神经元中活动依赖的批量内吞作用的分子机制_Journal of Epilepsy

Authors：

 周继秀 ,  肖争

重庆医科大学附属第一医院神经内科(重庆, 400016);

Corresponding author：

肖争, Email: xiaozhenghf@126.com

Keywords：

活动依赖的批量内吞作用; 内吞作用; 囊泡循环; 癫痫

DOI：

10.7507/2096-0247.20160078

Video：

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神经元之间的信息传递是通过突触囊泡释放神经递质实现的, 是大脑功能行使的重要环节。神经元的内吞作用可以回收经胞吐作用释放的神经递质, 补充消耗的突触囊泡; 神经末梢内高效的突触囊泡胞吞-胞吐循环对神经元之间持续的信息传递至关重要。目前研究已经发现4种内吞作用:网格蛋白介导的内吞作用、kiss-and-run、活动依赖的批量内吞作用以及超速内吞作用。它们能满足神经元在不同活动状态下对突触囊泡的需求, 现主要总结在神经元中活动依赖的批量内吞作用的分子机制及其与癫痫的关系。

Citation： 周继秀, 肖争. 神经元中活动依赖的批量内吞作用的分子机制. Journal of Epilepsy, 2016, 2(5): 433-436. doi: 10.7507/2096-0247.20160078 Copy

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11.	Morton A, Marland JRK, Cousin MA. Synaptic vesicle exocytosis and increased cytosolic calcium are both necessary but not sufficient for activity-dependent bulk endocytosis. Journal of Neurochemistry, 2015, 134(3):405-415.
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15.	Cheung G, Jupp OJ, Cousin MA. Activity-dependent bulk endocytosis and clathrin-dependent endocytosis replenish specific synaptic vesicle pools in central nerve terminals. The Journal of Neuroscience, 2010, 30(24):8151-8161.
16.	Voglmaier SM, Kam K, Yang H, et al. Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling. Neuron, 2006, 51(1):71-84.
17.	Kim SH, Ryan TA. Synaptic vesicle recycling at CNS synapses without AP-2. The Journal of Neuroscience, 2009, 29(12):3865-3874.
18.	Kokotos AC, Cousin MA. Synaptic vesicle generation from central nerve terminal endosomes. Traffic, 2015, 16(3):229-240.
19.	Cheung G, Cousin MA. Adaptor protein complexes 1 and 3 are essential for generation of synaptic vesicles from activity-dependent bulk endosomes. The Journal of Neuroscience, 2012, 32(17):6014-6023.
20.	Cheung G, Cousin MA. Synaptic vesicle generation from activity-dependent bulk endosomes requires calcium and calcineurin. The Journal of Neuroscience, 2013, 33(8):3370-3379.
21.	Wu Y, TO'Toole E, Girard M, et al. A dynamin 1-, dynamin 3-and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis. Elife, 2014, 3:e01621.
22.	Nicholson-Fish JC, Kokotos AC, Gillingwater TH, et al. VAMP4 Is an Essential cargo molecule for activity-dependent bulk endocytosis. Neuron, 2015, 88(5):973-984.
23.	Watanabe S, Rost BR, Camacho-Pérez M, et al. Ultrafast endocytosis at mouse hippocampal synapses. Nature, 2013, 504(7479):242-247.
24.	Saheki Y, De Camilli P. Synaptic vesicle endocytosis. Cold Spring Harbor Perspectives in Biology, 2012, 4(9):a005645.
25.	Wang C, Wang Y, Hu M, et al. Synaptotagmin-11 inhibits clathrin-mediated and bulk endocytosis. EMBO Reports, 2016, 17(1):47-63.
26.	Marland JRK, Smillie KJ, Cousin MA. Synaptic vesicle recycling is unaffected in the Ts65Dn mouse model of down syndrome. PloS One, 2016, 11(1):e0147974.

1. Cremona O, De Camilli P. Synaptic vesicle endocytosis. Current Opinion in Neurobiology, 1997, 7(3):323-330.
2. Clayton EL, Cousin MA. The molecular physiology of activity-dependent bulk endocytosis of synaptic vesicles. Journal of Neurochemistry, 2009, 111(4):901-914.
3. Cousin MA. Activity-dependent bulk synaptic vesicle endocytosis-a fast, high capacity membrane retrieval mechanism. Molecular Neurobiology, 2009, 39(3):185-189.
4. Watanabe S, Liu Q, Davis MW, et al. Ultrafast endocytosis at Caenorhabditis elegans neuromuscular junctions. Elife, 2013, 2(9):e00723.
5. He L, Wu LG. The debate on the kiss-and-run fusion at synapses. Trends in Neurosciences, 2007, 30(9):447-455.
6. Clayton EL, Evans GJO, Cousin MA. Bulk synaptic vesicle endocytosis is rapidly triggered during strong stimulation. The Journal of Neuroscience, 2008, 28(26):6627-6632.
7. Miller TM, Heuser JE. Endocytosis of synaptic vesicle membrane at the frog neuromuscular junction. The Journal of Cell Biology, 1984, 98(2):685-698.
8. Wenzel EM, Morton A, Ebert K, et al. Key physiological parameters dictate triggering of activity-dependent bulk endocytosis in hippocampal synapses. PloS One, 2012, 7(6):e38188.
9. Evans GJO, Cousin MA. Activity-dependent control of slow synaptic vesicle endocytosis by cyclin-dependent kinase 5. The Journal of Neuroscience, 2007, 27(2):401-411.
10. Clayton EL, Sue N, Smillie KJ, et al. Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles. Nature Neuroscience, 2010, 13(7):845-851.
11. Morton A, Marland JRK, Cousin MA. Synaptic vesicle exocytosis and increased cytosolic calcium are both necessary but not sufficient for activity-dependent bulk endocytosis. Journal of Neurochemistry, 2015, 134(3):405-415.
12. Ferguson SM, De Camilli P. Dynamin, a membrane-remodelling GTPase. Nature Reviews Molecular Cell Biology, 2012, 13(2):75-88.
13. Clayton EL, Anggono V, Smillie KJ, et al. The phospho-dependent dynamin-syndapin interaction triggers activity-dependent bulk endocytosis of synaptic vesicles. The Journal of Neuroscience, 2009, 29(24):7706-7717.
14. Smillie KJ, Cousin MA. Akt/PKB Controls the activity-dependent bulk endocytosis of synaptic vesicles. Traffic, 2012, 13(7):1004-1011.
15. Cheung G, Jupp OJ, Cousin MA. Activity-dependent bulk endocytosis and clathrin-dependent endocytosis replenish specific synaptic vesicle pools in central nerve terminals. The Journal of Neuroscience, 2010, 30(24):8151-8161.
16. Voglmaier SM, Kam K, Yang H, et al. Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling. Neuron, 2006, 51(1):71-84.
17. Kim SH, Ryan TA. Synaptic vesicle recycling at CNS synapses without AP-2. The Journal of Neuroscience, 2009, 29(12):3865-3874.
18. Kokotos AC, Cousin MA. Synaptic vesicle generation from central nerve terminal endosomes. Traffic, 2015, 16(3):229-240.
19. Cheung G, Cousin MA. Adaptor protein complexes 1 and 3 are essential for generation of synaptic vesicles from activity-dependent bulk endosomes. The Journal of Neuroscience, 2012, 32(17):6014-6023.
20. Cheung G, Cousin MA. Synaptic vesicle generation from activity-dependent bulk endosomes requires calcium and calcineurin. The Journal of Neuroscience, 2013, 33(8):3370-3379.
21. Wu Y, TO'Toole E, Girard M, et al. A dynamin 1-, dynamin 3-and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis. Elife, 2014, 3:e01621.
22. Nicholson-Fish JC, Kokotos AC, Gillingwater TH, et al. VAMP4 Is an Essential cargo molecule for activity-dependent bulk endocytosis. Neuron, 2015, 88(5):973-984.
23. Watanabe S, Rost BR, Camacho-Pérez M, et al. Ultrafast endocytosis at mouse hippocampal synapses. Nature, 2013, 504(7479):242-247.
24. Saheki Y, De Camilli P. Synaptic vesicle endocytosis. Cold Spring Harbor Perspectives in Biology, 2012, 4(9):a005645.
25. Wang C, Wang Y, Hu M, et al. Synaptotagmin-11 inhibits clathrin-mediated and bulk endocytosis. EMBO Reports, 2016, 17(1):47-63.
26. Marland JRK, Smillie KJ, Cousin MA. Synaptic vesicle recycling is unaffected in the Ts65Dn mouse model of down syndrome. PloS One, 2016, 11(1):e0147974.

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