刺激诱发出的脑电异常对重症患者脑功能的临床意义_Journal of Epilepsy

Authors：

王越 ^1,2 , 杨华俊 ^1,2 , 刘丽萍 ^1,2 ,  王群 ^1,2

1. ;
2. ;

Corresponding author：

王群, Email: qwang64@163.com

Keywords：

刺激诱发出的脑电异常; 连续脑电图监测; 神经重症患者

DOI：

10.7507/2096-0247.20170065

Video：

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刺激诱发出的节律性、周期性或者发作期放电(Stimulus-induced rhythmic，periodic，or ictal discharges，SIRPIDs)是Hirsch等在2004年首次命名的一种脑电现象，在意识障碍或者昏迷患者的长程脑电监测中所得。SIRPIDs机制可能与皮层下-皮层功能异常相关，尤其与丘脑皮层回路功能异常相关。但目前研究对于这一现象的病理生理学机制不甚明确。部分研究认为出现这一脑电现象提示患者预后较差，但从现有研究来看，该异常脑电活动能否引起神经损伤，或者这些异常是否仅仅为脑损伤严重的表现，以及是否需要药物干预治疗，临床中尚无法确定。文章目的是综述现有的文献了解SIRPIDs的概念、病理生理学机制、临床相关性，以及其对于神经重症患者脑功能的提示。

Citation： 王越, 杨华俊, 刘丽萍, 王群. 刺激诱发出的脑电异常对重症患者脑功能的临床意义. Journal of Epilepsy, 2017, 3(5): 414-418. doi: 10.7507/2096-0247.20170065 Copy

1.	Hirsch LJ, Claassen J, Mayer SA, et al. Stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs): a common EEG phenomenon in the critically ill.Epilepsia, 2004, 45(2): 109-123.
2.	Hirsch LJ, LaRoche SM, Gaspard N, et al. American clinical neurophysiology society's standardized critical care EEG terminology: 2012 version.Clin Neurophysiol, 2013, 30(1): 1-27.
3.	Hirsch JL, Pang T, Claassen J, et al. Focal motor seizures induced by alerting stimuli in critically ill patients.Epilepsia, 2008, 49(6): 968-973.
4.	Steriade M.Arousal: revisiting the reticular activating system.Science 1996, 272(5259): 225-226.
5.	Steriade M.Corticothalamic resonance, states of vigilance and mentation.Neuroscience, 2000, 101(2): 243-276.
6.	Steriade M.Synchronized activities of coupled oscillators in the cerebral cortex and thalamus at different levels of vigilance.Cereb Cortex, 1997, 7(6): 583-604.
7.	Anzelloti F, Franciotti R, Onofrj M.Stimulus aborted periodic epileptiform discharges: a case description and possible relationship with stimulus induced discharges.Epilepsy Res, 2013, 105(1-2): 256-259.
8.	Zeiler SR, Turtzo LC, Kaplan PW.SPECT-negative SIRPIDs argues against treatment as seizures.ClinNeurophysiol, 2011, 28(5): 493-496.
9.	Smith CC, Tatum WO, Gupta V, et al. SPECT-negative SIRPIDs: less aggressive neurointensive care.ClinNeurophysiol, 2014, 31(3): e6-e10.
10.	Alvarez V, Oddo M, Rossetti AO.Stimulus-induced rhythmic, periodic or ictal discharges (SIRPIDs) in comatose survivors of cardiac arrest: characteristics and prognostic value.Clin Neurophysiol, 2013, 124(1): 204-208.
11.	Fluri F, Balestra G, Christ M, et al. Stimulus-induced rhythmic, periodic or ictal discharges (SIRPIDs) elicited by stimulating exclusively the ophthalmic nerve.Clin Neurophysiol, 2008, 119(8): 1934-1938.
12.	Nascimento FA, Borlot F, Aljaafari D, et al. Search for epileptiform electroencephalogram activity by external stimulation in critically ill patients.Can J Neurol Sci 2016, 43(5): 710-712.
13.	Tjepkema-Cloostermans MC, Wijers ET, van Putten MJ.Stimulus induced bursts in severe postanoxic encephalopathy.Clin Neurophysiol, 2016, 127(11): 3492-3497.
14.	Chatrian G, Shaw C, Leffman H.The significance of periodic lateralized epileptiform discharges in EEG: an electrographic, clinical and pathological study.Electroencephalogr Clin Neurophysiol, 1964, 17: 177-193.
15.	Fisch BJ, Klass DW.The diagnostic specificity of triphasic wave patterns.Electroencephalogr Clin Neurophysiol, 1988, 70(1): 1-8.
16.	Fernandez-Torre JL, Hernández-Hernández MA.Acute stimulus-sensitive postanoxic myoclonus: the importance of sensory stimulation in comatose patients.Clin EEG Neurosci, 2012, 43(4): 312-314.
17.	Koutroumanidis M, Tsatsou K, Bonakis A, et al. Stimulus-induced bilateral central periodic discharges, cortical myoclonus and arousal responses in mild reversible coma.Clin Neurophysiol, 2008, 119(11): 2459-2464.
18.	Rossetti AO, Dunand M.Creutzfeldt-Jakob disease: evolution from nonconvulsive status epilepticus, through SIRPIDs, to generalized periodic discharges.Clin Neurophysiol, 2007, 118(11): 2533-2538.
19.	Emily J, Yousef H, Nirma CM, et al. Cefepime-associated SIRPIDs in a patient with normal renal function.The Neurohospitalist, 2016, 6(4): 167-169.
20.	Murphy MM.SlRPIDs: a case study.Am J END Technol, 2006, 46(2): 159-164.
21.	Ong C, Gilmore E, Claassen J, et al. Impact of prolonged periodic epileptiform discharges on coma prognosis.Neurocrit Care, 2012, 17(1): 39-44.
22.	van Straten AF, Fesler JR, Hakimi R, et al. SIRPIDs: Prevalence and outcome in critically ill patients.Clin Neurophysiol, 2014, 31(5): 418-421.
23.	Braksick SA, Burkholder DB, Tsetsou S, et al. Associated factors and prognostic implications of stimulus-induced rhythmic, periodic, or ictal discharges.JAMA Neurology.2016, 73(5): 585-590.
24.	Chong DJ, Hirsch LJ.Which EEG patterns warrant treatment in the critically ill Reviewing the evidence for treatment of periodic epileptiform discharges and related patterns.Clin Neurophysiol, 2005, 22(2): 79-91.

1. Hirsch LJ, Claassen J, Mayer SA, et al. Stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs): a common EEG phenomenon in the critically ill.Epilepsia, 2004, 45(2): 109-123.
2. Hirsch LJ, LaRoche SM, Gaspard N, et al. American clinical neurophysiology society's standardized critical care EEG terminology: 2012 version.Clin Neurophysiol, 2013, 30(1): 1-27.
3. Hirsch JL, Pang T, Claassen J, et al. Focal motor seizures induced by alerting stimuli in critically ill patients.Epilepsia, 2008, 49(6): 968-973.
4. Steriade M.Arousal: revisiting the reticular activating system.Science 1996, 272(5259): 225-226.
5. Steriade M.Corticothalamic resonance, states of vigilance and mentation.Neuroscience, 2000, 101(2): 243-276.
6. Steriade M.Synchronized activities of coupled oscillators in the cerebral cortex and thalamus at different levels of vigilance.Cereb Cortex, 1997, 7(6): 583-604.
7. Anzelloti F, Franciotti R, Onofrj M.Stimulus aborted periodic epileptiform discharges: a case description and possible relationship with stimulus induced discharges.Epilepsy Res, 2013, 105(1-2): 256-259.
8. Zeiler SR, Turtzo LC, Kaplan PW.SPECT-negative SIRPIDs argues against treatment as seizures.ClinNeurophysiol, 2011, 28(5): 493-496.
9. Smith CC, Tatum WO, Gupta V, et al. SPECT-negative SIRPIDs: less aggressive neurointensive care.ClinNeurophysiol, 2014, 31(3): e6-e10.
10. Alvarez V, Oddo M, Rossetti AO.Stimulus-induced rhythmic, periodic or ictal discharges (SIRPIDs) in comatose survivors of cardiac arrest: characteristics and prognostic value.Clin Neurophysiol, 2013, 124(1): 204-208.
11. Fluri F, Balestra G, Christ M, et al. Stimulus-induced rhythmic, periodic or ictal discharges (SIRPIDs) elicited by stimulating exclusively the ophthalmic nerve.Clin Neurophysiol, 2008, 119(8): 1934-1938.
12. Nascimento FA, Borlot F, Aljaafari D, et al. Search for epileptiform electroencephalogram activity by external stimulation in critically ill patients.Can J Neurol Sci 2016, 43(5): 710-712.
13. Tjepkema-Cloostermans MC, Wijers ET, van Putten MJ.Stimulus induced bursts in severe postanoxic encephalopathy.Clin Neurophysiol, 2016, 127(11): 3492-3497.
14. Chatrian G, Shaw C, Leffman H.The significance of periodic lateralized epileptiform discharges in EEG: an electrographic, clinical and pathological study.Electroencephalogr Clin Neurophysiol, 1964, 17: 177-193.
15. Fisch BJ, Klass DW.The diagnostic specificity of triphasic wave patterns.Electroencephalogr Clin Neurophysiol, 1988, 70(1): 1-8.
16. Fernandez-Torre JL, Hernández-Hernández MA.Acute stimulus-sensitive postanoxic myoclonus: the importance of sensory stimulation in comatose patients.Clin EEG Neurosci, 2012, 43(4): 312-314.
17. Koutroumanidis M, Tsatsou K, Bonakis A, et al. Stimulus-induced bilateral central periodic discharges, cortical myoclonus and arousal responses in mild reversible coma.Clin Neurophysiol, 2008, 119(11): 2459-2464.
18. Rossetti AO, Dunand M.Creutzfeldt-Jakob disease: evolution from nonconvulsive status epilepticus, through SIRPIDs, to generalized periodic discharges.Clin Neurophysiol, 2007, 118(11): 2533-2538.
19. Emily J, Yousef H, Nirma CM, et al. Cefepime-associated SIRPIDs in a patient with normal renal function.The Neurohospitalist, 2016, 6(4): 167-169.
20. Murphy MM.SlRPIDs: a case study.Am J END Technol, 2006, 46(2): 159-164.
21. Ong C, Gilmore E, Claassen J, et al. Impact of prolonged periodic epileptiform discharges on coma prognosis.Neurocrit Care, 2012, 17(1): 39-44.
22. van Straten AF, Fesler JR, Hakimi R, et al. SIRPIDs: Prevalence and outcome in critically ill patients.Clin Neurophysiol, 2014, 31(5): 418-421.
23. Braksick SA, Burkholder DB, Tsetsou S, et al. Associated factors and prognostic implications of stimulus-induced rhythmic, periodic, or ictal discharges.JAMA Neurology.2016, 73(5): 585-590.
24. Chong DJ, Hirsch LJ.Which EEG patterns warrant treatment in the critically ill Reviewing the evidence for treatment of periodic epileptiform discharges and related patterns.Clin Neurophysiol, 2005, 22(2): 79-91.

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