈建庭, 朱青安.生酮饮食在神经系统疾病治疗中的应用.中华神经医学杂志, 2015, 14(3):306-309.

1. 梁卫兰.儿童言语和语言障碍的诊断与治疗.中国儿童保健杂志, 2011, 19(10):876-877.
2. 章依文.语言与言语障碍的发病机理、诊断与防治.中国儿童保健杂志, 2011, 19(10):878-880.
3. 陈敏, 华丽, 郝燕, 等. MRI在儿童语言发育迟缓中的应用.放射学实践, 2014, 29(12):1468-1470.
4. 梁巍.语言障碍的分类与界定.中国听力语言康复科学杂志, 2011, 9(1):59-61.
5. Myklebust H. Minimal Brain Damage in Children:Final Report. Neurological and Sensory Disease Control Program.Washington DC:Department of Health, Education, and Welfare, 1969.
6. 王贞, 李胜利.不同儿童语言障碍特点及主要相关因素.中国康复理论与实践, 2013, 19(6):536-540.
7. 刘巧云, 张艳丽, 黄昭鸣.儿童词汇语义发展特点及其对听障儿童康复的启示.中国听力语言康复科学杂志, 2015, 13(3):226-229.
8. 刘晓, 金星明.婴幼儿语言发育研究进展.临床儿科杂志, 2006, 24(3):234-235.
9. 章依文, 金星明, 沈晓明, 等.2~3岁儿童词汇和语法发展的多因素研究.中华儿科杂志, 2002, 40(11):646-649.
10. 潘虹地, 赵亚茹.儿童发育性语言障碍的研究现状.国际儿科学杂志, 2012, 39(4):387-389.
11. Shriberg LD, Tomblin JB, McSweeny JL. Prevalence of speech delay in 6-year old children and comorbidity with language impairment. J Speech Lang Hear Res, 1999, 42(6):1461-1481.
12. Allen DA, Rapin I, Wizhitzer M. Communication disorders of preschool children:the physician's responsibility. J Dev Behav Peds, 1998, 9(3):164-170.
13. Parry-Fielder B, Nolan TM, Collins KJ, et al. Developmental language disorders and epilepsy. J Paediatr Child Health, 1997, 33(4):277-280.
14. Bartha-Doering L, Trinka E.The interictal language profile in adult epilepsy. Epilepsia, 2014, 55(10):1512-1525.
15. Caplan R, Siddarth P, Vona P, et al. Language in pediatric epilepsy. Epilepsia, 2009, 50(11):2397-2407.
16. Hermann B, Seidenberg M, Bell B, et al. The neurodevelopmental impact of childhood-onset temporal lobe epilepsy on brain structure and function. Epilepsia, 2002, 43(9):1062-1071.
17. Helmstaedter C, Reuber M, Elger CC. Interaction of cognitive aging and memory deficits related to epilepsy surgery. AnnNeurol, 2002, 52(1):89-94.
18. 于萍.儿童言语和语言障碍的研究现状.中华耳科学杂志, 2013, 11(3):408-512.
19. Sepeta LN, Croft LJ, Zimmaro LA, et al. Reduced language connectivity in pediatric epilepsy. Epilepsia, 2015, 56(2):273-282.
20. Debiais S, Tuller L, Barthez MA, et al. Epilepsy and language development:the continuous spike-waves during slow sleep syndrome. Epilepsia, 2007, 48(6):1104-1110.
21. Turner SJ, Morgan AT, Perez ER, et al. New genes for focal epilepsies with speech and language disorders. Curr Neurol Neurosci Rep, 2015, 15(6):35-47.
22. Wheless JW. History and Origin of the Ketogenic Diet In Stafstrom CE, Rho JM.Epilepsy and the Ketogenic Diet. Totowa:Humana Press, 2004:31-50.
23. Danial NN, Hartman AL, Stafstrom CE, et al. How does the ketogenic diet work? Four potential mechanisms. Journal of Child Neurology, 2013, 28(8):1027-1033.
24. Kossoff EH, Pyzik PL, Mcgrogan JR, et al. Efficacy of the ketogenic diet for infantile spasms. Pediatrics, 2002, 109(5):780-783.
25. 费凌霞, 李花, 胡湘蜀, 等. 22例难治性癫痫患儿生酮饮食治疗前后的脑电图分析.癫痫与神经电生理学杂志, 2012, 21(4):220-223.
26. Lambrechts DA, Bovens MJ, de la Parra NM, et al. Ketogenic diet effects on cognition, mood, and psychosocial adjustment in children. Acta Neurologica Scandinavica, 2013, 127(2):103-108.
27. 郭超凡, 陈建庭, 朱青安.生酮饮食在神经系统疾病治疗中的应用.中华神经医学杂志, 2015, 14(3):306-309.

Previous Article
立体定向脑电图引导下射频热凝术治疗局灶性癫痫研究进展
Next Article
神经元中活动依赖的批量内吞作用的分子机制

Journal of Epilepsy

难治性癫痫合并语言障碍的生酮饮食治疗

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content